Category: 56523-59-2

Ng, Cheng Yang published the artcileFluorogenic probes to monitor cytosolic phospholipase A2 activity, Recommanded Product: 15-Bromopentadecanoic acid, the main research area is fluorogenic probe monitor cytosolic phospholipase A.

Arachidonic acid derivatives equipped with either one or two fluorescent groups attached to the tip of the alkyl chains were synthesized and shown to function as inhibitor and substrate probes of cPLA2. The inhibitor probe was demonstrated to perform dual functions of inhibition and imaging while the substrate probe could be used for activity assay.

Chemical Communications (Cambridge, United Kingdom) published new progress about fluorogenic probe monitor cytosolic phospholipase A. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Recommanded Product: 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Satpati, Drishty published the artcilePreparation and Evaluation of 99mTc(CO)3-Labeled Pentadecanoic Acid Derivative and Its Suspension in Lipiodol, Application of 15-Bromopentadecanoic acid, the main research area is bromopentadecanoic acid lipiodol stability.

Transarterial embolization by the intra-arterial administration of 131I-lipiodol is a modality used in the treatment of liver cancer. Long-chain fatty acids, being highly lipophilic, are also known to localize in the liver, thus constituting favorable vectors for this modality of treatment. Toward this, we envisaged the derivatization of 15-bromopentadecanoic acid, rendering it suitable for incorporation of a tridentate chelating moiety, for radiolabeling with the [99mTc(CO)3(H2O)3]+ precursor. The complex prepared, being lipophilic, was expected to behave as a lipiodol surrogate. The radiolabeled complex could be obtained in >95% radiochem. yield, as characterized by high-performance liquid chromatog. The i.v. injection of the radiolabeled complex in mice resulted in 23.5% ± 4.3% uptake of injected dose (ID) organ in the liver at 3 h postinjection. However, the uptake of the lipiodol suspension of the complex at 3 h postinjection in the liver was found to be 43.8 ± 13.4% ID/organ, when injected via the portal vein.

Cancer Biotherapy and Radiopharmaceuticals published new progress about Blood. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Pedersen, Simon S. published the artcileA Nickel(II)-Mediated Thiocarbonylation Strategy for Carbon Isotope Labeling of Aliphatic Carboxamides, SDS of cas: 56523-59-2, the main research area is aliphatic carboxamide preparation; alkyl zinc halide methyldiphenylsilanecarboxylic acid amine thiocarbonylation nickel catalyst; aliphatic carboxamides; aminocarbonylation; isotope labeling; nickel; thioesters.

A series of pharmaceutically relevant small mols. and biopharmaceuticals bearing aliphatic carboxamides have been successfully labeled with carbon-13. Key to the success of this novel carbon isotope labeling technique is the observation that 13C-labeled Ni(II)-acyl complexes, formed from a 13CO insertion step with Ni(II)-alkyl intermediates, rapidly react in less than one minute with 2,2′-dipyridyl disulfide to quant. form the corresponding 2-pyridyl thioesters. Either the use of 13C-SilaCOgen or 13C-COgen allows for the stoichiometric addition of isotopically labeled carbon monoxide. Subsequent one-pot acylation of a series of structurally diverse amines provides the desired 13C-labeled carboxamides in good yields. A single electron transfer pathway is proposed between the Ni(II)-acyl complexes and the disulfide providing a reactive Ni(III)-acyl sulfide intermediate, which rapidly undergoes reductive elimination to the desired thioester. By further optimization of the reaction parameters, reaction times down to only 11 min were identified, opening up the possibility of exploring this chem. for carbon-11 isotope labeling. Finally, this isotope labeling strategy could be adapted to the synthesis of 13C-labeled liraglutide and insulin degludec, representing two antidiabetic drugs.

Chemistry – A European Journal published new progress about Acylation. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, SDS of cas: 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tomoi, Masao published the artcilePolymer-supported bases, 4. Macrolide synthesis from ω-bromocarboxylic acids using polymer-supported 1,8-diazabicyclo[5.4.0]undec-7-ene, Synthetic Route of 56523-59-2, the main research area is macrolide synthesis polymer diazabicycloundecene; bromo carboxylic acid lactonization.

The macrolide yield in the title synthesis is a function of the degree of ring substitution and of crosslinking, which governs the effective concentration of the fixed substrate within the polymeric reagent. The effect of the polystyrene matrix on the macrolide yield in the heterogeneous system was compared with the corresponding homogeneous reaction.

Makromolekulare Chemie published new progress about Lactonization. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Synthetic Route of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Neu, Henrik published the artcileSynthesis of saturated fatty acids 11C(13C)-labeled in the ω-methyl position, Category: bromides-buliding-blocks, the main research area is fatty acid omega labeled preparation; zerovalent copper catalyst methylation.

A method for the preparation of ω-labeled saturated fatty acids 11C(13C)H3(CH2)nCO2H (n = 1,2,3,,6,10,14) is described. A highly reactive zerovalent copper complex was prepared from lithium naphthalenide reduced lithium(2-thienyl)iodocuprate. The labeling precursors were obtained by addition of tert-Bu ω-iodocarboxylates to the organocuprate and these were reacted with [11C]methyl iodide to form 11C-labeled, protected intermediates. The tert-Bu ester protecting group was rapidly removed with trifluoroacetic acid, affording fatty acids 11C-labeled in the ω-Me position. A solid phase extraction method was developed and preceded final HPLC purification In a typical run starting with 2.75 GBq of [11C]methyl iodide, 375 MBq (66%) [16-11C]palmitic acid was obtained within 46 min from the end of radionuclide production

Journal of Labelled Compounds & Radiopharmaceuticals published new progress about Methylation. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Galli, Carlo published the artcileRing closure reactions. IV. Quantitative approach to the synthesis of many-membered rings. Lactonization of some ω-bromo fatty acids, Application of 15-Bromopentadecanoic acid, the main research area is lactonization bromoalkanoic acid yield calculation; kinetics cyclization; fatty acid bromo lactonization.

A math. treatment, designed to predict the yields of cyclic compounds from α,ω-bifunctional precursors under dilute and high dilution conditions, was developed using a kinetic reaction scheme; a feed rate parameter was developed for yield optimization under high dilution conditions. The calculated and observed yields for the lactonization of ω-bromoalkanoic acids agreed under high dilution conditions.

Gazzetta Chimica Italiana published new progress about Cyclization. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Application of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sarkar, Ramkrishna published the artcileProbing Polymer Chain Folding in Solution Using Second Harmonic Light Scattering, Synthetic Route of 56523-59-2, the main research area is probing polymer chain folding solution harmonic scattering.

Periodically grafted amphiphilic copolymers (PGACs) were earlier shown by us to adopt a zigzag folded conformation in the solid state, which enabled the backbone and pendant segments to segregate and occupy alternate layers in a lamellar structure. The conformational transition from a random coil to a zigzag folded chain in solution is an interesting problem, which is largely unexplored. To examine this, an orthogonally clickable parent polyester was sequentially clicked with two types of poly(ethylene glycol) (PEG) segments: one is a simple PEG and the other is a PEG that carries a dipolar chromophore. These two hydrophilic PEG segments, installed in a periodic and alternating fashion along the hydrocarbon-rich (HC) polyester backbone, ensure that the Janus folded chains are formed upon folding and carry chromophoric dipoles oriented along the same direction, thereby generating a large net dipole. The folding-induced alignment of chromophores in solution was followed using second harmonic light scattering (SHLS), wherein the intensity of the frequency-doubled scattered light (I2ω) is measured. Folding was induced by adding a polar solvent, like methanol, to a chloroform solution of the polymer; methanol desolvates the HC backbone but solubilizes the pendant PEG segments, thus inducing folding. The second harmonic intensity (I2ω) increased initially with methanol concentration and then saturated; in contrast, I2ω remained invariant with the solvent composition in the case of an analogous model chromophore. Furthermore, in a model PGAC carrying chromophore-bearing PEG segments on every repeat unit, I2ω decreased with increasing methanol composition, revealing the formation of a centrosym. folded chain, wherein the chromophoric dipoles on either side cancel each other. Thus, this study clearly reveals that the zigzag chain folding of PGACs can be induced by a segment-selective solvent, resulting in the rather elusive directional ordering of chromophoric dipoles in solution

Langmuir published new progress about Amphiphiles. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Synthetic Route of 56523-59-2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sarkar, Ramkrishna published the artcilePrecise control of grafting density in periodically grafted amphiphilic copolymers: an alternate strategy to fine-tune the lamellar spacing in the sub-10 nm regime, Safety of 15-Bromopentadecanoic acid, the main research area is amphiphilic hydrocarbon rich polyester graft copolymer synthesis click chem; lamellar morphol thermal property.

A series of hydrocarbon-rich polyesters were prepared by condensing a long chain diol bearing a centrally located clickable propargyl group, with diacid chlorides of different lengths, ranging from oxalyl chloride to eicosanedioic acid chloride (C2 to C20). Hydrophilic PEG550 segments were then clicked onto the periodically located propargyl groups using the alkyne-azide click reaction; these amphiphilic graft copolymers underwent microphase separation via zigzag folding of the backbone, thereby generating a lamellar morphol., wherein inter-lamellar spacing was fine-tuned in the sub-10 nm level by the choice of the diacid comonomer. In contrast to our previous report (S. Chanda and S. Ramakrishnan, Macromols., 2016, 49, 3254-3263), here the crystallizable HC backbone was varied; the linear variation of the inter-lamellar spacing with the number of methylene units in the dicarboxylic acid permitted us to retrieve an increment of 0.127 nm per methylene unit, which matches remarkably well with the expected increment for an all-trans extended hydrocarbon chain. This observation not only provides strong evidence for the zigzag folded conformation of the polymer backbone within the lamellae but also demonstrates fine-tuning of lamellar dimension at the sub-nanometer level. The modular synthetic strategy presented here provides scope for easy variation of the pendant graft segments and, therefore, could be used to create other interesting periodically spaced functional materials.

Polymer Chemistry published new progress about Amphiphiles. 56523-59-2 belongs to class bromides-buliding-blocks, name is 15-Bromopentadecanoic acid, and the molecular formula is C15H29BrO2, Safety of 15-Bromopentadecanoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary