Category: 556-96-7

Application of 556-96-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 556-96-7, name is 1-Bromo-3,5-dimethylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Heck coupling reactions were carried out in air. In a typicalexperiment, an oven-dried, sealed tube equipped with amagnetic stir bar was charged with aryl bromide (0.1 mmol),styrene (0.12 mmol) and a base (0.12 mmol). The catalyst solution(0.0004 mmol catalyst in 2.0 ml solvent) was then added.The reaction mixture was placed in a silicon oil bath at 140Cand stirred. After the required reaction time, the mixture wasallowed to cool to room temperature, dilutedwith CH2Cl2, andwashed withHCl aqueous solution and brine. The organic phasewas separated and dried over Na2SO4, and the solventwas evaporated.The residue was chromatographed on silica gel using anethyl acetate/hexane (1:5) mixture as eluent. Conversion percentageswere determined fromthe solution by GC analysis, andisolated yields, which were characterized by 1H and 13C NMR,determined by GC based on ArBr

The synthetic route of 1-Bromo-3,5-dimethylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Altan, Orhan; Serinda?, Osman; Say?n, Koray; Karaka?, Duran; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 7; (2016); p. 993 – 999;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 556-96-7, name is 1-Bromo-3,5-dimethylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 556-96-7, Formula: C8H9Br

General procedure: To a mixture of copper salt (0.3 mmol) and ligand 3 (0.8mmol) in DMF (2.5 mL), aryl halide (1.0 mmol), base (0.25mmol), KI (0.5 mmol), K4Fe(CN)6 (0.2 mmol) and DMF (2.5 mL) were added and the mixture was vigorously stirredat 130 C for 8 h under a dry nitrogen atmosphere. Aftercompletion (as monitored by TLC with EtOAc and nhexane),H2O was added and the organic layer was extractedwith EtOAc, washed with brine, dried over MgSO4, filteredand evaporated under reduced pressure. The residue waspurified by column chromatography. The purity of the compoundswas checked by 1H NMR and yields are based onaryl bromide. All the products are known and the spectroscopicdata (FT-IR and NMR) and melting points were consistentwith those reported in the literature [3-8].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Sajadi, S. Mohammad; Maham, Mehdi; Letters in Organic Chemistry; vol. 11; 2; (2014); p. 136 – 140;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 556-96-7, These common heterocyclic compound, 556-96-7, name is 1-Bromo-3,5-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Magnesium turnings (5.10 g, 210 mmol, 6 equiv) were washed with hexanes and dried in a 120 C oven for 1 h. The vacuum. Upon cooling to room temperature, a small amount of iodine (50 mg) was added to the flask, and the solids were suspended in THF (120 mL). The flask was fitted with a reflux condenser, then vacuum purged/backfilled with nitrogen three times, and warmed to 50 C in an oil bath. A vent needle was added at the top of the reflux condenser to allow rapid gas release during the initiation of Grignard formation. Neat 3,5-dimethylbromobenzene (14.3 mL, 105 mmol, 3 equiv) was then added at a slow dropwise pace. Formation of the Grignard reagent was indicated by the disappearance of the dark brown THF-iodine adduct, at which point the addition was halted until a controlled, gentle reflux was obtained, and the vent needle was removed. Dropwise addition of the bromide was resumed so as to maintain a gentle reflux. After the addition was complete, the solution was stirred at 50 C for 30 mm, then removed from its bath and cooled to 0 C in an ice/water bath. Diethyl phosphite (4.5 mL, 35 mmol, 1 equiv) was added at a fast dropwise pace, and the solution was stirred at 0 C for 1 h. At this time, the reflux condenser was replaced with an addition funnel, and ice cold 6M HC1 (40 mL, prepared by mixing 20 g ice with 20 mL concentrated HC1) was added at a slow dropwise pace. 300 mL water was added and the solution was stirred vigorously for 1 h. The layers were separated and the aqueous phase was thrice extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The product was purified by column chromatography (1-3-5% MeOH/DCM). White solid, 7.58 g, 29.3 mmol, 84% yield. NMR spectra were identical to the previously isolated compound.??H NMR (300 MHz, CDC13) oe 7.94 (d, J 477 Hz, 1H), 7.32 (dt, J 1.5, 0.7 Hz, 2H), 7.28 (dt, J= 1.6, 0.7 Hz, 2H),7.17 (tp, J 1.7, 0.8 Hz, 2H), 2.34 (p, J= 0.6 Hz, 12H); 3?P NMR (121 MHz, CDC13) o 22.71.

Statistics shows that 1-Bromo-3,5-dimethylbenzene is playing an increasingly important role. we look forward to future research findings about 556-96-7.

Reference:
Patent; CALIFORNIA INSTITUTE OF TECHNOLOGY; STOLTZ, Brian, M.; WELIN, Eric, R.; VIRGIL, Scott, C.; TADROSS, Pamela; POTOTSCHNIG, Gerit, Maria; NGAMNITHIPORN, Aurapat (Fa); NEGORO, Kenji; LAPOINTE, Guillaume; KLATTE, Max; HALEY, Christopher; GRUENANGER, Christian; GLIBSTRUP, Emil; GILMORE, Christopher; ALLAN, Kevin, McCormack; (114 pag.)WO2019/18539; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 556-96-7, These common heterocyclic compound, 556-96-7, name is 1-Bromo-3,5-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Under a dry nitrogen atmosphere, a mixture of aryl bromide(1.0 mmol), K4Fe(CN)6 (0.22 mmol), base (1.0 mmol) and Pd(0)-EGCG-CF (2.0 mol%) in DMF (5 mL) was stirred at 130 C for 8 h (Table 2). After completion (as monitoredby TLC), H2O was added and the organic layer was extracted with EtOAc, washed with brine, dried over MgSO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography. All of the desired product(s) were characterized by comparison of their physical data with those of known compounds [4,5c,7]. The formation of aryl nitriles was confirmed by IR spectra, which showed one characteristic peak for the CN stretching band between 2225-2360 cm-1.

The synthetic route of 556-96-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bahari, Siavash; Letters in Organic Chemistry; vol. 10; 7; (2013); p. 523 – 526;,
Bromide – Wikipedia,
bromide – Wiktionary

556-96-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 556-96-7, name is 1-Bromo-3,5-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

N-Hexyl-3,5-dimethylaniline (, entry 1) Using the general procedure, 5-bromo-m-xylene (136 muL, 1.0 mmol) was coupled with n-hexylamine (198 muL, 1.5 mmol). Purification of the crude product by column chromatography on silica gel using hexane/ethyl acetate (20:1) as eluent afforded the desired product as a colorless oil (185 mg, 90% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Buchwald, Stephen L.; Klapars, Artis; Antilla, Jon C.; Job, Gabriel E.; Wolter, Martina; Kwong, Fuk Y.; Nordmann, Gero; Hennessy, Edward J.; US2003/65187; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary