Category: 586-76-5

Dilauro, Giuseppe; Azzollini, Claudia S.; Vitale, Paola; Salomone, Antonio; Perna, Filippo M.; Capriati, Vito published an article in 2021. The article was titled 《Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands》, and you may find the article in Angewandte Chemie, International Edition.Computed Properties of C7H5BrO2 The information in the text is summarized as follows:

Pd-catalyzed Negishi cross-coupling reactions between organozinc compounds and (hetero)aryl bromides have been reported when using bulk water as the reaction medium in the presence of NaCl or the biodegradable choline chloride/urea eutectic mixture Both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings have been found to proceed smoothly, with high chemoselectivity, under mild conditions (room temperature or 60°C) in air, and in competition with protonolysis. Addnl. benefits include very short reaction times (20 s), good to excellent yields (up to 98%), wide substrate scope, and the tolerance of a variety of functional groups. The proposed novel protocol is scalable, and the practicability of the method is further highlighted by an easy recycling of both the catalyst and the eutectic mixture or water. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Computed Properties of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Computed Properties of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 586-76-5In 2019 ,《C-H and N-H bond annulation of aryl amides with unactivated olefins by merging cobalt(III) and photoredox catalysis》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Kalsi, Deepti; Barsu, Nagaraju; Chakrabarti, Sagnik; Dahiya, Pardeep; Rueping, Magnus; Sundararaju, Basker. The article conveys some information:

A mild, environment-friendly protocol was developed to carry out the [4+2] annulation of aryl amides with unactivated olefins. A range of sterically and electronically diverse aryl amides and unactivated olefins were successfully employed under the developed conditions to get a variety of dihydroisoquinolinones in good to excellent yields. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Related Products of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《General and selective syn-carboxylation-trifluoromethylation of terminal alkynes: application to the late-stage modification of dehydrocholic acid》 was written by Zhang, Song-Lin; Xiao, Chang; Wan, Hai-Xing; Zhang, Xiaoming. Formula: C7H5BrO2This research focused ontrifluoromethyl enol carboxylic ester preparation regioselective diastereoselective; terminal aryl alkyne carboxylic acid syn carboxylation trifluoromethylation. The article conveys some information:

A general and selective method is developed that allows difunctionalization of terminal alkynes by a Cu(III)-CF3 complex and a carboxylic acid regioselectively and with unusual syn-stereochem. This method is broadly applicable to various carboxylic acids and terminal alkynes, producing a range of biol. active trifluoromethyl enol carboxylic esters I (Ar = 4-ClC6H4, 4-EtC6H4, Ph, etc.; R = tBu, Bu, 4-BrC6H4, etc.). The synthetic potential of this method is further demonstrated by the late-stage functionalization of a complex pharmaceutical compound dehydrocholic acid. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Indo American Journal of Pharmaceutical Research included an article by Joshi, Shrinivas D.; Kulkarni, V. H.; Kumar, S. R. Prem; Basha, Jeelan. COA of Formula: C7H5BrO2. The article was titled 《Synthesis, antitubercular and antibacterial activities of novel N’-(substituted)-(2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamide derivatives》. The information in the text is summarized as follows:

A series of substituted N-(2-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl)benzamides I (R = H, 4-Cl, 4-Br, 4-F, 4-NO2, 3-Cl) was synthesized by reacting different substituted aromatic acids RC6H4C(O)OH with 2-(2,5-dimethyl-1H-pyrrol-1-yl)aniline by using HBTU as a coupling agent, DIEA as a catalyst and DMF as a solvent. Further they were tested for their anti-tubercular and antibacterial activities and compounds showed moderate to good activity. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5COA of Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.COA of Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Synthesis and biological activity of substituted 4-methyl-7- [(5-phenyl-1, 3, 4-oxadiazolidin-2-yl) methoxy]-2H-chromen-2-ones》 were Anushree, A. M.; Bandhavya, H. D.; Shetty, S. Ramachandra; Namratha, T. V.; Chaluvaraju, K. C.. And the article was published in International Journal of Research in Pharmacy and Chemistry in 2019. SDS of cas: 586-76-5 The author mentioned the following in the article:

In the current study, a series of five novel substituted 4-methyl-7-[(5-aryl-1,3,4-oxadiazole-2-yl)methoxy]-2H-chromen-2-one I [R = H, Cl, Br, NH2, NO2] was synthesized by a synthetic protocol in 4 steps. The intermediate involved were acetate derivative of coumarin synthesized from 7-hydroxy 4-Me coumarin in the presence of K2CO3, acetohydrazide by reacting acetate derivative of coumarin with hydrazine hydrate. The final derivatives I were obtained from acetohydrazide in the presence of POCl3 by reacting it with substituted benzoic acids. All the reactions were carried out by conventional methods. All the synthesized compounds I were evaluated for their anticoagulant and anti-inflammatory activity by tail bleeding model and HRBC method resp. The results of the study revealed that compound I [R = NO2] having strong electron withdrawing group showed anticoagulant activity and compounds I [R = Br, Cl] showed anti-inflammatory activity comparable to that of standard warfarin and diclofenac resp. While the compound I [R = H], showed moderate activities. However, the compound I [R = NH2] having electron donating groups had neg. impact on the potency and showed less anticoagulant and anti-inflammatory activity as compared to other derivatives In addition to this study using 4-Bromobenzoic acid, there are many other studies that have used 4-Bromobenzoic acid(cas: 586-76-5SDS of cas: 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.SDS of cas: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Doufene, Koceila; Malki, Yohan; Vincent, Laure-Anais; Cuq, Pierre; Devoisselle, Jean-Marie; Masurier, Nicolas; Aubert-Pouessel, Anne published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2021. The article was titled 《Vegetable Oil-based Hybrid Submicron Particles Loaded with JMV5038: A Promising Formulation against Melanoma》.Related Products of 586-76-5 The article contains the following contents:

The aim of this work was to carry out a preformulation study on JMV5038 as a new potent cytotoxic agent, and to develop its formulation within vegetable oil-based hybrid submicron particles (HNP) in order to obtain a versatile dosage form against melanoma. JMV5038 was first characterized through physico-chem. tests and it exhibited high m.p. and logP value, an important pH-sensitivity that led to the formation of well-identified degradation products at low pH, as well as a substantial solubility value in silylated castor oil (ICO). Then, JMV5038-loaded HNP were formulated through a thermostabilized emulsion process based on the sol-gel crosslinking of ICO. They showed high loading efficiency and their in vitro release kinetic assessed in a biorelevant PBS/octanol biphasic system showed a constant sustained release over one month. The cytotoxic activity and cytocompatibility of HNP were evaluated on A375 melanoma cells and NIH 3T3 cells, resp. JMV5038-loaded HNP exhibited a slightly enhanced cytotoxic activity of JMV5038 on melanoma cells while demonstrating their safety on NIH 3T3 cells. In conclusion, JMV5038-loaded HNP proved to be an efficient and safe drug s.c. delivery system that will be interesting to evaluate through preclin. studies. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Related Products of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Hydrogen-bonded molecular salts of reduced benzothiazole derivatives with carboxylates: a robust [inline formula omitted] (8) supramolecular motif (even when disordered)》 were Shaibah, Mohammed A. E.; Sagar, Belakavadi K.; Yathirajan, Hemmige S.; Cordes, David B.; Slawin, Alexandra M. Z.; Harrison, William T. A.. And the article was published in Acta Crystallographica, Section E: Crystallographic Communications in 2019. Application of 586-76-5 The author mentioned the following in the article:

The syntheses and structures of five mol. salts of protonated 4,4,7,7-tetramethyl-3a,5,6,7a-tetrahydrobenzothiazol-2-ylamine with diff. deprotonated carboxylic acids (4-methylbenzoic acid, 4-bromobenzoic acid, 3,5-dinitrobenzoic acid, fumaric acid and succinic acid) are reported. They are namely 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium 4-methylbenzoate, C11H19N2S+.C8H7O2-, (I), 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium 4-bromobenzoate, C11H19N2S+.C7H4BrO2-, (II), 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium 3,5-dinitrobenzoate, C11H19N2S+.C7H3N2O6-, (III), bis(2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium) fumarate, 2C11H19N2S+.C4H2O42-,(IV), and the 1:1 co-crystal of bis(2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium) succinate and 2-amino-4,4,7,7-tetramethyl-4,5,6,7-tetrahydro-1,3-benzothiazol-3-ium hydrogen succinate 4,4,7,7-tetramethyl-3a,5,6,7a-tetrahydrobenzothiazol-2-ylamine, 1.5C11H19N2S+.0.5C4H4O42-.0.5C4H5O4-.0.5C11H18N2S, (V). In every case, the cation protonation occurs at the N atom of the thiazole ring and the six-membered ring adopts a half-chair conformation (in some cases, the deviating methylene groups are disordered over two sets of sites). The C-N bond lengths of the nominal -NH+=C-NH2 fragment of the cation are indistinguishable, indicating a significant contribution of the -NH-C=N+H2 resonance form to the structure. The packing for (I)-(V) features a robust local R22(8) loop motif in which the cation forms two near-linear N-H…O hydrogen bonds from the N+-H group and syn H atom of the amine group to the carboxylate group of an adjacent anion [(V) shows disorder of one of these bonds over N-H…O and N…H-O contributors but the same R22(8) loop results for both disorder components]. The anti H atom of the -NH2 group also forms an N-H..O hydrogen bond, which results in [001] chains in (I) and (II), isolated centrosym.tetramers in (III) and [100] chains in (IV) and (V). Hirshfeld fingerprint plots and contact percentages for the different types of contacts of the cations are discussed. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Application of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Twelve 4-(4-methoxyphenyl)piperazin-1-ium salts containing organic anions: supramolecular assembly in one, two and three dimensions》 were Kiran Kumar, Haruvegowda; Yathirajan, Hemmige S.; Foro, Sabine; Glidewell, Christopher. And the article was published in Acta Crystallographica, Section E: Crystallographic Communications in 2019. SDS of cas: 586-76-5 The author mentioned the following in the article:

Twelve 4-(4-methoxyphenyl)piperazin-1-ium salts containing organic anions have been prepared and structurally characterized. The monohydrated benzoate, 4-fluorobenzoate, 4-chlorobenzoate and 4-bromobenzoate salts, C11H17N2O+·C7H5O2-·H2O (I), C11H17N2O+·C7H4FO2-·H2O (II), C11H17N2O+·C7H4ClO2-·H2O (III), and C11H17N2O+·C7H4BrO2-·H2O (IV), resp., are isomorphous and all exhibit disorder in the 4-methoxyphenyl unit: the components are linked by N-H···O and O-H···O hydrogen bond to form chains of rings. The unsolvated 2-hydroxybenzoate, pyridine-3-carboxylate and 2-hydroxy-3,5-dinitrobenzoate salts, C11H17N2O+·C7H5O3- (V), C11H17N2O+·C6H4NO2- (VI) and C11H17N2O+·C7H3N2O7- (VII), resp., are all fully ordered: the components of (V) are linked by multiple N-H···O hydrogen bonds to form a chain of rings; those of (VI) are linked into a three-dimensional framework by a combination of N-H···O, C-H···O and C-H···N hydrogen bonds and those of (VII), where the anion has a structure reminiscent of the picrate anion, are linked into a three-dimensional array by N-H···O and C-H···O hydrogen bonds. The hydrogensuccinate and hydrogenfumarate salts, C11H17N2O+·C4H5O4- (VIII) and C11H17N2O+·C4H3O3- (IX), resp., are isomorphous, and both exhibit disorder in the anionic component: N-H···O and O-H···O hydrogen bonds link the ions into sheets, which are further linked by C-H···π(arene) interactions. The anion of the hydrogenmaleate salt, C11H17N2O+·C4H3O3- (X), contains a very short and nearly sym. O···H···O hydrogen bond, and N-H···O hydrogen bonds link the anions into chains of rings. The ions in the trichloroacetate salt, C11H17N2O+·C2Cl3O2- (XI), are linked into simple chains by N-H···O hydrogen bonds. In the hydrated chloranilate salt, 2C11H17N2O+·C6Cl2O42-·2H2O (XII), which crystallizes as a non-merohedral twin, the anion lies across a center of inversion in space group P21/n, and a combination of N-H···O and O-H···O hydrogen bonds generates complex sheets. Comparisons are made with the structures of some related compounds In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5SDS of cas: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.SDS of cas: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary