Category: 56970-78-6

Bugera, Maksym published the artcileDeoxofluorination of Aliphatic Carboxylic Acids: A Route to Trifluoromethyl-Substituted Derivatives, Name: 3-Bromo-2-methylpropanoic acid, the publication is Journal of Organic Chemistry (2019), 84(24), 16105-16115, database is CAplus and MEDLINE.

A practical method for the synthesis of functionalized aliphatic trifluoromethyl-substituted derivatives from aliphatic acids was developed. The transformation proceeds with sulfur tetrafluoride in the presence of water as a key additive. Compared to previous methods, the reaction gives products with full retention of stereo- and absolute configuration of chiral centers.

Journal of Organic Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Name: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nobili, Alberto published the artcileSimultaneous Use of in Silico Design and a Correlated Mutation Network as a Tool To Efficiently Guide Enzyme Engineering, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is ChemBioChem (2015), 16(5), 805-810, database is CAplus and MEDLINE.

In order to improve the efficiency of directed evolution experiments, in silico multiple-substrate clustering was combined with an anal. of the variability of natural enzymes within a protein superfamily. This was applied to a Pseudomonas fluorescens esterase (PFE I) targeting the enantioselective hydrolysis of 3-phenylbutyric acid esters. Data reported in the literature for nine substrates were used for the clustering meta-anal. of the docking conformations in wild-type PFE I, and this highlighted a tryptophan residue (W28) as an interesting target. Exploration of the most frequently, naturally occurring amino acids at this position suggested that the reduced flexibility observed in the case of the W28F variant leads to enhancement of the enantioselectivity. This mutant was subsequently combined with mutations identified in a library based on anal. of a correlated mutation network. By interrogation of <80 variants, a mutant with 15-fold improved enantioselectivity was found.

ChemBioChem published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ladanyi, L. published the artcileDetermination of the enantiomeric composition of chiral carboxylic acids using chiral derivatization and HPLC, Product Details of C4H7BrO2, the publication is Chromatographia (1987), 477-81, database is CAplus.

The enantiomers of chiral carboxylic acids were separated as their diastereomeric amides with (1R,2R)-(-)-1-(4-nitrophenyl)-2-amino-1,3-propanediol (levo-base) and with dextrobase (the enantiomer of levobase) by high-performance liquid chromatog. using a conventional C-18 column and various solvent systems containing MeCN, MeOH, H₂O, and phosphoric acid.

Chromatographia published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Product Details of C4H7BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fischer, J. published the artcileSynthesis of N-(2-hydroxy-5-methylphenyl)-substituted amino acids, Category: bromides-buliding-blocks, the publication is Magyar Kemiai Folyoirat (1997), 103(7), 331-335, database is CAplus.

N-(2-hydroxy-5-methylphenyl)-substituted amino acids were prepared from 2-amino-4-methylphenol by (1) nucleophilic substitution with halogenated carboxylic acids, (2) condensation with α-keto carboxylic acid derivatives, and (3) reductive alkylation with α-keto esters. The advantages and disadvantages of these methods depend on the target mols.

Magyar Kemiai Folyoirat published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mayer, Anna published the artcileGas chromatographic method for the determination of isomeric bromoisobutyric acids and their chlorides, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Analyst (Cambridge, United Kingdom) (1987), 112(5), 657-9, database is CAplus.

A gas chromatog. method for the determination of 3-bromoisobutyric acid and the isomeric 2-bromoisobutyric acid, 2,3-dibromoisobutyric acid and methacrylic acid as their trimethylsilyl esters was developed. The determination of the corresponding acid chlorides was performed after their conversion to the corresponding morpholides.

Analyst (Cambridge, United Kingdom) published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yadav, Veejendra K. published the artcileAllylsilane-interrupted homo-Nazarov cyclization and synthesis of bicyclo[3.2.1]octan-8-ones, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Tetrahedron Letters (2014), 55(12), 2015-2018, database is CAplus.

The combination of homo-Nazarov cyclization of 2-(tert-butyldiphenylsilylmethyl)cyclopropyl vinyl ketone leading to oxyallyl cation and its subsequent [3+2] capture by allylsilane has been demonstrated as an useful strategy for the construction of functionalized bicyclo[3.2.1]octan-8-ones. The [3+2] capture proceeds exclusively in the exo mode to make the overall reaction diastereoselective. The less substituted end of the oxyallyl cation was found to react nearly two times faster than the more substituted end.

Tetrahedron Letters published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C8H5IO, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bhuyan, Bhaskar J. published the artcileSynthesis, characterization and antioxidant activity of angiotensin converting enzyme inhibitors, Formula: C4H7BrO2, the publication is Organic & Biomolecular Chemistry (2011), 9(5), 1356-1365, database is CAplus and MEDLINE.

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone bradykinin (a nonapeptide) to inactivate this hormone. Therefore, inhibition of ACE is generally used as one of the methods for the treatment of hypertension. Oxidative stress’ is another disease state caused by an imbalance in the production of oxidants and antioxidants. A number of studies suggest that hypertension and oxidative stress are interdependent. Therefore, ACE inhibitors having antioxidant property are considered beneficial for the treatment of hypertension. As selenium compounds are known to exhibit better antioxidant behavior than their sulfur analogs, we have synthesized a number of selenium analogs of captopril, an ACE inhibitor used as an antihypertensive drug. The selenium analogs of captopril not only inhibit ACE activity but also effectively scavenge peroxynitrite, a strong oxidant found in vivo.

Organic & Biomolecular Chemistry published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Formula: C4H7BrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Auwers, K. published the artcileDicarboxylic acids, C₈H₁₄O₄, Application In Synthesis of 56970-78-6, the publication is Berichte der Deutschen Chemischen Gesellschaft, 3005, database is CAplus.

Of the two acids obtained by the action of silver on ethyl α-bromisobutyrate (Abstract, 1889, 1145), the volatile acid is tetramethylsuccinic acid, whilst the non-volatile acid is symmetrical dimethyladipic acid, C₂H₄(CHMe.COOH)₂ (compare Zelinsky, preceding abstract). According to Hell (Ber., 10, 2229), a portion of the α-bromisobutyric acid decomposes into hydrogen bromide and methylacrylic acid, which unite, according to Fittig and Engelhorn (Annalen, 200, 65), to form β-bromisobutyric acid. The normal product of the action of silver on the latter would be the above dimethyladipic acid. In order to test the correctness of this view, the authors are studying β-bromisobutyric acid and especially its behaviour towards silver.

Berichte der Deutschen Chemischen Gesellschaft published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Application In Synthesis of 56970-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dalkas, Georgios A. published the artcileStudy of a lipophilic captopril analogue binding to angiotensin I converting enzyme, Recommanded Product: 3-Bromo-2-methylpropanoic acid, the publication is Journal of Peptide Science (2010), 16(2), 91-97, database is CAplus and MEDLINE.

Human ACE is a central component of the renin-angiotensin system and a major therapeutic target for cardiovascular diseases. The somatic form of the enzyme (sACE) comprises two homologous metallopeptidase domains (N and C), each bearing a zinc active site with similar but distinct substrate and inhibitor specificities. In this study, we present the biol. activity of silacaptopril, a silylated analog of captopril, and its binding affinity towards ACE. Based on the recently determined crystal structures of both the ACE domains, a series of docking calculations were carried out in order to study the structural characteristics and the binding properties of silacaptopril and its analogs with ACE. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.

Journal of Peptide Science published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Recommanded Product: 3-Bromo-2-methylpropanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yu, Wan-Ning published the artcileEffect of elimination on antifouling and pH-responsive properties of carboxybetaine materials, Application In Synthesis of 56970-78-6, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(65), 9143-9146, database is CAplus and MEDLINE.

Carboxybetaine (CB)-based zwitterionic materials have attracted considerable attention due to their dual antifouling and functionalizable properties. In this communication, the elimination effect on the antifouling and pH-responsive properties of CB materials was investigated. We synthesize β- and α-substituted Me CB materials to investigate the occurrence of elimination in the ethylene intercharge arm in a harsh basic solution This work provides mol. understanding of a structure-property relationship of the CB moiety for material development.

Chemical Communications (Cambridge, United Kingdom) published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C12H10FeO4, Application In Synthesis of 56970-78-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary