Category: 586-61-8

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 586-61-8, name is 1-Bromo-4-isopropylbenzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-4-isopropylbenzene

Under a stream of nitrogen, 2.55 g (105 mmol) of magnesium and 50 ml of anhydrous THF were put into a nitrogen-replaced 300 ml capacity reaction flask, followed by stirring. At room temperature, a 30 ml THF solution of 19.91 g (100 mmol) of 4-t-propylphenylbromobenzene was added dropwise thereto, followed by stirring at room temperature for 1 hour (synthesis of a Grignard compound).Next, the above-mentioned solution was cooled to 5 C. or less, and 10.05 g (50 mmol) of the (S)-proline-N-ethyl carbamate methyl ester obtained in Synthesis Example 2 was added dropwise thereto at 10 C. or less and allowed to undergo the reaction. Thereafter, this was heated under reflux for 3 hours and then cooled, and the reaction solution was added to 100 ml of saturated ammonium chloride aqueous solution, mixed with 100 ml of toluene for extraction, followed by stirring for 1 hour. This was transferred to a separating funnel, and the organic layer was separated and washed twice with saturated brine. After drying the organic layer with anhydrous sodium sulfate, the solvent was evaporated to obtain 16.22 g of (5S)-[3,3,0]-1-aza-2-oxo-3-oxa-4,4-bis-(4′-i-propylphenyl)-bicyclooctane.

The synthetic route of 586-61-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKASAGO INTERNATIONAL CORPORATION; US2010/324338; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 586-61-8, name is 1-Bromo-4-isopropylbenzene, A new synthetic method of this compound is introduced below., Product Details of 586-61-8

Under nitrogen conditions, o-aminobiphenyl (10.0 g, 59 l) was added to the reaction vessel,1-bromo-4′-isopropylbenzene (11.77 g, 59.1 mmol), tris (dibenzylideneacetone) dipalladium (0 ¡¤ lg), tri-tert-butylphosphine (15%, 0.3 g) (1.8 g) and toluene (300 mL) at 60 C for 12 hours. After the reaction solution was cooled, the silica gel filter was filtered and the solution was concentrated and subjected to column chromatography after dichloromethane and hexane to give Compound F-18 (11.50 g, yield 68%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Jilin Aolaide Optoelectric Materials Co., Ltd.; Qin Cuiying; Yu Danyang; Sun Feng; He Jinxin; Wang Shikai; Jin Furong; (19 pag.)CN107162916; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

586-61-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 586-61-8 name is 1-Bromo-4-isopropylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: n-BuLi (1.55 M solution in hexane, 2.32 mL, 3.6 mmol) was added dropwise to a solution of 4-methylphenyl bromide (513 mg, 3.0 mmol) in THF (6.0 mL) at -50 C under Ar atmosphere. After 30 min, DMF (278 muL, 3.6 mmol) was added and the obtained mixture was gradually warmed to r.t. After 1 h at the same temperature, NH2OHxHCl (313 mg, 4.5 mmol) and K2CO3 (622 mg, 4.5 mmol) were added and the obtained mixture was stirred for 2 h at r.t. Then, after removal of the solvent under reduced pressure, toluene (3.0 mL), DPPA (1.61 mL, 7.5 mmol), and DBU (1.57 mL, 10.5 mmol) were added to the obtained residue under Ar atmosphere. After being stirred for 16 h under refluxing conditions, the mixture was cooled to r.t. and then, saturated NaHCO3 aq. (15.0 mL) was added. After being stirred for 5 min, the mixture was diluted with water (5.0 mL). The aqueous layer was then washed with AcOEt (25.0 mL) and acidified with 1.0 M HCl aq. to pH 2. The aqueous layer was extracted with AcOEt (2 x 25.0 mL). Removal of the solvent, followed by purification of the residue by short column chromatography on neutral silica gel (AcOEt: hexane = 1:3-1:1) gave 5-(4?-methylphenyl)tetrazole 3A (336.1 mg, 70%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-isopropylbenzene, and friends who are interested can also refer to it.

Reference:
Article; Kobayashi, Eiji; Togo, Hideo; Tetrahedron; vol. 74; 31; (2018); p. 4226 – 4235;,
Bromide – Wikipedia,
bromide – Wiktionary

586-61-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 586-61-8 as follows.

5-cyano-2-fluorobenzeneboronic acid pinacol ester (1.98 g, 8.0 mmol) and 4-bromoisopropylbenzene (2.39 g, 12 mmol) were dissolved in 20 ml of dioxane, and Pd(PPh3)4 was added. (924 mg, 0.8 mmol) and CsCO3 (5.2 g, 16.0 mmol) were reacted at 90 C overnight under nitrogen. The reaction liquid was filtered through diatomaceous earth.The filtrate was spin-dried and then subjected to petroleum ether column chromatography to yield 1.35 g of colorless oily liquid, yield: 70.6%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 586-61-8, and friends who are interested can also refer to it.

Reference:
Patent; China Pharmaceutical University; You Qidong; Xu Xiaoli; Jiang Fen; Guo Anping; Xu Jiachen; (26 pag.)CN108147978; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

586-61-8, Name is 1-Bromo-4-isopropylbenzene, 586-61-8, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

A mixture of 10 g(50 mmol) 1-bromo-4-isopropylbenzene, 7.4 g(55 mmol) of 4-isopropylaniline, 0.25 g(1 mmol) of palladium(II)acetate, 0.75 g(2.0 mmol) of 2-(dicyclohexylphosphino)biphenyl, 9.6 g(100 mmol) of sodium tert-butoxide and 100 ml of o-xylene was refluxed under nitrogen overnight. After finishing the reaction, the solution was filtered at 100 C., to receive the filtrate, and the filtrate was added to 1 L MeOH, while stirring and the precipitated product was filtered off with suction. To give 4.7 g(yield 37%) of yellow product which was recrystallized from hexane.

Statistics shows that 1-Bromo-4-isopropylbenzene is playing an increasingly important role. we look forward to future research findings about 586-61-8.

Reference:
Patent; LUMINESCENCE TECHNOLOGY CORPORATION; Yen, Feng-Wen; (56 pag.)US9537103; (2017); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 586-61-8 as follows. 586-61-8

To fuming nitric acid (5 mL) cooled to 5 was added neat 4-bromoisopropylbenzene(1.0 g, 5.023 mmol) dropwise at such a rate that the reaction temperature remained below 10. The reaction was stirred for 2 hours at 5-10, quenched with ice (50 g), extracted with ethyl acetate (50 mL), and the organic extract was washed with water (2×25 mL) and brine (25 mL), then dried over magnesium sulfate. filtered and concentrated by rotary evaporation. The residue was purified by silica gel flash chromatography eluting with 5:95 ethyl acetate/hexanes to afford the title compound as a light yellow solid (1.03 g, 4.22 mmol, 84%). 1H NMR (300 MHz, CHLOROFORM-D) delta ppml.27 (d, J=6.99 Hz, 6 H) 2.75 – 3.23 (m, 1 H) 7.29 (dd, J=8.82, 2.21 Hz, 1 H) 7.63 (d, J=8.09 Hz, 1 H) 7.69 (d, J=2.21 Hz, 1 H); MS (DCI) m/z 261/263 (M+NH4)+.

According to the analysis of related databases, 586-61-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBOTT LABORATORIES; WO2008/133753; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary