Category: 583-70-0

Application of 583-70-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-70-0, name is 2,4-Dimethylbromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 2: to a suspension of magnesium powder (239 mg, 9.79 mmol) in dry THF(small amount) was added dropwise 1 -bromo-2,4-dimethylbenzene (1.64 g, 8.86mmol) diluted in dry THF (20 mL) and the reaction was heated at 40C. Aftercompletion of Grignard reagent, 2-methyl-N-[(5-methylfuran-2-yl)methylidene]propane-2-sulfinamide (995 mg, 4.66 mmol) diluted in THF (10mL) was added to the solution. The reaction mixture was stirred at rt overnight.Water was added to quench the reaction. The two layers were partitionated andthe organic layer was dried over Mg504, filtered and the solution wasconcentrated under reduced pressure. The crude material was purified by silicagel column chromatography using a gradient of hexanes/EtOAc ([5:1] to [4:1]) to afford N-[(2,4-di methyl phenyl)(5-methylfuran-2-yl)methyl]-2-methylpropane-2- sulfinamide (1 .27 g, 85%) as yellowish oil

The synthetic route of 2,4-Dimethylbromobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; BONNET, Pascal; FOGHA, Jade; (82 pag.)WO2018/138354; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-70-0, name is 2,4-Dimethylbromobenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H9Br

(e) (2,4-dimethyiphenyl)(phenyl)methanamine hydrochloride: To a suspension of Mg (1.32g, 55 nunol) in TI-iF (60 mnL) was added a catalytic aniount of 12 and ibrorno-2,4diniethylbenzene(0.5 g). The reaction was initiated by heating and then additional i-bromo-2,4-dimethylbenzene (8.75 g) was added dropwise. The mixture was stirred at it for 4 h under nitrogen. Benzonitrlie (5.15 g, 50 mmol) was added dropwise into the solution . After the addition, the reaction mixture was stirred at it for 16 Ii. Then the reaction was quenched by the addition 20 mL of MeOH,followed by NaBI-i, (1.9 g, 50 mniol) in portions. After stirring at rt for 5 h, the reaction was quenched by the addition of 20 nL water. Solvent was removed under reduced pressure. The residue was extracted with EtOAc (3 x 100 mE). IN aq. HCI was added to the combined organic layers during which a white solid precipitated. The white solid was collected by filtration (8.8 g, 84%). LCMS-Pi: 195 FM-NT-I2]4 IT-, = 1.232 mm. ?El NMR (500 MHz, DMSO-d6) 6 ppm9.15 (s, 2H), 7.55 (d,J 8.0 Hz, iT-i), 7.45 7.32 (in, 5Ff), 7.12 (d,.1 8.0 Hz, IT-i), 7.04 (s, iFi),5.64 5.62 (in, 1H), 2.27 (s, 3H), 2.22(s, 3H).

According to the analysis of related databases, 583-70-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; WO2013/19626; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 583-70-0, name is 2,4-Dimethylbromobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 583-70-0

General procedure: To a flask containing Mg turnings (0.29 g, 12 mmol) was added1-bromo-4-methylbenzene (1.37 g, 8.0 mmol) in THF (8 mL) at room temperature. After being stirred for 2 h, DMF (1.3 mL,12 mmol) was added to the reaction mixture. The obtained mixturewas stirred for 2 h at 0 C. Then, aq NH3 (7 mL, 28-30%) and I2 (4.06 g, 16 mmol) were added to the reaction mixture. After beingstirred for 2 h at room temperature, the reaction mixture waspoured into satd aq Na2SO3 solution and was extracted with CHCl3 (3*30 mL). The organic layer was dried over Na2SO4 and filtered.After removal of the solvent, the residue was purified by shortcolumn chromatography on silica gel (eluent: hexane/ethylacetate=9:1, v/v) to provide pure 4-methyl-1-benzonitrile (0.77 g) in 82% yield.

The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ishii, Genki; Harigae, Ryo; Moriyama, Katsuhiko; Togo, Hideo; Tetrahedron; vol. 69; 5; (2013); p. 1462 – 1469;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 583-70-0,Some common heterocyclic compound, 583-70-0, name is 2,4-Dimethylbromobenzene, molecular formula is C8H9Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under the protection of nitrogen,Add in a 100ml reaction bottle2.67 g of 2,4-dimethylaniline (molecular weight: 121, 22 mmol),2.68 g of 2,4-dimethylbromobenzene (molecular weight 184, 20 mmol),5.76 g of sodium tert-butoxide (molecular weight 96,60 mmol),Pd2(dba)3 183mg (molecular weight 916, 0.2mmol),P(tBu)3 121 mg (molecular weight 202, 0.6 mmol).Anhydrous toluene 50 ml. Plus,The oil bath is slowly heated to reflux reaction.TLC monitors the end of the reaction,The reaction was completed in 10 hours.Cool, add water to quench the reaction,Extracted with 50 ml of dichloromethane,The organic phase was dried over anhydrous MgSO4.The organic phase is evaporated to dryness.The obtained solid is separated by column chromatography.3.8 g of a white solid,Molecular weight 225, yield 85% by weight.

The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Sun Entao; Gao Wenzheng; Fan Hongtao; Zhang Xianghui; (44 pag.)CN109134456; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 583-70-0, name is 2,4-Dimethylbromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 583-70-0

To a dried 3-necked round-bottomed flask equipped with a condenser, thermometer, and N 2 purge was added Pd(dba) 2 (3.80 g, 6.61 mmol), KOH (37.5 g, 568.12 mmol), and 4-aminobutanoic acid (5; 23.0 g, 223 mmol), and the ligand di-tert-butyl(2′-isopropoxy-1,1′-binaphthyl-2-yl)phosphine (13; 3.25 g, 6.41 mmol). The mixture was degassed with N2 . Compound 4 (40.0 g, 216.14 mmol) and t-BuOH (1.50 L) were added to the brown mixture. The mixture was degassed with N2 and heated to 90 C for 18 h. The reaction progress was monitored by LCMS. After the completion of the reaction, majority of t-BuOH was removed under vacuum. A brown residue was obtained. H2O (100 mL) and CH2Cl2 (500 ml) were added to the reaction mixture. The pH of the aqueous layer was adjusted to 3-4 by aq 4 M HCl. The contents were filtered through a pad of Celite and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (500 mL). The organic phase was dried (MgSO4), filtered, and concentrated to half of the volume and petroleum ether (bp 40-60 C) (200 mL) was added. The brown solution was cooled to 5-10 C for 2 h to obtain a slurry, which upon filtration and drying provided a brownish solid; yield: 36 g (78%)

The synthetic route of 2,4-Dimethylbromobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Vaid, Radhe K.; Boini, Sathish K.; Alt, Charles A.; Spitler, Jeremy T.; Hadden, Chad E.; Frank, Scott A.; Moher, Eric D.; Synthesis; vol. 46; 18; (2014); p. 2463 – 2470;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 583-70-0, name is 2,4-Dimethylbromobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 583-70-0, Safety of 2,4-Dimethylbromobenzene

General procedure: A solution of 4-methoxybromobenzene (2.67 mmol)and cyclopent-2-en-1-one (3.2 mmol) in DMSO was stirred at ambient temperaturefor 10 min under nitrogen, and treated with Na2CO3 (8.01mmol) and tri-tert-butylphosphonium tetrafluoroborate (0.53 mmol).The reaction mixture was degassed with nitrogen for 10 min and treated withPd(PPh3)2Cl2 (0.13 mmol) and X-Phos (0.26mol), and stirred at 100 0C for 12 h. The reaction mixture was cooledto ambient temperature, diluted with water, and extracted with AcOEt (3 x 50ml). The combined organic layers were washed with brine, dried over anhydrousNa2SO4, and evaporated. Flash chromatograph on silica gel(AcOEt:cyclohexane 1:3) provided the Heck coupling product as brown solid (340mg, 68%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dimethylbromobenzene, and friends who are interested can also refer to it.

Reference:
Article; Gowala, Tarak Nath; Pabba, Jagadish; Tetrahedron Letters; vol. 56; 14; (2015); p. 1801 – 1804;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 583-70-0,Some common heterocyclic compound, 583-70-0, name is 2,4-Dimethylbromobenzene, molecular formula is C8H9Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a three-necked, 50mLflask equipped with a magnetic stirring bar, 15mL of THF, 2.5mmol of ester(1 equiv), 0.375mmol of CuO (15%equiv), 7.5 mmol of aryl halides and magnesium chips (3 equiv) or 15mmol ofalkyl bromides and magnesium chips(6 equiv) were added. The reaction mixturewas heated at 65 Cfor 4 h. Theprogress of the reaction was monitored by TLC. Then, the reaction was quenchedby saturated aqueous NH4Cl (5 mL), extracted with AcOEt (10 mL ¡Á 3),dried over sodium sulfate, filtered, and evaporated to give the raw product.Pure product could be obtained by TLC with petroleum /AcOEt = 5/1 as eluent

The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gao, Fei; Deng, Xiang-Jun; Tang, Yu; Tang, Jin-Peng; Yang, Jun; Zhang, Yuan-Ming; Tetrahedron Letters; vol. 55; 4; (2014); p. 880 – 883;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 583-70-0, name is 2,4-Dimethylbromobenzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C8H9Br

Step 2: to a suspension of magnesium powder (239 mg, 9.79 mmol) in dry THF (small amount) was added dropwise 1 -bromo-2,4-dimethylbenzene (1.64 g, 8.86 mmol) diluted in dry THF (20 mL) and the reaction was heated at 40C. After completion of Grignard reagent, 2-methyl-N-[(5-methylfuran-2-yl)methylidene]propane-2-sulfinamide Ex.8a (995 mg, 4.66 mmol) diluted in THF Ex.8b (10 mL) was added to the solution. The reaction mixture was stirred at rt overnight. Water was added to quench the reaction. The two layers were partitionated and the organic layer was dried over MgSO4, filtered and the solution was concentrated under reduced pressure. The crude material was purified by silica gel column chromatography using a gradient of hexanes/EtOAc ([5:1 ] to [4:1 ]) to afford N-[(2,4-dimethylphenyl)(5-methylfuran-2-yl)methyl]-2-methylpropane-2-sulfinamide (1.27 g, 85%) as yellowish oil.

According to the analysis of related databases, 583-70-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; BONNET, Pascal; FOGHA, Jade; (76 pag.)WO2018/138356; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 583-70-0, The chemical industry reduces the impact on the environment during synthesis 583-70-0, name is 2,4-Dimethylbromobenzene, I believe this compound will play a more active role in future production and life.

(Diethylamino)-bis(2,4-dimethylphenyl)phosphine (B46): A solution of 2.92 ml (21.61 mmol) of 4-bromo-1,3-dimethylbenzene in 3 ml of Et2O were added at 0 C. to a suspension of 0.5 g (20.56 mmol) of magnesium turnings in 7 ml of THF and 7 ml of Et2O and also a crystal of iodine. The mixture was heated to room temperature, stirred further overnight and slowly added dropwise at 0 C. to a solution of 1.5 ml (10.31 mmol) of Et2NPCl2 in 8 ml of THF. The mixture was heated to 5-10 C., stirred for a further 2 hours and the solvent was subsequently removed under reduced pressure. After adding 60 ml of hexane, the mixture was filtered through Celite under argon and the solvent was subsequently removed under reduced pressure. Yield: 1.37 g (59% of theory). 1H NMR (400 MHz, CDCl3) delta, 6.9 (m, 6H), 3.03 (m, 4H, CH2), 2.20 (s, 12H, CH3), 0.81 (t, 3J=7.0 Hz, 6H, CH3) 31P NMR (161.9 MHz, CDCl3) delta, 47.8.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dimethylbromobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Meseguer, Benjamin; Militzer, Hans-Christian; Castillon, Sergio; Claver, Carmen; Diaz, Yolanda; Aghmiz, Mohamed; Guiu, Ester; Aghmiz, Ali; Masdeu, Anna; US2005/80047; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 583-70-0, name is 2,4-Dimethylbromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H9Br

General procedure: By using 3,6-di-tert-butyldimethylsilyloxy-Si-xanthone obtained in Example 1, the step (6), Compounds (a) to (e) were synthesized by the following procedures. (0134) A bromobenzene derivative (1.0 mmol) and anhydrous tetrahydrofuran (THF, 5 mL) were added to a sufficiently dried flask under an argon atmosphere. The mixture was cooled to -78 C., and then 1 M sec-butyllithium (0.5 mmol) was added thereto, and the mixture was stirred for 20 minutes. 3,6-Di-tert-butyldimethylsilyloxy-Si-xanthone (0.015 to 0.019 mmol) dissolved in anhydrous THF (5 mL) was slowly added to the mixture at the same temperature, and the mixture was brought to room temperature. The mixture was stirred at room temperature for 1 hour, and then 2 N hydrochloric acid (5 mL) was added thereto, and the mixture was stirred for 20 minutes. The reaction mixture was extracted with dichloromethane, and the organic layer was washed with brine, and dried over anhydrous sodium sulfate. The solvent was removed, and then the residue was purified by HPLC to obtain the objective substance.

The synthetic route of 583-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF TOKYO; Nagano, Tetsuo; Hanaoka, Kenjiro; Koide, Yuichiro; Egawa, Takahiro; US9170266; (2015); B2;,
Bromide – Wikipedia,
bromide – Wiktionary