In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59557-90-3 as follows. Safety of 4-Bromo-3,5-dimethylaniline
To a solution of cat. (0.36 g) in H2O2 (5.6 g). This was followed by the addition of a solution of 4-bromo-3,5-dimethylbenzenamine (2 g, 8.26 mmol) in methanol (8 mL) which was added dropwise with stirring, while maintaining the temperature of 0-20 C. To the mixture was added methanol (8 mL). To the above was added H2O2 (7.9 g) dropwise with stirring, while cooling to a temperature of 0-10 C. The resulting solution was allowed to react, with stirring, for 3 hours while the temperature was maintained at room temperature. The resulting solution was extracted three times with 50 mL of CH2Cl2 and the combined organic layers were dried over Na2SO4 and concentrated in vacuo. The residue was purified by column chromatography eluting with 1:100 EtOAc/petroleum ether to afford the title compound (1.6 g) as a white solid.
According to the analysis of related databases, 59557-90-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Kalypsys, Inc.; US2005/234046; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary