Category: 58929-72-9

LeMahieu, Ronald A. published the artcileSubstituted (aryloxy)alkanoic acids as antagonists of slow-reacting substance of anaphylaxis, Related Products of bromides-buliding-blocks, the main research area is aryloxyalkanoic acid preparation leukotriene antagonist activity; slow reacting substance anaphylaxis antagonist preparation; antiasthmatic aryloxyalkanoic acid preparation.

A series of aryloxyalkanoic acids [e.g., I, X = CH2)5, n = 3] containing the 4-acetyl-3-hydroxy-2-propylphenoxy moiety of the standard slow-reacting substances of anaphylaxis (SRS-A) antagonist, FPL-55712, was prepared Thus, dihydroxypropylacetophenone II (R = R1 = H) was successively alkylated by treatment with Br(CH2)3CO2Et and K2CO3 in DMF, followed by Br(CH2)5Br in Me2CO to give II [R = Br(CH2)5, R1 = EtO2C(CH2)3] which was treated with II (R = R1 = H) and K2CO3, and then NaOH in aqueous MeOH to give I [X = (CH2)5, n = 3]. The compounds were evaluated for their ability to antagonize SRS-A-induced contractions of guinea pig ilea and leukotriene E4-induced bronchoconstriction in the guinea pig. The results showed that the compounds were all less potent than FPL-55712 in vitro, yet surprisingly, most were more potent by the inhalation route of administration. Some of the most potent analogs were selected for further pharmacol. evaluation and exhibited selective antagonism of leukotrienes as compared with platelet activating factor or histamine. In comparison to FPL-55712, compounds I [X = (CH2)5 n = 1] and I [X = (CH2)3O(CH2)3, n = 3] were more potent against leukotriene E4 and (40- and 80-fold, resp.), leukotriene D4 (4- and 3-fold, resp.), and leukotriene C4 (27- and 20-fold, resp.) induced bronchoconstriction when tested by inhalation.

Journal of Medicinal Chemistry published new progress about Antiasthmatics. 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Braeu, Elmar published the artcileOn heterocyclic systems containing bismuth(III). 2. Eight-membered heterocycles Cl/Br/I-M(CH2CH2CH2)2X with Lewis acidic group 15 atoms M = As, Sb, Bi and donor atoms X = NR, S: a contribution to the value of the electronegativity of bismuth(III), Computed Properties of 58929-72-9, the main research area is Pauling electronegativity Group VA element; Group VA element heterocycle transannular interaction; crystal structure antimony nitrogen heterocycle; mol structure antimony nitrogen heterocycle; metallocane.

Paths to the ligands (XCH2CH2CH2)2Z [X = Cl, Br; Z = NR (R = Me, PhCH2, CHMe2, iso-Bu), O, S, Se], to the diGrignard reagents (XMgCH2CH2CH2)2Z (same X, Z), and to the eight-membered Group 15 heterocycles XM(CH2CH2CH2)2Z [I; X = Cl, Br, iodo; M = As, Sb, Bi; Z = NR (R = Me PhCH2, iso-Bu), S] are given. 13C-NMR, IR and Raman spectra are discussed; for the compound ClSb(CH2CH2CH2)2NMe the crystal structure anal. is given: the antimony atom is clearly Lewis acidic with ψ-trigonal-bipyramidal coordination and a transannular Sb…N interaction of 2.385(2)Å. For such a configuration the values of the 13C-NMR chem. shifts of the α-CH2-groups (e.g. ClM(αCH2CH2CH2)2NMe (M = As, Sb, Bi) 34.6, 25.9, 46.6 ppm) display clearly a sequence N > Bi > P ≈ As > Sb for the Pauling electronegativities of the group 15 elements: a value as high as 2.3 for bismuth is suggested.

Polyhedron published new progress about Crystal structure. 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Computed Properties of 58929-72-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mueller, Ralf published the artcileLong Hydrocarbon Chain Ether Diols and Ether Diacids That Favorably Alter Lipid Disorders in Vivo, Safety of 1-Bromo-3-(3-bromopropoxy)propane, the main research area is hydrocarbon ether diol diacid lipid structure activity relationship antiobesity.

Long hydrocarbon chain ethers with bis-terminal hydroxyl or carboxyl groups have been synthesized and evaluated for their potential to favorably alter lipid disorders including metabolic syndrome. Compounds were assessed for their effects on the de novo incorporation of radiolabeled acetate into lipids in primary cultures of rat hepatocytes as well as for their effects on lipid and glycemic variables in female obese Zucker fatty rats following 1 and 2 wk of daily oral administration. The most active compounds were found to be sym. with four to five methylene groups separating the central ether functionality and the gem di-Me or methyl/aryl substituents. Biol. activity was found to be greatest for tetramethyl-substituted ether diols, while bis(arylmethyl) derivatives, diethers , and di-Ph ethers were the least active. For the most biol. active compound 28, we observed as much as a 346% increase in serum HDL-cholesterol and a 71% reduction in serum triglycerides at the highest dose administered (100 mg/kg) after 2 wk of treatment. For one compound we observed a 69% reduction in non-HDL-cholesterol, accompanied by a 131% increase in HDL-cholesterol and an 84% reduction in serum triglycerides under the same treatment conditions.

Journal of Medicinal Chemistry published new progress about Antiobesity agents. 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Safety of 1-Bromo-3-(3-bromopropoxy)propane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ambartsumova, R. F. published the artcileOn interaction of 2-aminobenzothiazoles with halohydrins, Application of 1-Bromo-3-(3-bromopropoxy)propane, the main research area is benzothiazolamine halohydrin alkylation oxidation dimerization; iminobenzothiazoline preparation; benzothiazolylideneammonium chloride preparation.

On heating on a boiling water bath, 2-aminobenzothiazoles react with Cl(CH2)2OH to yield mainly the corresponding 3-(2-chloroethyl)benzothiazolin-2-ones. Reducing the reaction temperature increases the fraction of 2-imino-3-(2-hydroxyethyl)benzothiazolines. In both instances, formation of bis[3-(2-hydroxyethyl)benzothiazol-2-ylidene]ammonium chlorides is observed The reaction of 2-aminobenzothiazole with Br(CH2)3OH gives only the corresponding amino alcs. The anomalous products from the reaction of β-chloroethyl derivatives of benzothiazolinones result from a dominating side-reaction of the starting 2-aminobenzothiazoles with the Cl(CH2)2OH thermolysis products that are formed on boiling.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Halohydrins Role: RCT (Reactant), RACT (Reactant or Reagent). 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Application of 1-Bromo-3-(3-bromopropoxy)propane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cristau, Henri-Jean published the artcileSynthesis of diphosphine dioxides for extraction of actinides using supported liquid membranes technology, COA of Formula: C6H12Br2O, the main research area is diphosphine dioxide preparation extraction actinide; organophosphorus extractant diphosphine dioxide preparation; radioactive liquid waste treatment organophosphorus extractant; plutonium extraction diphosphine dioxide; neptunium extraction diphosphine dioxide; supported liquid membrane actinide extraction organophosphorus.

A recurrent method for synthesis of diphosphine dioxides to be used for extraction of actinides from acidic aqueous solution is described. Selective phosphonium salt formation and cleavage permits the stepwise introduction of different bridges between the P atoms as well as various chains on them. The influence of the structural parameters on liquid-liquid extraction properties of Pu, Np, and Am was studied. Pu and Np can be efficiently removed from radioactive contaminated liquid wastes, using the supported liquid membranes technol. with the more lipophilic organophosphorus extractants, e.g., I.

Heteroatom Chemistry published new progress about Actinides Role: REM (Removal or Disposal), PROC (Process). 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, COA of Formula: C6H12Br2O.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Leyva-Perez, Antonio published the artcileOxyhalogenation of Activated Arenes with Nanocrystalline Ceria, Name: 1-Bromo-3-(3-bromopropoxy)propane, the main research area is nanocrystalline ceria oxyhalogenation activated arene.

Arenes can be chlorinated, brominated, and iodinated in the presence of CeO2 nanoparticles under aerobic conditions. In a biomimetic approach, active electrophilic halogen species are generated from either organic or inorganic halogen compounds and are trapped by arenes. This C-H transformation can be applied to the synthesis of naturally occurring products.

ACS Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Name: 1-Bromo-3-(3-bromopropoxy)propane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary