Category: 586-76-5

The author of 《A new family of oxime palladacycles mixed with unsymmetrical phosphorus ylides; synthesis, structural, cytotoxicity and catalytic activity studies》 were Samiee, Sepideh; Shiralinia, Ahmadreza; Hoveizi, Elham; Gable, Robert W.. And the article was published in Journal of Organometallic Chemistry in 2019. Product Details of 586-76-5 The author mentioned the following in the article:

In the present investigation, the reactivity of an oxime-derived palladacycle [Pd{C,N-C6H4{C(Me) = NOH}-2}(μ-Cl)]2 toward various unsym. phosphorus ylides has been studied. When the ylide was added to a solution of oxime complex in dichloromethane (2:1 ratio), the new oxime palladacycles of the types [Pd{C,N-C6H4{C(Me) = NOH}-2}(Ph2PCH2PPh2C(H)C(O)C6H4X)]ClO4 (X = Cl (1), Br (2), NO2(3) or OCH3 (4)) were formed by means of bridge-splitting reaction. These are the first description of oxime-based palladacycles mixed with phosphorus ylides. All of complexes were fully characterized by elemental anal., IR and NMR spectroscopies. The crystal structure of 3 were determined by single-crystal x-ray diffraction anal. that confirmed breaking of Pd-Cl bonds in the initial precursor and allowing phosphorus ylide act as P,C-chelating ligand. In addition, the catalytic activity of 3 was evaluated in the Suzuki cross-coupling reactions of a variety of arylbromides with phenylboronic acid. This complex was also used for the assessment of their anticancer activities against three human carcinoma cell lines: A549 (human lung carcinoma), HT29 (human colon carcinoma), and HeLa (human cervical carcinoma). The results show that the new family of oxime-derived palladacycles could be introduced as promising innovative anticancer complexes and considered as an efficient catalyst in the cross coupling reactions. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Product Details of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2021 ,《Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors》 was published in European Journal of Medicinal Chemistry. The article was written by Wu, Tianxiao; Zhang, Chu; Lv, Ruicheng; Qin, Qiaohua; Liu, Nian; Yin, Wenbo; Wang, Ruifeng; Sun, Yin; Wang, Xiaoyan; Sun, Yixiang; Zhao, Dongmei; Cheng, Maosheng. The article contains the following contents:

Synthesis, biol. evaluation and pharmacophore model anal. of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives I [Ar1 = Ph, 2-FC6H4, 3-ClC6H4, etc.] and II [R1 = H, F; R2 = H, F; Ar2 = 4-FC6H4, 2-naphthyl, 4-morpholinophenyl, etc.] as potential TRKs inhibitors were obtained using scaffold hopping strategy. Compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] significantly inhibited the proliferation of TRK-dependent cell lines (Km-12), while it had no inhibitory effect on TRK-independent cell lines (A549 and THLE-2). Furthermore, kinases selectivity profiling showed that in addition to TRKs, compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] only displayed relatively strong inhibitory activity on ALK. These data might indicated that compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] had a good drug safety. Partial ADME properties were evaluated in vitro and in vivo and compound II [R1 = H; R2 = F; Ar2 = 4-(4-methylpiperazin-1-yl)-phenyl] exhibited a good AUC values and volume of distribution and low clearance in the pharmacokinetics experiment of rats. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5Category: bromides-buliding-blocks)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C7H5BrO2In 2019 ,《Design and synthesis of new norfloxacin-1,3,4-oxadiazole hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)》 was published in European Journal of Pharmaceutical Sciences. The article was written by Guo, Yong; Xu, Ting; Bao, Chongnan; Liu, Zhiyan; Fan, Jiangping; Yang, Ruige; Qin, Shangshang. The article contains the following contents:

Toward the search of new antibacterial agents to control methicillin-resistant Staphylococcus aureus (MRSA), aclass of new norfloxacin-1,3,4-oxadiazole hybrids were designed and synthesized. Antibacterial activities againstdrug-sensitive bacteria S. aureus and clin. drug resistant isolates of MRSA were evaluated. Compound 5k exhibited excellent antibacterial activities against S. aureus (MIC: 2μg/mL) and MRSA1-3 (MIC: 0.25-1μg/mL). The time-kill kinetics demonstrated that compound 5k had an advantage over commonly used antibiotics vancomycin in killing S. aureus and MRSA. Moreover, compound 5k could inhibit the bacteria and destroy their membranes in a short time and showed very low cytotoxicity to NRK-52E cells. Some interesting structureactivity relationships (SARs) were also discussed. These results indicated that these norfloxacin-1,3,4-oxadiazole hybrids could be further developed into new antibacterial agents against MRSA. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Application of Hammett equation to hydrogen bond interactions of benzoic acid in chloroform/water system and explanation for non-linear Hammett relation to partition coefficients for the same system》 was published in Computational & Theoretical Chemistry in 2020. These research results belong to Rachuru, Sanjeev; Skelton, Adam A.; Vandanapu, Jagannadham. Reference of 4-Bromobenzoic acid The article mentions the following:

It is well known that benzoic acid distributes itself between chloroform and water. The partition coefficients (Kp) of seven different benzoic acids in chloroform/water are documented in the literature. Plausible hydrogen bonded structures of these seven benzoic acids with the two immiscible solvents were envisaged and the DFT calculation for these hydrogen bonds were carried out. Further, the conformity of Hammett relation to the hydrogen bond interactions was assessed. Application of Hammett equation to the hydrogen bonding of distribution of different para-substituted benzoic acids to these immiscible solvents is done for the first time. Further, an explanation for non-linear plot of partition coefficients logKp of para-substituted benzoic acids in chloroform-water system vs. Hammett σ value has been explained for the first time. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Reference of 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Reference of 4-Bromobenzoic acid It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Quality Control of 4-Bromobenzoic acidIn 2021 ,《Influence of Isomerism on Radioluminescence of Purely Organic Phosphorescence Scintillators》 appeared in Angewandte Chemie, International Edition. The author of the article were Dong, Chaomin; Wang, Xiao; Gong, Wenqi; Ma, Wenbo; Zhang, Meng; Li, Jingjie; Zhang, Yuan; Zhou, Zixing; Yang, Zhijian; Qu, Shuli; Wang, Qian; Zhao, Zhu; Yang, Guohui; Lv, Anqi; Ma, Huili; Chen, Qiushui; Shi, Huifang; Yang, Yang; An, Zhongfu. The article conveys some information:

There are few reports about purely organic phosphorescence scintillators, and the relation between mol. structures and radioluminescence in organic scintillators is still unclear. An isomerism strategy to study the effect of mol. structures on radioluminescence is presented. Bromobenzoic acid (BA) isomers can achieve phosphorescence efficiency of ≤22.8% by UV irradiation Under x-ray irradiation, both m-BA and p-BA show excellent radioluminescence, while o-BA has almost no radioluminescence. Through exptl. and theor. study, radioluminescence was not only affected by nonradiation in emissive process, but also highly depended on the material conductivity caused by the different mol. packing. This study allows clear understanding of the relation between the mol. structures and radioluminescence and provides a guidance to rationally design new organic scintillators.4-Bromobenzoic acid(cas: 586-76-5Quality Control of 4-Bromobenzoic acid) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Quality Control of 4-Bromobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,European Journal of Organic Chemistry included an article by Kianmehr, Ebrahim; Nasab, Sepideh Bahrami. Category: bromides-buliding-blocks. The article was titled 《Ruthenium-Catalyzed Regioselective Direct Ortho-Acyloxylation of Azoarenes with Carboxylic Acids via C-H Bond Activation》. The information in the text is summarized as follows:

A highly regio and chemo-selective procedure for the synthesis of ortho-acyloxy-azoarene derivatives I [R = H, 4-Me, 4-Cl, etc.; R1 = H, 3-Et, 4-OH, etc.; R2 = i-Pr, Ph, Bn, etc.] was described via Ru-catalyzed C-H acyloxylation of azoarenes with inexpensive alkyl and aryl carboxylic acids as an acyloxylation agent. The reaction demonstrated a broad substrate scope and good functional group tolerance.4-Bromobenzoic acid(cas: 586-76-5Category: bromides-buliding-blocks) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Category: bromides-buliding-blocks It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Applied Catalysis, B: Environmental included an article by Samudrala, Priya S.; Nakhate, Akhil V.; Gupta, Shyam Sunder R.; Rasal, Kalidas B.; Deshmukh, Gunjan P.; Gadipelly, Chandrakanth R.; Theegala, Srinivas; Dumbre, Deepa K.; Periasamy, Selvakannan; Komandur, V. R. Chary; Bhargava, Suresh K.; Mannepalli, Lakshmi Kantam. HPLC of Formula: 586-76-5. The article was titled 《Oxidative coupling of carboxylic acids or benzaldehydes with DMF using hydrotalicite-derived oxide catalysts》. The information in the text is summarized as follows:

Hydrotalcite-derived (HT-derived) oxide catalysts were synthesized from hydrotalcite-like (HT-like) materials prepared by co-precipitation method (Cu-Al, Cu-Fe, Mg-Al, Mg-Fe, Ni-Fe and Ni-Al) followed by calcination and their catalytic activity was studied for oxidative amidation of carboxylic acids and substituted benzaldehydes with DMF. Catalyst screening was done using benzoic acid and DMF as a model reaction. Subsequently, the authors have optimized the reaction with different reaction parameters, catalyst loading, temperatures and oxidants. Cu-Fe HT-derived oxide catalyst showed excellent activity towards oxidative amidation using TBHP as an oxidant at 80° in 10 h. The fresh and spent catalysts were thoroughly characterized by different anal. techniques; XRD, SEM, HRTEM, TPD, N2 adsorption-desorption isotherm and XPS. Also, the catalyst was easily separated by simple filtration and reused up to four cycles without significant loss in catalytic activity. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5HPLC of Formula: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.HPLC of Formula: 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kircher, Theresa; Pantsar, Tatu; Oder, Andreas; Peter von Kries, Jens; Juchum, Michael; Pfaffenrot, Bent; Kloevekorn, Philip; Albrecht, Wolfgang; Selig, Roland; Laufer, Stefan published an article in 2021. The article was titled 《Design and synthesis of novel fluorescently labeled analogs of vemurafenib targeting MKK4》, and you may find the article in European Journal of Medicinal Chemistry.SDS of cas: 586-76-5 The information in the text is summarized as follows:

The azaindole-based scaffold of FDA-approved BRAF inhibitor vemurafenib 1, which displays off-target activity on mitogen-activated protein kinase kinase 4 (MKK4), as a starting point in fluorescent compound design was utilized. Chem. variation of the scaffold and optimization led to a selection of fluorescent 5-TAMRA derivatives I (R = Pr, benzyl; R1 = -NHC(O)-, -C(O)NH-; X = CH; Y = N, CH; n = 1, 4), II (R = n-propyl; R1 = -NHC(O)-, -C(O)NH-; X = CH, N; Y = CH, N; n = 1-6) which possess high binding affinities on MKK4. Compound II (R = n-propyl; R1 = -NHC(O)-; X = CH; Y = N; n = 4) represents a suitable tool compound for fluorescence polarization assays to identify new small-mol. inhibitors of MKK4.4-Bromobenzoic acid(cas: 586-76-5SDS of cas: 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.SDS of cas: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Journal of the American Chemical Society included an article by Phelan, James P.; Lang, Simon B.; Sim, Jaehoon; Berritt, Simon; Peat, Andrew J.; Billings, Katelyn; Fan, Lijun; Molander, Gary A.. Synthetic Route of C7H5BrO2. The article was titled 《Open-Air Alkylation Reactions in Photoredox-Catalyzed DNA-Encoded Library Synthesis》. The information in the text is summarized as follows:

DNA-encoded library (DEL) technol. is a powerful tool commonly used by the pharmaceutical industry for the identification of compounds with affinity to biomol. targets. Success in this endeavor lies in sampling diverse chem. libraries. However, current DELs tend to be deficient in C(sp3) carbon counts. The authors report unique solutions to the challenge of increasing both the chem. diversity of these libraries and their C(sp3) carbon counts by merging Ni/photoredox dual catalytic C(sp2)-C(sp3) cross-coupling as well as photoredox-catalyzed radical/polar crossover alkylation protocols with DELs. The successful integration of multiple classes of radical sources enables the rapid incorporation of a diverse set of alkyl fragments. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Copper (II) immobilized on magnetically separable L-arginine-β-cyclodextrin ligand system as a robust and green catalyst for direct oxidation of primary alcohols and benzyl halides to acids in neat conditions》 was published in Journal of Organometallic Chemistry in 2020. These research results belong to Nejad, Masoumeh Jadidi; Salamatmanesh, Arefe; Heydari, Akbar. Application of 586-76-5 The article mentions the following:

Copper (II) immobilized on L-arginine-β-cyclodextrin-functionalized magnetite nanoparticles (nano-Fe3O4@L-arginine-CD-Cu(II)) were successfully synthesized and fully characterized using FT-IR, XRD, SEM, EDX, ICP, TGA and VSM techniques. The catalytic activity of these magnetically retrievable nanoparticles was evaluated in the direct oxidation of primary alcs. and benzyl halides to acids in neat conditions that was observed to proceed well and products were obtained in good yields. In addition to showing good catalytic activity, the magnetic catalyst is easy to synthesize and could be recycled at least five times with little loss in activity. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Application of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary