Category: 55099-31-5

Muramoto, Yokichi published the artcileEthyl 3-oxoglutarate derivatives. III. Synthesis of long chain oxodicarboxylic esters from ethyl 3-oxoglutarate, Application of Ethyl 10-bromodecanoate, the main research area is glutarate oxo alkylation haloester; alkylation oxoglutarate haloester; oxoalkanedioate dialkyl; carboxylic diester aliphatic oxo.

The monoanion of the Mg chelate prepared from Et 3-oxoglutarate (I) and Mg(OEt)2 was alkylated with a haloester to give a monoalkylated derivative A second alkylation with a different haloester in the presence of NaOEt followed by decarboxylative hydrolysis and esterification gave an unsymmetrical long chain oxodicarboxylic ester, such as di-Et 5-oxoheptadecanedioate, di-Me 6-methyl-8-oxopentadecanedioate di-Et 6-methyl-4-oxopentadecanedioate, or di-Et 2-methyl-4-oxopentadecanedioate. Moreover, di-Et 8-oxopentadecanedioate was obtained by the alkylation of I with Et 6-bromohexanoate in the presence of NaOEt alone as a catalyst. These esters appear suitable for cyclization to macrocyclic ketones.

Agricultural and Biological Chemistry published new progress about Esters. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Application of Ethyl 10-bromodecanoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Perpetuini, Giorgia published the artcileInfluence of FLO1 and FLO5 genes on aroma profile of sparkling wines, Category: bromides-buliding-blocks, the main research area is sparkling wine aroma FLO gene influence.

This study investigated the influence of S. cerevisiae F6789A strain and its derivative mutants – harbouring FLO1 gene deletion (F6789A-ΔFLO1) and FLO5 gene deletion (F6789A-ΔFLO5) – on secondary fermentation, autolysis outcome and aroma compounds production Data revealed differences in terms of metabolic behavior leading to the production of sparkling wines with different characteristics. F6789A showed the best fermentation kinetic reaching a pressure of 5 bar inside the bottle, while F6789A-ΔFLO1 and F6789A-ΔFLO5 reached 4 bar and 3.8 bar, resp. Cell viability was in agreement with fermentation kinetics. In fact, F6789A showed the highest number of cells. An early autolysis was observed for F6789A-ΔFLO5. Differences were observed especially for esters in terms of number and quantity of esters released. In particular, the parental strains produced 39 different esters while F6789A-ΔFLO1 and F6789A-ΔFLO5 27 and 35, resp. F6789A-ΔFLO5 was the main ester producer with a total amount of about 89 mg/L. Sensory anal. showed that all the strains produced balanced sparkling wines with neg. and pos. attributes arranged in good proportions, showing good aroma descriptors. Obtained data suggested that FLO1 or FLO5 genes had a pleiotropic effect affecting not only flocculation ability but also other metabolic traits.

LWT–Food Science and Technology published new progress about Acidity. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Sumiya, Tomio published the artcileSynthesis of imidazole and indole hybrid molecules and antifungal activity against rice blast, Application of Ethyl 10-bromodecanoate, the main research area is Magnaporthe rice blast imidazole indole hybrid mol antifungal.

Azole and indole are parent substances of many natural and synthetic compounds with significant biol. activity. However, the biol. activity of the indole and azole conjugates are lack of investigation. In the present work, a series of hybrid mols. with imidazole and indole moiety were designed by using camalexin as a mol. scaffold. Compounds with different length of the carboxylic acid (4a-4f) were prepared The antifungal activity of this synthetic series together with the Et esters analogs (3a-3f) against Magnaporthe oryzae were determined by using agar cup plate assay. Data obtained from the structure-activity relationship studies indicated that the ester analogs displayed antifungal activity against Magnaporthe oryzae while the carboxylic acid derivatives did not. This result indicated that the carboxylic acid Et ester moiety is important to antifungal activity. Among all the synthesized compounds, we found that, at a concentration of 100 μM, compound 3c displays the most potent inhibition activity with 38.8 ± 2.5% on the inhibition of the diameter of the mycelial mat of Magnaporthe oryzae while the pos. control of propiconazole (10 μM) was found 39.3 ± 2.9%.

International Journal of Chemical Engineering and Applications published new progress about Fungicides. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Application of Ethyl 10-bromodecanoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hara, Daiki published the artcileTracking the Oxygen Status in the Cell Nucleus with a Hoechst-Tagged Phosphorescent Ruthenium Complex, Related Products of bromides-buliding-blocks, the main research area is lung cancer cell oxygen hoechst tagged phosphorescent ruthenium complex; Hoechst 33258; cell nuclei; imaging agents; oxygenation; phosphorescent probes; ruthenium.

Mol. oxygen in living cells is distributed and consumed inhomogeneously, depending on the activity of each organelle. Therefore, tractable methods that can be used to monitor the oxygen status in each organelle are needed to understand cellular function. Here we report the design of a new oxygen-sensing probe for use in the cell nucleus. We prepared “”Ru-Hoechsts””, each consisting of a phosphorescent ruthenium complex linked to a Hoechst 33258 moiety, and characterized their properties as oxygen sensors. The Hoechst unit shows strong DNA-binding properties in the nucleus, and the ruthenium complex shows oxygen-dependent phosphorescence. Thus, Ru-Hoechsts accumulated in the cell nucleus and showed oxygen-dependent signals that could be monitored. Of the Ru-Hoechsts prepared in this study, Ru-Hoechst b, in which the ruthenium complex and the Hoechst unit were linked through a hexyl chain, showed the most suitable properties for monitoring the oxygen status. Ru-Hoechsts are probes with high potential for visualizing oxygen fluctuations in the nucleus.

ChemBioChem published new progress about Cell nucleus. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lalitha, R. published the artcilePhytochemical analysis of Scinaia bengalica by GC-MS, Product Details of C12H23BrO2, the main research area is Scinaia oleic octanoic acid calcitriol hexadecanol.

Marine red algae consist of various medicinal activities. Marine sources are more active than the other natural sources. One of the most important red algae is Scinaia Bengalica(SB)known for its phytochem. anal. by GC-MS revealed 19 chem. constituents. SB consist major constituents like oleic acid, octanoic acid, 2 hexyl-1-octanol,hexadecanol, calcitriol, bromine compounds

International Journal of ChemTech Research published new progress about Phytochemicals. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Product Details of C12H23BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Beibei published the artcileSurface Functionalization of Zinc Oxide by Carboxyalkylphosphonic Acid Self-Assembled Monolayers, Quality Control of 55099-31-5, the main research area is carboxyalkylphosphonic acid self assembled monolayer zinc oxide antibody biosensor.

Two carboxyalkylphosphonic acids (HOOC(CH2)nP(O)(OH)2, n = 2 for 3-PPA and n = 9 for 10-PDA) were deposited onto 1-dimensional zinc oxide (ZnO) nanowires and bare ZnO wafers to form stable self-assembled monolayers (SAMs). The samples were systematically characterized using wettability, at. force microscopy (AFM), FTIR spectroscopy (FTIR), and XPS. 3-PPA was bound to the ZnO surfaces mainly through the CO2H headgroup, and 10-PDA formed self-assembled monolayers on the nanoscaled ZnO surface through the PO3H2 headgroups. To verify the potential use of the functionalized surfaces in the construction of biosensors or bioelectronics, IgG protein immobilization through SAM bridging was demonstrated. This work expands the application of phosphonic acid-based surface functionalization on sensing and optoelectronic devices.

Langmuir published new progress about Binding energy. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Quality Control of 55099-31-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Seemaisamy, Revathi published the artcileAnti-microbial and anti-cancer activity of Aegle marmelos and gas chromatography coupled spectrometry analysis of their chemical constituents, Application In Synthesis of 55099-31-5, the main research area is Staphylococcus Bacillus Aegle breast cancer cell anticancer antimicrobial.

In this study, we investigated anti-cancer and antimicrobial activity of Aegle marmelos leaf extracts and their chem. profile characterized by gas chromatog. coupled mass spectrometry (GC-MS). A. marmelos leaves were extracted with acetone, methanol, ethanol, and chloroform. Presence of phenolic compounds was identified in these extracts by qual. anal. All the extracts were subjected for anti-bacterial activity against the different strains of bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Bacillus ariyabattai, Bacillus megaterium, Pseudomonas putida, Klebsiella pneumonia, Serratia marcescens, and Escherichia coli). It is noteworthy that acetone extract elicited maximum growth inhibition on Serratia marcescens. Based on profound anti bacterial activity, acetone and methanol extract of A. marmelos were checked for cytotoxicity against MDA-MB-231, HEp-2 and vero cells. MDA-MB-231 cells were more sensitive to acetone extract of A. marmelos with an IC50 value of 79.62 μg/mL where as HEp-2 cells are more sensitive to methanol extract of A. marmelos with an IC50 value of 47.08 μg/mL. Vero cells withstand 24 h treatment of both extract, and it is evidenced that both acetone and methanol extract of A. marmelos exhibited chemo sensitive property towards cancer cells. GCMS anal. was performed to characterize the active principles of acetone and methanol extracts of A. marmelos. GC MS data revealed the presence of ten major components. Overall, both acetone and methanol extract of A. marmelos found to be promising anti antibacterial and anti-cancer agent however the active principle of these should be isolated and characterized before reaching a concrete scientific conclusion.

International Journal of Pharmaceutical Sciences and Research published new progress about Aegle marmelos. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Application In Synthesis of 55099-31-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jaradat, Nidal published the artcileIsolation, identification, and antimycotic activity of plumbagin from Plumbago europaea L. roots, leaves and stems, Formula: C12H23BrO2, the main research area is Plumbago root leaf stem plumbagin antimycotic.

Plumbago europaea L. is a plant utilized in Palestinian ethnomedicine for the treatment of various dermatol. diseases. The current investigation was designed to isolate plumbagin from P. europaea leaves, roots and for the first time from the stems. Moreover, it aimed to evaluate the antimycotic activity against three human fungal pathogens causing dermatophytosis, also against an animal fungal pathogen. The qual. anal. of plumbagin from the leaves, stems, and roots was conducted using HPLC and spectrophotometer techniques, while the structure of plumbagin was established utilizing Proton and Carbon-13 NMR (NMR) and IR (IR) techniques. The entire plant constituents were determined by GC-MS. Moreover, the antimycotic activity against Ascosphaera apis, Microsporum canis, Trichophyton rubrum, and Trichophyton mentagrophytes was assessed utilizing the poison food technique method. The percentage of plumbagin recorded in the leaves, stems, and roots was found to be 0.51±0.001%, 0.16±0.001%, and 1.65±0.015%, resp. The GC-MS examination declared the presence of 59 mols. in the plant extract The plant extract and pure plumbagin exhibited complete inhibition against all tested dermatophytes at 6.0mg/mL for the extracts and 0.2mg/mL for plumbagin. P. europaea root is the best source of plumbagin and the plant extract could represent a potential drug candidate for the treatment of dermatophytosis infections. Further studies required to design suitable dosage forms from the natural P. europaea root extracts or plumbagin alone, to be utilized for the treatment of dermatol. and veterinary ailments.

Pakistan Journal of Pharmaceutical Sciences published new progress about Ascosphaera apis. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Formula: C12H23BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ghalib, Raza Murad published the artcilePhytochemical analysis, cytotoxic activity and constituents-activity relationships of the leaves of Cinnamomum iners (Reinw. ex Blume-Lauraceae), Related Products of bromides-buliding-blocks, the main research area is Cinnamomum antitumor leaf tumor.

The leaves of Cinnamomum iners (Reinw. ex Blume-Lauraceae) have been refluxed successively with chloroform and alc. to get chloroform extract and alc. extract Both the extracts have been assayed for cytotoxicity against human colorectal tumor cells. The chloroform extract exhibited significant cytotoxicity with IC50 31 μg mL-1 (p < 0.01). However, ethanol extract was found to be much less cytotoxic with IC50 > 200 μg mL-1. The chloroform extract has been further proceeded for chem. anal. by GC-TOFMS and 178 components were identified including acids, amines, amides, aldehydes, alcs., esters, benzene derivatives, bicyclic compounds, terpenes, hydrocarbons, naphthalene derivatives, furan derivatives, azulenes, etc. Nine components representing 51.73% of the total chloroform extract were detected as major components. Caryophyllene (14.41%) and Eicosanoic acid Et ester (12.17%) are the most prominent components of the chloroform extract Components of the chloroform extract β-Caryophyllene (14.41%) as most abundant compound supports potent cytotoxicity as shown by chloroform extract

Natural Product Research published new progress about Antitumor agents. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cui, Pei H. published the artcileAntiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2, Application In Synthesis of 55099-31-5, the main research area is antitumor antimetastatic monounsaturated fatty acid preparation breast cancer; structure activity antitumor monounsaturated fatty acid preparation breast cancer.

Cyclooxygenase-2 (COX-2) is overexpressed in many human cancers and converts the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid to prostaglandin E2 (PGE2), which drives tumorigenesis; in contrast, n-3 PUFA inhibit tumorigenesis. We tested the hypothesis that these antitumor actions of n-3 PUFA may involve the n-3 olefinic bond. n-3 Monounsaturated fatty acids (MUFAs) of chain length C16-C22 were synthesized and evaluated in MDA-MB-468 breast cancer cells that stably overexpressed COX-2 (MDA-COX-2 cells). Longer chain (C19-C22) n-3 MUFAs inhibited proliferation, activated apoptosis, decreased PGE2 formation, and decreased cell invasion; C16-C18 analogs were less active. Mol. modeling showed that interactions of Arg120, Tyr355, and several hydrophobic amino acid residues in the COX-2 active site with C19-C22 MUFA analogs were favored. Thus, longer-chain n-3 MUFAs may be prototypes of novel anticancer agents that decrease the formation of PGE2 in tumor cells that contain high levels of COX-2.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Application In Synthesis of 55099-31-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary