585-76-2 Archives - Page 4 of 14 - Bromides-buliding-blocks

Xu, Songbo team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | 585-76-2

Application In Synthesis of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Application In Synthesis of 585-76-2.

Xu, Songbo;Zhang, Xiaomin;Xiong, Wenjie;Li, Ping;Ma, Wentao;Hu, Xingbang;Wu, Youting research published 《 Aerobic oxidation of aldehydes to acids in water with cyclic (alkyl)(amino)carbene copper under mild conditions》, the research content is summarized as follows. In this work, cyclic (alkyl)(amino)carbene copper ((CAAC)Cu) catalyzed aerobic oxidation of aldehydes in water at room temperature was reported. Good to excellent yields were obtained using different substrates. A possible reaction mechanism was proposed, in which (CAAC)Cu dioxygen activates the C-H bond of aldehyde with a low barrier of 10.6 kcal mol^-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Yong-Ling team published research in Heterocycles in 2021 | 585-76-2

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Reference of 585-76-2

Wu, Yong-Ling;Yan, Yong;Pan, Tin-Tin;Wang, Dou-dou research published 《 Natural osthole-based ester derivatives as potential fungicidal agents: design, synthesis and quantitative structure-activity relationship (QSAR)》, the research content is summarized as follows. Turning potential natural products into value-added fungicides is a bioactivity-guided mixed synthesis method. Thirty-two osthole based ester derivatives I (R = Me, Ph, 3-ClC₆H₄, etc.) were designed and synthesized to improve the potential use of the osthole, a natural coumarin pharmacophore. Compound I (R = 3-ClC₆H₄) showed a high in vitro and in vivo antifungal activity than other derivatives The preliminary structure-activity relationships (SARs) demonstrated that compounds with a short aliphatic chain or electron-withdrawing groups on Ph ring would have more desirable potency. Meanwhile, the quant. structure-activity relationship (QSAR) model (R² = 0.928, F = 83.54, S² = 0.0042) were performed using Gaussian and CODESSA software with optimal conformers and heuristic regression anal., which revealed a correlation of antifungal activity and mol. structures. Thus, these results laid the foundation for further design of improved crop-protection agents based on osthole scaffold.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Shuai team published research in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2021 | 585-76-2

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application of C7H5BrO2.

Wang, Shuai;Shu, Haiyang;Han, Xianchao;Wu, Xiaofu;Tong, Hui;Wang, Lixiang research published 《 A highly efficient purely organic room-temperature phosphorescence film based on a selenium-containing emitter for sensitive oxygen detection》, the research content is summarized as follows. Developing purely organic room-temperature phosphorescence (RTP) materials with high phosphorescence efficiency in film states is important for their applications but remains a great challenge. Herein, a donor-acceptor type RTP mol. (SeX-CzPh) with 9H-selenoxanthen-9-one and 9-phenyl-9H-carbazole as the acceptor and donor units, resp., is designed and synthesized. SeX-CzPh shows a high phosphorescence quantum yield of 44.3% in a doped polystyrene film at room temperature, which is 4-fold higher than that of its analog TX-CzPh with 9H-thioxanthene-9-one as the acceptor unit. The heavy selenium atom plays a key role in achieving high phosphorescence quantum yields, owing to the effective ISC process through strong spin-orbit coupling. Moreover, the SeX-CzPh-based oxygen film sensor exhibits a wide detection range (0-2.1 x 10⁵ ppm), a high K_SV (1.27 x 10^-4 ppm^-1) and a low detection limit (4.9 ppm). This work demonstrates that 9H-selenoxanthen-9-one is a promising building block for the rational design of highly efficient purely organic RTP materials.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Xiaochen team published research in ACS Catalysis in 2022 | 585-76-2

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organic compounds having carbon bonded to bromine are called organic bromides. COA of Formula: C7H5BrO2.

Wang, Xiaochen;Zhu, Binbing;Liu, Yuxiu;Wang, Qingmin research published 《 Combined Photoredox and Carbene Catalysis for the Synthesis of α-Amino Ketones from Carboxylic Acids》, the research content is summarized as follows. Herein, a mild, operationally simple method for direct acylation of α-amino C(sp³)-H bonds from carboxylic acids RC(O)OH (R = cyclopropyl, Ph, 2-chlorophenyl, etc.) via the merger of carbene and photoredox catalysis was reported. Specifically, cross-coupling reactions between a wide range of carboxylic acids, a class of feedstock chems., and readily available N-alkyl anilines R¹CH₂N(R²)R³ (R¹ = H; R² = Me; R¹R² = -(CH₂)₃-, -(CH₂OCH₂CH₂)-; R³ = Ph, 4-bromophenyl, pyridin-2-yl, etc.) and 1-phenyl-2,3-dihydro-1H-indole by means of single-electron N-heterocyclic carbene catalysis combined with photocatalysis provided access to structurally diverse α-amino ketones RC(O)CH(R¹)N(R²)R³ and (1-phenylindolin-2-yl)(p-tolyl)methanone. The method features a broad substrate scope and is compatible with a wide array of functional groups. To demonstrate the potential applications of the method, one of the α-amino ketone products was subjected to further transformations.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Kai-Kai team published research in RSC Advances in 2021 | 585-76-2

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid, Application of C7H5BrO2

Wang, Kai-Kai;Li, Yan-Li;Zhao, Ying-Chao;Zhang, Shan-Shan;Chen, Rongxiang;Sun, Aili research published 《 Facile synthesis of O-acylhydroxamates via reaction of oxime chlorides with carboxylic acids》, the research content is summarized as follows. A simple and efficient method for the synthesis of O-acylhydroxamate derivatives from oxime chlorides and carboxylic acids was developed. The reaction affords clean and facile access to diverse O-acylhydroxamates in high yields (up to 85%).

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Peng-Zi team published research in Angewandte Chemie, International Edition in 2021 | 585-76-2

Wang, Peng-Zi;Wu, Xue;Cheng, Ying;Jiang, Min;Xiao, Wen-Jing;Chen, Jia-Rong research published 《 Photoinduced Copper-Catalyzed Asymmetric Three-Component Coupling of 1,3-Dienes: An Alternative to Kharasch-Sosnovsky Reaction》, the research content is summarized as follows. Herein, an alternative to the asym. Kharasch-Sosnovsky reaction that utilized a chiral copper catalyst and purple-LED irradiation to enable the three-component coupling of 1,3-dienes RCH=CHC(R¹)=CHR² (R = H, Me; R¹ = H, Me; R² = Ph, 2-phenylethyl, furan-3-yl, etc.), oxime esters I (R³ = H, Me; R⁴ = H; R³R⁴ = -CH=CH-CH=CH-; R⁵ = H; R⁴R⁵ = -CH₂N(Boc)CH₂-, -(CH₂)₂N(Boc)(CH₂)₂-), and carboxylic acids R⁶C(O)OH (R⁵ = t-Bu, Ph, 2H-1,3-benzodioxol-5-yl, etc.) is reported. This protocol features mild conditions, remarkable scope and functional group tolerance as evidenced by >80 examples and utility in the late-stage modification of pharmaceuticals and natural products. Detailed mechanistic studies provide evidences for the radical-based reaction pathway.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vanjare, Balasaheb D. team published research in Molecular Diversity in | 585-76-2

Recommanded Product: 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: 3-Bromobenzoic acid.

Vanjare, Balasaheb D.;Choi, Nam Gyu;Eom, Young Seok;Raza, Hussain;Hassan, Mubashir;Lee, Ki Hwan;Kim, Song Ja research published 《 Synthesis, carbonic anhydrase inhibition, anticancer activity, and molecular docking studies of 1,3,4-oxadiazole derivatives》, the research content is summarized as follows. In this work, various organic compounds possessing 1,3,4-oxadiazole as a core structure and the structure of the newly synthesized target compounds I (X = H, 2-Br, 3-Br, 4-Br; R = Ph, 4-fluorophenyl, pyridin-3-yl, etc.) has been revealed using different anal. approaches such as FT-IR, LCMS, and NMR (proton and carbon), resp. The in vitro carbonic anhydrase potentials of these synthesized 17 different analogs were investigated. The result suggests that compound I (X = H; R = pyridin-3-yl), a 3-pyridine substituted analog with an IC₅₀ of 0.1 μM, was found to have the most potent carbonic inhibitory activity (11-fold more active) than the pos. control (acetazolamide) with an IC₅₀ of 1.1 ± 0.1 μM. Besides, among the series I approved in the identification of four potent carbonic anhydrase inhibitors with the IC₅₀ standards varies from 0.1 to 1.0 ± 0.1 μM. Addnl., the non-competitive behavior for potent compound II was analyzed using the Lineweaver-Burk plot from the kinetic study. Furthermore, the anticancer activity of all the synthesized compounds screened against B16F10 melanoma cells using the MTT assay method. Addnl., the mol. docking studies revealed that II inhibitor shows good binding energy as well as good binding interaction pattern along with enzyme.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Venteicher, Brooklynn team published research in ChemMedChem in 2021 | 585-76-2

Venteicher, Brooklynn;Merklin, Kasey;Ngo, Huy X.;Chien, Huan-Chieh;Hutchinson, Keino;Campbell, Jerome;Way, Hannah;Griffith, Joseph;Alvarado, Cesar;Chandra, Surabhi;Hill, Evan;Schlessinger, Avner;Thomas, Allen A. research published 《 The effects of prodrug size and a carbonyl linker on L-type amino acid transporter 1-targeted cellular and brain uptake》, the research content is summarized as follows. The L-type amino acid transporter 1 (LAT1, SLC7A5) imports dietary amino acids and amino acid drugs (e. g., L-DOPA) into the brain, and plays a role in cancer metabolism Though there have been numerous reports of LAT1-targeted amino acid-drug conjugates (prodrugs), identifying the structural determinants to enhance substrate activity has been challenging. In this work, we investigated the position and orientation of a carbonyl group in linking hydrophobic moieties including the anti-inflammatory drug ketoprofen to L-tyrosine and L-phenylalanine. We found that esters of meta-carboxyl L-phenylalanine had better LAT1 transport rates than the corresponding acylated L-tyrosine analogs. However, as the size of the hydrophobic moiety increased, we observed a decrease in LAT1 transport rate with a concomitant increase in potency of inhibition. Our results have important implications for designing amino acid prodrugs that target LAT1 at the blood-brain barrier or on cancer cells.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Verdirosa, Federica team published research in ChemMedChem in 2022 | 585-76-2

Product Details of C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Verdirosa, Federica;Gavara, Laurent;Sevaille, Laurent;Tassone, Giusy;Corsica, Giuseppina;Legru, Alice;Feller, Georges;Chelini, Giulia;Mercuri, Paola Sandra;Tanfoni, Silvia;Sannio, Filomena;Benvenuti, Manuela;Cerboni, Giulia;De Luca, Filomena;Bouajila, Ezeddine;Vo Hoang, Yen;Licznar-Fajardo, Patricia;Galleni, Moreno;Pozzi, Cecilia;Mangani, Stefano;Docquier, Jean-Denis;Hernandez, Jean-Francois research published 《 1,2,4-Triazole-3-Thione Analogues with a 2-Ethylbenzoic Acid at Position 4 as VIM-type Metallo-β-Lactamase Inhibitors》, the research content is summarized as follows. Metallo-β-lactamases (MBLs) are increasingly involved as a major mechanism of resistance to carbapenems in relevant opportunistic Gram-neg. pathogens. Unfortunately, clin. efficient MBL inhibitors still represent an unmet medical need. We previously reported several series of compounds based on the 1,2,4-triazole-3-thione scaffold. In particular, Schiff bases formed between diversely 5-substituted-4-amino compounds and 2-carboxybenzaldehyde were broad-spectrum inhibitors of VIM-type, NDM-1 and IMP-1 MBLs. Unfortunately, these compounds were unable to restore antibiotic susceptibility of MBL-producing bacteria, probably because of poor penetration and/or susceptibility to hydrolysis. To improve their microbiol. activity, we synthesized and characterized compounds where the hydrazone-like bond of the Schiff base analogs was replaced by a stable Et link. This small change resulted in a narrower inhibition spectrum, as all compounds were poorly or not inhibiting NDM-1 and IMP-1, but showed a significantly better activity on VIM-type enzymes, with Ki values in the μM to sub-μM range. The resolution of the crystallog. structure of VIM-2 in complex with one of the best inhibitors yielded valuable information about their binding mode. Interestingly, several compounds were shown to restore the β-lactam susceptibility of VIM-type-producing E. coli laboratory strains and also of K. pneumoniae clin. isolates. In addition, selected compounds were found to be devoid of toxicity toward human cancer cells at high concentration, thus showing promising safety.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vishwanath, Divakar team published research in Molecules in 2022 | 585-76-2

HPLC of Formula: 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Vishwanath, Divakar;Girimanchanaika, Swamy S.;Dukanya, Dukanya;Rangappa, Shobith;Yang, Ji-Rui;Pandey, Vijay;Lobie, Peter E.;Basappa, Basappa research published 《 Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase》, the research content is summarized as follows. Novel PARP inhibitors with selective mode-of-action have been approved for clin. use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells, wherein seven compounds were observed to possess significant IC₅₀ values in the range of 1.4 to 25 μM. Furthermore, compound 5u, inhibited the viability of MCF-7 cells with an IC₅₀ value of 1.4μM, when compared to Olaparib (IC₅₀ = 3.2 μM). Compound 5s also decreased cell viability in MCF-7 and MDA-MB-231 cells with IC₅₀ values of 15.3 and 19.2 μM, resp. Treatment of MCF-7 cells with compounds 5u and 5s produced PARP cleavage, H2AX phosphorylation and CASPASE-3 activation comparable to that observed with Olaparib. Compounds 5u and 5s also decreased foci-formation and 3D Matrigel growth of MCF-7 cells equivalent to or greater than that observed with Olaparib. Finally, in silico anal. demonstrated binding of compound 5s towardsthe catalytic site of PARP-1, indicating that these novel oxadiazoles synthesized herein may serve as exemplars for the development of new therapeutics in cancer.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary