Category: 5469-19-2

These common heterocyclic compound, 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Bromo-2,4,5-trimethylbenzene

c. N,N,,N”,N”‘-(4,4,,4″,4,”-methanetetrayltetrakis(benzene-4, 1 – diyl))tetrakis(2,4,5-trimethyl-N-(2,4,5-trimethylphenyl)aniline) In a dry box, 4,4’,4″,4″‘-methanetetrayltetraaniline (1 .00 g, 3.08 mmol), 1 – bromo-2,4,5-trimethylbenzene (1 .35 g, 3.67 mmol), tris(tert- butyl)phosphine (0.1 0 g, 0.50 mmol) and Pd2(DBA)3 (0.23 g, 0.25 mmol) were combined in round bottom flask and dissolved in 120 ml of dry toluene. The solution was stirred for a minute and followed by sodium tert- butoxide (2.72 g, 28.33 mmol) and 5 ml of dry toluene. A heating mantle was added and the reaction heated to 80C for 18 hour. More 1 -bromo- 2,4,5-trimethylbenzene (350mg) and NaOtBu (180mg) were added and the reaction stirred at 80C for another 24 hour. The reaction mixture was then cooled to room temperature and filtered, washing with toluene (200 mL). The solvent was removed by rotary evaporation and the residue was re-dissolved in chloroform (40ml_). The crude product was precipitated into methanol (300ml_) and collected (3.3g, 85% pure) by filtration. The crude product was purified further by silica gel column chromatography using a gradient of chloroform in hexanes (5-21 %). Recrystallization from chloroform and ethanol yielded 2.60 g (64%) of product as a pale yellow solid. 1 H NMR (CDCI3) is consistent with structure for Compound 2.

The synthetic route of 1-Bromo-2,4,5-trimethylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WANG, Ying; WU, Weishi; DOBBS, Kerwin, D.; WO2011/49904; (2011); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 5469-19-2

1-Bromo-2,4,5-trimethylbenzene (25.0 g, 0.125 mol) was dissolved in methylene chloride (500 mL). Aluminum chloride (20.1 g, 0.151 mol) and dichloromethyl methyl ether (13.7 mL, 0.151 mol) were added in a nitrogen atmosphere at -78C. After stirring at -78C for five minutes, water (500 mL) was added, followed by extraction with methylene chloride (400 mL). The organic layer was washed with brine and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate = 25/1) to give the target compound (14.4 g, yield: 51%) as a white solid. 1H-NMR (CDCl3, 400MHz):delta ppm: 2:27 (3H, s), 2.36 (3H, s), 2.55 (3H, s), 7.51 (1H, s), 10.53 (1H, s). MS (EI) m/z: 226 (M+)

The synthetic route of 5469-19-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP1914229; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 5469-19-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 8 3-diethylamino-6-methyl-7-(2′,4′,5′-trimethylanilino)fluoran STR17 30 g. of 3-methoxy-6-acetylaminotoluene, 40 g. of 2,4,5-trimethylbromobenzene, 15 g. of potassium carbonate, 1 g. of copper powder and 0.1 g. of iodine were reacted for 75 hours at 220 to 230 C. Then 15 g. of potassium hydroxide and 30 ml. of iso-propylalcohol were added and refluxed for 24 hours. The resultant was poured into 200 ml. of water and precipitate was filtered off, distilled in a vacuum to obtain 35.5 g. (83 percent of theoretical yields) of 4-methoxy-2,2′,4′,5′-tetramethyldiphenylamine as a light brown crystal having a melting point of 87 to 88 C., and boiling point of 165 to 168 C./3 mmHg.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2,4,5-trimethylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Yamamoto Kagaku Gosei Kabushiki Kaisha; US4330473; (1982); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 5469-19-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5469-19-2 name is 1-Bromo-2,4,5-trimethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

i 2,4,5-Trimethylbenzoic acid n-Butyllithium (100 ml of a 2.5M solution in hexanes) was added to a solution of 5-bromo-1,2,4-trimethylbenzene (50 g) in tetrahydrofuran (600 ml) at -70 C. After 1.5 hours the solution was warmed to -40 C. then cooled to -70 C. Carbon dioxide gas was bubbled through the solution for 10 minutes and the mixture was allowed to warm to room temperature. The solvent was evaporated and the residue partitioned between water and isohexane. The aqeous layer was acidified to pH 1 and extracted with dichloromethane. The organic solution was dried (MgSO4) and evaporated under reduced pressure. Yield 36.7 g. 1H NMR: delta (CDCl3) 7.85(s, 1H), 7.04(s, 1H), 2.59(s, 3H), 2.28(s, 3H), 2.27(s, 3H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2,4,5-trimethylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; AstraZeneca U.K. Limited; US6162808; (2000); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., category: bromides-buliding-blocks

Example 2 This example illustrates the preparation of a triarylaminehaving Formula II I, 4′,4″-(diphenylmethylene)bis(N,N-bis(2,4,5- trimethylphenyl)biphenyl-3-amine), Compound 1 . Compound 1 In a dry box, 4′,4″-(diphenylmethylene)dibiphenyl-3-amine (0.95 g,1 .80 mmol), 1 -bromo-2,4,5-trimethylbenzene (1 .52 g, 7.58 mmol), tris(tert- butyl)phosphine (0.029 g, 0.144 mmol) and Pd2(DBA)3 (0.066 g, 0.072 mmol) were combined in round bottom flask and dissolved in 35 ml of dry toluene. The solution was stirred for a minute and followed by sodium tert- butoxide (0.76 g, 7.94 mmol) and 5 ml of dry toluene. A heating mantle was added and the reaction heated to 60C for 18 hour. The reaction mixture was then cooled to room temperature and filtered, washing with chloroform. The solvent was removed by rotary evaporation and the residue was purified further by silica gel column chromatography using a gradient of chloroform in hexanes (0-36%). The product containing fractions were collected and combined. The solvent was removed by rotary evaporation. The residue was crystallized from dichloromethane and ethanol to give 1 .20 g (68%) product as a white powder. 1 H NMR (CDCI3) is consistent with the structure for Compound 1 .

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5469-19-2.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WANG, Ying; WU, Weishi; DOBBS, Kerwin, D.; WO2011/49904; (2011); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 5469-19-2

1-Bromo-2,4,5-trimethylbenzene (25.0 g, 0.125 mol) was dissolved in methylene chloride (500 mL). Aluminum chloride (20.1 g, 0.151 mol) and dichloromethyl methyl ether (13.7 mL, 0.151 mol) were added in a nitrogen atmosphere at -78C. After stirring at -78C for five minutes, water (500 mL) was added, followed by extraction with methylene chloride (400 mL). The organic layer was washed with brine and then dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (elution solvent: hexane/ethyl acetate = 25/1) to give the target compound (14.4 g, yield: 51%) as a white solid. 1H-NMR (CDCl3, 400MHz):delta ppm: 2:27 (3H, s), 2.36 (3H, s), 2.55 (3H, s), 7.51 (1H, s), 10.53 (1H, s). MS (EI) m/z: 226 (M+)

The synthetic route of 5469-19-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP1914229; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 5469-19-2

c. N,N,,N”,N”‘-(4,4,,4″,4,”-methanetetrayltetrakis(benzene-4, 1 – diyl))tetrakis(2,4,5-trimethyl-N-(2,4,5-trimethylphenyl)aniline) In a dry box, 4,4’,4″,4″‘-methanetetrayltetraaniline (1 .00 g, 3.08 mmol), 1 – bromo-2,4,5-trimethylbenzene (1 .35 g, 3.67 mmol), tris(tert- butyl)phosphine (0.1 0 g, 0.50 mmol) and Pd2(DBA)3 (0.23 g, 0.25 mmol) were combined in round bottom flask and dissolved in 120 ml of dry toluene. The solution was stirred for a minute and followed by sodium tert- butoxide (2.72 g, 28.33 mmol) and 5 ml of dry toluene. A heating mantle was added and the reaction heated to 80C for 18 hour. More 1 -bromo- 2,4,5-trimethylbenzene (350mg) and NaOtBu (180mg) were added and the reaction stirred at 80C for another 24 hour. The reaction mixture was then cooled to room temperature and filtered, washing with toluene (200 mL). The solvent was removed by rotary evaporation and the residue was re-dissolved in chloroform (40ml_). The crude product was precipitated into methanol (300ml_) and collected (3.3g, 85% pure) by filtration. The crude product was purified further by silica gel column chromatography using a gradient of chloroform in hexanes (5-21 %). Recrystallization from chloroform and ethanol yielded 2.60 g (64%) of product as a pale yellow solid. 1 H NMR (CDCI3) is consistent with structure for Compound 2.

The synthetic route of 1-Bromo-2,4,5-trimethylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WANG, Ying; WU, Weishi; DOBBS, Kerwin, D.; WO2011/49904; (2011); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene, molecular formula is C9H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Bromo-2,4,5-trimethylbenzene

d. N,N’-(4,4′-(cyclohexane-1 ,1 -diyl)bis(4, 1 -phenylene))bis(2,4,5-trimethyl- N-(2,4,5-trimethylphenyl)aniline) In a dry box, 4,4′-(cyclohexane-1 , 1 -diyl)dianiline (6.75 g, 25.09 mmol), 1 – bromo-2,4,5-trimethylbenzene (21 .19 g, 105.36 mmol), tris(tert- butyl)phosphine (0.41 g, 2.01 mmol) and Pd2(DBA)3 (0.92 g, 1 .00 mmol) were combined in round bottom flask and dissolved in 450 ml of dry toluene. The solution was stirred for a minute and followed by sodium tert- butoxide (10.61 g, 1 10.38 mmol) and 50 ml of dry toluene. A heating mantle was added and the reaction heated to 80C for 18 hour. The reaction mixture was then cooled to room temperature and filtered, washing with chloroform. The solvent was removed by rotary evaporation and the residue was purified further by silica gel column chromatography using a gradient of chloroform in hexanes (0-25%). The product containing fractions were collected and combined. The solvent was removed by rotary evaporation. The crude product was dissolved in DCM (100 ml_) and precipitated into methanol (700 ml_) to give 1 7.47 g (94%) product as a white powder. 1 H NMR (CDCI3) is consistent with structure.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5469-19-2, its application will become more common.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WANG, Ying; WU, Weishi; DOBBS, Kerwin, D.; WO2011/49904; (2011); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 5469-19-2, name is 1-Bromo-2,4,5-trimethylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5469-19-2, COA of Formula: C9H11Br

Bromo-2,4,5-trimethyl-benzene (1) (2.64 g, 13.26 mmol), benezene- 1 ,4-diboronic acid (3) (1.00 g, 6.03 mmol) and a catalytic amount of tetrakis(triphenylphosphine)palladium(0) (0.10 g, 0.08 mmol) were added into a two-necked flask fitted with an Allihn condenser. The system was degassed and refilled with nitrogen three times. Then, 60 mL of distilled THF was injected, followed with an aqueous solution of potassium carbonate (0.15 g, 20 mL). After stifling at 85 C for 24 h, the mixture was extracted with DCM. The organic layer was collected and washed with deionized water and brine, and dried over anhydrous sodium sulfate. After filtration, the filtrate was evaporated under reduced pressure, and the crude product was purified by silica gel column chromatography using hexanelDCM (5/1, v/v) as eluent. A white powder of TPh-TM was obtained in 75.3% yield (1.42 g, 4.52 mmol).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY; TANG, Benzhong; ZHANG, Haoke; (64 pag.)WO2018/137558; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5469-19-2 as follows. 5469-19-2

Preparation 1 d: 2-tert-Butyl 5-methyl 6-hromo-2,3-dibydro-1H-isoiiidole-2,5-dicarboxylateStep A: S-Brornobenzene-1,2,4-tricarboxylic acidBromotrimethyl benzene (40.7 g, 205 mmol) was added to a mixture of water (3.25 L), potassium permanganate (232 g, 1.468 mol) and sodium carbonate (28.5 g, 206 mmol). The mixture was stirred at reflux for 60 h. Ethanol (820 mE) was added dropwise, and theresultant mixture was filtered hot through celite, then allowed to cool to ambient temperature. The filtrate was acidified with concentrated aqueous HCI, and the organic solvent was removed in vacuo, The solid product was isolated by filtration.

According to the analysis of related databases, 5469-19-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; DAVIDSON, James, Edward, Paul; MURRAY, James, Brooke; CHEN, I-Jen; WALMSLEY, Claire; DODSWORTH, Mark; MEISSNER, Johannes, W., G.; BROUGH, Paul; FEJES, Imre; TATAI, Janos; NYERGES, Miklos; KOTSCHY, Andras; SZLAVIK, Zoltan; GENESTE, Olivier; LE TIRAN, Arnaud; LE DIGUARHER, Thierry; HENLIN, Jean-Michel; STARCK, Jerome-Benoit; GUILLOUZIC, Anne-Francoise; DE NANTEUIL, Guillaume; WO2015/11164; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary