Category: 586-76-5

Recommanded Product: 4-Bromobenzoic acidIn 2021 ,《DEAD-Mediated Oxidative Ugi/Aza-Wittig Reaction for the Synthesis of 5-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-1,3,4-oxadiazoles Starting from (N-Isocyanimine)triphenylphosphorane》 was published in Synthesis. The article was written by Sun, Mei; Zhao, Long; Yu, Yan-Ling; Ding, Ming-Wu. The article contains the following contents:

A one-pot protocol for the synthesis of 5-(1,2,3,4-tetrahydroisoquinolin-1-yl)-1,3,4-oxadiazoles I [R1 = Me, i-Pr, 4-MeC6H4, etc.; R2 = H, 6,7-di-MeO; Ar = Ph, 4-MeC6H4, 2-ClC6H4, 4-BrC6H4] via DEAD-mediated oxidative Ugi/aza-Wittig reaction was developed. The reaction of (N-isocyanimine)triphenylphosphorane, carboxylic acids and N-aryl-1,2,3,4-tetrahydroisoquinolines produced polysubstituted 5-(1,2,3,4-tetrahydroisoquinolin-1-yl)-1,3,4-oxadiazoles directly in good yields in the presence of DEAD as an oxidant. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Recommanded Product: 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Recommanded Product: 4-Bromobenzoic acid

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Synlett included an article by Cao, Hongen; Chen, Tian; Yang, Chenggen; Ye, Jianqing; Zhang, Xu. SDS of cas: 586-76-5. The article was titled 《Diphenyl Diselenide Catalyzed Oxidative Degradation of Benzoin to Benzoic Acid》. The information in the text is summarized as follows:

The di-Ph diselenide catalyzed oxidative degradation of benzoins RC(O)CH(OH)R (R = Ph, 4-tolyl, benzyl, etc.) to benzoic acids RCOOH has been reported. As this reaction can convert the malodorous compound into an odorless and innocuous product under mild conditions, it might be useful for pollutant disposal. The reaction does not require a transition-metal catalyst or a chem. oxidant, so that it can be performed at low cost and without generation of wastes. This is believed to be the first example of the use of organoselenium catalysis technol. in pollutant destruction, thereby expanding its range of applications. In the experiment, the researchers used many compounds, for example, 4-Bromobenzoic acid(cas: 586-76-5SDS of cas: 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.SDS of cas: 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Synthesis included an article by Singh, Mala; Singh, Anoop S.; Mishra, Nidhi; Agrahari, Anand K.; Tiwari, Vinod K.. Product Details of 586-76-5. The article was titled 《Trichloroisocyanuric Acid Mediated High-Yielding Synthesis of N-Acylbenzotriazoles under Mild Reaction Conditions》. The information in the text is summarized as follows:

N-Acylbenzotriazoles I (R = C6H5, (E)-CH3(CH2)7CH=CH(CH2)7, furan-2-yl, etc.) are achieved in good yields from the corresponding carboxylic acids RC(O)OH by using only 0.35 equiv of trichloroisocyanuric acid and 1.2 equiv of PPh3. The salient features of the developed reaction path include an economic, facile, base-free, and equally useful method in milligram to gram scale. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Product Details of 586-76-5 It was used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Acylation of 25-hydroxyprotopanaxatriol with aromatic acids increases cytotoxicity》 were Lv, Liyan; Lu, Jincai; Zhang, Hongyu; Wang, Xude; Su, Guangyue; Piao, Huri; Zhao, Yuqing. And the article was published in Fitoterapia in 2019. Product Details of 586-76-5 The author mentioned the following in the article:

20(R)-25-hydroxyprotopanaxadiol (25-OH-PPD) is a natural compound showing a variety of anti-tumor effects. In an attempt to discover a new anti-cancer compound with higher antitumor activities, we designed and synthesized a series of 25-OH-PPD derivatives The cytotoxicity assay of these derivatives towards MCF-7, A549, U87, HO-8901, Hela cancer cell lines and normal IOSE144 cell lines were tested by MTT assay. Results showed that compared with compound 25-OH-PPD, acylated derivatives I [R = 4-ClC6H4, 2-FC6H4, 2,4-F2C6H3, 2-O2NC6H4, 3,5-(O2N)2C6H3] showed strong anticancer activity, and all compounds showed low toxicity or no toxicity for normal cells. In particular, compound I (R = 2,4-F2C6H3) (II) exhibited the best anti-tumor activity in all cancer cell lines (MCF-7, A549, U87, HO-8901, and Hela) with IC50 values of 5.04μM, 1.36μM, 3.24μM, 3.47μM, 4.57μM, resp. Among the five cell lines, all the compounds showed strong inhibition on A549 cells. Further studies showed that II significantly inhibited the proliferation of A549 cells by inducing apoptosis. Our results indicate that II is a potential anticancer inhibitor and provides a theor. basis for further research. In addition to this study using 4-Bromobenzoic acid, there are many other studies that have used 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5) was used in this study.

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Product Details of 586-76-5 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Pd(CH3CN)2Cl2/pipecolinic acid as a highly efficient catalytic system for Suzuki-Miyaura cross-coupling reaction of bromoaryl carboxylic acids in water》 were Li, Xiaogang; Zhang, Wenbin; Fu, Leiqing; Guo, Mengping. And the article was published in Catalysts in 2019. Application of 586-76-5 The author mentioned the following in the article:

In this study, a convenient and highly efficient catalytic system for the Suzuki-Miyaura coupling reaction was investigated under mild conditions. A combination of Pd(CH3CN)2Cl2 and pipecolinic acid showed excellent catalytic performance and afforded high turnover numbers; turnover numbers were up to 4.9 × 105 for the coupling reaction of 4-bromobenzoic acid and tetraphenylboron sodium. The catalytic system was also effective for the indexes of 4-bromobenzoic acid, and high turnover numbers were obtained. In the part of experimental materials, we found many familiar compounds, such as 4-Bromobenzoic acid(cas: 586-76-5Application of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Application of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C7H5BrO2In 2019 ,《Catalyst-Free Approach for Hydroboration of Carboxylic Acids under Mild Conditions》 appeared in ACS Omega. The author of the article were Xu, Xiaojuan; Yan, Dandan; Zhu, Zhangye; Kang, Zihan; Yao, Yingming; Shen, Qi; Xue, Mingqiang. The article conveys some information:

Aryl and alkyl carboxylic acids underwent hydroboration with pinacolborane under solvent-free conditions or in THF to yield primary alkyl pinacolborate esters. Seven of the borate esters were hydrolyzed to the corresponding primary alcs. in 90-93% yields with silica in MeOH. Benzoic acid was reduced under solvent-free conditions to yield benzyl pinacol borate in 98% yield on 15 mmol scale. After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Synthetic Route of C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Synthetic Route of C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Divergent Synthesis of Isoquinolone and Isocoumarin Derivatives by the Annulation of Benzoic Acid with N-Vinyl Amide》 were Sun, Rui; Yang, Xiao; Li, Qianggen; Xu, Ke; Tang, Juan; Zheng, Xueli; Yuan, Maolin; Fu, Haiyan; Li, Ruixiang; Chen, Hua. And the article was published in Organic Letters in 2019. Formula: C7H5BrO2 The author mentioned the following in the article:

A simple and efficient method for the synthesis of isoquinolone and isocoumarin derivatives is reported. The method for the first time provides a one-step divergent synthesis of important isoquinolone and isocoumarin skeletons from benzoic acid by switching the coupling partners. In addition, a reliable mechanism has been proposed on the basis of exptl. investigations, including kinetic isotope effect experiments, 13C labeling experiments, time-tracking experiments, and competitive experiments, as well as DFT calculation studies. The results came from multiple reactions, including the reaction of 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Formula: C7H5BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Construction of esters through sulfuryl fluoride (SO2F2) mediated dehydrative coupling of carboxylic acids with alcohols at》 were Wang, Shi-Meng; Alharbi, Njud S.; Qin, Hua-Li. And the article was published in Synthesis in 2019. Safety of 4-Bromobenzoic acid The author mentioned the following in the article:

A facile method for the construction of esters R1C(O)OR2 [R1 = Et, Ph, 2-furyl, etc.; R2 = Et, cyclohexyl, Bn, etc.] through dehydrative coupling of carboxylic acids with alcs. was developed. The reactions were mediated by sulfuryl fluoride (SO2F2) at room temperature and proceeded with high efficiency. The method had several advantages including broad substrate scope, mild conditions, excellent functional group compatibility and afforded high yields, even on gram scale. In the experimental materials used by the author, we found 4-Bromobenzoic acid(cas: 586-76-5Safety of 4-Bromobenzoic acid)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Safety of 4-Bromobenzoic acid It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 586-76-5In 2019 ,《Tetrabutylammonium Iodide-Promoted Acyloxylation-Peroxidation of Alkenes with Carboxylic Acid and tert-Butyl Hydroperoxide》 was published in Synlett. The article was written by Chen, Rongxiang; Chen, Wei; Shen, Yuntao; Wang, Zhan-Yong; Dai, Wei; Wang, Kai-Kai; Liu, Lantao. The article contains the following contents:

An efficient synthesis of tert-Bu peroxides such as RCO2CHR1CH2OOt-Bu [R = 2-naphthyl, 2-thienyl, 4-tert-BuC6H4, etc.; R1 = CO2Me, CO2Et, CO2t-Bu] through TBAI-promoted acyloxylation-peroxidation of alkenes by using a carboxylic acid and tert-Bu hydroperoxide was developed. Simple and com. available TBHP would act as the source of the peroxygen radical. The synthetic utility of this method was enhanced by simple manipulations, easily available starting materials, and a wide substrate scope. In the experiment, the researchers used 4-Bromobenzoic acid(cas: 586-76-5Product Details of 586-76-5)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography. It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.Product Details of 586-76-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

De Silva, Viraj; Averkiev, Boris B.; Sinha, Abhijeet S.; Aakeroy, Christer B. published an article in 2021. The article was titled 《The Balance between Hydrogen Bonds, Halogen Bonds, and Chalcogen Bonds in the Crystal Structures of a Series of 1,3,4-Chalcogenadiazoles》, and you may find the article in Molecules.Formula: C7H5BrO2 The information in the text is summarized as follows:

In order to explore how specific atom-to-atom replacements change the electrostatic potentials on 1,3,4-chalcogenadiazole derivatives, and to deliberately alter the balance between intermol. interactions, four target mols. were synthesized and characterized. DFT calculations indicated that the atom-to-atom substitution of Br with I, and S with Se enhanced the σ-hole potentials, thus increasing the structure directing ability of halogen bonds and chalcogen bonds as compared to intermol. hydrogen bonding. The delicate balance between these intermol. forces was further underlined by the formation of two polymorphs of 5-(4-iodophenyl)-1,3,4-thiadiazol-2-amine; Form I displayed all three interactions while Form II only showed hydrogen and chalcogen bonding. The results emphasize that the deliberate alterations of the electrostatic potential on polarizable atoms can cause specific and deliberate changes to the main synthons and subsequent assemblies in the structures of this family of compounds After reading the article, we found that the author used 4-Bromobenzoic acid(cas: 586-76-5Formula: C7H5BrO2)

4-Bromobenzoic acid(cas: 586-76-5) has been used to study the metabolic fate of 2-,3-and 4-bromo benzoic acids in rat hepatocytes incubation using high temperature liquid chromatography.Formula: C7H5BrO2 It was used in bromine-specific detection of the metabolites of 2-,3-and 4-bromobenzoic acid in the urine and bile of rats by inductively coupled plasma mass spectrometry.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary