Category: 57293-19-3

Reactivity in Nickel-Catalyzed Multi-component Sequential Reductive Cross-Coupling Reactions was written by Chen, Haifeng;Yue, Huifeng;Zhu, Chen;Rueping, Magnus. And the article was included in Angewandte Chemie, International Edition in 2022.Application of 57293-19-3 This article mentions the following:

The nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and Et chloroformate is described. Et chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Exptl. and DFT mechanistic studies highlight the complexity of the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Discovery of Orally Available Runt-Related Transcription Factor 3 (RUNX3) Modulators for Anticancer Chemotherapy by Epigenetic Activation and Protein Stabilization was written by Yang, Jee Sun;Lee, Chulho;Cho, Misun;Kim, Hyuntae;Kim, Jae Hyun;Choi, Seonghwi;Oh, Soo Jin;Kang, Jong Soon;Jeong, Jin-Hyun;Kim, Hyun-Jung;Han, Gyoonhee. And the article was included in Journal of Medicinal Chemistry in 2015.Category: bromides-buliding-blocks This article mentions the following:

Recently, the authors identified a novel strategy for anticancer chemotherapy by restoring runt-related transcription factor 3 (RUNX3) levels via lactam-based histone deacetylase (HDAC) inhibitors that stabilize RUNX3. Described here are the synthesis, biol. evaluation, and pharmacokinetic evaluation of new synthetic small mols. based on pyridone-based HDAC inhibitors that specifically stabilize RUNX3 by acetylation and regulate its function. Many of the newly synthesized compounds showed favorable RUNX activities, HDAC inhibitory activities, and inhibitory activities on the growth of human cancer cell lines. Notably, one of these new derivatives, I , significantly restored RUNX3 in a dose-dependent manner and showed high metabolic stability, a good pharmacokinetic profile with high oral bioavailability and long half-life, and strong antitumor activity. This study suggests that pyridone-based analogs modulate RUNX3 activity through epigenetic regulation as well as strong transcriptional and post-translational regulation of RUNX3 and could be potential clin. candidates as orally available RUNX3 modulators for the treatment of cancer. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fluorination of orthothioesters through oxidative desulfurization-fluorination was written by Furuta, Satoru;Kuroboshi, Manabu;Hiyama, Tamejiro. And the article was included in Bulletin of the Chemical Society of Japan in 1998.Reference of 57293-19-3 This article mentions the following:

The oxidative desulfurization-fluorination of orthothioesters of type RCH₂C(SMe)₃ using n-Bu₄NH₂F₃ and 1,3-dibromo-5,5-dimethylhydantoin gave bromodifluorination products RCHBrCF₂SMe in good yields. The products were converted into bromodifluoro olefins RCBr:CF₂ via oxidation and thermolysis. In a similar way, the orthothioesters of type RCH(OH)C(SMe)₃ or RCH(OAc)C(SMe)₃ were fluorinated to afford difluoro ketones RCOCF₂SMe or difluoro acetates RCH(OAc)CF₂SMe, resp. The difluoro acetates were reduced to RCH(OAc)CF₂H by radical reduction The mechanisms are discussed for difluorination accompanied by bromination or oxidation In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Reference of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Reference of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of compounds allied to rhododendrin was written by Kim, Ki-U. And the article was included in Yakugaku Zasshi in 1943.HPLC of Formula: 57293-19-3 This article mentions the following:

In order to exam. the pharmacol. action of compounds allied to rhododendrin, the following compounds were synthesized. 1-(p-Hydroxyphenyl)-2-propanol: p-MeOC₆H₄CH:CHMe(+ Br) 闂?MeOC₆H₄CHBrCHBrMe (+ CaO) 闂?MeOC₆H₄CH(OH)CHBrMe (+ 2.5% alkali) 闂?MeOC₆H₄CH(OH)CH(OH)Me (heating to 180闁? 闂?MeOC₆H₄CH₂COMe (+ Na + EtOH) 闂?MeOC₆H₄CH₂CH(OH)Me (+ Grignard reagent) 闂?p-HOC₆H₄CH₂CH(OH)Me. 5-(p-Hydroxyphenyl)-2-pentanol: p-MeOC₆H₄CHO + AcOEt (+ Na) 闂?MeOC₆H₄CH:CHCO₂Et (+ H) 闂?MeOC₆H₄CH₂CH₂CO₂Et (+ Na + AmOH) 闂?MeOC₆H₄(CH₂)₃OH (+ PBr₃) 闂?MeOC₆H₄(CH₂)₃Br 闂?MeOC₆H₄(CH₂)₃CN (+ MeMgI) 闂?MeOC₆H₄(CH₂)₃COMe 闂?MeOC₆H₄(CH₂)₃CH(OH)Me 闂?HOC₆H₄(CH₂)₃CH(OH)Me. By similar methods were prepared: 6-(p-hydroxyphenyl)-2-hexanol, from p-MeOC₆H₄CHO and EtCOMe; 1-(m-hydroxyphenyl)-3-butanol, from m-MeOC₆H₄CHO and Me₂CO; 1-(4-hydroxy-3-methoxyphenyl)-3-butanol, from vanillin and Me₂CO; 1-(p-hydroxyphenyl)-3-pentanol, from p-MeOC₆H₄CHO and AcOEt; 1-(4-hydroxy-3-methylphenyl)-3-butanol from 3,4-Me(HO)C₆H₃CHO (prepared from m-MeC₆H₄OH, HCN, AlCl₃, and HCl) and Me₂CO; 1-(4-hydroxy-2-methylphenyl)-3-butanol, from 2,4-Me(HO)C₆H₃CHO and Me₂CO; and 1-(4-hydroxy-5-isopropyl-2-methylphenyl)-3-butanol, from 5,2-Me(Me₂CH)C₆H₃OH through 2,5,4-Me(Me₂CH)(HO)C₆H₂CHO. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis was written by Ding, Chao;Ren, Yaoyu;Sun, Caocao;Long, Jiao;Yin, Guoyin. And the article was included in Journal of the American Chemical Society in 2021.Related Products of 57293-19-3 This article mentions the following:

Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Related Products of 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Related Products of 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lewis base-promoted carbon-carbon sp³-sp³ coupling reactions of 濞?silyl silylethers was written by Brekan, Jonathan A.;Chernyak, Dmitri;White, Kolby L.;Scheidt, Karl A.. And the article was included in Chemical Science in 2012.Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene This article mentions the following:

A Lewis base-promoted addition of 濞?silyl silylethers to primary halides has been developed. This new carbon-carbon sp³-sp³ bond-forming process accesses an unconventional reactivity pattern (d¹ synthon) from easily accessible precursors. The strategy accommodates a variety of primary alkyl, allylic and benzylic electrophiles and 濞?silyl silylethers. These d¹ synthons have also been used in the synthesis of cross pinacol and benzil products. Mechanistic studies indicate significant intermol. silyl group exchange during the reaction. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application In Synthesis of 1-(3-Bromopropyl)-4-methoxybenzene

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Introduction of Cyclopropyl and Cyclobutyl Ring on Alkyl Iodides through Cobalt-Catalyzed Cross-Coupling was written by Andersen, Claire;Ferey, Vincent;Daumas, Marc;Bernardelli, Patrick;Guerinot, Amandine;Cossy, Janine. And the article was included in Organic Letters in 2019.Category: bromides-buliding-blocks This article mentions the following:

A cobalt-catalyzed cross-coupling between alkyl iodides and cyclopropyl, cyclobutyl, and alkenyl Grignard reagents is disclosed. The reaction allows the introduction of strained rings on a large panel of primary and secondary alkyl iodides. The catalytic system is simple and nonexpensive, and the reaction is general, chemoselective, and diastereoconvergent. The alkene resulting from the cross-coupling can be transformed to substituted cyclopropanes using a Simmons-Smith reaction. The formation of radical intermediates during the coupling is hypothesized. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Category: bromides-buliding-blocks).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of quinoline-based NNN-pincer nickel(II) Complexes: a robust and improved catalyst system for C-H bond alkylation of azoles with alkyl halides was written by Patel, Ulhas N.;Pandey, Dilip K.;Gonnade, Rajesh G.;Punji, Benudhar. And the article was included in Organometallics in 2016.HPLC of Formula: 57293-19-3 This article mentions the following:

The quinoline-based pincer nickel(II) complexes I (2a,b, X = Cl, R = Me, Et; 3a,b, X = Br, R = Me, Et; 4a, X = OAc, R = Me) were prepared by the reaction of the ligand precursors N-[(2-dialkylamino)phenyl]-8-quinolinamines with (DME)NiCl₂ (THF)₂NiBr₂ or Ni(OAc)₂ in the presence of Et₃N. All of these complexes were characterized by ¹H and ¹³C NMR spectroscopy as well as by elemental anal. Further, the mol. structures of 2a and 3a,b were elucidated by x-ray crystallog. Complex 2a is found to be an efficient catalyst for the direct C-H bond alkylation of substituted benzothiazoles and oxazoles in 2-position with various unactivated alkyl halides containing 閻?hydrogens under mild reaction conditions. The catalyst 2a is very robust and was recycled and reused five times for the alkylation reaction without a decrease in its catalytic activity. Preliminary studies reveal that the catalyst 2a acts as an active catalyst and the alkylation reaction appears to operate via a radical pathway. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Highly efficient synthesis of alkylboronate esters via Cu(II)-catalyzed borylation of unactivated alkyl bromides and chlorides in air was written by Bose, Shubhankar Kumar;Brand, Simon;Omoregie, Helen Oluwatola;Haehnel, Martin;Maier, Jonathan;Bringmann, Gerhard;Marder, Todd B.. And the article was included in ACS Catalysis in 2016.Synthetic Route of C10H13BrO This article mentions the following:

A copper(II)-catalyzed borylation of alkyl halides with bis(pinacolato)diboron (B₂pin₂) has been developed, which can be carried out in air, providing a wide range of primary, secondary, and some tertiary alkylboronates in high yields. A variety of functional groups are tolerated and the protocol is also applicable to unactivated alkyl chlorides (including 1,1- and 1,2-dichlorides). Preliminary mechanistic investigations show that this borylation reaction involves one-electron processes. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3Synthetic Route of C10H13BrO).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C10H13BrO

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Combination of Methods for in Vitro Study of Antioxidant Properties of Chemical Compounds was written by Menshchikova, E. B.;Zenkov, N. K.;Kandalintseva, N. V.;Prosenko, A. E.. And the article was included in Bulletin of Experimental Biology and Medicine in 2008.HPLC of Formula: 57293-19-3 This article mentions the following:

We proposed a combination of methods to study antioxidant properties of compounds, including evaluation of the capacity of the test preparations to inhibit peroxidation of unsaturated lipids (in model systems with oxidation of Et oleate; aqueous emulsion medium) and low-d. lipoproteins (in the presence of transition metal ions), generation of superoxide anion radical (system of lucigenin, xanthine oxidase, and xanthine) and NO璺?ONOO- (system of SIN-1 and lucigenin), and induction of respiratory burst in blood granulocytes (luminol-induced and lucigenin-induced reaction after zymosan stimulation). In vitro study showed that the antioxidant properties of synthetic watersol. phenols depend strongly on masking of the phenol OH group and nature of the ionogenic fragment in the p-Pr substituent. In the experiment, the researchers used many compounds, for example, 1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3HPLC of Formula: 57293-19-3).

1-(3-Bromopropyl)-4-methoxybenzene (cas: 57293-19-3) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 57293-19-3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary