Category: 58971-11-2

The chemical industry reduces the impact on the environment during synthesis 58971-11-2, name is 3-Bromophenethylamine, I believe this compound will play a more active role in future production and life. 58971-11-2

To a solution of methanesulfonyl chloride(1.60 mmol, 0.12 mL, 1.0 equiv) in ethanol (3 mL), 2-(3-bromophenyl)ethan-1-amine (3.20 mmol, 639mg, 2.0 equiv) was added and the mixture was stirred at room temperature. The reaction wasmonitored by TLC. After completion the solvent was removed under reduced pressure and theremaining solid dissolved in a small amount of water. The solution was applied to a C18 precolumnbefore purification on a 60 g C18 column with a gradient of acetonitrile in water (10-80%). The titlecompound (1.07 mmol, 295 mg, 66%) was obtained as a white solid.

The chemical industry reduces the impact on the environment during synthesis 58971-11-2. I believe this compound will play a more active role in future production and life.

Reference:
Article; Akhter, Sundus; Lund, Bjarte Aarmo; Ismael, Aya; Langer, Manuel; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S.; Bayer, Annette; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 634 – 648;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 58971-11-2, name is 3-Bromophenethylamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58971-11-2, 58971-11-2

3-fluoro-2- [5- (4-fluorophenyl) -1 H-pyrazol-3-yl] benzoic acid (0.057 g)In N, N-dimethylformamide (1.5 mL) was added2- (3-bromophenyl) ethylamine (0.038 g), 1-hydroxybenzotriazole monohydrate (0.035 g),1-Ethyl-3- (3-dimethylaminopropyl) carbodimiDehydrochloride (0.044 g) and triethylamine (0.058 g), and the mixture was stirred overnight at room temperature. Water was added to the reaction mixture, and the crude product was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate / methanol)N- [2- (3-bromophenyl) ethyl] -3-fluoro-2- [5- (4-fluorophenyl) -1 H-pyrazol-3-yl] benzamide (0.052 g).The product (0.052 g) In n-propanol (1.5 mL) was addedN-methylpyrrolidone (0.5 mL), triethylamine (0.033 g), 1,1′-bis (diphenylphosphino) ferrocene (0.006 g) and 1,1′-bis (diphenylphosphino) ferrocene palladium (II ) Dichloride dichloromethane adduct (0.009 g), and the mixture was stirred under a carbon monoxide atmosphere at 100 C. for 13 hours. After cooling the reaction mixture to room temperature, hydrochloric acid (1 mol / L) was added. The crude product was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatographyPurification by fee (elution solvent: ethyl acetate / n-hexane)3- (2- {3-fluoro-2- [5- (4-fluorophenyl) -1 H-pyrazol-3-yl] benzoylamino} ethyl)Benzoic acid propyl ester (0.026 g).An aqueous solution of sodium hydroxide (2 mol / L, 0.5 mL) was added to a methanol (0.5 mL) solution of the product (0.026 g), and the mixture was stirred at 60 C. for 2 hours. After cooling the reaction mixture to room temperature, hydrochloric acid (2 mol / L, 0.5 mL) was added. The precipitate was collected by filtration to give the title compound (0.021 g). Structural formula, spectral data and purification conditions are shown in Table 112.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; Hirasawa, Hideaki; Tanada, Fumiya; Mutai, Yousuke; Fushimi, Nobuhiko; Kobayashi, Junichi; Kijima, Yoshiro; (267 pag.)JP2018/108988; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary