Category: 586-76-5

The author of 《A Protocol for the Ortho-Deuteration of Acidic Aromatic Compounds in D2O Catalyzed by Cationic RhIII》 were Garreau, Alyssa L.; Zhou, Hanyang; Young, Michael C.. And the article was published in Organic Letters in 2019. Recommanded Product: 586-76-5 The author mentioned the following in the article:

Methods to catalytically introduce deuterium in synthetically useful yields ortho to a carboxylic acid directing group on arenes typically requires D2 or high catalyst loadings, which makes using these approaches cost prohibitive for large-scale synthesis (equipment and reagent costs resp.). Herein, we present a simplified approach using low catalyst loadings of cationic RhIII and D2O as both deuterium source and solvent and show its application to H/D exchange on various carboxylic acid substrates. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: 4-Bromobenzoic acidIn 2020 ,《Accelerated Reactivity Mechanism and Interpretable Machine Learning Model of N-Sulfonylimines toward Fast Multicomponent Reactions》 was published in Organic Letters. The article was written by Jethava, Krupal P.; Fine, Jonathan; Chen, Yingqi; Hossain, Ahad; Chopra, Gaurav. The article contains the following contents:

We introduce chem. reactivity flowcharts to help chemists interpret reaction outcomes using statistically robust machine learning models trained on a small number of reactions. We developed fast N-sulfonylimine multicomponent reactions for understanding reactivity and to generate training data. Accelerated reactivity mechanisms were investigated using d. functional theory. Intuitive chem. features learned by the model accurately predicted heterogeneous reactivity of N-sulfonylimine with different carboxylic acids. Validation of the predictions shows that reaction outcome interpretation is useful for human chemists. The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5Name: 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Name: 4-Bromobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Access to Aryl and Heteroaryl Trifluoromethyl Ketones from Aryl Bromides and Fluorosulfates with Stoichiometric CO》 was published in Organic Letters in 2020. These research results belong to Johansen, Martin B.; Gedde, Oliver R.; Mayer, Thea S.; Skrydstrup, Troels. Safety of 4-Bromobenzoic acid The article mentions the following:

A sequential one-pot preparation of aromatic trifluoromethyl ketones RC(O)CF3 (R = 3,5-dimethoxyphenyl, quinolin-3-yl, 4-adamantylphenyl, etc.) starting from readily accessible aryl bromides/fluorosulfates RX (X = Br, OS(O)2F), the latter easily prepared from the corresponding phenols ROH were reported. The methodol. utilizes low pressure carbon monoxide generated ex situ from COgen to generate Weinreb amides as reactive intermediates that undergo monotrifluoromethylation affording the corresponding aromatic trifluoromethyl ketones (TFMKs) in good yields. The stoichiometric use of CO enables the possibility for accessing 13C-isotopically labeled TFMK by switching to the use of 13COgen. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Safety of 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Safety of 4-Bromobenzoic acid It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《1,2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids》 was written by Wang, Xujie; Li, Gangsheng; Yang, Yanan; Jiang, Jianshuang; Feng, Ziming; Zhang, Peicheng. Quality Control of 4-Bromobenzoic acid And the article was included in Chinese Chemical Letters in 2020. The article conveys some information:

The 1,2-dibromoethane- and KI-mediated α-acyloxylation of ketones is reported in moderate to good yield without the use of transition metals and strong oxidants. Various acids are well tolerated with wide functional group compatibility. An 1,2-dibromoethane- and KI-catalyzed reaction mechanism is proposed based on the results of control experiments The experimental part of the paper was very detailed, including the reaction process of 4-Bromobenzoic acid(cas: 586-76-5Quality Control of 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Quality Control of 4-Bromobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Chang-Cheng; Zhang, Guo-Xiang; Zuo, Zhi-Wei; Zeng, Rong; Zhai, Dan-Dan; Liu, Feng; Shi, Zhang-Jie published their research in Science China: Chemistry in 2021. The article was titled 《Photo-induced deep aerobic oxidation of alkyl aromatics》.Synthetic Route of C7H5BrO2 The article contains the following contents:

In this report, e.g., photo-induced deep aerobic oxidation of (poly)alkyl benzene toluene to benzene (poly)carboxylic acids e.g., benzoic acid was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alc. as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chems. from naturally abundant petroleum feedstocks. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Visible- and UV-Light-Induced Decarboxylative Radical Reactions of Benzoic Acids Using Organic Photoredox Catalysts》 was published in Journal of Organic Chemistry in 2020. These research results belong to Kubosaki, Suzuka; Takeuchi, Haruka; Iwata, Yutaka; Tanaka, Yosuke; Osaka, Kazuyuki; Yamawaki, Mugen; Morita, Toshio; Yoshimi, Yasuharu. Application of 586-76-5 The article mentions the following:

Photoinduced decarboxylative radical reactions of benzoic acids with electron-deficient alkenes, diborane, and acetonitrile under organic photoredox catalysis conditions and mild heating afforded adducts, arylboronate esters, and the reduction product, resp. The reaction is thought to involve single-electron transfer promoted the generation of aryl radicals via decarboxylation. A diverse range of benzoic acids were found to be suitable substrates for this photoreaction. Only two-mol. organic photoredox system can work well for the direct photoinduced decarboxylation of benzoic acids. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocksIn 2020 ,《Synthesis and Characterization of a Series of Sulfamethazine Multicomponent Crystals with Various Benzoic Acids》 was published in Crystal Growth & Design. The article was written by Scheepers, Matthew C.; Lemmerer, Andreas. The article contains the following contents:

Nine multi-component crystals consisting of sulfamethazine (sz) with HOBz and its derivatives were synthesized and characterized. Eight of the 9 multi-component crystals are co-crystals, while 1 is a mol. salt. The co-formers used to form multi-component crystals with sz include: 2-chloro-4-nitrobenzoic acid (2c4n), 2-chloro-5-nitrobenzoic acid (2c5n), salicylic acid (2hba), 3-hydroxybenzoic acid (3hba), 4-hydroxybenzoic acid (4hba), 4-bromobenzoic acid (4Brba), HOBz (ba), cinnamic acid (ca) and toluic acid (ta). These multi-component crystals were characterized by single-crystal x-ray diffraction (SC-XRD), Powder X-ray diffraction (PXRD) and Differential Scanning Calorimetry (DSC). SC-XRD showed that 8 of the co-formers that interacted with sz formed the amidine-carboxyl synthon; with the only exception to this were sz+4hba which formed the imidine-carboxyl synthon formed instead. PXRD confirmed that the single crystals were representative of the bulk material. DSC showed most of the multi-component crystals to have only a melting phase transition, which differed from the m.ps. of the co-formers. The only exceptions were sz+4brba and sz+ca, where an addnl. endothermic peak was observed, which corresponds to an amorphous phase transition before melting. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Category: bromides-buliding-blocks)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ramachandran, P. Veeraraghavan; Hamann, Henry J. published their research in Organic Letters in 2021. The article was titled 《Ammonia-borane as a Catalyst for the Direct Amidation of Carboxylic Acids》.Name: 4-Bromobenzoic acid The article contains the following contents:

Ammonia-borane serves as an efficient substoichiometric (10%) precatalyst for the direct amidation of both carboxylic acids RC(O)OH (R = Me, Ph, cyclohexyl, pyridin-2-yl, etc.) with amines R1NHR2 [R1 = hexyl, cyclohexyl, Bn, etc.; R2 = H, Me, pentyl, Bn; R1R2 = -(CH2)5-] for the preparation of carboxamides RC(O)N(R1)R2. In situ generation of amine-boranes R1NH(R2)BH3 precedes the amidation and, unlike the amidation with stoichiometric amine-boranes, this process is facile with 1 equiv of the acid. This methodol. has high functional group tolerance and chromatog.-free purification but is not amenable for esterification. The latter feature has been exploited to prepare hydroxyl- and thiol-containing amides RC(O)N(R1)R2 (R = 2-phenylethyl, R1 = 2-hydroxyethyl, R2 = H; R = Ph, R1 = 2-sulfanylethyl, R2 = H). In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Name: 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Name: 4-Bromobenzoic acid It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Clickable coupling of carboxylic acids and amines at room temperature mediated by SO2F2: A significant breakthrough for the construction of amides and peptide linkages》 were Wang, Shi-Meng; Zhao, Chuang; Zhang, Xu; Qin, Hua-Li. And the article was published in Organic & Biomolecular Chemistry in 2019. Electric Literature of C7H5BrO2 The author mentioned the following in the article:

A mild, simple, efficient and robust protocol was developed for the synthesis of amides RC(O)NR1R2 [R = Et, Ph, 2-furyl, 4-pyridyl, etc., R1 = H, Et, Bn, etc., R2 = Et, Ph, 3-pyridyl, etc.] via SO2F2-mediated clickable coupling of carboxylic acids with amines. Peptide linkages were also prepared using this methodol. The direct click reactions of acids and amines on gram scale were also demonstrated using an extremely easy work-up and purification process of washing with 1 M aqueous HCl to provide the desired amides in greater than 99% purity and excellent yields. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Electric Literature of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Electric Literature of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of Betulin Bromobenzoate, Dicinnamate, and Disuccinate in Melts of the Corresponding Acids》 was published in Chemistry of Natural Compounds in 2020. These research results belong to Levdansky, V. A.; Kondrasenko, A. A.; Levdansky, A. V.; Kuznetsov, B. N.. Related Products of 586-76-5 The article mentions the following:

The goal of the research was to develop synthetic methods for betulin 28-p-bromobenzoate, 3,28-dicinnamate and 3,28-disuccinate I [R1 = H, R2 = (4-bromophenyl)carbonyl; R1 = R2 = 3-phenylprop-2-enoyl; R1 = R2 = 3-carboxypropanoyl] via esterification of betulin in melts of corresponding acids R2OH. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Related Products of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary