585-76-2 Archives - Page 10 of 14 - Bromides-buliding-blocks

Gavara, Laurent team published research in Bioorganic Chemistry in 2021 | 585-76-2

585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , Formula: C7H5BrO2

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Formula: C7H5BrO2.

Gavara, Laurent;Legru, Alice;Verdirosa, Federica;Sevaille, Laurent;Nauton, Lionel;Corsica, Giuseppina;Mercuri, Paola Sandra;Sannio, Filomena;Feller, Georges;Coulon, Remi;De Luca, Filomena;Cerboni, Giulia;Tanfoni, Silvia;Chelini, Giulia;Galleni, Moreno;Docquier, Jean-Denis;Hernandez, Jean-Francois research published ã?4-Alkyl-1,2,4-triazole-3-thione analogues as metallo-Î²-lactamase inhibitorsã? the research content is summarized as follows. In Gram-neg. bacteria, the major mechanism of resistance to Î²-lactam antibiotics is the production of one or several Î²-lactamases (BLs), including the highly worrying carbapenemases. Whereas inhibitors of these enzymes were recently marketed, they only target serine-carbapenemases (e.g. KPC-type), and no clin. useful inhibitor is available yet to neutralize the class of metallo-Î²-lactamases (MBLs). We are developing compounds based on the 1,2,4-triazole-3-thione scaffold, which binds to the di-zinc catalytic site of MBLs in an original fashion, and we previously reported its promising potential to yield broad-spectrum inhibitors. However, up to now only moderate antibiotic potentiation could be observed in microbiol. assays and further exploration was needed to improve outer membrane penetration. Here, we synthesized and characterized a series of compounds possessing a diversely functionalized alkyl chain at the 4-position of the heterocycle. We found that the presence of a carboxylic group at the extremity of an alkyl chain yielded potent inhibitors of VIM-type enzymes with Ki values in the Î¼M to sub-Î¼M range, and that this alkyl chain had to be longer or equal to a Pr chain. This result confirmed the importance of a carboxylic function on the 4-substituent of 1,2,4-triazole-3-thione heterocycle. As observed in previous series, active compounds also preferentially contained Ph, 2-hydroxy-5-methoxyphenyl, naphth-2-yl or m-biphenyl at position 5. However, none efficiently inhibited NDM-1 or IMP-1. Microbiol. study on VIM-2-producing E. coli strains and on VIM-1/VIM-4-producing multidrug-resistant K. pneumoniae clin. isolates gave promising results, suggesting that the 1,2,4-triazole-3-thione scaffold worth continuing exploration to further improve penetration. Finally, docking experiments were performed to study the binding mode of alkanoic analogs in the active site of VIM-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Yatong team published research in Inorganic Chemistry in 2022 | 585-76-2

Quality Control of 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid, Quality Control of 585-76-2

Fu, Yatong;Li, Yu;Luo, Donghong;Lu, Yibo;Huang, Jiajun;Yang, Ziyi;Lu, Jian;Jiang, Yuan-Ye;Lu, Ju-You research published ã?Palladium-Catalyzed Regioselective B(3,4)-H Acyloxylation of o-Carboranesã? the research content is summarized as follows. The authors disclosed herein an efficient regioselective B(3,4)-H activation via a ligand strategy, affording B(3)-monoacyloxylated and B(3,4)-diacyloxylated o-carboranes. The identification of amino acid and H₃PO₄ ligand was crucial for the success of B(3)-mono- and B(3,4)-diacyloxylation, resp. This ligand approach was compatible with a broad range of carboxylic acids. The functionalization of complex drug mols. was demonstrated. Other acyloxyl sources, including NaOBz, benzoic anhydride and iodobenzene diacetate, were also tolerated.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fang, Ze-Yu team published research in Chemistry & Biodiversity in 2022 | 585-76-2

Fang, Ze-Yu;Zhang, Yi-Heng;Chen, Chong-Hao;Zheng, Qi;Lv, Peng-Cheng;Ni, Lei-Qiang;Sun, Juan;Wu, Yuan-Feng research published ã?Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitorsã? the research content is summarized as follows. A series of novel quinazolinone hydrazide derivatives were designed and synthesized as EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti-tumor cell proliferation and EGFR inhibitory activities. In the comprehensive anal. of all the tested compounds, the target compound 9c showed the best anti-tumor cell proliferation activity, (IC50=1.31 Î¼M for MCF-7, IC50=1.89 Î¼M for HepG2, IC50=2.10 Î¼M for SGC), and IC50=0.59 Î¼M for the EGFR inhibitory activity. Docking results showed that compound 9c could ideally insert the active site and interact with the critical amino acid residues (Val702, Lys721, Met769, Asp831) in the active site.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Empel, Claire team published research in Organic Letters in 2021 | 585-76-2

Safety of 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Organic compounds having carbon bonded to bromine are called organic bromides. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 3-Bromobenzoic acid.

Empel, Claire;Nguyen, Thanh Vinh;Koenigs, Rene M. research published ã?Tropylium-Catalyzed O-H Insertion Reactions of Diazoalkanes with Carboxylic Acidsã? the research content is summarized as follows. Herein, the application of a nonbenzenoid aromatic carbocation, namely tropylium, as an organic Lewis acid catalyst in O-H functionalization reactions of diazoalkanes with benzoic acids is described. The newly developed protocol is applicable to a wide range of diazoalkane and carboxylic acid substrates with excellent efficiency (43 examples, up to 99% yield).

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dikusar, E. A. team published research in Russian Journal of General Chemistry in 2022 | 585-76-2

Dikusar, E. A.;Akishina, E. A.;Petkevich, S. K.;Zhukouskaya, N. A.;Alekseyev, R. S.;Bumagin, N. A.;Shahab, S. N.;Filippovich, L. N.;Potkin, V. I. research published ã?Synthesis of Bisacridine Derivatives with Pyridine and 1,2-Azole Fragmentsã? the research content is summarized as follows. The authors developed a convenient one-step method for the synthesis of new bisacridine derivatives, containing 5-arylisoxazoles, 4,5-dichloroisothiazole, as well as isonicotinic acid residues covalently attached by ester groups to various positions of the aromatic core. A three-component cascade condensation of 1,5-naphthalenediamine, aldehydes, and cyclic Î²-dicarbonyl compounds was carried out by refluxing in butanol. Quaternary ammonium salts of the synthesized bisacridine derivatives were obtained. Tthe synthesized bisacridine compounds form complexes with palladium LPdCl₂, which exhibit high catalytic activity in a model Suzuki reaction in water in the absence of organic co-solvent.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dong, Chaomin team published research in Angewandte Chemie, International Edition in 2021 | 585-76-2

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 585-76-2.

Dong, Chaomin;Wang, Xiao;Gong, Wenqi;Ma, Wenbo;Zhang, Meng;Li, Jingjie;Zhang, Yuan;Zhou, Zixing;Yang, Zhijian;Qu, Shuli;Wang, Qian;Zhao, Zhu;Yang, Guohui;Lv, Anqi;Ma, Huili;Chen, Qiushui;Shi, Huifang;Yang, Yang;An, Zhongfu research published ã?Influence of Isomerism on Radioluminescence of Purely Organic Phosphorescence Scintillatorsã? the research content is summarized as follows. There are few reports about purely organic phosphorescence scintillators, and the relation between mol. structures and radioluminescence in organic scintillators is still unclear. An isomerism strategy to study the effect of mol. structures on radioluminescence is presented. Bromobenzoic acid (BA) isomers can achieve phosphorescence efficiency of â?2.8% by UV irradiation Under x-ray irradiation, both m-BA and p-BA show excellent radioluminescence, while o-BA has almost no radioluminescence. Through exptl. and theor. study, radioluminescence was not only affected by nonradiation in emissive process, but also highly depended on the material conductivity caused by the different mol. packing. This study allows clear understanding of the relation between the mol. structures and radioluminescence and provides a guidance to rationally design new organic scintillators.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Wenbo team published research in Advanced Synthesis & Catalysis in 2022 | 585-76-2

Hu, Wenbo;Yan, Liqin;Zuo, Youpeng;Kong, Shuwen;Pu, Yue;Tang, Qiang;Wang, Xinyu;He, Xinwei;Shang, Yongjia research published 《 Rhodium(III)-Catalyzed Three-Component Cascade Annulation for Modular Assembly of N-Alkoxylated Isoindolin-1-Ones with Quaternary Carbon Center》, the research content is summarized as follows. A cascade C-H activation, annulation and etherification of N-hydroxybenzamides with propargylamines provided a flexible route to N-alkoxylated 3-arylisoindolin-1-ones. Three new bonds (C-C, C-N, and C-O) were generated to afford a series of isoindolin-1-ones bearing a tetrasubstituted carbon in 49-82% yield. The utility of this method was showcased by gram-scale synthesis and synthetic transformations of the product to access structurally diverse isoindolinones.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Xiao-Qiang team published research in Organic Chemistry Frontiers in 2021 | 585-76-2

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 585-76-2, formula is C7H5BrO2, Name is 3-Bromobenzoic acid. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application In Synthesis of 585-76-2.

Hu, Xiao-Qiang;Hou, Ye-Xing;Liu, Zi-Kui;Gao, Yang research published 《 Ruthenium-catalyzed C-H/C-N bond activation: facile access to isoindolinones》, the research content is summarized as follows. A facile ruthenium-catalyzed C-H/C-N bond activation and the subsequent annulation of readily available benzoic acids with in situ generated formaldimines was reported. The choice of solvent and base was critical for this reaction. This protocol allowed the efficient synthesis of a wide range of biol. important isoindolinones I [R = Ts, 4-ClC₆H₄SO₂, 4-t-BuC₆H₄SO₂, 4-F₃COC₆H₄SO₂; R¹ = H, Me, Ph, etc.; R² = H, Br, OPh, etc.; R³ = H, n-Bu, Cl, etc.; R⁴ = H, Cl, Br; R¹R² = (CH₂)₄; R²R³ = CH=CH-CH=CH] in useful to excellent yields without the use of any external oxidants. The late-stage modification of bioactive acids such as adapalene, bexarotene and flufenamic acid demonstrated the synthetic utility of this methodol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Xiao-Qiang team published research in Organic Letters in 2021 | 585-76-2

HPLC of Formula: 585-76-2, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Hu, Xiao-Qiang;Liu, Zi-Kui;Hou, Ye-Xing;Xu, Ji-Hang;Gao, Yang research published 《 Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis》, the research content is summarized as follows. The merger of strain-release of 1,2-oxazetidines I (R = 4-Me, 2,4,5-(OMe)₃, 4-Br, etc.) with carboxylic acids 2-R¹-3-R²-4-R³-5-R⁴C₆HC(O)OH [R¹ = H, Me, Bn, I, etc.; R² = H, Ph, Br, Me, etc.; R¹R² = -(CH₂)₄-; R³ = H, Me, t-Bu, Br, etc.; R²R³ = -CH=CH-CH=CH-; R⁴ = H, OMe] directed C-H activation in catalytic synthesis of isoindolinones II was reported for the first time. This reaction opens a new and sustainable avenue to prepare a range of structurally diverse isoindolinone skeletons II from readily available benzoic acids. The success of late-stage functionalization of some bioactive acids II, and concise synthesis of biol. important skeletons demonstrated its great synthetic potential in drug discovery. Mechanistic studies indicated a plausible C-H activation/β-carbon elimination/intramol. cyclization cascade pathway.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hoque, Emdadul Md team published research in Angewandte Chemie, International Edition in 2022 | 585-76-2

Name: 3-Bromobenzoic acid, 3-bromobenzoic acid is a bromobenzoic acid carrying a single bromo subsituent at the 3-position.
3-Bromobenzoic acid, also known as 3-Bromobenzoic acid, is a useful research compound. Its molecular formula is C7H5BrO2 and its molecular weight is 201.02 g/mol. The purity is usually 95%.
3-bromobenzoic acid is used as a reagent in the synthesis of deoxypodophyllotoxin derivatives with insecticidal activity. Also used as a reagent in the synthesis of thiazole derivatives with antibacterial activity.
3-bromobenzoic acid is a molecule that is classified as a Group P2. It has an electronegativity of 1.3 and an acidity of 0.8, which are both in the middle range of values for this group. 3-Bromobenzoic acid is soluble in water and is soluble in ethanol, acetone, and ether. The chemical structure of 3-bromobenzoic acid can be determined by its monoclonal antibody binding sites, electrochemical impedance spectroscopy data, and Langmuir adsorption isotherm data. 3-Bromobenzoic acid reacts with hydrochloric acid to form benzoate and HCl gas. Chronic exposure to 3-bromobenzoic acid has been shown to cause glutamate dehydrogenase inhibition, leading to an accumulation of p-hydroxybenzoic acid in the body. , 585-76-2.

Hoque, Emdadul Md;Bisht, Ranjana;Unnikrishnan, Anju;Dey, Sayan;Mahamudul Hassan, Mirja Md;Guria, Saikat;Rai, Rama Nand;Sunoj, Raghavan B.;Chattopadhyay, Buddhadeb research published 《 Iridium-Catalyzed Ligand-Controlled Remote para-Selective C-H Activation and Borylation of Twisted Aromatic Amides》, the research content is summarized as follows. A method of para-selective borylation of fully twisted aromatic amides ArCONBoc₂ is described, yielding boronamides 4-pinBC₆H_nX_4-nCONBoc₂ (X = alkyl, alkoxy, aryl, halo, CN). The borylation proceeded via an unprecedented substrate-ligand distortion between the twisted aromatic amides and a newly designed ligand framework, 4,5-diaza-9H-fluorene (defa) that is different from the traditionally used ligand (dtbpy) for the C-H borylation reactions. The designed ligand defa has led to the development of a new type of catalytic system that shows excellent para selectivity for a range of aromatic amides. Moreover, the designed ligand has shown excellent reactivity and selectivity for a range of heterocyclic aromatic amides. The identification of key transition states and intermediates using the DFT computations associated with the three regio-isomeric pathways revealed that the most efficient catalytic pathway with the defa ligand leads to the para borylation while in the case of bpy the borylation at the para and meta sites compete.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary