Category: 586-76-5

In 2022,Kirihara, Masayuki; Sakamoto, Yugo; Yamahara, Sho; Kitajima, Atsuhito; Kugisaki, Naoki; Kimura, Yoshikazu published an article in Synlett. The title of the article was 《Aerobic Photooxidation of Toluene Derivatives into Carboxylic Acids with Bromine-Water under Catalyst-Free Conditions》.Application In Synthesis of 4-Bromobenzoic acid The author mentioned the following in the article:

The photoirradiation of toluene derivatives with two equivalent of bromine in benzotrifluoride-water provided a satisfactory yield of the corresponding benzoic acid derivatives Either a fluorescent lamp, blue LED (454 nm), or UV LED (385 nm) was used for the photoreaction. The reaction pathway might proceed through the dibromination of benzylic carbon, generation of the benzylic radical via oxidative C-H abstraction, formation of benzoyl bromide, and hydrolysis of carboxylic acid. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Application In Synthesis of 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Application In Synthesis of 4-Bromobenzoic acid It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Miao, Yu-Qi; Kang, Jia-Xin; Ma, Yan-Na; Chen, Xuenian published their research in Green Chemistry in 2021. The article was titled 《Visible light-mediated synthesis of amides from carboxylic acids and amine-boranes》.Recommanded Product: 4-Bromobenzoic acid The article contains the following contents:

Here, a photocatalytic deoxygenative amidation protocol using readily available amine-boranes RNH(R1)BH3 (R = H, Me, Et; R1 = H, Me, Bn, 4-fluorophenyl, etc.; RR1 = -(CH2)5, -(CH2)2O(CH2)2-) and carboxylic acids R2C(O)OH (R2 = 4-methoxyphenyl, 3,5-dichlorophenyl, 1-benzofuran-5-yl, 4-(dipropylsulfamoyl)phenyl, etc.) is described. This approach features mild conditions, moderate-to-good yields, easy scale-up, and up to 62 examples of functionalized amides R2C(O)NRR1 with diverse substituents. The synthetic robustness of this method was also demonstrated by its application in the late-stage functionalization of several pharmaceutical mols. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 4-Bromobenzoic acid It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhao-Yang; Peng, Wei-Yu; Akram, Waseem; Lai, Jia-Wei; Zhang, Hao; Liu, Hai-Yang published their research in Heterocycles in 2021. The article was titled 《Copper corrole catalyzed esterification of C(sp3)-H with carboxylic acids via cross-dehydrogenative coupling reaction》.Name: 4-Bromobenzoic acid The article contains the following contents:

Copper corrole complex was firstly used as catalyst for oxidative esterification of un-reactive C(sp3)-H bond of cyclic ether and carboxylic acid via cross-dehydrogenative coupling (CDC) reaction using di-tert-Bu peroxide (DTBP) as oxidant. A wide range of carboxylic acids can react with cyclic ether with good to excellent yields, showing copper corrole is a new kind of promising catalyst for CDC reaction. Under gram-level test, the turnover number (TON) may achieve 8400 with 84% yield at only 0.01% catalyst loading, demonstrating its practical uses. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Name: 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Name: 4-Bromobenzoic acid It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 586-76-5In 2020 ,《Palladium-Catalyzed N-Acylation of Tertiary Amines by Carboxylic Acids: A Method for the Synthesis of Amides》 was published in Organic Letters. The article was written by Li, Zhaohui; Liu, Long; Xu, Kaiqiang; Huang, Tianzeng; Li, Xinyi; Song, Bin; Chen, Tieqiao. The article contains the following contents:

A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids was achieved through C-N cleavage. This reaction showed a wide substrate scope. Both aromatic and aliphatic acids served well as the acylating reagents and coupled with tertiary amines to gave the corresponding amides RC(O)N(R1)2 [R = n-pentyl, Ph, 2-naphthyl, etc.; R1 = Me, Et, n-Pr] in good to excellent yields. With the strategy, bioactive carboxylic acids were also efficiently modified, highlighting the synthetic value of the process in organic synthesis. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-Catalyzed Tandem Dehydrogenative [4 + 2] Annulation of Terminal Olefins with N-Sulfonyl Amides via C-H Activations》 was written by Sun, Manman; Chen, Weida; Xia, Xiangyu; Shen, Guodong; Ma, Yongmin; Yang, Jianguo; Ding, Hanfeng; Wang, Zhiming. Application of 586-76-5This research focused onvinyl heterocyclic compound preparation stereoselective green chem; terminal olefin sulfonyl amide tandem dehydrogenative annulation palladium catalyst. The article conveys some information:

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp2)-H activation, allylic C(sp3)-H activation, and homoallylic C(sp3)-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and com. olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Combining Flavin Photocatalysis and Organocatalysis: Metal-Free Aerobic Oxidation of Unactivated Benzylic Substrates》 were Zelenka, Jan; Svobodova, Eva; Tarabek, Jan; Hoskovcova, Irena; Boguschova, Veronika; Bailly, Sarah; Sikorski, Marek; Roithova, Jana; Cibulka, Radek. And the article was published in Organic Letters in 2019. Category: bromides-buliding-blocks The author mentioned the following in the article:

The authors report a system with ethylene-bridged flavinium salt I which catalyzes the aerobic oxidation of toluenes and benzyl alcs. with high oxidation potential (Eox > +2.5 V vs SCE) to give the corresponding benzoic acids under visible light irradiation This is caused by the high oxidizing power of excited I (E(I*) = +2.67 V vs SCE) involved in photooxidation and by the accompanying dark organocatalytic oxygenation provided by the in situ formed flavin hydroperoxide I-OOH. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Category: bromides-buliding-blocks)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Category: bromides-buliding-blocks It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Site-selective C-H activation and regiospecific annulation using propargylic carbonates》 were Lu, Qingquan; Mondal, Shobhan; Cembellin, Sara; Gressies, Steffen; Glorius, Frank. And the article was published in Chemical Science in 2019. Product Details of 586-76-5 The author mentioned the following in the article:

An unprecedented RuII-catalyzed site-selective and regiospecific annulation of benzoic acids ArC(O)OH (2-CH3C6H4, thiophen-2-yl, 1-methyl-1H-indol-3-yl, etc.) with propargylic carbonates R1CCC(R2)(R3)(OCO2CH3) [R1 = C6H5, thiophen-3-yl; R2 = Me, Et, n-propyl; R3 = Me, Et; R2R3 = -(CH2)4-] has been described. The weakly coordinating carboxylic acid moiety outperformed other typically used directing groups in C-H activation, including ketone, nitrile, sulfonamide, amide and strongly coordinating nitrogen heterocycles. This is an important step towards the application of C-H activation reactions in complex (functional) real-world mols.4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Product Details of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Directing-Group-Controlled Ring-Opening Addition and Hydroarylation of Oxa/azabenzonorbornadienes with Arenes via C-H Activation》 was published in Organic Letters in 2020. These research results belong to Zhang, Keyang; Khan, Ruhima; Chen, Jingchao; Zhang, Xuexin; Gao, Yang; Zhou, Yongyun; Li, Kangkui; Tian, Youxian; Fan, Baomin. Related Products of 586-76-5 The article mentions the following:

An efficient method for the directing group controlled rhodium-catalyzed addition reaction of oxa/azabicylic alkenes with aromatic ketones and benzoic acids has been developed. The ketones and benzoic acids afforded different addition products when reacted with oxa/azabicyclic alkenes. The reaction between ketones and azabenzonorbornadienes furnished the ring-opening addition products. The reaction between benzoic acids and aza/oxabicyclic alkenes proceeded in the absence of silver salt, giving the 1:2 hydroarylation products in yields up to 96%. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Related Products of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Related Products of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Green Chemistry included an article by Hazra, Susanta; Kushawaha, Ajay Kishor; Yadav, Deepak; Dolui, Pritam; Deb, Mayukh; Elias, Anil J.. Quality Control of 4-Bromobenzoic acid. The article was titled 《Table salt as a catalyst for the oxidation of aromatic alcohols and amines to acids and imines in aqueous medium: effectively carrying out oxidation reactions in sea water》. The information in the text is summarized as follows:

A simple, efficient, sustainable and economical method for the oxidation of alcs. and amines was developed based on chloride, a sea abundant anionic catalyst for the practical synthesis of a wide range of carboxylic acids, ketones and imines. Oxidation of aromatic alcs. was carried out using NaCl (20 mol%) as the catalyst, NaOH (50 mol%) and aqueous TBHP (4 equivalent) as the oxidant in 55-92% isolated yields. Oxidation of aromatic amines to imines was achieved by using only 20 mol% of NaCl and aqueous TBHP (4 equivalent) in 32-93% isolated yields. The chlorine species formed during the reaction as the active oxidation catalyst was identified as ClO2- for alcs. and ClO-/ClO2- for amines by control experiments This method was mostly free from chromatog. purification, which made it suitable for large-scale synthesis. The synthesis of carboxylic acids and imines scaled up to 30 g scale in good yields and was also carried out efficiently this new method using filtered sea water as the solvent and catalyst. The experimental process involved the reaction of 4-Bromobenzoic acid(cas: 586-76-5Quality Control of 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Quality Control of 4-Bromobenzoic acid It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Deoxygenative Tri- and Difluoromethylthiolation of Carboxylic Acids with Benzothiazolium Reagents》 was published in Organic Letters in 2020. These research results belong to Tironi, Matteo; Maas, Lilian M.; Garg, Arushi; Dix, Stefan; Goetze, Jan P.; Hopkinson, Matthew N.. Computed Properties of C7H5BrO2 The article mentions the following:

Deoxygenative syntheses of fluorinated thioesters directly from carboxylic acids have been developed employing benzothiazolium reagents. The process using BT-SCF3 represents an attractive approach toward these SCF3-containing compounds that avoids the use of metal -SCF3 salts or preactivated acyl electrophiles. Moreover, the in situ activation of BT-SCF2H allows for an unprecedented nucleophilic difluoromethylthiolation reaction. DFT calculations support a mechanistic scenario involving a four-membered transition state where acyl substitution occurs without the formation of an unstable free -SCF2H anion. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Computed Properties of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Computed Properties of C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary