Category: 574-98-1

On June 18, 2021, Luedtke, Matthew W.; Pisano, Joseph; Paquin, Lucas; Walker, Joel; Madalengoitia, Jose S. published an article.Computed Properties of 574-98-1 The title of the article was Broadening the Scope of the Zwitterionic 1,3-Diaza-Claisen Rearrangement through a Tethering Strategy. And the article contained the following:

Expansion of the scope of the 1,3-diaza-Claisen rearrangement beyond bridged-bicyclic tertiary allylic amines has been investigated through a tethering strategy. Isothioureas tethered to tertiary allylic amines are converted to carbodiimides through a reaction with AgOTf/Et3N. Intramol. cyclization of the tertiary allylic amine to the carbodiimide equilibrates with a zwitterionic intermediate. Heating the carbodiimide/zwitterion affords a rearrangement product. Heating carbodiimide/zwitterion with a deuterated allyl group results in the scrambling of the deuterium label, which is consistent with an ionic mechanism involving heterolytic cleavage of the allylic C-N bond, followed by trapping of the allyl cation at either terminal carbon. The ionic mechanism is attributed to silver salt contamination since pushing deuterium-labeled carbodiimide/zwitterion through silica gel prior to heating results in clean deuterium transposition consistent with a sigmatropic mechanism, and adding back silver salts results in deuterium scrambling. Overall, the tethering strategy broadens the scope of the rearrangement to simpler allylic substrates. D. functional theory (DFT) calculations of the sigmatropic rearrangement are in agreement with reactivity trends observed with reactions run under silver-free conditions. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Computed Properties of 574-98-1

The Article related to zwitterionic diaza claisen rearrangement sothiourea tethered tertiary allylic amine, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 13, 2021, Zimmermann, Birte M.; Ngoc, Trung Tran; Tzaras, Dimitrios-Ioannis; Kaicharla, Trinadh; Teichert, Johannes F. published an article.Category: bromides-buliding-blocks The title of the article was A Bifunctional Copper Catalyst Enables Ester Reduction with H2: Expanding the Reactivity Space of Nucleophilic Copper Hydrides. And the article contained the following:

Employing a bifunctional catalyst based on a copper(I)/NHC complex and a guanidine organocatalyst, catalytic ester reductions to alcs. with H2 as terminal reducing agent are facilitated. The approach taken here enables the simultaneous activation of esters through hydrogen bonding and formation of nucleophilic copper(I) hydrides from H2, resulting in a catalytic hydride transfer to esters. The reduction step is further facilitated by a proton shuttle mediated by the guanidinium subunit. This bifunctional approach to ester reductions for the first time shifts the reactivity of generally considered “soft” copper(I) hydrides to previously unreactive “hard” ester electrophiles and paves the way for a replacement of stoichiometric reducing agents by a catalyst and H2. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Category: bromides-buliding-blocks

The Article related to bifunctional azaheterocyclic carbene copper catalyst guanidine ester reduction alc, General Organic Chemistry: Synthetic Methods and other aspects.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Torres, Gerardo M.; Liu, Yi; Arndtsen, Bruce A. published an article in 2020, the title of the article was A dual light-driven palladium catalyst: Breaking the barriers in carbonylation reactions.Application of 574-98-1 And the article contains the following content:

Transition metal-catalyzed coupling reactions have become one of the most important tools in modern synthesis. However, an inherent limitation to these reactions is the need to balance operations, because the factors that favor bond cleavage via oxidative addition ultimately inhibit bond formation via reductive elimination. Here, we describe an alternative strategy that exploits simple visible-light excitation of palladium to drive both oxidative addition and reductive elimination with low barriers. Palladium-catalyzed carbonylations can thereby proceed under ambient conditions, with challenging aryl or alkyl halides and difficult nucleophiles, and generate valuable carbonyl derivatives such as acid chlorides, esters, amides, or ketones in a now-versatile fashion. Mechanistic studies suggest that concurrent excitation of palladium(0) and palladium(II) intermediates is responsible for this activity. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application of 574-98-1

The Article related to palladium catalyst carbonylation alkyl halide aryl carbon monoxide, General Organic Chemistry: Synthetic Methods and other aspects.Application of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 21, 2021, Xiong, Yuan; Donovan, Katherine A.; Eleuteri, Nicholas A.; Kirmani, Nadia; Yue, Hong; Razov, Anthony; Krupnick, Noah M.; Nowak, Radoslaw P.; Fischer, Eric S. published an article.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Chemo-proteomics exploration of HDAC degradability by small molecule degraders. And the article contained the following:

Targeted protein degradation refers to the use of small mols. that recruit a ubiquitin ligase to a target protein for ubiquitination and subsequent proteasome-dependent degradation While degraders have been developed for many targets, key questions regarding degrader development and the consequences of acute pharmacol. degradation remain, specifically for targets that exist in obligate multi-protein complexes. Here, we synthesize a pan-histone deacetylase (HDAC) degrader library for the chemo-proteomic exploration of acute degradation of a key class of chromatin-modifying enzymes. Using chemo-proteomics, we not only map the degradability of the zinc-dependent HDAC family identifying leads for targeting HDACs 1-8 and 10 but also explore important aspects of degrading epigenetic enzymes. We discover cell line-driven target specificity and that HDAC degradation often results in collateral loss of HDAC-containing repressive complexes. These findings potentially offer a new mechanism toward controlling chromatin structure, and our resource will facilitate accelerated degrader design and development for HDACs. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to hdac degradability small mol degrader chemoproteomics exploration, e3 ligase, hdac, imid, protac, collateral degradation, degrader, targeted degradation, ubiquitin, Placeholder for records without volume info and other aspects.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Sheng; Zhang, Fuwu; Yu, Guocan; Wang, Zhantong; Jacobson, Orit; Ma, Ying; Tian, Rui; Deng, Hongzhang; Yang, Weijing; Chen, Zhi-Yi; Chen, Xiaoyuan published an article in 2020, the title of the article was Zwitterionic-to-cationic charge conversion polyprodrug nanomedicine for enhanced drug delivery.Product Details of 574-98-1 And the article contains the following content:

Zwitterionic surface modification is a promising strategy for nanomedicines to achieve prolonged circulation time and thus effective tumor accumulation. However, zwitterion modified nanoparticles suffer from reduced cellular internalization efficiency. A polyprodrug-based nanomedicine with zwitterionic-to-cationic charge conversion ability (denoted as ZTC-NMs) was developed for enhanced chemotherapeutic drug delivery. The polyprodrug consists of pH-responsive poly(carboxybetaine)-like zwitterionic segment and glutathione-responsive camptothecin prodrug segment. The ZTC-NMs combine the advantages of zwitterionic surface and polyprodrug. Compared with conventional zwitterionic surface, the ZTC-NMs can respond to tumor microenvironment and realize ZTC surface charge conversion, thus improve cellular internalization efficiency of the nanomedicines. This ZTC method offers a strategy to promote the drug delivery efficiency and therapeutic efficacy, which is promising for the development of cancer nanomedicines. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Product Details of 574-98-1

The Article related to polyprodrug nanomedicine zwitterionic cationic charge conversion drug delivery, charge conversion, nanomedicine, polyprodrug, triggered drug release, zwitterionic, Placeholder for records without volume info and other aspects.Product Details of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On March 31, 2020, Babin, Victor; Tournier, Benjamin B.; Davis, Audrey; Dubost, Emmanuelle; Pigree, Gilbert; Lohier, Jean-Francois; Reboul, Vincent; Cailly, Thomas; Bouillon, Jean-Philippe; Millet, Philippe; Fabis, Frederic published an article.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Design of iodinated radioligands for SPECT imaging of central human 5-HT4R using a ligand lipophilicity efficiency approach. And the article contained the following:

A series of iodinated ligands for the SPECT imaging of 5-HT4 receptors was designed starting from the previously reported hit MR-26132. We focused on the modulation of the piperidine-containing lateral chain by introducing hydrophilic groups in order to decrease the lipophilicity of the new ligands. All the synthesized compounds were tested for their binding affinities on 5-HT4Rs and based on the Ligand Lipophilicity Efficiency approach, compound 13 was further selected for radioiodination with iodine-125 and imaging experiments Compound 13 showed its ability to displace the specific signal of the reference compound [125I]SB-207710 but no significant detection of [125I]13 was observed in vivo in SPECT experiments The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to iodinated radioligand preparation spect imaging 5ht4 receptor lipophilicity, 5-ht(4), lle, radio-iodination, spect imaging, serotonin, Placeholder for records without volume info and other aspects.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ruan, Qing; Gan, Qianqian; Zhang, Xuran; Fang, Sian; Zhang, Junbo published an article in 2021, the title of the article was Preparation and bioevaluation of novel 99mTc-labeled complexes with a 2-nitroimidazole HYNIC derivative for imaging tumor hypoxia.Recommanded Product: 574-98-1 And the article contains the following content:

To develop novel 99mTc-labeled single-photon emission computed tomog. (SPECT) radiotracers for imaging hypoxia, a novel HYNICNM ligand (6-hydrazinonicotinamide (HYNIC) 2- nitroimidazole derivative)was designed and synthesized. Itwas radiolabeledwith technetium-99musing tricine/trisodiumtriphenylphosphine-3,3′′,3′′-trisulfonate (TPPTS), tricine/sodiumtriphenylphosphine-3-monosulfonate (TPPMS) and tricine as co-ligands to obtain [99mTc]Tc-tricine-TPPTS-HYNICNM, [99mTc]Tc-tricine-TPPMS-HYNICNM, and [99mTc]Tc-(tricine)2-HYNICNM, resp. The three technetium-99m complexes were radiolabeled in one step with a high yield (95%) and had good stability in saline and mouse serum. In vitro cellular uptake results showed that these complexes exhibited good hypoxic selectivity. The partition coefficient indicated that they were good hydrophilic complexes, and [99mTc]Tc-tricine-TPPTS-HYNICNM displayed the highest hydrophilicity (-3.02 ± 0.08). The biodistribution in mice bearing S180 tumors showed that [99mTc]Tc-tricine-TPPTS-HYNICNM exhibited higher tumor uptake (1.05 ± 0.27% IA/g); more rapid clearance from the liver, blood, muscle, and other non-target organs; and a higher tumor/non-target ratio, especially for the tumor/liver ratio (1.95), than [99mTc]Tc-tricine-TPPMS-HYNICNM and [99mTc]Tc-(tricine)2-HYNICNM. The results of single-photon emission computed tomog. (SPECT) imaging studies of [99mTc]Tctricine-TPPTS-HYNICNM were in accordance with the biodistribution results, which suggested that [99mTc]Tc-tricine-TPPTS-HYNICNM is a promising agent for imaging tumor hypoxia. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 574-98-1

The Article related to nitroimidazole technetium hydrazinonicotinamide tumor hypoxia imaging, 2-nitroimidazole, hynic, hypoxia, technetium-99m, tumor, Placeholder for records without volume info and other aspects.Recommanded Product: 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Athira, Ck; Manikandan, Priyadharshini; Kandasamy, Elango; Ramani, Prasanna published an article in 2019, the title of the article was Ionic liquid mediated synthesis of labeled peptide nucleic acid monomer.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

We have designed and synthesized phthalimido labeled peptide nucleic acid (PNA) monomer through N-alkylation of α-amino acid ester with N-bromo ethylphthalimide which was facilitated by using ionic liquids The alkylated product was condensed with nucleobase such as thymine-1-acetic acid to get the target compound The labeled-PNA monomer is a new mol. which bears a marker and can be easily prepared in two steps. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to peptide nucleic acid phthalimido labeled synthesis ionic liquid marker, amino acid ester alkylation bromo ethylphthalimide thymine acetic acid, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Safety of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On October 13, 2021, Kawamata, Yu; Hayashi, Kyohei; Carlson, Ethan; Shaji, Shobin; Waldmann, Dirk; Simmons, Bryan J.; Edwards, Jacob T.; Zapf, Christoph W.; Saito, Masato; Baran, Phil S. published an article.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Chemoselective Electrosynthesis Using Rapid Alternating Polarity. And the article contained the following:

Challenges in the selective manipulation of functional groups (chemoselectivity) in organic synthesis have historically been overcome either by using reagents/catalysts that tunably interact with a substrate or through modification to shield undesired sites of reactivity (protecting groups). Although electrochem. offers precise redox control to achieve unique chemoselectivity, this approach often becomes challenging in the presence of multiple redox-active functionalities. Historically, electrosynthesis has been performed almost solely by using d.c. (DC). In contrast, applying a.c. (AC) has been known to change reaction outcomes considerably on an anal. scale but has rarely been strategically exploited for use in complex preparative organic synthesis. Here we show how a square waveform employed to deliver elec. current-rapid alternating polarity (rAP)-enables control over reaction outcomes in the chemoselective reduction of carbonyl compounds, one of the most widely used reaction manifolds. The reactivity observed cannot be recapitulated using DC electrolysis or chem. reagents. The synthetic value brought by this new method for controlling chemoselectivity is vividly demonstrated in the context of classical reactivity problems such as chiral auxiliary removal and cutting-edge medicinal chem. topics such as the synthesis of PROTACs. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to electrochem chemoselective reduction ketone rapid alternating polarity, Heterocyclic Compounds (One Hetero Atom): General and other aspects.Application In Synthesis of 2-(2-Bromoethyl)isoindoline-1,3-dione

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

On September 2, 2020, Jang, Kyeongwoo; Horne, W. Seth; Asher, Sanford A. published an article.Application of 574-98-1 The title of the article was Human Serum Phenylpyruvate Quantification Using Responsive 2D Photonic Crystal Hydrogels via Chemoselective Oxime Ligation: Progress toward Developing Phenylalanine-Sensing Elements. And the article contained the following:

There is a need to develop at-home phenylalanine (Phe) test kits, analogous to home glucose meters, for phenylketonuria patients who must measure their blood Phe levels frequently to adjust their diet. Unfortunately, such test kits are not available yet because of the lack of simple and inexpensive Phe-sensing elements. With the goal of developing a Phe-sensing element, we fabricated two-dimensional photonic crystal (2DPC) hydrogels that quantify human serum phenylpyruvate (PhPY), which is the product of the reaction between Phe and the enzyme phenylalanine dehydrogenase. The PhPY-sensing hydrogels have oxyamine recognition groups that link PhPY to the hydrogel polymer network via chemoselective oxime ligation. This structural modification induces the hydrogel to swell, which then increases interparticle spacings within the embedded 2DPC. The PhPY-induced particle spacing changes are measured from light diffraction and used to quantify the PhPY concentrations The estimated limit of detection of PhPY in human serum for a detection time of 30 min is 19μM, which is comparable to the min. blood Phe concentrations of healthy people. Besides the potential application for developing Phe-sensing elements, this new hydrogel sensing approach via chemoselective oxime ligation is generalizable to the development of other chem. sensors working in complex biol. environments. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Application of 574-98-1

The Article related to phenylpyruvate blood photonic crystal hydrogel phenylalanine sensing, oxime ligation, phenylalanine, phenylketonuria, photonic crystal, responsive hydrogel, Biochemical Methods: Spectral and Related Methods and other aspects.Application of 574-98-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary