Category: 59734-92-8

Reference of 59734-92-8,Some common heterocyclic compound, 59734-92-8, name is 1-Bromo-2-cyclohexylbenzene, molecular formula is C12H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of CuI (19 mg, 0.10 mmol) and NaI (0.6 g, 4.0 mmol) in pentanol (3 niL) was added (18 mg, 0.2 mmol) and l-bromo-2- cyclohexylbenzene (0.48 g, 2.0 mmol). The mixture was purged for 5 min with argon and heated overnight at reflux. The resulting mixture was purified by silica gel chromatography using hexanes to afford the title compound as clear oil (0.51 g, 90%).[0132] 1H NMR (500 MHz, CDCl3): delta 1.21-1.30 (m, IH), 1.33-1.53 (m, 4H), 1.76-1.90 (m, 5H), 2.77 (tt, J = 11.7, 3.1 Hz, IH), 6.86 (td, J = 7.7, 1.6 Hz, IH), 7.20 (dd, J= 7.8, 1.6 Hz, IH), 7.27 (q, J = 7.5 Hz, IH), 7.81 (d, J = 7.9 Hz, IH)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-cyclohexylbenzene, its application will become more common.

Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59734-92-8, name is 1-Bromo-2-cyclohexylbenzene, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks

A Schlenk tube was charged with Cul (9.6 mg, 0.050 mmol, 5.0 mol%), NaI (300 mg, 2.00 mmol), evacuated and backfilled with argon. Racemic [TRANS-N, N’-DIMETHYL-1,] 2- cyclohexanediamine (16 RL, 0.10 mmol, 10 mol%), 1-bromo-2-cyclohexylbenzene (97% pure; Lancaster; 186 [(IL,] 1.00 mmol), n-pentanol (1 mL) were added under argon. The Schlenk tube was sealed with a Teflon valve and the reaction mixture was stirred at [130 C] for 40 h. The resulting suspension was allowed to reach room temperature and filtered through silica gel (1 x0. 5 cm) eluting with hexane (50 mL). The filtrate was concentrated, and the residue was purified by flash chromatography on silica gel (hexane) to provide the known [1-IODO-2-CYCLOHEXYLBENZENE] (283 mg, 99% yield; ca. 97% pure) as a colorless liquid. [SEE MCGUINE,] T. H.; Dull, M. F. J. Am. [CHEM. SOC.] 1947, 69, [1469.’H NMR] (400 MHz, [CDC13)] : 8 7. 85 (dd, [J= 7.] 5,1. [2 HZ,] 1H), 7.32 (td, J= 7.5, 1. [2 HZ,] 1H), 7.23 (dd, [J= 7.] 5,1. [7 HZ,] 1H), 6.90 [(TD,] [J= 7.] 5,1. [7 HZ,] 1H), 2.81 (tt, J= 11.7, 3. [0 HZ, 1H),] 1.97-1. 74 (m, [5H),] 1.55-1. 23 (m, [5H).] [13CNMR] (100 MHz, [CDC13)] : 8 149.3, 139.5, 128.4, 127.6, 126.6, 101.5, 48. 5,33. 4,26. 8,26. 1.

According to the analysis of related databases, 59734-92-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2004/13094; (2004); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59734-92-8, name is 1-Bromo-2-cyclohexylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 59734-92-8

Example 82; Synthesis of 2-(2-cyclohexylphenylami?o)-3H-benzimidazole-5-carboxylic acid (lH-indazol-6-yl)-amideTo a solution of l-bromo-2-cyclohexyl-benzene (5 mmol) in dioxane (20 mL) was added solid Pd(OAc)2 (0.1 g) and solid CsCO3 (10 mmol). tert-Buty] carbamate (7 mmol) was added to the reaction mixture, and the contents were heated at 80 0C for 2 h. The reaction mixture was cooled to room temperature and filtered through Celite. The solvent was removed in vacuo and the residue obtained was purified by flash column chromatography using DCM as elupsilonant to yield (2-cyclohexylphenyI)-carbamic acid tert-hvtiy ester.The carbamate obtained as above was treated with 4 M HCl in dioxane following the procedure described in Example 80 to afford 2-cyclohexylphenylamine as a hydrochloride salt.To a solution of aforementioned amine hydrochloride (1 mmol) in dry DMF (2 mL) was added DIEA (1.5 mmol) and lj’-thiocarbonylimidazole (1 mmol). The reaction mixture was heated at 700C for Ih to provide l-cyclohexyl-2-isothiocyanatobenzene as described in general procedure A.The isothiocyanate (0.5 mmol) was reacted with 3,4-diamino-N-(lH-mdazol-6-yl)- benzamide (0.5 mmol; see Example 25) according to general procedure B to yield 2-(2- cyclohexylphenylamino)-3H-benzimidazole-5-carboxylic acid (lH-indazol-6-yl)-amide. MS: m/z 451 (M+H)+.

The synthetic route of 59734-92-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TRANSTECH PHARMA, INC.; WO2007/95124; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 59734-92-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59734-92-8, name is 1-Bromo-2-cyclohexylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

46.7 ml (117 mmol) of 2.5M n-butyl lithium solution in hexane is slowly treated at -73C with24.0 g (97.3 mmol) of 1-bromo-2-cyclohexyl-benzene in 200 ml of THF under argonatmosphere, letting the temperature not rise above -70C. Addition is completed after 90minutes, giving a white suspension, and stirring continued at -73C during 30 minutes. 15.3g (147 mmol) of trimethylborate are slowly added during 20 minutes at -73C, letting the temperature not rise above -70C. The colorless solution is further stirred at -74C during one hour, and the temperature let raising to room temperature during three hours. The colorless solution is further stirred at room temperature during 16 hours, followed by theslow addition of 30 ml of 10% aqueous hydrochloric acid solution during 15 minutes. Stirring is continued at room temperature during three hours, and the reaction mixture two times extracted with 100 ml of ethyl acetate. The organic phase is dried over sodium sulfate, concentrated under vacuum, and further purified by chromatography (silica gel, heptane/ethyl actate 4:1), giving the title product as an off-white solid (yield: 10.1 g (51%)).1HNMR (400 MHz, CDCI3): = 1.24-2.11 (m, 10 H), 3.72-3.91 (m, I H), 7.33 (dt, I H), 7.49 (d, I H), 7.56 (dt, I H), 8.26 (dd, I H).

The synthetic route of 1-Bromo-2-cyclohexylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; MURER, Peter; BATTAGLIARIN, Glauco; DORMANN, Korinna; METZ, Stefan; WAGENBLAST, Gerhard; BENEDITO, Flavio Luiz; WATANABE, Soichi; LENNARTZ, Christian; GESSNER, Thomas; WO2015/14835; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary