Category: 58971-11-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58971-11-2, name is 3-Bromophenethylamine, A new synthetic method of this compound is introduced below., name: 3-Bromophenethylamine

2-(3-Bromo-phenyl)-ethylamine (0.5 mmol) and formaldehyde (2.5 mmol) were mixed in 5 ml of 1,2-dichloroethane in a process vial, which was sealed with a septum. Sodium triacetoxyborohydride (1 mmol) was added under argon atmosphere. The suspension was subjected to microwave irradiating conditions (CEM Discover equipped with a CEM Explorer automated reaction handling module). The reaction mixture was heated for 5 min at 120C and then cooled. The crude was evaporated to dryness and then suspended in aqueous NaHCO3. The product was extracted with CH2Cl2 and washed with aqueous NaHCO3. The CH2Cl2 extract was dried with anhydrous Na2SO4, filtered and evaporated to dryness to give the crude product [2-(3-bromo-phenyl)-ethyl]-dimethyl-amine. The crude was purified by flash column chromatography (CH2Cl2-MeOH as eluents) by using a CombiFlash Companion system to yield the title compound (86%) as colourless oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Laboratorios del Dr. Esteve S.A.; EP1997493; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 58971-11-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 58971-11-2, name is 3-Bromophenethylamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Add 200 mL of dichloromethane to the three-neck bottle.32.0 g of 3-bromophenethylamine and 17.0 g of triethylamine at 10 C,16.0 g of methyl chloroformate was added dropwise, and after completion of the dropwise addition, the reaction was continued for 2 hours.Add 300 mL of hot water, separate the organic phase, and wash with ammonium chloride solution.Wash with saturated brine and dry over anhydrous sodium sulfate.Concentration gave 38.4 g (96.7%) of methyl 3-bromophenethylcarbamate.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nantong University; Zhu Jinli; Ding Jinjin; Wang Miao; Zhu Xiting; Tian Dan; Sun Tongming; Tian Liang; Zhu Liangliang; Hong Chuanxia; (5 pag.)CN103880745; (2018); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 58971-11-2, The chemical industry reduces the impact on the environment during synthesis 58971-11-2, name is 3-Bromophenethylamine, I believe this compound will play a more active role in future production and life.

General procedure: To compound 5, 6 or 7 (1 equiv) and the appropriate alkylamine(1.3 equiv) in anhydrous DMF (10 mL/mmol) were added DIEA (3equiv) and PyBOP (1 equiv), and the reaction mixturewas stirred atroom temperature under argon. When the reaction was complete(2 h – 4 h), the solvents were removed under reduced pressure togive a residue that was taken up in CH2Cl2. The solution waswashed with saturated aqueous NaHCO3, then water. The organiclayer was dried over Na2SO4 and then evaporated in vacuo. Purificationby flash chromatography afforded the corresponding amidederivatives 8, 9 or 10 (yield: 40-76%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Paoletti, Julie; Assairi, Liliane; Gelin, Muriel; Huteau, Valerie; Nahori, Marie-Anne; Dussurget, Olivier; Labesse, Gilles; Pochet, Sylvie; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 1041 – 1056;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 58971-11-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 58971-11-2, name is 3-Bromophenethylamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

o a solution of 2-bromophenethyl amine (2.0 g, 0.01 mol) in acetonitrile at room temperature was added di-tert-butyl dicarbonate (2.1 g, 0.01 mol) in one portion. After stirring at room temperature for 72 hr the reaction mixture was concentrated in vacuo and the residue was dissolved in ethyl acetate. The solution was washed with brine, dried (Na2SO4), filtered and concentrated in vacuo to give 1,1-dimethylethyl[2-(3-bromophenyl)ethyl]carbamate as a yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORP; COWAN, D. J; LARKIN, A. L.; ZHANG, CUNYU; MUSSO, D. L.; GREEN, G. M.; CADILLA, R.; SPEARING, P.K.; BISHOP, M. J.; SPEAKE, J. D.; (219 pag.)CN102516115; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 58971-11-2, A common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 3-bromobenzeneethanamine (2.00 g, 10.0 mmol) and 2,6-lutidine (1.2 mL, 10.3 mmol) in dry CH2C12 (40 mL) was cooled to 0 C. Trifluoroacetic anhydride (1.4 mL, 9.9 mmol) was added dropwise, and the reaction was then warmed to room temperature and allowed to stir for 16 h. Water (40 mL) was added to the reaction, the phases were separated, and the aqueous layer was extracted with CHZCLZ (2 x 40 mL). The combined organic phases were washed successively with 1 M HCl (40 mL) and saturated NAHC03 (40 mL), and then dried over NazS04, filtered, and concentrated in vacuo to provide the title compound (2.93 g, 100%). The crude compound was used in subsequent steps. 1H-NMR (CDCl3): 8 7.40 (d, J=8. 0 Hz, 1H), 7.36 (s, 1H), 7.21 (t, J=7. 6 Hz, 1H), 7.12 (d, J=7. 6 Hz, 1H), 6.33 (br s, 1H), 3.59 (q, J=6. 8 Hz, 2H), 2.87 (t, J=7. 2 Hz, 2H). MS (ESI) (M+H) += 296/298.

The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2004/60882; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 58971-11-2,Some common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 2-(3-bromophenyl)ethanamine (500mg) and tetrakis(triphenylphosphine)palladium(0) (60mg) in pyrrolidine (4ml) under nitrogen, was added a solution of (5R)-3-[6-(but-3-ynyloxy)hexyl]-5-(2,2-dimethyl4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one (example 1 vi) (912mg) in pyrrolidine (4ml) and the reaction mixture was heated to 80C. After 18h, water (10ml) was added and extracted with EtOAc (3x25ml), the combined organic layers dried (MgSO4) and the solvent removed in vacuo. The residue was dissolved in CH2Cl2 (25ml) and applied to a Biotage cartridge (40g) and eluted with CH2Cl2, EtOAc and CH2Cl2 : EtOH: aq NH3 (100 : 8 : 1) to give the title compound (668mg). LCMS RT=3.09min.

The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2003/72539; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 58971-11-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 58971-11-2 as follows.

To a solution of 2-(3-bromophenyl)ethanamine (2 g, 10 mmol) in DCM (30 mL) were added Et3 (3 mL, 20.99 mmol) and AC2O (2 mL, 20.99 mmol). The reaction was stirred at rt overnight, then washed with H20 (50 mL x 3) followed by brine (50 mL x 3), dried over anhydrous a2S04, filtered and concentrated in vacuo to yield the crude product (2.42 g, 100%). MS (ESI, pos. ion) m/z: 242.0 [M + H]+; NMR (400 MHz, CDC13) delta (ppm): 7.36-7.33 (d, J= 9.2 Hz, 2H), 7.18-7.14 (t, J= 7.6 Hz, 1H), 7.12-7.10 (d, J= 8.0 Hz, 1H), 3.49-3.44 (t, J= 6.8 Hz, 2H), 2.79-2.76 (t, J= 7.2 Hz, 2H), 2.2 (s, 1H), 1.93 (s, 3H).

According to the analysis of related databases, 58971-11-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD; XI, Ning; WANG, Ruyong; WANG, Liang; WO2014/89324; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 58971-11-2, name is 3-Bromophenethylamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H10BrN

General procedure: Amine (1 equiv.) and aldehyde (5 equiv.) were dissolved in a 1:1 mixture of methanol/phosphatebuffer (10 mL, 0.25 M solution at pH 6). The resulting solution was stirred at 100 C for 12 h. The crudemixture was cooled to r.t. and purified by preparative HPLC (Gradient 1). Fractions containing thedesired product were combined, concentrated under vacuum and co-evaporated with methanol(3 x 20 mL).

The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pesnot, Thomas; Gershater, Markus C.; Edwards, Martin; Ward, John M.; Hailes, Helen C.; Molecules; vol. 22; 4; (2017);,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 3-Bromophenethylamine

General procedure: 4-[(Ethoxycarbonyl)amino]butanoic acid (12a, 700 mg, 4mmol) was dissolved in an hydrous dichloromethane (14 mL) under argon atmosphere. The solution was cooled to 0 C. Triethylamine (1.2 mL, 870 mg, 8.6 mmol) and 3-fluorophenethylamine (0.6 mL, 4.6 mmol) were added consecutively. Afterwards EDC-HCl (900 mg, 4.7 mmol)was added in one portion. Catalytic amount DMAP (30 mg)was added, the resulting mixture was stirred for 1 h at 0 C and then for 16 h at room temperature. The reaction mixture was diluted with dichloromethane (30 mL) and consecutively washed with 1M HCl, saturated NaHCO3 solution and water (20 mL of each). The combined extracts were dried (Na2SO4) and evaporated to give an oily residue.The crude product was crystallized from hexane

The synthetic route of 3-Bromophenethylamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav; Marton, Janos; Froeyen, Mathy; Olberg, Dag Erlend; Diederich, Marc; Bormans, Guy; Letters in drug design and discovery; vol. 14; 7; (2017); p. 787 – 797;,
Bromide – Wikipedia,
bromide – Wiktionary

58971-11-2, name is 3-Bromophenethylamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H10BrN

Step 2: N-[2-(3-bromophenyl)ethyl]-2,2,2-trifluoroacetamide To a solution of 2-(3-bromophenyl)ethanamine (28.1 mmol) in DMC (100 mL) was added 2,6-lutidine (29 mmol). The reaction mixture was cooled to 0 C. and then TFAA (28.1 mmol) was slowly added. The reaction mixture was allowed to stir and warm to rt overnight. Water (90 mL) was added and the organic solution was separated. The aqueous solution was extracted with DCM. The organic solutions were combined, washed with 1N HCl and aq. Sat. NaHCO3, dried over Na2SO4, filtered and concentrated to give N-[2-(3-bromophenyl)ethyl]-2,2,2-trifluoroacetamide (25.1 mmol, 89%) as a white solid which was used without further purification.

The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2008/171754; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary