Category: 56523-59-2

Choi, Yunsoo published the artcileFunctionalized N-Heterocyclic Carbene Monolayers on Gold for Surface-Initiated Polymerizations, Safety of 15-Bromopentadecanoic acid, the main research area is heterocyclic carbene adsorbed monolayer surface polymerization; N-heterocyclic carbenes (NHCs); azo surface initiator; benzimidazolium methanesulfonates; photoinitiated radical polymerization; polymer brushes; self-assembled monolayers (SAMs); surface-initiated polymerization; thickness control.

Although N-heterocyclic carbenes (NHCs) are superior to thiol adsorbates in that they form remarkably stable bonds with gold, the generation of NHC-based self-assembled monolayers (SAMs) typically requires a strong base and an inert atm., which limits the utility of such films in many applications. Herein, we report the development and use of bench-stable NHC adsorbates, benzimidazolium methanesulfonates, for the direct formation of NHC films on gold surfaces under an ambient atm. at room temperature without the need for extraordinary precautions. The generated NHC SAMs were fully characterized using ellipsometry, XPS, polarization modulation IR reflection-absorption spectroscopy (PM-IRRAS), and contact angle measurements, and they were compared to analogous SAMs generated from an NHC bicarbonate adsorbate. Based on these findings, a unique radical initiator α,ω-bidentate azo-terminated NHC adsorbate, NHC15AZO[OMs], was designed and synthesized for the preparation of SAMs on gold surfaces with both NHC headgroups bound to the surface. The adsorbate mols. in NHC15AZO SAMs can exist in a hairpin or a linear conformation depending on the concentration of the adsorbate solution used to prepare the SAM. These conformations were studied by a combination of ellipsometry, XPS, PM-IRRAS, and scanning tunneling microscopy using gold nanoparticles (AuNPs) as a tag material. Moreover, the potential utility of these unique radical-initiating NHC films as surface-initiated polymerization platforms was demonstrated by controlling the thickness of polystyrene brush films grown from azo-terminated NHC monolayer surfaces simply by adjusting the reaction time of the photoinitiated radical polymer growth process.

ACS Applied Materials & Interfaces published new progress about Adsorbed monolayers. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Safety of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Salomon, Adi published the artcileStable Room-Temperature Molecular Negative Differential Resistance Based on Molecule-Electrode Interface Chemistry, COA of Formula: C15H29BrO2, the main research area is stable room temperature mol neg resistance mol electrode interface.

The authors show reproducible, stable neg. differential resistance (NDR) at room temperature in mol.-controlled, solvent-free devices, based on reversible changes in mol.-electrode interface properties. The active component is the cyclic disulfide end of mols. adsorbed onto Hg. As this active component is reduced, the Hg-mol. contact is broken, and an insulating barrier at the mol.-electrode interface is formed. Therefore, the alignment of the mol. energy levels, relative to the Fermi levels of the electrodes, is changed. This effect results in a decrease in the current with voltage increase as the reduction process progresses, leading to the so-called NDR behavior. The effect is reproducible and repeatable over >50 scans without any reduction in the current. The stability of the system, which is in the solid state except for the Hg, is due to the mol. design where long alkyl chains keep the mols. aligned with respect to the Hg electrode, even when they are not bound to it any longer.

Journal of the American Chemical Society published new progress about Adsorbed substances. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, COA of Formula: C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hoang, Johnson published the artcileQuaternary Ammonium-Terminated Films Formed from Mixed Bidentate Adsorbates Provide a High-Capacity Platform for Oligonucleotide Delivery, Application of 15-Bromopentadecanoic acid, the main research area is quaternary ammonium films bidentate adsorbates oligonucleotide delivery; binary-mixed SAMs; oligonucleotide delivery; quaternary ammonium; self-assembled monolayer; single-stranded DNA.

The exposure of quaternary ammonium groups on surfaces allows self-assembled monolayers (SAMs) to serve as architectural platforms for immobilizing oligonucleotides. The current study describes the preparation of SAMs derived from four unique bidentate adsorbates containing two different ammonium termini (i.e., trimethyl- and triethyl-) and comparison to their monodentate analogs. Our studies found that SAMs derived from the bidentate adsorbates offered considerable enhancements in oligonucleotide binding when compared to SAMs derived from their monodentate analogs. The generated SAMs were analyzed using ellipsometry, XPS, contact angle goniometry, polarization modulation IR reflection-absorption spectroscopy, and electrochem. quartz crystal microbalance. These analyses showed that the immobilization of oligonucleotides was affected by changes in the terminal functionalities and the relative packing densities of the monolayers. In efforts to enhance further the immobilization of oligonucleotides on these SAM surfaces, we explored the use of adsorbates having aliphatic linkers with systematically varying chain lengths to form binary SAMs on gold. Mixed monolayers with 50:50 ratios of adsorbates showed the greatest oligonucleotide binding. These studies lay the groundwork for oligonucleotide delivery using gold-based nanoparticles and nanoshells.

ACS Applied Materials & Interfaces published new progress about Adsorbed substances. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shibuya, Kimiyuki published the artcileDesign, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors, Application of 15-Bromopentadecanoic acid, the main research area is ACAT SOAT inhibitor aorta selectivity antiatherosclerotic lipid accumulation atherosclerosis; ACAT-1 (aortic ACAT); ACAT-2 (intestinal ACAT); Acyl-CoA:cholesterol O-acyltransferase (ACAT/SOAT); Atherosclerosis; Cholesterol esters (CEs); Double-induced fit; Isoform-selectivity; Lipid-accumulation areas.

We describe our mol. design of aortic-selective acyl-CoA:cholesterol O-acyltransferase (ACAT, also abbreviated as SOAT) inhibitors, their structure-activity relationships (SARs) and their pharmacokinetic (PK) and pharmacol. profiles. The connection of two weak ligands-N-(2,6-diisopropylphenyl)acetamide (50% inhibitory concentration [IC50] = 8.6 μM) and 2-(methylthio)benzo[d]oxazole (IC50 = 31 μM)-via a linker comprising a 6 methylene group chains yielded a highly potent mol., 9-(benzo[d]oxazol-2-ylthio)-N-(2,6-diisopropylphenyl)nonanamide (3h) that exhibited high potency (IC50 = 0.004 μM) toward aortic ACAT. This head-to-tail design made it possible to markedly enhance the activity to 2150- to 7750-fold and to discriminate the isoform-selectivity based on the double-induced fit mechanism. At doses of 1 and 3 mg/kg, 3h significantly decreased the lipid-accumulation areas in the aortic arch to 74 and 69%, resp. without reducing the plasma total cholesterol level in high fat- and cholesterol-fed F1B hamsters. Here, we demonstrate the antiatherosclerotic effect of 3h in vivo via its direct action on aortic ACAT and its powerful modulator of cholesterol level. This mol. is a potential therapeutic agent for the treatment of diseases involving ACAT-1 overexpression.

Bioorganic & Medicinal Chemistry published new progress about Antiatherosclerotics. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Briand, Loic published the artcileCharacterization of a chemosensory protein (ASP3c) from honeybee (Apis mellifera L.) as a brood pheromone carrier, HPLC of Formula: 56523-59-2, the main research area is chemosensory protein sequence characterization honey bee.

We report the cloning of a honeybee chemosensory proteins (CSP) gene called ASP3c, as well as the structural and functional characterization of the encoded protein. The protein was heterologously secreted by the yeast Pichia pastoris using the native signal peptide. ASP3c disulfide bonds were assigned after trypsinolysis followed by chromatog. and mass spectrometry combined with microsequencing. The pairing (Cys(I)-Cys(II), Cys(III)-Cys(IV)) was found to be identical to that of Schistocerca gregaria CSPs, suggesting that this pattern occurs commonly throughout the insect CSPs. CD measurements revealed that ASP3c mainly consists of α-helixes, like other insect CSPs. Gel filtration anal. showed that ASP3c is monomeric at neutral pH. Using ASA, a fluorescent fatty acid anthroyloxy analog as a probe, ASP3c was shown to bind specifically to large fatty acids and ester derivatives, which are brood pheromone components, in the micromolar range. It was unable to bind tested general odorants and other tested pheromones (sexual and nonsexual). This is the 1st report on a natural pheromonal ligand bound by a recombinant CSP with a measured affinity constant

European Journal of Biochemistry published new progress about Antenna (anatomical). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, HPLC of Formula: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Talukdar, Abhijit published the artcileGas chromatography- mass spectrometric analysis of the essential oil of eaglewood (Aquilaria agallocha Roxb), Category: bromides-buliding-blocks, the main research area is Aquilaria essential oil furanoid aldehyde ketone alc acid.

Objective: The investigation was carried out to study the phytochem. constituents of agar oil of Aquilaria agallocha grown in Assam. Methods: Fungal infected agar laden wooden chips grown in Assam were soaked in water for 6 to 7 days and grounded into smaller pieces and hydro distilled to obtain the oil. 2 μL of the oil sample diluted in methanol was used for GC/MS anal. to study the chem. constituents. Results: GC-MS anal. of the oil has shown the presence of at least 35 different compounds, out of which 17 compounds were identified. Three furanoids viz. 3 methyl-2-(2 methyl-2-butenyl)-furan; 2-isobuteyl-3 Me furan and 3-methyl-2-(2-oxopropyl)furan were identified as the main aromatic components of the oil. Besides these, some acids, ketones alc. and aldehydes were also identified and reported here. Conclusion: Variation in the quality of the oil has been observed depending upon geog. region on which the trees are grown, age of the plant and extent of disease lesions formed in the wood, which was evident by studying the phytochem. constituents of the oil.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Aquilaria malaccensis. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Patrick published the artcileEffects of structural modification of (alkyldiene-imidazolium bromide)-based gemini monomers on the formation of the lyotropic bicontinuous cubic phase, HPLC of Formula: 56523-59-2, the main research area is alkyldiene imidazolium bromide gemini monomer lyotropic bicontinuous cubic phase.

Seven homologues of an amphiphilic gemini monomer were synthesized and screened for the ability to form a bicontinuous cubic (Q) lyotropic liquid crystal phase. Four of these homologues form a Q phase with glycerol or water that can be cross-linked with retention of the nanoporous structure, with one exhibiting a well-ordered Q phase with a wider phase window than the parent monomer.

Soft Matter published new progress about Liquid crystals, lyotropic. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, HPLC of Formula: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

DeVries, Vern G. published the artcileHypolipidemic alkoxybenzoic acids, Application In Synthesis of 56523-59-2, the main research area is hypolipidemic alkoxybenzoic acid derivative; benzoic acid alkoxy derivative hypolipidemic.

A series of ∼90 p-alkoxybenzoic acids (I) with aromatic ring substituents or modified alkyl or unsaturated chains (R1), prepared by alkylation of the appropriate hydroxybenzoate ester followed by saponification, was screened in rats for serum-sterol and triglyceride lowering activity. Alkyl chain substituents such as chloro and oximino enhanced activity, while azido, thiol, and some alkylthio groups resulted in retention of activity. Some alkylthio substituents on the alkyl chain and aryl ring substituents abolished sterol-lowering activity. The effect of alkyl chain branching was variable, while unsaturation had no adverse effect on activity except when located near either end of the chain.

Journal of Medicinal Chemistry published new progress about Anticholesteremic agents. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application In Synthesis of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Eggers, Paul K. published the artcileThe Effect of Surface Polarity on the Electrochemical Double Layer and Its Influence on the Measurement of the Standard Rate Constant of Electron Transfer, COA of Formula: C15H29BrO2, the main research area is surface polarity elec double layer electron transfer kinetics; mercaptoferrocenemethylcarboxamide preparation elec double layer gold.

The influence of surface polarity and, hence, the elec. double layer on long-range electron transfer was studied using 35 different electrode constructs. These constructs were prepared using 5 different lengths of ferrocene-modified alkanethiols (of general formula HS(CH2)nCONHCH2Fc where n was 7, 10, 11, 14, and 15 and Fc refers to ferrocene) mixed with an appropriate ratio of hydroxyl-terminated to Me-terminated alkanethiols as diluents. The mixtures of diluents in different ratios served not only to sep. and dilute the redox-active species but also to control the surface polarity of the self-assembled monolayer (SAM). The ratios of the 3 components in each SAM were 1:20:0, 1:16.6:3.4, 1:13.4:6.6, 1:10:10, 1:6.6:13.4, 1:16.6:3.4, and 1:0:20 of the ferrocene-, hydroxyl-, and Me-terminated species, resp. The formal redox potential and electron transfer rate constant were measured for each construct. It was found, 1st, that formal potentials changed according to the theory of interfacial potential distribution and, 2nd, that rate constants measured using cyclic voltammetry are strongly influenced by the Stern layer of the elec. double layer, which forms at the SAM-solution interface.

Journal of Physical Chemistry C published new progress about Chemical chains (length). 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, COA of Formula: C15H29BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jiang, Liang published the artcileDesign, synthesis, and biological evaluation of Bcr-Abl PROTACs to overcome T315I mutation, Related Products of bromides-buliding-blocks, the main research area is Bcr Abl proteolysis targeting chimeric degrader gatekeeper mutation; ALL, acute lymphoblastic leukemia; CML; CML, chronic myeloid leukemia; CRBN, cereblon; Clinical resistance; Co-IP, co-immunoprecipitation; DR, degradation rate; Degradation; IC50, cellular inhibition; LSCs, leukemic stem cells; NMPA, National Medical Products Administration; PROTAC; PROTAC, proteolysis-targeting chimeric; Ph+, Philadelphia chromosome; T315I mutation; T315I, threonine 315 to isoleucine 315; TGI, tumor growth inhibition; VHL, von Hippel-Lindau; cIAP1, cellular inhibitor of apoptosis protein 1.

Bcr-Abl threonine 315 to isoleucine 315 (T315I) gatekeeper mutation induced drug resistance remains an unmet clin. challenge for the treatment of chronic myeloid leukemia (CML). Chem. degradation of Bcr-AblT315I protein has become a potential strategy to overcome drug resistance. Herein, we first described the design, synthesis, and evaluation of a new class of selective Bcr-AblT315I proteolysis-targeting chimeric (PROTAC) degraders based on GZD824 (reported as Bcr-AblT315I inhibitor by our group). One of the degrader 7o with 6-member carbon chain linkage with pomalidomide exhibits the most potent degradation efficacy with DR of 69.89% and 94.23% at 100 and 300 nmol/L, resp., and has an IC50 value of 26.8 ± 9.7 nmol/L against Ba/F3T315I cells. Further, 7o also displays substantial tumor regression against Ba/F3-Bcr-AblT315I xenograft model in vivo.

Acta Pharmaceutica Sinica B published new progress about Antiproliferative agents. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary