Category: 591-19-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 591-19-5, name is 3-Bromoaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C6H6BrN

c. 3,4-Dibromoaniline. 3-Bromoaniline (3 g, 17.4 mmol) was dissolved in 15 ml CH2 Cl2 and the reaction mixture was cooled to -10 C. in an ice-salt bath. 2,4,4,6-Tetrabromo-2,5-cyclohexadienone, (9.29 g, 0.02 mmol) was added in small portions with constant stiting. The reaction mixture was stirred for a period of 7 hours at 0 C. after which the reaction was quenched with 2N NaOH (10 ml). The aqueous layer was extracted with CH2 Cl2 and the organic layer was dried over anhydrous Na2 SO4. The CH2 Cl2 layer was concentrated in vacuo and purified by column chromatography. Elution with 0-3% ethyl acetate/n-hexanes yielded 3.2 g (12.7 mmol, 73%) of pure product; mp 80-81 C.; IR (KBr) 3406, 3318, 3210, 1583, 1464, 1287, 1108, 860, 668; 1 H NMR (CDCl3) 6 6.49 (dd,1H,J=2.7,8.6), 6.7 (d,1H,J=2.64), 7.32 (d,1H,J=8.6); 13 C NMR (CDCl3) 6 112.6, 116, 120.1, 125.45, 134.26, 147.08.

The synthetic route of 591-19-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rutgers, The State University of New Jersey; US6063801; (2000); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 591-19-5, name is 3-Bromoaniline, molecular formula is C6H6BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H6BrN

Under nitrogen or argon atmosphere, 3-bromoaniline 0.4 mmol, 0. 2 mm ? Ir (ppy) (2 mg) And DMF (1 ml) were added to the reaction flask and then irradiated with a blue LED band (7W) at room temperature until complete conversion of the trivalent iodine reagent was completed. 10 ml of a saturated aqueous Na2C03 solution was added thereto, and the mixture was extracted three times with ethyl acetate. The organic layer was washed once with saturated brine, and the organic layer was dried over anhydrous Na2S04. Column chromatography (eluent: petroleum ether 60-90: ethyl acetate = 20: 1-10: 1) to afford the product NIH2Yield 27%; CF3 ? Br ^ A ^ NH2CF, yield 23%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 591-19-5, its application will become more common.

Reference:
Patent; Nanjing University; Zhu, ChengJian; Xie, jin; Xu, Pan; (13 pag.)CN103553857; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 591-19-5, name is 3-Bromoaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 591-19-5

In the preparation method of the trifluoromethyl aromatic amine of the present embodiment, the aromatic amine is m-bromoaniline, and the other reactions and post-treatment processes are the same as those in Example 28, and three kinds of trifluoromethyl aromatic amine products are obtained. The preparation method of the trifluoromethyl aromatic amine of the present embodiment, the aromatic amine is aniline, and the nickel compound is nickel hydroxide.The base is potassium carbonate, and the reaction process parameters are: 1-trifluoromethyl-1,2-phenyliodo-3(H)-one (0.5 mmol, 1.0 eq).Aromatic amine (1.5 mmol, 3.0 eq), nickel hydroxide 10 mol%, potassium carbonate (1.5 mmol, 3.0 eq),DMSO (2 mL) was reacted at 35 C for 2 h, and the other reactions and workup procedures were the same as in Example 1.

The synthetic route of 3-Bromoaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Zhengzhou Taijihongnuo Pharmaceutical Co., Ltd.; Wu Yusheng; Gao Xianying; Geng Yang; Han Shuaijun; Liang Apeng; Li Jingya; Zou Dapeng; Wu Yangjie; (19 pag.)CN108503552; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary