Category: 586-76-5

Saini, Parul; Krishnan, Anandhu; Yadav, Deepak; Hazra, Susanta; Elias, Anil J. published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《External Catalyst-Free Oxidation of Benzyl Halides to Benzoic Acids Using NaOH/TBHP in Water》.Recommanded Product: 586-76-5 The article contains the following contents:

An efficient and metal-free methodol. for the oxidation of benzyl halides to benzoic acids using an inexpensive and green oxidant (TBHP) in aqueous basic medium has been developed. This protocol offers an excellent way to avoid adding catalysts and involves the use of an in-situ generated halide ion as catalyst. It is also the first report on the oxidation of benzyl iodides to benzoic acids. A series of carboxylic acids were prepared from benzyl halides in high yields under mild reaction conditions by this method which does not require chromatog. purification Gram scale reactions for the synthesis of the carboxylic acids in good yields have been successfully carried out using benzyl chloride, bromide and iodide. As an industrial application, the synthesis of a key monomer used for the synthesis of polyethylene terephthalate (PET), i. e., terephthalic acid (PTA), has also been accomplished in good yields. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Recommanded Product: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Oxidation of Substituted Toluenes by Nitric Acid》 was written by Kazakov, P. V.; Gorelenko, S. V.; Derevyagina, I. D.; Lukashov, O. I.; Mirzabekova, N. S.. Electric Literature of C7H5BrO2This research focused ontoluene nitric acid oxidation; benzoic acid preparation. The article conveys some information:

Oxidation by HNO3 at atm. pressure of toluenes with electroneg. substituents on the benzene ring was studied. A method enabling the corresponding benzoic acids to be obtained in high yields with minimal wastes was developed. The method could be used in the laboratory and in production of medicines. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Electric Literature of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Electric Literature of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Supramolecular Energetic and Topological Study of Halogenated Aryl Carboxylic Acids》 was written by Teixeira Campos, Patrick; Cunha da Rosa, Bruno Felipe; Saija Hilsinger, Henrique; Auler Milani, Marceo; Uecker Kruger, Vanessa. HPLC of Formula: 586-76-5 And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

A supramol. energetic and topol. study of 12 monohalogenated aryl carboxylic acids (F, Cl, Br, I) in the ortho, meta, and para positions was performed. The energy of intermol. interactions was determined from long-range corrected hybrid d. functional theor. computational calculations, using the ωB97X-D3 method. The surface of contact between the mols. and the mol. coordination numbers were determined From these data, all intermol. interactions were classified, and the robustness of the interactions was evaluated. Thus, the mol. (Mn) allocations around a central mol. (M1) are proposed. In addition, the energy from the intermol. interactions present in the first coordination sphere, which involves the central mol., the energy resulting from the interactions between the peripheral mols. and the total energy of the cluster provided by all interactions, was determined The role of hydrogen bonding (O-H···O, C-H···O, and C-H···X), π···π interactions, and halogen bonding (X···X) were evaluated, in the formation of the first coordination sphere and in the nucleation process. Information from the first coordination sphere helps one to understand the crystal. There is a proposal for nucleation initiation from hydrogen bonds forming dimers and subsequent π···π interactions forming a block. The approximation of these blocks results in the interactions C-H···O, C-H···Cl, and halogen bonds, which lead to three-dimensional supramol. growth until the formation of the crystal. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5HPLC of Formula: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.HPLC of Formula: 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Isomechanical Groups in Molecular Crystals and Role of Aromatic Interactions》 was written by Gabriele, Benjamin P. A.; Williams, Craig J.; Lauer, Matthias Eckhard; Derby, Brian; Cruz-Cabeza, Aurora J.. Application of 586-76-5 And the article was included in Crystal Growth & Design in 2020. The article conveys some information:

We have measured mech. properties in mol. crystals of a series of para-substituted benzoic acids using nanoindentation. Two linear correlations were found for these materials: first between the Young’s modulus and the m.p. per unit of volume, and second between the hardness and the crystal cohesive energy d. These correlations, however, were found to only hold within isomech. groups. These are groups of materials with similar interaction strengths and dimensionalities. A close anal. of the intermol. interactions present in these crystals revealed that structures with aromatic rings interacting through t-type interactions may achieve higher interaction dimensionalities and thus result in harder crystals than those with rings interacting through aromatic stacking. In these systems, thus, the dimensionality of the aromatic interactions in the crystals appears to play the major role in their mech. behavior. We correlate mech. properties measured in mol. crystals of a series of para-substituted benzoic acids, first with their m.p. per unit of volume and second with the crystals’ cohesive energy d. Structures with aromatic rings interacting through t-type interactions may achieve higher interaction dimensionalities and thus result in harder crystals than those with rings interacting through aromatic stacking. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 586-76-5In 2021 ,《Synthesis and Acidity of 5-(m-Terphenyl-2′-yl)-1H-tetrazoles: Evidence for an Enhanced Polar-π Effect Compared to Carboxylic Acids》 was published in Journal of Medicinal Chemistry. The article was written by Bookser, Brett C.; Do, Quyen-Quyen; Sritana-Anant, Yongsak; Baldridge, Kim K.; Siegel, Jay S.. The article contains the following contents:

The polar-π effect on tetrazoles, medicinal chem. isosteres of carboxylate, is tested by a Hammett pKa (microtitration) anal. over a series of 5-(m-terphenyl-2′-yl)-1H-tetrazoles. A comparison with m-terphenyl-2′-yl-carboxylic acids supports the isostere analogy also in response to environmental changes. Computational (B97D/def2TZVPPD) extension of the series plus a scan of solvents (vacuum to water) demonstrates the trend with the dielec. constant The effect is energetically small but may make statistically significant contributions to the tetrazole pharmacol. profile. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,ACS Combinatorial Science included an article by de Pedro Beato, Eduardo; Priego, Julian; Gironda-Martinez, Adrian; Gonzalez, Fernando; Benavides, Jesus; Blas, Jesus; Martin-Ortega, Maria Dolores; Toledo, Miguel Angel; Ezquerra, Jesus; Torrado, Alicia. Formula: C7H5BrO2. The article was titled 《Mild and Efficient Palladium-Mediated C-N Cross-Coupling Reaction between DNA-Conjugated Aryl Bromides and Aromatic Amines》. The information in the text is summarized as follows:

DNA-encoded library technol. (ELT) has emerged in the pharmaceutical industry as a powerful tool for hit and lead generation. Over the last 10 years, a number of DNA-compatible chem. reactions have been published and used to synthesize libraries. Among the most commonly used reactions in medicinal chem. is the C-N bond formation, and its application to DNA-encoded library technol. affords an alternative approach to identify high-affinity binders for biol. relevant protein targets. Herein we report a newly developed Pd-promoted C-N cross coupling reaction between DNA-conjugated aryl bromides and a wide scope of arylamines in good to excellent yields. The mild reaction conditions should facilitate the synthesis of novel DNA-encoded combinatorial libraries. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

HPLC of Formula: 586-76-5In 2022 ,《SCP-7, a germacrane-type sesquiterpene lactone derivative, induces ROS-mediated apoptosis in NSCLC cells in vitro and in vivo》 was published in European Journal of Pharmacology. The article was written by Zhang, Yang-Yang; Ren, Hui; Yan, Qiu-Lin; Li, Ya-Ling; Liu, Qingbo; Yao, Guo-Dong; Song, Shao-Jiang. The article contains the following contents:

Scabertopin (SCP), an abundant germacrane-type sesquiterpene lactone (SLC) isolated from Elephantopus scaber, was selected as a reference compound for modification and evaluation as anticancer agents for non-small cell lung cancer (NSCLC) treatment. All derivatives (SCP-1-SCP-13) except for SCP-3 showed potential inhibitory effect (IC50 5.2-9.7 μM) against A549 cells. The most promising compound SCP-7 also showed good cytotoxic activity against another two NSCLC cell lines (H1299 and H460), with IC50 value of 4.4 and 8.9 μM, resp. Furthermore, SCP-7 could induce apoptotic cell death that was associated with the increased reactive oxygen species (ROS) generation, the loss of mitochondrial membrane potential, Bcl-2 family proteins modulation, caspases-3 and PARP cleavage. In addition, SCP-7 also inhibited cell growth by increasing Bax expression and reducing the Ki-67 pos. cells in vivo, but there were no obvious toxic and side effects on internal organs. Mechanistically, PharmMapper, mol. docking and Western blot anal. revealed that SCP-7 might interact with the epidermal growth factor receptor (EGFR) and inhibit its expression in lung cancer cells. Together, above results suggest further effective application of SCP-7 as a potential anti-tumor agent in the treatment of NSCLC. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5HPLC of Formula: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.HPLC of Formula: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Russian Journal of General Chemistry included an article by Yakantham, T.; Sreenivasulu, R.; Raju, R. R.. Formula: C7H5BrO2. The article was titled 《Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives》. The information in the text is summarized as follows:

A series of new 2-(3-(4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl)isoxazol-5-yl)-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives I (R = H, MeO, NO2; R1 = H, MeO, Br, Cl, Me, NO2; R2 = H, MeO, NO2) is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds I are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference All compounds I demonstrate good to moderate activity on all cell lines.4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Acceptorless dehydrogenative oxidation of primary alcohols to carboxylic acids and reduction of nitroarenes via hydrogen borrowing catalyzed by a novel nanomagnetic silver catalyst》 was published in Journal of Organometallic Chemistry in 2020. These research results belong to Yazdani, Elahe; Heydari, Akbar. COA of Formula: C7H5BrO2 The article mentions the following:

A novel silver nanomagnetic catalyst was devised for dehydrogenative oxidation of aromatic and aliphatic alcs. to the corresponding acid with water as the sole oxygen source and hydrogen gas as the only byproduct. The designed catalytic system advantages from easy recovery of magnetic materials i.e. magnetic decantation, being economically viable and environmentally friendly. Furthermore, the catalytic reaction is able to reduce aryl nitro compounds in the absence of any reducing agent. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5COA of Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.COA of Formula: C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic Reductions Without External Hydrogen Gas: Broad Scope Hydrogenations with Tetrahydroxydiboron and a Tertiary Amine》 was published in Advanced Synthesis & Catalysis in 2020. These research results belong to Korvinson, Kirill A.; Akula, Hari K.; Malinchak, Casina T.; Sebastian, Dellamol; Wei, Wei; Khandaker, Tashrique A.; Andrzejewska, Magdalena R.; Zajc, Barbara; Lakshman, Mahesh K.. Synthetic Route of C7H5BrO2 The article mentions the following:

Aryl bromides, iodides, chlorides, and triflates, benzylic halides and ethers, benzyl carbamates, alkenes, alkynes, azides, and aldehydes underwent reductive cleavage, hydrogenation, and reduction reactions using B2(OH)4 as reductant in the presence of Pd/C and 4-methylmorpholine. Aryl dihalides containing two different halogen atoms underwent selective reduction, with reduction of I favored over reduction of Br and Cl, and Br reduction favored over the reduction of Cl. Cyano groups were unaffected, but nitro group and ketones underwent reduction to a low extent. B2(OD)4 and N,N-bis(methyl-d3)pyridin-4-amine (DMAP-d6) were used as reagents for the reductive deuteration of aryl halides. Hydrogen gas has been observed to form with this reagent combination.4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary