Category: 56523-59-2

Beld, Joris published the artcileVersatility of Acyl-Acyl Carrier Protein Synthetases, Formula: C15H29BrO2, the main research area is acyl carrier protein synthetase fatty acid carboxylate lipid.

The acyl carrier protein (ACP) requires posttranslational modification with a 4′-phosphopantetheine arm for activity, and this thiol-terminated modification carries cargo between enzymes in ACP-dependent metabolic pathways. We show that acyl-ACP synthetases (AasSs) from different organisms are able to load even, odd, and unnatural fatty acids onto E. coli ACP in vitro. Vibrio harveyi AasS not only shows promiscuity for the acid substrate, but also is active upon various alternate carrier proteins. AasS activity also extends to functional activation in living organisms. We show that exogenously supplied carboxylic acids are loaded onto ACP and extended by the E. coli fatty acid synthase, including unnatural fatty acid analogs. These analogs are further integrated into cellular lipids. In vitro characterization of four different adenylate-forming enzymes allowed us to disambiguate CoA-ligases and AasSs, and further in vivo studies show the potential for functional application in other organisms.

Chemistry & Biology (Oxford, United Kingdom) published new progress about Carboxylic acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Formula: C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kendel, Melha published the artcileLipid composition, fatty acids and sterols in the seaweeds Ulva armoricana, and Solieria chordalis from Brittany (France): an analysis from nutritional, chemotaxonomic, and antiproliferative activity perspectives, Product Details of C15H29BrO2, the main research area is Ulva Solieria lipid fatty acid phytosterol glycolipid; Solieria chordalis; Ulva armoricana; chemotaxonomy; fatty acids; glycolipids; human lung cancer; hydroxy fatty acids; phospholipids; polyunsaturated fatty acids; sterols.

Lipids from the proliferative macroalgae Ulva armoricana (Chlorophyta) and Solieria chordalis (Rhodophyta) from Brittany, France, were investigated. The total content of lipids was 2.6% and 3.0% dry weight for U. armoricana and S. chordalis, resp. The main fractions of S. chordalis were neutral lipids (37%) and glycolipids (38%), whereas U. armoricana contained mostly neutral lipids (55%). Polyunsaturated fatty acids (PUFA) represented 29% and 15% of the total lipids in U. armoricana and S. chordalis, resp. In both studied algae, the phospholipids were composed of PUFA for 18%. In addition, PUFA were shown to represent 9% and 4.5% of glycolipids in U. armoricana and S. chordalis, resp. The essential PUFA were 16:4n-3, 18:4n-3, 18:2n-3, 18:2n-6, and 22:6n-3 in U. armoricana, and 20:4n-6 and 20:5n-3 in S. chordalis. It is important to notice that six 2-hydroxy-, three 3-hydroxy-, and two monounsaturated hydroxy fatty acids were also identified and may provide a chemotaxonomic basis for algae. These seaweeds contained interesting compounds such as squalene, α-tocopherol, cholest-4-en-3-one and phytosterols. The antiproliferative effect was evaluated in vitro on human non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) with an IC50 of 23 μg/mL for monogalactosyldiacylglycerols isolated from S. chordalis and 24 μg/mL for digalactosyldiacylglycerols from U. armoricana. These results confirm the potentialities of valorization of these two species in the fields of health, nutrition and chemotaxonomy.

Marine Drugs published new progress about Fatty acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Product Details of C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Briand, Loiec published the artcileEvidence of an Odorant-Binding Protein in the Human Olfactory Mucus: Location, Structural Characterization, and Odorant-Binding Properties, Computed Properties of 56523-59-2, the main research area is odorant binding protein OBP olfactory epithelium cleft mucus; hOBP isoform IIa alpha aldehyde fatty acid.

Odorant-binding proteins (OBPs) are small abundant extracellular proteins belonging to the lipocalin superfamily. They are thought to participate in perireceptor events of odor detection by carrying, deactivating, and/or selecting odorant mols. Putative human OBP genes (hOBP) have recently been described [Lacazette et al. (2000) Hum. Mol. Genet. 9, 289-301], but the presence of the corresponding proteins remained to be established in the human olfactory mucus. This paper reports the first evidence of such expression in the mucus covering the olfactory cleft, where the sensory olfactory epithelium is located. On the contrary, hOBPs were not observed in the nasal mucus covering the septum and the lower turbinate. To demonstrate the odorant binding activity of these proteins, a corresponding recombinant protein variant, hOBPIIaα, was secreted by the yeast Pichia pastoris and thoroughly characterized. It appears as a monomer with one disulfide bond located between C59 and C151, a conservative feature of all other vertebrate OBPs. By measuring the displacement of several fluorescent probes, we show that hOBPIIaα is able to bind numerous odorants of diverse chem. structures, with a higher affinity for aldehydes and large fatty acids. A computed 3D model of hOBPIIaα is proposed and reveals that two lysyl residues of the binding pocket may account for the increased affinity for aldehydes. The relatively limited specificity of hOBPIIaα suggests that other human OBPs are expected to take into account the large diversity of odorant mols.

Biochemistry published new progress about Disulfide group (C59-C151). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Computed Properties of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Perez, Alexander J. published the artcileω-Azido fatty acids as probes to detect fatty acid biosynthesis, degradation, and modification, COA of Formula: C15H29BrO2, the main research area is omega azido fatty acid biosynthesis metabolism HPLC MS; S-azidoacyl-N-acetylcysteamine; azido-fatty acids; click-chemistry; cyclooctyne; fatty acid desaturation; fatty acid metabolism; strained promoted cycloadditon; β-oxidation.

FAs play a central role in the metabolism of almost all known cellular life forms. Although GC-MS is regarded as a standard method for FA anal., other methods, such as HPLC/MS, are nowadays widespread but are rarely applied to FA anal. Here we present azido-FAs as probes that can be used to study FA biosynthesis (elongation, desaturation) or degradation (β-oxidation) upon their uptake, activation, and metabolic conversion. These azido-FAs are readily accessible by chem. synthesis and their metabolic products can be easily detected after click-chem. based derivatization with high sensitivity by HPLC/MS, contributing a powerful tool to FA anal., and hence, lipid anal. in general.

Journal of Lipid Research published new progress about High-performance liquid chromatography-mass spectrometry. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, COA of Formula: C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Park, Chul Soon published the artcileHydrophilic surfaces via the self-assembly of nitrile-terminated alkanethiols on gold, COA of Formula: C15H29BrO2, the main research area is cyanoalkanethiol self assembly glod preparation contact angle surface property.

A series of CN-terminated alkanethiols were synthesized and used to generate self-assembled monolayers (SAMs) on gold. The SAMs were characterized using ellipsometry, contact angle goniometry, polarization modulation IR reflection absorption spectroscopy (PM-IRRAS), and XPS. The SAMs were compared to those derived from a series of analogous CH3-terminated alkanethiols. The CN-terminated SAMs exhibited lower film thicknesses than the CH3-terminated SAMs, which was largely due to their greater tilt angle on the surface. Addnl., the CN-terminated SAMs form well-ordered films on flat gold surfaces with relative packing densities being indistinguishable from the CH3-terminated SAMs. The CN-terminated SAMs exhibited a less hydrophobic character than the SAMs derived from CH3-terminated adsorbates, which was attributed to the dipole moment of the terminal group as well as the lone pair of the nitrogen atom of the CN-terminal group.

AIMS Materials Science published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, COA of Formula: C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lindner, Sindy published the artcileAzide-Modified Membrane Lipids: Synthesis, Properties, and Reactivity, Related Products of bromides-buliding-blocks, the main research area is azide modified membrane lipid preparation property reactivity; azidolipid preparation property reactivity.

In the present work, we describe the synthesis and the temperature-dependent behavior of photoreactive membrane lipids as well as their capability to study peptide-lipid interactions. The modified phospholipids contained an azide group either in the middle part or at the end of an alkyl chain and also differed in the linkage (ester vs. ether) of the 2nd alkyl chain. The temperature-dependent aggregation behavior of the azidolipids was studied using differential scanning calorimetry (DSC), FTIR spectroscopy, and SAXS. Aggregate structures were visualized by stain and cryo-transmission electron microscopy (TEM) and were further characterized by dynamic light scattering (DLS). We showed that the position of the azide group and the type of linkage of the alkyl chain at the sn-2 position of the glycerol influenced the type of aggregates formed as well as their long-term stability: azidolipids P10AzSPC and r12AzSHPC showed the formation of extrudable liposomes, which were stable in size during storage. In contrast, azidolipids that carry a terminal azido moiety either formed extrudable liposomes, which showed time-dependent vesicle fusion (P15AzPdPC), or self-assembled in large sheet-like, non-extrudable aggregates (r15AzPdHPC) where the lipid mols. were arranged in an interdigitated orientation at temperatures below the Tm (LβI phase). Finally, a P10AzSPC:DMPC mixture was used for photochem.-induced crosslinking experiments with a transmembrane peptide (WAL-peptide) to demonstrate the applicability of the azidolipids for the anal. of peptide/lipid interactions. The efficiency of photocrosslinking was monitored by attenuated total reflection IR spectroscopy and mass spectrometry.

Langmuir published new progress about Liposomes. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lartigue, Audrey published the artcileX-ray structure and ligand binding study of a moth chemosensory protein, Application In Synthesis of 56523-59-2, the main research area is crystal structure ligand moth chemosensory protein; Mamestra chemosensory protein conformation.

Chemosensory proteins (CSPs) are believed to be involved in chem. communication and perception. Such proteins, of Mr 13,000, have been isolated from several sensory organs of a wide range of insect species. Several CSPs have been identified in the antennae and proboscis of the moth Mamestra brassicae. One of them, CSPMbraA6, a 112-amino acid antennal protein, has been expressed in large quantities and is soluble in the Escherichia coli periplasm. X-ray structure determination has been performed in parallel with ligand binding assays using tryptophan fluorescence quenching. The protein has overall dimensions of 25 × 30 × 32 Å and exhibits a novel type of α-helical fold with six helixes connected by α-α loops. A narrow channel extends within the protein hydrophobic core. Fluorescence quenching with brominated alkyl alcs. or fatty acids and modeling studies indicates that CSPMbraA6 is able to bind such compounds with C12-18 alkyl chains. These ubiquitous proteins might have the role of extracting hydrophobic linear compounds (pheromones, odors, or fatty acids) dispersed in the phospholipid membrane and transporting them to their receptor.

Journal of Biological Chemistry published new progress about Crystal morphology. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application In Synthesis of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

El-Shahawi, Manal Mohamed published the artcileSurface Active Properties and Biological Activities of Novel Anionic Surfactant Based on Oxapyridazinone Derivatives, Quality Control of 56523-59-2, the main research area is oxapyridazinone preparation anionic surfactant thermodn stability antibacterial antifungal.

A series of novel oxapyridazinone derivatives I (R = (CH2)12, (CH2)14, (CH2CH2O)6, (CH2CH2O)7) have been synthesized via cyclization of the corresponding sodium salt of α-sulfonated fatty acid hydrazides with chloroacetic acid in the presence of sodium acetate and acetic anhydride. The surface properties (surface tension, CMC value and area per mol.), the thermodn. stability and antimicrobial activities of the prepared compounds were determined and compared to standard trade material Texapone N-70. The prepared compounds exhibit surface activity comparable to the standard and thus can be used as anionic surfactants.

Journal of Surfactants and Detergents published new progress about Anionic surfactants. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Quality Control of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Uchinomiya, Shohei published the artcileFluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells, Recommanded Product: 15-Bromopentadecanoic acid, the main research area is fluorescence metabolism activity fatty acid beta oxidation pathway.

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, the authors report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.

Chemical Communications (Cambridge, United Kingdom) published new progress about Fluorescence imaging. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Recommanded Product: 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cimatu, Katherine published the artcileSum Frequency Generation Imaging Microscopy of Patterned Self-Assembled Monolayers with Terminal -CH3, -OCH3, -CF2CF3, -C=C-, -Phenyl, and -Cyclopropyl Groups, Name: 15-Bromopentadecanoic acid, the main research area is methyl group SFG imaging microscopy patterned selfassembled monolayer; perfluoroethyl group SFG imaging microscopy patterned selfassembled monolayer; phenyl group SFG imaging microscopy patterned selfassembled monolayer; ethenediyl group SFG imaging microscopy patterned selfassembled monolayer; cyclopropyl group SFG imaging microscopy patterned selfassembled monolayer; methoxy group SFG imaging microscopy patterned selfassembled monolayer.

Vibrational spectroscopic imaging is demonstrated for a variety of organic monolayer-functionalized surfaces patterned using microcontact printing. The images from sum frequency generation imaging microscopy (SFGIM) are analyzed using different contrast mechanisms in the interpretation of the transition from stamped to backfilled regions of interest. For this experiment, microcontact printing is used to spatially control the surface monolayers by using a patterned stamp and by varying the terminal functional group of the backfilling solutions Anal. by the three different methods suggests that significant mixing occurs between the stamped and backfilled regions, which influence the contrast in the images at the resonant peaks. The interference between the resonant peaks and nonresonant background also has an effect on the appearance of the image.

Journal of Physical Chemistry C published new progress about Functional groups. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Name: 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary