Category: 56970-78-6

Truscott, Roger J. W. published the artcileTwo new sulfur-containing amino acids in man, Category: bromides-buliding-blocks, the publication is Biomedical Mass Spectrometry (1981), 8(3), 99-104, database is CAplus and MEDLINE.

Two unusual S-containing amino acids were isolated from the urine of a baby (of 1st cousin parents) who died with major phys. malformations and failure of growth and development. These acids were identified as (S)-(2-carboxypropyl)-cysteamine and -cysteine by mass spectral anal. and by synthesis. A recessively inherited error in valine metabolism at the level of methacrylyl-CoA hydratase, with conjugation of the methacrylic acid so formed with cysteine, is proposed as the origin of the compounds Possibly methacrylic acid or one of its derivatives caused the malformations in the baby.

Biomedical Mass Spectrometry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C25H23NO4, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chan-Seng, Delphine published the artcilePrimary Structure Control of Oligomers Based on Natural and Synthetic Building Blocks, Related Products of bromides-buliding-blocks, the publication is ACS Macro Letters (2014), 3(3), 291-294, database is CAplus and MEDLINE.

Solid-phase synthesis was exploited for the preparation of oligomers constructed from natural and synthetic building blocks by combining the formation of amide bonds and copper-assisted alkyne-azide cycloaddition reactions extending the variety of oligomers with well-defined primary structures accessible through this technique and providing control over the spacing between amino acids.

ACS Macro Letters published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chan-Seng, Delphine published the artcilePrimary Structure Control of Oligomers Based on Natural and Synthetic Building Blocks, Related Products of bromides-buliding-blocks, the publication is ACS Macro Letters (2014), 3(3), 291-294, database is CAplus and MEDLINE.

Solid-phase synthesis was exploited for the preparation of oligomers constructed from natural and synthetic building blocks by combining the formation of amide bonds and copper-assisted alkyne-azide cycloaddition reactions extending the variety of oligomers with well-defined primary structures accessible through this technique and providing control over the spacing between amino acids.

ACS Macro Letters published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Szabo, L. P. published the artcileLaboratory scale resolution of short chain chiral carboxylic acid, Safety of 3-Bromo-2-methylpropanoic acid, the publication is Special Publication – Royal Society of Chemistry (1994), 496-504, database is CAplus.

Zeolite A was used as a support and onto the surface via ethylene-diamine spacer L-leucine, L-glutamic acid, L-lysine and L-phenylalanine were chem. bonded to prepare chiral stationary phases. The laboratory scale resolution of (+/-)-3-bromo-2-methyl-propionic acid (DL-BMPA) on these stationary phases was studied. The new packings proved to be efficient for the laboratory scale resolution of DL-BMPA.

Special Publication – Royal Society of Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C13H17BF3NO2, Safety of 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mravec, D. published the artcileSynthesis of the structural analogs of LSD, Formula: C4H7BrO2, the publication is Cesko-Slovenska Farmacie (1975), 24(3), 110-15, database is CAplus.

MeNH2 added to CH2:CMeCO2Me in MeOH to give MeNHCH2CHMeCO2Me, which was hydrolyzed to the acid; PrCO2H was converted to MeNHCH2CHEtCO2Me by successive bromination, esterification with MeOH, modified Reformatskii reaction to give HOCH2CHEtCO2Me, bromination, and amination with MeNH2. CH2:CRCO2H (R = Me, Et) were successively hydrobrominated, brominated, amidated with Et2NH, and aminated with MeNH2 to give MeNHCH2CHRCONEt2. MeNHCH2CHRCOR1 (R = Me, Et; R1 = OH, OMe, NEt2) reacted with 3-(2-bromoethyl)indole (from the esterification, LiAlH4 reduction, and bromination of indole-3-acetic acid) to give 5 LSD analogs I.

Cesko-Slovenska Farmacie published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Formula: C4H7BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

He, Yali published the artcilePyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer, Related Products of bromides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2020), 63(21), 12642-12665, database is CAplus and MEDLINE.

We report herein the design, synthesis, and pharmacol. characterization of a library of novel aryl pyrazol-1-yl-propanamides as selective androgen receptor degraders (SARDs) and pan-antagonists that exert broad-scope AR antagonism. Pharmacol. evaluation demonstrated that introducing a pyrazole moiety as the B-ring structural element in the common A-ring-linkage-B-ring nonsteroidal antiandrogens’ general pharmacophore allowed the development of a new scaffold of small mols. with unique SARD and pan-antagonist activities even compared to our recently published AF-1 binding SARDs such as UT-155 and UT-34. Novel B-ring pyrazoles exhibited potent AR antagonist activities, including promising distribution, metabolism, and pharmacokinetic properties, and broad-spectrum AR antagonist properties, including potent in vivo antitumor activity. I was able to induce an 80% tumor growth inhibition of xenografts derived from the enzalutamide-resistant (Enz-R) VCaP cell line. These results represent an advancement toward the development of novel AR antagonists for the treatment of Enz-R prostate cancer.

Journal of Medicinal Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Murakami, Yukito published the artcileHydrophobic vitamin B₁₂. XI. Preparation, characterization, and enantioselective alkylation of hydrophobic vitamin B₁₂ bearing a binaphthyl moiety, SDS of cas: 56970-78-6, the publication is Bulletin of the Chemical Society of Japan (1992), 65(11), 3094-102, database is CAplus.

Hydrophobic vitamin B₁₂ derivatives bearing a chiral binaphthyl moiety, hexamethyl 7¹-decarboxy-7¹-[(R)-2′-methoxy-1,1′-binaphthyl-2-carboxymethyl]cobyrinate perchlorate [B₁₂-BINAP(R)] and hexamethyl 7¹-decarboxy-7¹-[(S)-2′-methoxy-1,1′-binaphthyl-2-carboxymethyl]cobyrinate perchlorate [B₁₂-BINAP(S)], were prepared from cyanocobalamin. These complexes were characterized by means of electronic and CD spectroscopy as well as by cyclic voltammetry in comparison with those data for a hydrophobic vitamin B₁₂ without a binaphthyl moiety. The enantioselective alkylation of hydrophobic vitamin B₁₂ derivatives at the β-axial site was examined in methanol with various 3-bromo-2-methylpropionic esters by means of ¹H NMR spectroscopy. B₁₂-BINAP(R), and B₁₂-BINAP(S) bound (S)-2-methylpropionates more favorably than (R)-2-methylpropionates. The cause of such S-enantioselectivity was discussed with attention to stereochem. configurations of the peripheral substituents placed in the corrin ring.

Bulletin of the Chemical Society of Japan published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, SDS of cas: 56970-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Murakami, Yukito published the artcileHydrophobic vitamin B₁₂. V. Electrochemical carbon-skeleton rearrangement as catalyzed by hydrophobic vitamin B₁₂. Reaction mechanisms and migratory aptitude of functional groups, SDS of cas: 56970-78-6, the publication is Bulletin of the Chemical Society of Japan (1987), 60(1), 311-24, database is CAplus.

The C-skeleton rearrangements catalyzed by heptamethyl cobyrinate perchlorate (I) were investigated under electrochem. conditions. The controlled-potential electrolysis of 2,2-bis(ethoxycarbonyl)-1-bromopropane, which is considered to be a model substrate for methylmalonyl-CoA mutase, was catalyzed by I in DMF to give 1,2-bis(ethoxycarbonyl)propane as a major product at -1.5 V vs. SCE (standard C electrode)in the presence of acetic acid and at potentials more cathodic than -1.8 V vs. SCE without acetic acid in the dark. The electrochem. C-skeleton rearrangement was postulated to proceed via formation of anionic intermediates. The electrolysis of 1-bromo-2-cyano-2-ethoxycarbonylpropane, 2-acetyl-1-bromo-2-ethoxycarbonylpropane, and 1-bromo-2-[(ethylthio)carbonyl]propane with I also afforded the corresponding skeleton rearrangement products. The results indicated that substrates with 2 electron-withdrawing groups placed on the β-carbon atom with combinations of 1 carboxylic ester and 1 of carboxylic ester, acetyl, or cyano moiety readily gave the corresponding rearrangement products which were derived from individual migration of the substituent groups. Substrates with only 1 of the electron-withdrawing groups, (carboxylic ester, acetyl, or cyano) did not give any rearrangement product, but a substrate with thioester group afforded the corresponding rearrangement product. The migratory aptitude of electron-withdrawing groups decreased in the order: COSR>COR>COOR>CN. Both electronic character and steric bulkiness of the migrating groups are apparently reflected on this tendency, even though relative contributions of these effects are much dependent on the nature of β-substituents.

Bulletin of the Chemical Society of Japan published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, SDS of cas: 56970-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Liu, Renyong published the artcileImproved synthetic method of captopril, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Shenyang Yaoke Daxue Xuebao (1997), 14(4), 262-264, database is CAplus.

An improved synthetic method for captopril using methacrylic acid as the starting material was described. Treatment of methacrylic acid with hydrogen bromide gave 3-bromo-2-methylpropanoic acid which underwent chlorination with thionyl chloride, condensation with L-proline gave N-(R,S-3-bromo-2-methylpropanoyl)-L-prolin (I). I was resolved into optically pure stereo-isomer, which was treated with sodium trithiocarbonate to give captopril.

Shenyang Yaoke Daxue Xuebao published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nam, Doo H. published the artcileAn improved synthesis of captopril, Safety of 3-Bromo-2-methylpropanoic acid, the publication is Journal of Pharmaceutical Sciences (1984), 73(12), 1843-4, database is CAplus and MEDLINE.

An improved synthesis of captopril using methacrylic acid as the starting material is described. Treatment of methacrylic acid with a hydrogen halide gave the 3-halogneo-2-methylpropanoic acids, which were treated with SOCl₂ to yield the corresponding 3-halogeno-2-methylpropanoyl chlorides. Treatment of the chlorides with L-proline yielded the N-(R,S-3-halogeno-2-methylpropanoyl)-L-prolines (I, R = Br, Cl) (II) which were separated into optically pure R– and S-diastereoisomers using dicyclohexylamine. Treatment of (R)-II with methanolic NH₄SH gave captopril (I, R = SH).

Journal of Pharmaceutical Sciences published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Safety of 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary