Category: 574-98-1

On March 12, 2020, Varghese, Swapna; Rahmani, Raphael; Russell, Stephanie; Deora, Girdhar Singh; Ferrins, Lori; Toynton, Arthur; Jones, Amy; Sykes, Melissa; Kessler, Albane; Eufrasio, Amanda; Cordeiro, Artur Torres; Sherman, Julian; Rodriguez, Ana; Avery, Vicky M.; Piggott, Matthew; Baell, Jonathan B. published an article.Electric Literature of 574-98-1 The title of the article was Discovery of Potent N-Ethylurea Pyrazole Derivatives as Dual Inhibitors of Trypanosoma brucei and Trypanosoma cruzi. And the article contained the following:

Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, resp. Together, these diseases affect 68 million people around the world. Current treatments are unsatisfactory, frequently associated with intolerable side-effects, and generally inadequate in treating all stages of disease. In this paper, we report the discovery of N-ethylurea pyrazoles that potently and selectively inhibit the viability of T. brucei and T. cruzi. Sharp and logical SAR led to the identification of 54 as the best compound, with an in vitro IC50 of 9 nM and 16 nM against T. b. brucei and T. cruzi, resp. Compound 54 demonstrates favorable physicochem. properties and was efficacious in a murine model of Chagas disease, leading to undetectable parasitemia within 6 days when CYP metabolism was inhibited. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Electric Literature of 574-98-1

The Article related to ethylurea pyrazole derivative preparation trypanosoma brucei cruzi chagas, Pharmacology: Structure-Activity and other aspects.Electric Literature of 574-98-1

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Bromide – Wikipedia,
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On May 15, 2019, Hochegger, Patrick; Faist, Johanna; Seebacher, Werner; Saf, Robert; Maeser, Pascal; Kaiser, Marcel; Weis, Robert published an article.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. And the article contained the following:

The substitution of 6-fluoroquinolines was modified in ring positions 2 and 4. The new compounds were tested in vitro for their activities against a sensitive and a multidrug resistant strain of Plasmodium falciparum. Some physicochem. parameters were calculated (log P, log D, ligand efficiency) or determined exptl. (permeability). The most promising compounds were tested for their in vivo activity against Plasmodium berghei in a mouse model. The 6-fluoro-2-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-N-[2-(pyrrolidin-1-yl)ethyl]quinoline-4-carboxamide possessed proper physicochem. properties and showed high antiplasmodial activity in vitro (IC50 ≤ 0.0029 μM) and in vivo (99.6% activity). The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to preparation structure fluoroquinoline derivative antiplasmodial malaria, antimalarial, plasmodium berghei, plasmodium falciparum, quinoline derivatives, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 2-(2-Bromoethyl)isoindoline-1,3-dione

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On April 30, 2019, Wu, Pengfei; Zhu, Ruimin; Liu, Heyuan; Zhao, Baohua; Chen, Yanli; Li, Xiyou published an article.COA of Formula: C10H8BrNO2 The title of the article was Surface decorating of CH3NH3PbBr3 nanoparticles with chemically adsorbed porphyrin. And the article contained the following:

An organolead halide (CH3NH3PbBr3) nanoparticle was modified successfully with a porphyrin (POR) bearing an -NH3+ head group. The nanoparticles are homogeneous with high crystallinity. The photoluminescence of CH3NH3PbBr3 is quenched completely by the chem. adsorbed POR mols. The efficient energy transfer from CH3NH3PbBr3 to POR is responsible for the fluorescence quenching. The modified nanoparticles can be dispersed in organic solvents and the resulting dispersion remains stable for several days. This result provides a new way to tune the photophys. properties of organolead halide CH3NH3PbBr3 nanoparticles. [Figure not available: see fulltext.]. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).COA of Formula: C10H8BrNO2

The Article related to carbon hydrogen nitrogen lead bromide porphyrin surface decoration, Surface Chemistry and Colloids: Other and other aspects.COA of Formula: C10H8BrNO2

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Bromide – Wikipedia,
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On December 31, 2022, Heo, Jinyeong; Koh, Dahae; Woo, Minjeong; Kwon, Doyoon; de Almeida Falcao, Virginia Carla; Wood, Connor; Lee, Honggun; Kim, Kideok; Choi, Inhee; Jang, Jichan; Brodin, Priscille; Shum, David; Delorme, Vincent published an article.COA of Formula: C10H8BrNO2 The title of the article was A combination screening to identify enhancers of para-aminosalicylic acid against Mycobacterium tuberculosis. And the article contained the following:

Para-aminosalicylic acid (PAS) is an antibiotic that was largely used for the multi-therapy of tuberculosis in the twentieth century. To try to overcome the inconvenience of its low efficacy and poor tolerance, we searched for novel chem. entities able to synergize with PAS using a combination screening against growing axenic Mycobacterium tuberculosis. The screening was performed at a sub-inhibitory concentration of PAS on a library of about 100,000 small mols. Selected hit compounds were analyzed by dose-response and further probed with an intracellular macrophage assay. Scaffolds with potential additive effect with PAS are reported, opening interesting prospects for mechanism of action studies. We also report here evidence of a yet unknown bio-activation mechanism, involving activation of pyrido[1,2-a]pyrimidin-4-one (PP) derivatives through the Rv3087 protein. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).COA of Formula: C10H8BrNO2

The Article related to mycobacterium tuberculosis paraaminosalicylic acid combination screening, Placeholder for records without volume info and other aspects.COA of Formula: C10H8BrNO2

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Bromide – Wikipedia,
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On February 29, 2020, Ruan, Qing; Zhang, Xuran; Gan, Qianqian; Fang, Si-an; Zhang, Junbo published an article.HPLC of Formula: 574-98-1 The title of the article was Preparation of two 99mTc(CO)3 labelled complexes with a 4-nitroimidazole isocyanide at different temperatures for molecular imaging of tumor hypoxia. And the article contained the following:

A 4-nitroimidazole isocyanide derivative (6) was synthesized and radiolabeled with 99mTc(CO)3 core in high yield. It was interesting to note that 99mTc(CO)3-6a and 99mTc(CO)3-6b can be prepared at 100 °C and 25 °C, resp. 99mTc(CO)3-6a had three 6 mols. while 99mTc(CO)3-6b contained two 6 mols. The corresponding rhenium complexes were prepared to confirm the structure of the 99mTc complexes. Both complexes showed good stability in vitro and hypoxic selectivity. The partition coefficient results indicated both of them were hydrophilic and 99mTc(CO)3-6a was more hydrophilic than 99mTc(CO)3-6b. From the biodistribution study results, 99mTc(CO)3-6a showed higher tumor/blood and tumor/muscle ratios at 2 h post-injection. Further, single photon emission computed tomog. (SPECT) imaging study of 99mTc(CO)3-6a showed there was an observable tumor uptake, suggesting it would be a potential tracer for imaging of tumor hypoxia. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).HPLC of Formula: 574-98-1

The Article related to preparation technetium nitroimidazole isocyanide complex temperature tumor hypoxia imaging, Placeholder for records without volume info and other aspects.HPLC of Formula: 574-98-1

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Bromide – Wikipedia,
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On March 31, 2020, Hamdani, Syeda Shamila; Khan, Bilal Ahmad; Hameed, Shahid; Batool, Farwa; Saleem, Hafiza Nosheen; Ullah Mughal, Ehsan; Saeed, Muhammad published an article.HPLC of Formula: 574-98-1 The title of the article was Synthesis and evaluation of novel S-benzyl- and S-alkylphthalimide- oxadiazole -benzenesulfonamide hybrids as inhibitors of dengue virus protease. And the article contained the following:

Direct acting antiviral drugs (DAADs) are becoming therapeutics of choice for the treatment of viral infections. Successful development of anti HIV and HCV drugs by targeting the viral proteases has provided impetus for discovering newer DAADs. Dengue virus (DENV) protease, which is composed of two nonstructural proteins, NS2B and NS3pro, can be likewise exploited for discovering new anti-dengue therapeutics. In this study, we have linked together two pharmaceutically interesting motifs, namely 1,3,4-oxadiazole and benzenesulfonamide in two alternative series to develop novel S-benzylated and S-alkylphthalimidated hybrids. For the first series of hybrids, 4-aminobenzoic acid (1) was reacted with substituted benzenesulfonyl chlorides via its amino group, whereas the carboxylic acid side was elaborated to sulfonamido-1,3,4-oxadiazole-2-thiols (6a/b) in three steps. At this stage, the intermediates 6a/b were bifurcated to either S-alkylphthalimidated (8a-j) or S-benzylated (9a-c) hybrids by reacting with corresponding halides. For the alternative series of hybrids, the carboxylic acid group of probenecid (10) was similarly elaborated to sulfonamido-1,3,4-oxadiazole-2-thiols (13), and diverged to S-alkylphthalimidated (14a-f) and S-benzylated hybrids (15a-e). Bioactivity assays demonstrated that 8g and 8h are the most potent inhibitors among the synthesized analogs, exhibiting the IC50 values of 13.9 μM and 15.1 μM, resp. Computational assessment predicted the binding of the inhibitors at an allosteric site developed in the open conformation of DENV2 NS2B/NS3pro. Taken together these findings point out that the synthesized hybrid inhibitors possess a great potential for further antiviral drug development. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).HPLC of Formula: 574-98-1

The Article related to dengue virus protease antiviral drug binding benzenesulfonamide oxadiazole hybrids, Placeholder for records without volume info and other aspects.HPLC of Formula: 574-98-1

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Bromide – Wikipedia,
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Auti, Prashant S.; Nandi, Arijit; Kumari, Vijeta; Paul, Atish T. published an article in 2022, the title of the article was Design, synthesis, biological evaluation and molecular modelling studies of oxoacetamide warhead containing indole-quinazolinone based novel hybrid analogues as potential pancreatic lipase inhibitors.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione And the article contains the following content:

A novel series of indolyl oxoacetamide-quinazolinone hybrid analogs (9aa-9df) were designed, synthesized, and evaluated for their in vitro pancreatic lipase (PL) inhibitory potential which may lead to efficient anti-obesity agents. All the synthesized hybrid analogs exhibited moderate to potent PL inhibitory activity (IC50 = 32.51 to 4.86 μM). Among all the analogs, 9ak, 9af, 9aj, and 9ah were found to have the most potent PL inhibitory activity (IC50 = 4.86, 5.73, 5.83, and 5.94 μM resp.), as compared to orlistat (IC50 = 0.86 μM). The most potent analogs 9af and 9ak were found to inhibit PL competitively with an inhibition constant (Ki) of 2.136, 1.648 μM. Furthermore, the docking study confirmed the binding of analogs 9ak and 9af (MolDock score of -161.25, -133.67 kcal mol-1) that exhibited docking interactions with important active site amino acids, namely Phe 77, Tyr 114, Ser 152, Arg 256, His 263, etc. Also, the anal. of analog 9ak and 9af in SeeSAR revealed the covalent inhibition of PL. In mol. dynamics simulations of 100 ns, the complex between each analog (9ak & 9af) and PL was found to be stable (RMSD < 1.5 Å). The present work highlights the importance of a hybrid drug design approach for the development of indole and quinazolinone containing hybrids as potential PL inhibitors. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to obesity indole quinazolinone mol modeling pancreatic lipase inhibitor antiobesity, Placeholder for records without volume info and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

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On January 15, 2021, Falkowski, Michal; Kucinska, Malgorzata; Piskorz, Jaroslaw; Wieczorek-Szweda, Ewelina; Popenda, Lukasz; Jurga, Stefan; Sikora, Adam; Mlynarczyk, Dariusz T.; Murias, Marek; Marszall, Michal P.; Goslinski, Tomasz published an article.Related Products of 574-98-1 The title of the article was Synthesis of sulfanyl porphyrazines with bulky peripheral substituents – Evaluation of their photochemical properties and biological activity. And the article contained the following:

Alkylation reaction of dimercaptomaleonitrile disodium salt with N-(2-bromoethyl)phthalimide in N,N-dimethylformamide, and potassium carbonate led to novel maleonitrile derivative This compound was used in the Linstead tetramerization reaction in n-butanol in the presence of magnesium n-butoxide towards magnesium(II) sulfanyl porphyrazine with phthalimide peripheral substituents. Its demetallation and subsequent zinc(II) ion insertion led to zinc(II) sulfanyl porphyrazine derivative All obtained compounds were thoroughly characterized using UV-vis, MS, and 1H and 13C NMR spectroscopy. The purity of macrocycles was assessed using HPLC. Novel sym. porphyrazines were found to generate singlet oxygen in N,N-dimethylformamide and DMSO in low yields. The highest, over 4% yield of singlet oxygen generation, was noted for zinc(II) porphyrazine derivative in DMSO. In the biol. study, the cytotoxicities and photocytotoxicities of sym. sulfanyl porphyrazines with phthalimide peripheral substituents were compared with lately obtained unsym. sulfanyl tribenzoporphyrazine, 22,23-bis[3,5-bis(3,5-dimethoxybenzyloxy)benzylsulfanyl]tribenzo[b,g,l]porphyrazinato magnesium(II). The in vitro study was performed on androgen-sensitive human prostate adenocarcinoma (LNCaP) and human prostate cancer (PC3) cell lines using MTT assay. The data obtained for liposomal formulations containing sulfanyl porphyrazines with phthalimide substituents indicated their low and light-independent cytotoxicity against cancer cells. On the contrary, the sulfanyl tribenzoporphyrazine was studied in its free form and after incorporation in liposomes. In the free form it revealed moderate photocytotoxicity against both cancer cell lines with IC50 values of 7.71 μM and 8.82 μM for LNCaP and PC3 cells, resp. Moreover, the liposomal DOTAP : POPC formulation containing sulfanyl tribenzoporphyrazine revealed over 10-fold higher effectiveness reaching the IC50 up to 0.52 μM against LNCaP cancer cells in comparison to its free form. On the contrary, liposomal PG formulation of sulfanyl tribenzoporphyrazine was found to be inactive on the human cancer cells. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Related Products of 574-98-1

The Article related to sulfanyl porphyrazine peripheral substituent photochem property biol activity, Placeholder for records without volume info and other aspects.Related Products of 574-98-1

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Bromide – Wikipedia,
bromide – Wiktionary

On September 5, 2021, Singh, Ved Prakash; Dowarah, Jayanta; Marak, Brilliant N.; Sran, Balkaran Singh; Tewari, Ashish Kumar published an article.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione The title of the article was Study of the structure-bioactivity of fleximers: synthesis, crystal structure, Hirshfeld surface analysis, and anti-inflammatory assays. And the article contained the following:

Synthesized and natural pyridones/pyridines derivatives exhibiting diverse biol. activities. 2-Pyridone has lactam-lactim tautomerization like thymine and uracil bases. In this study, COX-2 target based series of pyridone/pyridine linked fleximers were designed, synthesized and studied. All analogs binding affinity with COX-2 active site were studied through mol. docking, and anti-inflammatory activity studied by in vivo anal. Weak interactions were studied to find binding sites among analogs through crystal packing, Hirshfeld surface anal. and in silico anal. All the analogs exhibited anti-inflammatory activity, while compound (3) is the most active analog among the series. In contrast, since compound (3) is a pyridine-phthalimide ring-containing analog, the presence of a phthalimide group probably favors anti-inflammatory activity over other types of rings. The results suggested further investigations on compounds as anti-inflammatory prodrugs. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

The Article related to pyridone pyridine linked fleximer crystal packing hirshfeld surface analysis, Placeholder for records without volume info and other aspects.Quality Control of 2-(2-Bromoethyl)isoindoline-1,3-dione

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Bromide – Wikipedia,
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Ramachandran, Mohanraj; Syed, Asad; Marraiki, Najat; Anandan, Sambandam published an article in 2021, the title of the article was The aqueous dependent sensing of hydrazine and phosphate anions using a bis-heteroleptic Ru(II) complex with a phthalimide-anchored pyridine-triazole ligand.Synthetic Route of 574-98-1 And the article contains the following content:

Selective turn-on luminescence properties are shown by a non-luminescent metalloreceptor upon the addition of phosphate anions in CH3CN and hydrazine in CH3CN/H2O (6/4, volume/volume). The non-luminescent metalloreceptors [RuII(phen)2(TpH)]2PF6- (RtpH) and [RuII(Phen)2(TpI)]2PF6- (RtpI) {phen = 1,10-phenanthroline; TpH = 2-(2-(4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)ethyl)isoindoline-1,3-dione; and TpI = 2-(2-(5-iodo-4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)ethyl)isoindoline-1,3-dione} were synthesized and characterized. Both metalloreceptors have excellent sensing properties for phosphate anions (H2PO4- and H2P2O72-) over other anions in CH3CN. The limit of detection (LOD) values were calculated to be 79 nM and 48 nM for H2PO4- upon addition to RtpH and RtpI, resp. Noncovalent interactions play a key role in the sensing of phosphate anions, among which the halogen-anion interaction showed superior recognition properties over the hydrogen-anion interaction. Comparative electrochem. experiments, 1H NMR titration, 31P NMR titration, and lifetime studies also show that RtpI has better sensing properties, as evidenced by its more drastic emission response to H2PO4- anions compared with RtpH. Moreover, the metalloreceptors showed a remarkable fluorescence increase (at ~584 nm) upon the addition of hydrazine, without the interference of other amines in CH3CN/H2O (6/4, volume/volume). Interestingly, fluorescence enhancement was observed within live HeLa cells upon hydrazine addition, which is caused by the efficient photoinduced electron transfer process. The experimental process involved the reaction of 2-(2-Bromoethyl)isoindoline-1,3-dione(cas: 574-98-1).Synthetic Route of 574-98-1

The Article related to hydrazine phosphate detection luminescent indicator ruthenium complex, Placeholder for records without volume info and other aspects.Synthetic Route of 574-98-1

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Bromide – Wikipedia,
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