Category: 5437-45-6

In 2019,Journal of Organic Chemistry included an article by Baydoun, Orsola; De Rycke, Nicolas; Leonce, Estelle; Boutin, Celine; Berthault, Patrick; Jeanneau, Erwann; Brotin, Thierry. Safety of Benzyl 2-bromoacetate. The article was titled 《Synthesis of Cryptophane-223-Type Derivatives with Dual Functionalization》. The information in the text is summarized as follows:

The authors present the synthesis of new cryptophane-type hosts capable of binding xenon in aqueous media and that may be useful for the development of xenon-based magnetic resonance imaging derivatives The synthetic route proposed was chosen to facilitate both the introduction of water-solubilizing substituents and the functionalization of the host with a single arm showing recognition properties that constitute two crucial steps. This was made possible by preparing new cryptophane-223 derivatives bearing two different chem. functions that can be easily modified at a later stage. Thus, subsequent reactions allowed the design of a new cryptophane host able to bind zinc or nickel cations. The ability of this mol. to bind cationic species was assessed by calorimetric titration experiments and hyperpolarized 129Xe NMR. The advantages and disadvantages of this approach are discussed. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vantourout, Julien C.; Mason, Andrew M.; Yuen, Josephine; Simpson, Graham L.; Evindar, Ghotas; Kuai, Letian; Hobbs, Michael; Edgar, Emma; Needle, Saul; Bai, Xiaopeng; Wilson, Steve; Scott-Stevens, Paul; Traylen, William; Lambert, Kim; Young, Neil; Bunally, Shenaz; Summerfield, Scott G.; Snell, Richard; Lad, Rakesh; Shi, Eric; Skinner, Steven; Shewchuk, Lisa; Watson, Allan J. B.; Chung, Chun-wa; Pal, Sandeep; Holt, Dennis A.; Kallander, Lara S.; Prendergast, Joanne; Rivera, Katrina; Washburn, David G.; Harpel, Mark R.; Arico-Muendel, Christopher; Isidro-Llobet, Albert published their research in Bioconjugate Chemistry in 2021. The article was titled 《In Vivo Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders》.Quality Control of Benzyl 2-bromoacetate The article contains the following contents:

Reducing the required frequence of drug dosing can improve the adherence of patients to chronic treatments. Hence, drugs with longer in vivo half-lives are highly desirable. One of the most promising approaches to extend the in vivo half-life of drugs is conjugation to human serum albumin (HSA). In this work, we describe the use of AlbuBinder 1, a small-mol. noncovalent HSA binder, to extend the in vivo half-life and pharmacol. of small-mol. BMP1/TLL inhibitors in humanized mice (HSA KI/KI). A series of conjugates of AlbuBinder 1 with BMP1/TLL inhibitors were prepared In particular, conjugate c showed good solubility and a half-life extension of >20-fold vs. the parent mol. in the HSA KI/KI mice, reaching half-lives of >48 h with maintained maximal inhibition of plasma BMP1/TLL. The same conjugate showed a half-life of only 3 h in the wild-type mice, suggesting that the half-life extension was principally due to specific interactions with HSA. It is envisioned that conjugation to AlbuBinder 1 should be applicable to a wide range of small mol. or peptide drugs with short half-lives. In this context, AlbuBinders represent a viable alternative to existing half-life extension technologies. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Quality Control of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Quality Control of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Selective Capture of Thallium and Cesium by a Cryptophane Soluble at Neutral pH》 was written by Brotin, Thierry; Berthault, Patrick; Pitrat, Delphine; Mulatier, Jean-Christophe. Reference of Benzyl 2-bromoacetateThis research focused onwater soluble cryptophane preparation Thallium Cesium capture complexation. The article conveys some information:

We report in this article the synthesis of an asym. cryptophane derivative (possessing only C3-symmetry) bearing three phenol groups and three other carboxylic acid functions, each of these groups on the aromatic rings. Thanks to isothermal titration calorimetry experiments, we show that this compound binds large monovalent cations, such as Cs+ and Tl+, with a binding constant significantly lower than its congeners bearing a larger number of phenol groups grafted on the benzene rings. However, higher selectivity for Cs+ and Tl+ was observed with this compound since it does not show any affinity for other alkali cations. More importantly, due to the greater solubility of this derivative in pure water, we show for the first time that effective thallium(I) complexation takes place at neutral pH. This result demonstrates that cryptophane derivatives decorated with a higher number of phenol groups are promising host mols. for removing traces of thallium(I) from aqueous phases at neutral pH or above. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Reference of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Reference of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hasegawa, Yoko; Cantin, Thomas; Decaens, Jonathan; Couve-Bonnaire, Samuel; Charette, Andre B.; Poisson, Thomas; Jubault, Philippe published an article in 2022. The article was titled 《Catalytic Asymmetric Syntheses of Alkylidenecyclopropanes from Allenoates with Donor-Acceptor and Diacceptor Diazo Reagents》, and you may find the article in Chemistry – A European Journal.Safety of Benzyl 2-bromoacetate The information in the text is summarized as follows:

The first diastereo- and enantioselective cyclopropanation reactions of electron-deficient allenes with donor-acceptor and diacceptor diazo reagents was described. The desired enantioenriched alkylidenecyclopropanes (ACPs) were obtained in high yields with high diastereo- and enantioselectivities in the presence of Rh2((S)-TCPTAD)4 or Rh2((R)-BTPCP)4 catalysts (up to 95% yield, >95 : 5 d.r. and 99 : 1 e.r.). This methodol. gave a direct access to ACPs bearing multiple electron-deficient substituents and allows to further expand the availability of ACPs chem. Interestingly, during the examination of the scope of this reaction, the asym. intramol. C-H insertion reaction into tert-Bu group was observed as a side reaction with up to 94 : 6 e.r. In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of Benzyl 2-bromoacetateIn 2020 ,《Diastereoselective synthesis of spiro-cyclopropanyl-cyclohexadienones via direct sulfide-catalyzed [2 + 1] annulation of para-quinone methides with bromides》 appeared in Organic & Biomolecular Chemistry. The author of the article were Su, Yingpeng; Zhao, Yanan; Chang, Bingbing; Ling, Qinqin; Feng, Yawei; Zhao, Xiaolong; Huang, Danfeng; Wang, Ke-Hu; Huo, Congde; Hu, Yulai. The article conveys some information:

An efficient sulfide-catalyzed [2 + 1] annulation of para-quinone methides (p-QMs) with diverse bromides was achieved. This catalytic strategy provided an efficient and straightforward protocol for accessing a variety of spiro-cyclopropanyl-cyclohexadienone compounds in good to excellent yields (64% to 96% yields) with outstanding diastereoselectivities (>20 : 1 dr) displaying good functional group tolerance as well as gram-scale capacity. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Reference of Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Reference of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Pharmacia (Sofia, Bulgaria) included an article by Severina, Hanna I.; Skupa, Olha O.; Voloshchuk, Natalya I.; Suleiman, Marharyta M.; Georgiyants, Victoriya A.. Recommanded Product: Benzyl 2-bromoacetate. The article was titled 《Synthesis and anticonvulsant activity of 6-methyl-2-((2-oxo-2-arylethyl)thio) pyrimidin-4(3H)-one derivatives and products of their cyclization》. The information in the text is summarized as follows:

The alkylation of 6-methyl-2-thioxo-2,3-dihydro-1H-pyrimidine-4-one with phenacyl bromides RC6H4C(O)CH2Br (R = H, 4-Br, 3-OMe, 4-OMe, 4-F, 4-NO2), bromo-acetic acid benzyl ester under different conditions was investigated. It was found that during the reaction in the medium of DMF/K2CO3, a mixture of 2-(2-aryl-2-oxoethyl)thio-6-methyl-pyrimidine-4(3H)-ones I and 3-hydroxy-3-aryl-7-methyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-5-ones II was formed. The holding of the resulting mixture in the concentrated sulfuric acid leads to the formation of cyclization products III with high yields. Individual S-alkylated derivatives I, benzyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetate were obtained by reacting in methanol in the presence of sodium methoxide. Pharmacol. screening of synthesized compounds I (R = H, 4-Br, 3-OMe, 4-OMe), III, benzyl [(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetate for anticonvulsant activity on the model of pentylenetetrazole seizures in rats was carried out and some regularity “”structure-activity”” was established. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: Benzyl 2-bromoacetate)

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Recommanded Product: Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Motornov, Vladimir A.; Tabolin, Andrey A.; Ioffe, Sema L. published an article in New Journal of Chemistry. The title of the article was 《Oxidative [3+2]-annulation of nitroalkenes and azolium ylides in the presence of Cu(II): efficient synthesis of [5,5]-annulated N-fused heterocycles》.Computed Properties of C9H9BrO2 The author mentioned the following in the article:

A facile synthesis of [5,5]-annulated N-fused heterocycles – pyrrolo[2,1-b]thiazoles and pyrrolo[1,2-b]indazoles via oxidative [3+2]-annulation between nitroalkenes and azolium ylides in the presence of copper(II) was developed. The reaction proceeds in mild conditions with the copper(II) trifluoroacetate/2,6-lutidine system. The method is applicable to a broad range of nitroalkenes and azolium salts, providing the target N-fused heterocycles in moderate to good yields. In the case of α-fluoronitroalkenes, unique fluorinated derivatives were accessed via this methodol. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Computed Properties of C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Computed Properties of C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C9H9BrO2In 2020 ,《On the electron withdrawing nature of ethers in glycosylation chemistry》 appeared in Carbohydrate Research. The author of the article were Marqvorsen, Mikkel H. S.; Brinkoe, Anne; Jensen, Henrik H.. The article conveys some information:

The present review paper is a commentary on the electronic effects that protecting groups exert on glycosylation chem (with new data). Specifically, its purpose is to rectify the misguided use of the term electron donating benzyl groups, which hardly makes sense in the context of protecting groups on alcs. in saturated systems such as carbohydrates. It is argued that benzyl ethers (OBn) should rightfully be referred to as being inductively electron withdrawing, even if they are less so than benzoyl esters (OBz). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6COA of Formula: C9H9BrO2)

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.COA of Formula: C9H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Su, Yingpeng; He, Haiyang; Zhao, Yanan; Li, Qinling; Feng, Yawei; Cao, Guiyan; Huang, Danfeng; Wang, Ke-Hu; Huo, Congde; Hu, Yulai published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《Sulfide-Catalyzed Diastereoselective Spirocyclopropanation: Constructing Spiro-cyclopropanyl-pyrazolones From α-Arylidenepyrazolones》.Category: bromides-buliding-blocks The article contains the following contents:

An efficient and diastereoselective [2+1] annulation of arylidenepyrazolones with bromides was developed that relies on in-situ formation of sulfur ylide via a direct sulfide-catalyzed process. A variety of spirocyclopropanyl pyrazolones were achieved in good to excellent yields (up to 93% yield) with high diastereoselectives (up to 20 : 1 dr). Meanwhile, several spirocyclopropanyl compounds were also prepared from corresponding enones. This catalytic strategy exhibited good functional group tolerance, gram-scale capacity and broad substrate scope and provided various spirocyclopropanyl derivativesBenzyl 2-bromoacetate(cas: 5437-45-6Category: bromides-buliding-blocks) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Peukert, Carsten; Langer, Laura N. B.; Wegener, Sophie M.; Tutov, Anna; Bankstahl, Jens P.; Karge, Bianka; Bengel, Frank M.; Ross, Tobias L.; Broenstrup, Mark published an article in 2021. The article was titled 《Optimization of Artificial Siderophores as 68Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections》, and you may find the article in Journal of Medicinal Chemistry.Safety of Benzyl 2-bromoacetate The information in the text is summarized as follows:

The diagnosis of bacterial infections at deep body sites benefits from noninvasive imaging of mol. probes that can be traced by positron emission tomog. (PET). We specifically labeled bacteria by targeting their iron transport system with artificial siderophores. The cyclen-based probes contain different binding sites for iron and the PET nuclide gallium-68. A panel of 11 siderophores with different iron coordination numbers and geometries was synthesized in up to 8 steps, and candidates with the best siderophore potential were selected by a growth recovery assay. The probes [68Ga]7 and [68Ga]15 were found to be suitable for PET imaging based on their radiochem. yield, radiochem. purity, and complex stability in vitro and in vivo. Both showed significant uptake in mice infected with Escherichia coli and were able to discern infection from lipopolysaccharide-triggered, sterile inflammation. The study qualifies cyclen-based artificial siderophores as readily accessible scaffolds for the in vivo imaging of bacteria. In addition to this study using Benzyl 2-bromoacetate, there are many other studies that have used Benzyl 2-bromoacetate(cas: 5437-45-6Safety of Benzyl 2-bromoacetate) was used in this study.

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Safety of Benzyl 2-bromoacetate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary