Category: 574-98-1

Mumtaz, Saira; Robertson, Mark J.; Oelgemoller, Michael published an article in 2019, the title of the article was Continuous flow photochemical and thermal multi-step synthesis of bioactive 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

An effective multi-step continuous flow approach towards N-(diamino)alkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones I [R = H, Me, OMe, F, R1 = Me, Et, X = (CH2)n, n = 2, 3], including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochem.-thermal-thermal flow setup rapidly provides the desired target compounds I in superior yields and significantly shorter reaction times. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to arylmethylene isoindolinone preparation continuous flow photochem thermal, bromoalkyl phthalimide arylactetate continuous flow photochem thermal reaction, arylmethylene isoindolinones, continuous-flow photochemistry, multi-step synthesis, photochemistry, photodecarboxylation, phthalimide and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 1, 2018, Erokhina, Svetlana A.; Stogniy, Marina Yu.; Suponitsky, Kyrill Yu.; Kosenko, Irina D.; Sivaev, Igor B.; Bregadze, Vladimir I. published an article.COA of Formula: C10H8BrNO2 The title of the article was Synthesis of new nido-carborane based carboxylic acids and amines. And the article contained the following:

New nido-carborane based carboxylic acids 10-HOOC(CH2)n(Me)S-7,8-C2B9H11 (n = 1-4) were prepared by alkylation of Bu4N salt of 10-methylthio-7,8-dicarba-nido-borane with ω-haloalkyl esters or nitriles followed by acid hydrolysis. Likewise nido-carborane based amines 10-H2N(CH2)n(Me)S-7,8-C2B9H11 (n = 2, 3) were obtained using ω-bromoalkylphthalimides as alkylating agents followed by removal of the protecting group with hydrazine. Structure of 10-C6H4(CO)2NCH2CH2(Me)S-7,8-C2B9H11 was determined by single crystal x-ray diffraction. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).COA of Formula: C10H8BrNO2

The Article related to amine carboranylthioalkyl derivative preparation, carboxylic acid carboranylthioalkyl derivative preparation, carboranyl thioalkylphthalimide preparation crystal structure reaction hydrazine, mol structure carboranyl thioalkylphthalimide, alkylation thiodicarbaborane haloalkyl ester nitrile and other aspects.COA of Formula: C10H8BrNO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Miranda, Alexandre S.; Marcos, Paula M.; Ascenso, Jose R.; Robalo, M. Paula; Bonifacio, Vasco D. B.; Berberan-Santos, Mario N.; Hickey, Neal; Geremia, Silvano published an article in 2021, the title of the article was Conventional vs. microwave- or mechanically-assisted synthesis of dihomooxacalix[4]arene phthalimides: NMR, X-ray and photophysical analysis.Product Details of 574-98-1 And the article contains the following content:

Direct O-alkylation of p-tert-Bu dihomooxacalix[4]arene with N-(bromopropyl)- or N-(bromoethyl)phthalimides and K2CO3 in acetonitrile were conducted under conventional heating (reflux) and using microwave irradiation and ball milling methodologies. The reactions afforded mono- and mainly distal di-substituted derivatives in the cone conformation, in a total of eight compounds I [Y1=Y2=Y3=Y4 = H, phthalimidoethyl, phthalimidopropyl]. The compounds I were isolated by column chromatog., and their conformations and the substitution patterns were established by NMR spectroscopy (1H, 13C, COSY and NOESY experiments). The X-ray structures of four dihomooxacalix[4]arene phthalimide derivatives I[Y1=Y2=Y3 = H, Y4 = phthalimidopropyl or phthalimidoethyl; Y1=Y3 = phthalimidopropyl, Y2=Y4 = H; Y1=Y2 = H, Y3=Y4 = phthalimidopropyl] were reported, as well as their photophys. properties. The microwave (MW)-assisted alkylations drastically reduced the reaction times (from days to less than 45 min) and produced higher yields of both 1,3-di-substituted phthalimides I [Y1=Y3 = phthalimidoethyl; Y2=Y4 = H, Y1=Y3 = phthalimidopropyl; Y2=Y4 = H] with higher selectivity. Ball milling did not revealed to be a good method for this kind of reaction. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1

The Article related to dihomooxacalixarene bromolalkyl phthalimide alkylation microwave, phthalimidoalkoxy dihomooxacalixarene preparation crystal structure, nmr spectroscopy, x-ray diffraction, ball milling, conventional synthesis, dihomooxacalix[4]arenes, electronic absorption and fluorescence studies, microwave irradiation, phthalimide derivatives and other aspects.Product Details of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oliver, Martin; Le Corre, Laurent; Poinsot, Melanie; Corio, Alessandra; Madegard, Lea; Bosco, Michael; Amoroso, Ana; Joris, Bernard; Auger, Rodolphe; Touze, Thierry; Bouhss, Ahmed; Calvet-Vitale, Sandrine; Gravier-Pelletier, Christine published an article in 2021, the title of the article was Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors.Computed Properties of 574-98-1 And the article contains the following content:

The straightforward synthesis of aminoribosyl uridines substituted by a 5′-methylene-urea is described. 90Their convergent synthesis involves the urea formation from various activated amides and an azidoribosyl uridine substituted at the 5′ position by an aminomethyl group. This common intermediate resulted from the diastereoselective glycosylation of a phthalimido uridine derivative with a ribosyl fluoride as a ribosyl donor. The inhibition of the MraY transferase activity by the synthesized 11 urea-containing inhibitors was evaluated and 10 compounds revealed MraY inhibition with IC50 ranging from 1.9μM to 16.7μM. Their antibacterial activity was also evaluated on a panel of Gram-pos. and Gram-neg. bacteria. Four compounds exhibited a good activity against Gram-pos. bacterial pathogens with MIC ranging from 8 to 32μg mL-1, including methicillin resistant Staphylococcus aureus (MRSA) and Enterococcus faecium. Interestingly, one compound also revealed antibacterial activity against Pseudomonas aeruginosa with MIC equal to 64μg mL-1. Docking experiments predicted two modes of positioning of the active compounds urea chain in different hydrophobic areas (HS2 and HS4) within the MraY active site from Aquifex aeolicus. However, mol. dynamics simulations showed that the urea chain adopts a binding mode similar to that observed in 5CKR structural model and targets the hydrophobic area HS2. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Computed Properties of 574-98-1

The Article related to stereoselective glycosylation nucleoside mol modeling enzyme active site, methicillin drug resistant staphylococcus aureus enterococcus faecium hydrogen bond, peptide mol modeling urea mray antibacterial enzyme active site, mol modeling inhibitor mray inhibitor synthesis antibacterial transferase phosphoacetylmuramoylpeptidetransferase and other aspects.Computed Properties of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary