585-76-2 Archives - Page 2 of 14 - Bromides-buliding-blocks

Yu, Min team published research in Letters in Organic Chemistry in 2021 | 585-76-2

Formula: C7H5BrO2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Formula: C7H5BrO2.

Yu, Min;Wu, Chaolong;Zhou, Li;Zhu, Li;Yao, Xiaoquan research published 《 Aerobic Oxidation of Aldehydes to Carboxylic Acids Catalyzed by Recyclable Ag/C₃N₄ Catalyst》, the research content is summarized as follows. A simple, efficient and recyclable protocol for aerobic oxidation of aldehydes to carboxylic acid RCOOH [R = Ph, 4-ClC₆H₄, 1-naphthyl, etc.] by using C₃N₄ supported silver nanoparticles (Ag/C₃N₄) as a catalyst in aqueous solution under mild conditions was reported. Under standard conditions, the corresponding carboxylic acids could be obtained in good to excellent yields. In addition, Ag/C₃N₄ was convenient for recovery and could be reused three times with satisfactory yields.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yoshimori, Atsushi team published research in ChemMedChem in 2021 | 585-76-2

Reference of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Reference of 585-76-2.

Yoshimori, Atsushi;Asawa, Yasunobu;Kawasaki, Enzo;Tasaka, Tomohiko;Matsuda, Seiji;Sekikawa, Toru;Tanabe, Satoshi;Neya, Masahiro;Natsugari, Hideaki;Kanai, Chisato research published 《 Design and Synthesis of DDR1 Inhibitors with a Desired Pharmacophore Using Deep Generative Models》, the research content is summarized as follows. Discoidin domain receptor 1 (DDR1) inhibitors with a desired pharmacophore were designed using deep generative models (DGMs). DDR1 is a receptor tyrosine kinase activated by matrix collagens and implicated in diseases such as cancer, fibrosis and hypoxia. Herein we describe the synthesis and inhibitory activity of compounds generated from DGMs. Three compounds were found to have sub-micromolar inhibitory activity. The most potent compound (N-(4-chloro-3-((pyridin-3-yloxy)methyl)phenyl)-3-(trifluoromethyl)benzamide), had an IC₅₀ value of 92.5 nM. Furthermore, these compounds were predicted to interact with DDR1, which have a desired pharmacophore derived from a known DDR1 inhibitor. The results of synthesis and experiments indicated that our de novo design strategy is practical for hit identification and scaffold hopping.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhu, Yuan-Yuan team published research in Green Chemistry in 2021 | 585-76-2

Zhu, Yuan-Yuan;Zhang, Tao;Zhou, Linlin;Yang, Shang-Dong research published 《 Concise synthesis of N-phosphorylated amides through three-component reactions》, the research content is summarized as follows. N-Phosphorylated amides continue to be an unparalleled asset for the development of pharmaceutical mols., and the importance of this framework has inspired researchers to look for concise and efficient methods for the synthesis of this unit. In this work, a new strategy was developed in which a one-pot synthesis of N-phosphorylated amides was achieved by a three-component reaction with carboxylic acids, phosphorus chlorides and azides under mild reaction conditions. To authors knowledge, this is the first study in which this framework was constructed through a multicomponent reaction, which is innovative, efficient and economical.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zuo, Youpeng team published research in Advanced Synthesis & Catalysis in 2021 | 585-76-2

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Application In Synthesis of 585-76-2

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 585-76-2.

Zuo, Youpeng;He, Xinwei;Tang, Qiang;Hu, Wangcheng;Zhou, Tongtong;Hu, Wenbo;Shang, Yongjia research published 《 Palladium-Catalyzed 5-exo-dig Cyclization Cascade, Sequential Amination/Etherification for Stereoselective Construction of 3-Methyleneindolinones》, the research content is summarized as follows. An cascade intramol. 5-exo-dig cyclization of N-(2-iodophenyl)propiolamides and sequential amination/etherification (with N-hydroxybenzamides, Ph hydroxycarbamate) protocol for the synthesis of amino- and phenoxy-substituted 3-methyleneindolinones I [R = Ph, 2-naphthyl, 2-thienyl, etc.; R¹ = H, 6-Me, 7-Cl, etc.; R² = Me, Et, Ph, OPh; R³ = Me, Et, allyl, Bn] using unexpensive Pd(PPh₃)₄ as catalyst was developed. The protocol enabled the assembly of structurally important oxindole cores featuring moderate functional group tolerance (particularly the halo group), affording a broad spectrum of products with diverse substituents in good to excellent yields.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Wenjuan team published research in European Journal of Medicinal Chemistry in 2021 | 585-76-2

Electric Literature of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Zhou, Wenjuan;Xu, Chenhao;Dong, Guanjun;Qiao, Hui;Yang, Jing;Liu, Hongmin;Ding, Lina;Sun, Kai;Zhao, Wen research published 《 Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction》, the research content is summarized as follows. Defective in cullin neddylation 1(DCN1) is a co-E3 ligase that is important for cullin neddylation. Dysregulation of DCN1 highly correlates with the development of various cancers. Herein, from the initial high-throughput screening, a novel hit compound 5a containing a phenyltriazole thiol core (IC50 value of 0.95μM for DCN1-UBC12 interaction) was discovered. Further structure-based optimization leads to the development of SK-464 (IC50 value of 26 nM). We found that SK-464 not only directly bound to DCN1 in vitro, but also engaged cellular DCN1, suppressed the neddylation of cullin3, and hindered the migration and invasion of two DCN1-overexpressed squamous carcinoma cell lines (KYSE70 and H2170). These findings indicate that SK-464 may be a novel lead compound targeting DCN1-UBC12 interaction.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Xiao-Yu team published research in Synthesis in 2021 | 585-76-2

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. SDS of cas: 585-76-2.

Zhou, Xiao-Yu;Chen, Xia research published 《 Oxidative C-H Acyloxylation of Acetone with Carboxylic Acids under Iodine Catalysis》, the research content is summarized as follows. Iodine-catalyzed oxidative C(sp³)-H acyloxylation of acetone with carboxylic acids was developed. The method employed iodide as catalyst and sodium chlorite as oxidant. Substituted benzoic acids, naphthoic acids and heteroaromatic carboxylic acids could be used and 2-oxopropyl carboxylates ArC(O)OCH₂C(O)CH₃ [Ar = Ph, 4-BrC₆H₄, 2-furyl, etc.] were obtained with good to excellent yields.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Yuan team published research in Pesticide Biochemistry and Physiology in 2021 | 585-76-2

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid, Electric Literature of 585-76-2

Zhou, Yuan;Cai, Meng;Zhou, Huan;Hou, Leifeng;Peng, Hao;He, Hongwu research published 《 Discovery of efficient inhibitors against pyruvate dehydrogenase complex component E1 with bactericidal activity using computer aided design》, the research content is summarized as follows. Computer aided optimization of lead compounds is of great significance to the design and discovery of new agrochems. A series of 2,6-dimethyl-4-aminopyrimidine acylhydrazones 6 was rationally designed as pyruvate dehydrogenase complex component E1 (PDHc-E1) inhibitors using computer aided drug design. Compounds in series 6 showed excellent inhibitory activity against Escherichia coli PDHc-E1, which was considerably higher than that of the lead compound A2. Compound 6l showed the best inhibitory activity (IC50 = 95 nM). Mol. docking, site-directed mutagenesis, and enzymic assays revealed that the compounds bound in a “straight” conformation in the active site of E. coli PDHc-E1. Compounds 6b, 6e, and 6l showed negligible inhibition against porcine PDHc-E1. The in vitro antibacterial activity indicated that 6a, 6d, 6e, 6g, 6h, 6i, 6m, and 6n exhibited 61%-94% inhibition against Ralstonia solanacearum at 100 μg/mL, which was better than com. thiodiazole-copper (29%) and bismerthiazol (55%). These results demonstrated that a lead structure for a highly selective PDHc-E1 inhibitor as a bactericide could be obtained using computer aided drug design.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Guanyu team published research in Synthesis in 2022 | 585-76-2

Zhou, Guanyu;Huang, Zhibin;Xu, Xu;Fang, Zhang;Huang, Pengcheng;Deng, Zefeng;Li, Bao;Zhao, Yingsheng research published 《 Rhodium(III)-Catalyzed Synthesis of Quinazolin-4(3H)-ones with N-Methoxyamides as Synthesis Reagents》, the research content is summarized as follows. A practical method to synthesize quinoxalinones I [R = H, 6-Me, 7-Et, etc.; R¹ = H, 3-Br, 3-MeO, etc.] via intra/intermol. amination using rhodium as the catalyst was developed. A wide variety of quinoxalinones I were prepared from N-methoxybenzamides in moderate to excellent yields. Gram-scale reactions were also achieved, highlighting the synthetic importance of this new transformation.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhou, Muxing team published research in Angewandte Chemie, International Edition in 2021 | 585-76-2

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organic compounds having carbon bonded to bromine are called organic bromides. Electric Literature of 585-76-2.

Zhou, Muxing;Gridneva, Tatiana;Zhang, Zhenfeng;He, Ende;Liu, Yangang;Zhang, Wanbin research published 《 Chiral Bicyclic Imidazole-Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters》, the research content is summarized as follows. Utilizing a chiral bicyclic imidazole organocatalyst, I, and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3-hydroxyphthalides through enantioselective acylation (up to 99% ee). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure anal. of the key transition states shows that the CH-π interaction, and not the previously considered cation/π-π interactions between the catalyst and substrate, is the dominant factor giving rise to the observed stereocontrol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Zeshuai team published research in ChemistrySelect in 2022 | 585-76-2

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 585-76-2, formula is C7H5BrO2, The most pervasive is the naturally produced bromomethane. Quality Control of 585-76-2

Zhang, Zeshuai;Wen, Fei;Liu, Haiyan;Li, Zheng research published 《 Selective N-Monovinylation of Primary Aromatic Amides Using Calcium Carbide as an Alkyne Source》, the research content is summarized as follows. An efficient method for the selective N-monovinylation of primary aromatic amides using calcium carbide as an alkyne source was described. A series of N-vinylbenzamides (enamides) RC(O)NHCH=CH₂ [R = Ph, 2-MeC₆H₄, 4-ClMeC₆H₄, etc.] were readily synthesized by this strategy. The salient features for this protocol were the use of inexpensive, easy-to-handle solid alkyne source, high chemoselectivity, transition metal catalyst-free, good functional group tolerance, and simple work-up procedures. These reactions was also be extended to the gram-scale level.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary