5437-45-6 Archives - Page 6 of 7 - Bromides-buliding-blocks

Shcherbakov, Dmitriy’s team published research in ACS Medicinal Chemistry Letters in 2022 | CAS: 5437-45-6

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Safety of Benzyl 2-bromoacetate

In 2022,Shcherbakov, Dmitriy; Baev, Dmitriy; Kalinin, Mikhail; Dalinger, Alexander; Chirkova, Varvara; Belenkaya, Svetlana; Khvostov, Aleksei; Krut’ko, Dmitry; Medved’ko, Aleksei; Volosnikova, Ekaterina; Sharlaeva, Elena; Shanshin, Daniil; Tolstikova, Tatyana; Yarovaya, Olga; Maksyutov, Rinat; Salakhutdinov, Nariman; Vatsadze, Sergey published an article in ACS Medicinal Chemistry Letters. The title of the article was 《Design and Evaluation of Bispidine-Based SARS-CoV-2 Main Protease Inhibitors》.Safety of Benzyl 2-bromoacetate The author mentioned the following in the article:

For the first time, derivatives of 3,7-diazabicyclo[3.3.1]nonane (bispidine) were proposed as potential inhibitors of the SARS-CoV-2 main viral protease (3-chymotrypsin-like, 3CLpro). Based on the created pharmacophore model of the active site of the protease, a group of compounds were modeled and tested for activity against 3CLpro. The 3CLpro activity was measured using the fluorogenic substrate Dabcyl-VNSTLQSGLRK(FAM)MA; the efficiency of the proposed approach was confirmed by comparison with literature data for ebselen and disulfiram. The results of the experiments performed with bispidine compounds showed that 14 compounds exhibited activity in the concentration range 1-10μM, and 3 samples exhibited submicromolar activity. The structure-activity relationship studies showed that the mols. containing a carbonyl group in the ninth position of the bicycle exhibited the maximum activity. Based on the exptl. and theor. results obtained, further directions for the development of this topic were proposed.Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yamatsugu, Kenzo’s team published research in Protein Expression and Purification in 2022 | CAS: 5437-45-6

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Safety of Benzyl 2-bromoacetate

In 2022,Yamatsugu, Kenzo; Katoh, Hiroto; Yamashita, Takefumi; Takahashi, Kazuki; Aki, Sho; Tatsumi, Toshifumi; Kaneko, Yudai; Kawamura, Takeshi; Miura, Mai; Ishii, Masazumi; Ohkubo, Kei; Osawa, Tsuyoshi; Kodama, Tatsuhiko; Ishikawa, Shumpei; Kanai, Motomu; Sugiyama, Akira published an article in Protein Expression and Purification. The title of the article was 《Antibody mimetic drug conjugate manufactured by high-yield Escherichia coli expression and non-covalent binding system》.Safety of Benzyl 2-bromoacetate The author mentioned the following in the article:

Antibody-drug conjugates (ADCs) are a major therapeutic tool for the treatment of advanced cancer. Malignant cells in advanced cancer often display multiple genetic mutations and become resistant to monotherapy. Therefore, a therapeutic regimen that simultaneously targets multiple mols. with multiple payloads is desirable. However, the development of ADCs is hampered by issues in biopharmaceutical manufacturing and the complexity of the conjugation process of low-mol.-weight payloads to biologicals. Here, we report antibody mimetic-drug conjugates (AMDCs) developed by exploiting the non-covalent binding property of payloads based on high-affinity binding of mutated streptavidin and modified iminobiotin. Miniprotein antibodies were fused to a low immunogenic streptavidin variant, which was then expressed in Escherichia coli inclusion bodies, solubilized, and refolded into functional tetramers. The AMDC developed against human epidermal growth factor receptor 2 (HER2) effectively killed cultured cancer cells using bis-iminobiotin conjugated to photo-activating silicon phthalocyanine. The HER2-targeting AMDC was also effective in vivo against a mouse KPL-4 xenograft model. This AMDC platform provides rapid, stable, and high-yield therapeutics against multiple targets. In the part of experimental materials, we found many familiar compounds, such as Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Saiter, Jeremy’s team published research in European Journal of Organic Chemistry in 2021 | CAS: 5437-45-6

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Quality Control of Benzyl 2-bromoacetate

《Direct Trifluoromethoxylation without OCF3-Carrier through In Situ Generation of Fluorophosgene》 was written by Saiter, Jeremy; Guerin, Thomas; Donnard, Morgan; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic R.. Quality Control of Benzyl 2-bromoacetateThis research focused ontrifluoromethoxy compound preparation; fluorophosgene aryl halide trifluoromethoxylation. The article conveys some information:

The method represented the preparation of a range of trifluoromethoxylated structures R-OCF3 [R = undecanyl, (CH2)2Ph, 4-BrC6H4CH2, etc.] with no use of an intermediate trifluoromethoxylating reagent, but in situ construction and use of the F3CO anion as a salt, avoiding the presence of a useless side-product resulting from activation of an OCF3 carrier. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zeng, Linwei’s team published research in Angewandte Chemie, International Edition in 2022 | CAS: 5437-45-6

《Rhodium-Catalyzed Atroposelective Click Cycloaddition of Azides and Alkynes》 was written by Zeng, Linwei; Li, Jiaming; Cui, Sunliang. Computed Properties of C9H9BrO2This research focused ontriazole preparation enantioselective; azide alkyne atroposelective click cycloaddition rhodium catalyst; Atroposelectivity; Click Chemistry; Cycloaddition; Rhodium Catalysis; Triazoles. The article conveys some information:

Herein, a rhodium-catalyzed enantioselective click cycloaddition of azides R1N3 (R1 = benzyl, 2-naphthyl, pyridin-3-yl, etc.) and alkynes R3CCR2 (R2 = Ph, 2-naphthyl, cyclopropyl, etc.; R3 = 2-hydroxynaphthalen-1-yl, 6-bromo-2-hydroxynaphthalen-1-yl, 6-hydroxyquinolin-5-yl, etc.) for rapid and modular access to atropisomeric triazoles I in excellent yields and enantioselectivities was reported. The process is mild, efficient and scalable, and features broad substrate scope. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Computed Properties of C9H9BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Upp, David M.’s team published research in Angewandte Chemie, International Edition in 2021 | CAS: 5437-45-6

Upp, David M.; Huang, Rui; Li, Ying; Bultman, Max J.; Roux, Benoit; Lewis, Jared C. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Engineering Dirhodium Artificial Metalloenzymes for Diazo Coupling Cascade Reactions》.Formula: C9H9BrO2 The article contains the following contents:

Artificial metalloenzymes (ArMs) are commonly used to control the stereoselectivity of catalytic reactions, but controlling chemoselectivity remains challenging. In this study, we engineer a dirhodium ArM to catalyze diazo cross-coupling to form an alkene that, in a one-pot cascade reaction, is reduced to an alkane with high enantioselectivity (typically >99% ee) by an alkene reductase. The numerous protein and small mol. components required for the cascade reaction had minimal effect on ArM catalysis. Directed evolution of the ArM led to improved yields and E/Z selectivities for a variety of substrates, which translated to cascade reaction yields. MD simulations of ArM variants were used to understand the structural role of the cofactor on ArM conformational dynamics. These results highlight the ability of ArMs to control both catalyst stereoselectivity and chemoselectivity to enable reactions in complex media that would otherwise lead to undesired side reactions. In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Formula: C9H9BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Merad, Jeremy’s team published research in Journal of the American Chemical Society in 2022 | CAS: 5437-45-6

Merad, Jeremy; Grant, Phillip S.; Stopka, Tobias; Sabbatani, Juliette; Meyrelles, Ricardo; Preinfalk, Alexander; Matyasovsky, Jan; Maryasin, Boris; Gonzalez, Leticia; Maulide, Nuno published an article in 2022. The article was titled 《Direct stereodivergent olefination of carbonyl compounds with sulfur ylides》, and you may find the article in Journal of the American Chemical Society.Application of 5437-45-6 The information in the text is summarized as follows:

The reactivity of phosphorus and sulfur ylides towards carbonyl compounds constitutes a well-known dichotomy: the former gives olefins, while the latter gives epoxides. Herein, a stereodivergent carbonyl olefination which challenges this dichotomy, showcasing thiuronium ylides as valuable olefination reagents is presented. With this method, aldehydes are converted to Z-alkenes with high stereoselectivity and broad substrate scope, while N-tosylimines provide a similarly proficient entry to E-alkenes. In-depth computational and exptl. studies clarified the mechanistic details of this unusual reactivity. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Application of 5437-45-6) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Ju-Song’s team published research in Angewandte Chemie, International Edition in 2022 | CAS: 5437-45-6

In 2022,Yang, Ju-Song; Lu, Ka; Li, Chen-Xiao; Zhao, Zu-Hang; Zhang, Xiao-Ming; Zhang, Fu-Min; Tu, Yong-Qiang published an article in Angewandte Chemie, International Edition. The title of the article was 《Chiral 1,2,3-Triazolium Salt Catalyzed Asymmetric Mono- and Dialkylation of 2,5-Diketopiperazines with the Construction of Tetrasubstituted Carbon Centers》.SDS of cas: 5437-45-6 The author mentioned the following in the article:

Novel asym. mono- and dialkylation reactions of α-substituted 2,5-diketopiperazines catalyzed by new chiral spirocyclic-amide-derived triazolium organocatalysts was developed, resulting in a range of enantioenriched 2,5-diketopiperazine derivatives containing one or two tetrasubstituted carbon stereocenters. The reactions featured high yields (up to 98%) and excellent cis-diastereo- and enantioselectivities (up to >20:1 dr, >99% ee) and they provided a new asym. synthetic approach to important functionalized 2,5-diketopiperazine skeletons. Furthermore, a possible reaction mechanism was proposed based on both control experiments and extensive DFT calculations In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6SDS of cas: 5437-45-6) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Danqing’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 5437-45-6

In 2019,Angewandte Chemie, International Edition included an article by Zheng, Danqing; Studer, Armido. Quality Control of Benzyl 2-bromoacetate. The article was titled 《Asymmetric Synthesis of Heterocyclic γ-Amino-Acid and Diamine Derivatives by Three-Component Radical Cascade Reactions》. The information in the text is summarized as follows:

An enantioselective three-component radical reaction of quinolines or pyridines with enamides and α-bromo carbonyl compounds by dual photoredox and chiral Bronsted acid catalysis is presented. A range of valuable chiral γ-amino-acid derivatives are accessible in high chemo-, regio-, and enantioselectivity from simple, readily available starting materials under mild reaction conditions. Using the same strategy, the asym. synthesis of 1,2-diamine derivatives is also reported. Thus, e.g., 4-methylquinoline + N-vinylacetamide + Me bromoacetate → I (88%, 96:4 er). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baiula, Monica’s team published research in ACS Pharmacology & Translational Science in 2021 | CAS: 5437-45-6

Baiula, Monica; Cirillo, Martina; Martelli, Giulia; Giraldi, Valentina; Gasparini, Elisa; Anelli, Alessandro Claudio; Spampinato, Santi Mario; Giacomini, Daria published their research in ACS Pharmacology & Translational Science in 2021. The article was titled 《Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil》.Recommanded Product: 5437-45-6 The article contains the following contents:

Drug conjugates consisting of an antineoplastic drug and a targeting receptor ligand could be effective to overcome the heavy side effects of unselective anticancer agents. To address this need, we report here the results of a project aimed to study agonist and antagonist integrin ligands as targeting head of mol. cargoes for the selective delivery of 5-fluorouracil (5-FU) to cancer or noncancer cells. Initially, two fluorescent β-lactam-based integrin ligands were synthesized and tested for an effective and selective internalization mediated by α4β1 or α5β1 integrins in Jurkat and K562 cells, resp. No cellular uptake was observed for both fluorescent compounds in HEK293 noncancerous control cells. Afterward, three conjugates composed of the β-lactam-based integrin ligand, suitable linkers, and 5-FU were realized. The best compound E (I), acting as α5β1 integrin agonist, is able to selectively deliver 5-FU into tumor cells, successfully leading to cancer cell death. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: 5437-45-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hafner, Susanne’s team published research in Advanced Therapeutics (Weinheim, Germany) in 2019 | CAS: 5437-45-6

In 2019,Advanced Therapeutics (Weinheim, Germany) included an article by Hafner, Susanne; Raabe, Marco; Wu, Yuzhou; Wang, Tao; Zuo, Zhi; Rasche, Volker; Syrovets, Tatiana; Weil, Tanja; Simmet, Thomas. Category: bromides-buliding-blocks. The article was titled 《High-Contrast Magnetic Resonance Imaging and Efficient Delivery of an Albumin Nanotheranostic in Triple-Negative Breast Cancer Xenografts》. The information in the text is summarized as follows:

Triple-neg. breast cancer (TNBC) is a fast growing and strong metastasizing tumor, which presents almost no cellular receptors that can be addressed by targeted therapeutics. In addition, TNBC is often characterized by high tumor grading, fast growth rates, and early metastasis. Therefore, multifunctional drug carriers allowing efficient drug delivery and bioimaging to treat and track TNBC tissue in vivo would be highly desirable. A human serum albumin-based polyethylene glycol copolymer (dcHSA-Gd-Dox) is synthesized combining multiple copies of the chemotherapeutic drug doxorubicin and gadolinium (III) (Gd(III))-based magnetic resonance imaging (MRI) contrast agent. The biodegradable albumin-based nanocarriers reveal high-contrast tumor imaging and efficient drug delivery in a preclin. TNBC xenograft model, where the xenografts are grown on the chorioallantoic membrane of fertilized chick eggs. dcHSA-Gd-Dox is injected i.v., and the distribution of the compound is monitored by MRI and inductively coupled optical plasma emission spectrometry. dcHSA-Gd-Dox is rapidly taken up into MDA-MB-231 cells and exhibits significant cytotoxic efficacy. dcHSA-Gd-Dox combines high tissue enrichment with low systemic toxicity and high-contrast MRI rendering it an attractive nanotheranostic for TNBC.Benzyl 2-bromoacetate(cas: 5437-45-6Category: bromides-buliding-blocks) was used in this study.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary