5437-45-6 Archives - Page 2 of 7 - Bromides-buliding-blocks

Liu, Yong-Liang’s team published research in Tetrahedron in 2022 | CAS: 5437-45-6

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is a synthetic chemical produced for industry from benzyl alcohol and acetic acid, but is also naturally present in the essential oils of many plants, including jasmine and ylang ylang.Synthetic Route of C9H9BrO2

Liu, Yong-Liang; Wang, Xiao-Ping; Wei, Jie; Li, Ya published an article in 2022. The article was titled 《PPh3-catalyzed β-selective addition of α-fluoro β-dicarbonyl compounds to allenoates》, and you may find the article in Tetrahedron.Synthetic Route of C9H9BrO2 The information in the text is summarized as follows:

A highly selective phosphine-catalyzed β-addition of α-fluoro β-dicarbonyl compounds to allenoates was developed. Both α-fluoro β-diketones and α-fluoro β-keto esters prove to be competent fluorocarbon nucleophiles, giving a series of the β-addition products bearing a fluorinated quaternary carbon center in good to excellent yields and with excellent regioselectivities. A plausible reaction pathway was presented. In the experiment, the researchers used many compounds, for example, Benzyl 2-bromoacetate(cas: 5437-45-6Synthetic Route of C9H9BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hu, Qi-Long’s team published research in Organic Letters in 2021 | CAS: 5437-45-6

Benzyl 2-bromoacetate(cas: 5437-45-6) has been used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.Computed Properties of C9H9BrO2

Hu, Qi-Long; Liu, Jia-Tian; Li, Jian; Ge, Yang; Song, Zhendong; Chan, Albert S. C.; Xiong, Xiao-Feng published an article in 2021. The article was titled 《Demethylative alkylation of methionine residue by employing the sulfonium as the key intermediate》, and you may find the article in Organic Letters.Computed Properties of C9H9BrO2 The information in the text is summarized as follows:

Methionine (Met) offers a valuable handle to achieve peptide chem. modification owing to its unique thioether functional group. In contrast with cysteine, the site-selective functionalization of the hydrophobic and redox-sensitive thioether motif on peptides is still challenging, and strategies for diversification on the Met residue are rarely disclosed. Herein we report a transition-metal-free and redox-neutral approach for Met diversification with substrate diversity, which could be applied to synthesize cyclic peptides. The experimental process involved the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Computed Properties of C9H9BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Wangbing’s team published research in Organic Letters in 2021 | CAS: 5437-45-6

Li, Wangbing; Lu, Zhichao; Hammond, Gerald B.; Xu, Bo published their research in Organic Letters in 2021. The article was titled 《Unbalanced-Ion-Pair-Catalyzed Nucleophilic Fluorination Using Potassium Fluoride》.Electric Literature of C9H9BrO2 The article contains the following contents:

An unbalanced ion pair promoter (e.g., tetrabutylammonium sulfate), consisting of a bulky and charge-delocalized cation and a small and charge-localized anion, greatly accelerated nucleophilic fluorinations using easy handling KF. An inexpensive and com. available ion-exchange resin was successfully converted to the polymer-supported ion pair promoter (A26-SO42-), which could be reused after filtration. Moreover, A26-SO42- could be used in continuous flow conditions. Water was well-tolerated. The experimental part of the paper was very detailed, including the reaction process of Benzyl 2-bromoacetate(cas: 5437-45-6Electric Literature of C9H9BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Lvyin’s team published research in ChemistrySelect in 2021 | CAS: 5437-45-6

Electric Literature of C9H9BrO2In 2021 ,《Green Catalyst- and Additive-Free Three-Component Deamination Cyclization Synthesis of 3-Substituted-4- oxo-2-quinazolinonyl Sulfides》 appeared in ChemistrySelect. The author of the article were Zheng, Lvyin; Xie, Zhen; Cai, Liuhuan; Liu, Gongping; Mei, Weijie; Zou, Xiaoying; Zhuo, Xiaoya; Fan, Xiaolin; Guo, Wei. The article conveys some information:

An efficient three-component deamination annulation of 2-aminobenzamides 2-NH2-RC6H4C(O)NH2 (R = H, 3-Me, 4-F, 5-Cl, etc.), isothiocyanates R1NCS (R1 = Ph, Bn, Me, etc.) and alkyl bromides R2R3CHBr (R2 = ethoxycarbonyl, benzyloxycarbonyl, Ph, etc.; R3 = H, Et, Pr, Bu, phenyl) for the synthesis of valuable 3-substituted-4-oxo-2-quinazolinonyl sulfides I (R4 = H, 6-Me, 7-Cl, 8-Br, etc.) is reported. The reaction proceeds in the absence of any external catalysts and additives. The facile process has the advantages of broad substrate scopes, mild reaction conditions and environmental friendliness, which might provide the synthetic applications for 3-substituted-4-oxo-2-quinazolinonyl sulfides I as potential anti-cancer agents in medicinal chem. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Electric Literature of C9H9BrO2)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Goh, Jeffrey’s team published research in Organic Letters in 2021 | CAS: 5437-45-6

《Synthesis of Vinylic Sulfones in Aqueous Media》 was written by Goh, Jeffrey; Maraswami, Manikantha; Loh, Teck-Peng. Application In Synthesis of Benzyl 2-bromoacetateThis research focused onvinylic sulfone green preparation regioselective; allenic carbonyl compound sulfinic acid sulfination. The article conveys some information:

A green method for the sulfination of allenic carbonyl compounds to access a wide variety of vinylic sulfones RC(O)CH2C(SO2R1)=CH2 [R = hexyl, Ph, 2-furyl, etc.; R1 = Me, cyclopropyl, Ph, etc.] was developed. This reaction worked in aqueous media under very mild conditions. This reaction was atom economic. A wide variety of vinylic sulfones could be obtained in moderate to excellent yields with wide functional group tolerance. The efficiency of this method was demonstrated in some reactions where the desired products could be isolated by filtration. After reading the article, we found that the author used Benzyl 2-bromoacetate(cas: 5437-45-6Application In Synthesis of Benzyl 2-bromoacetate)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lin, Ling-Zhi’s team published research in Organic Letters in 2019 | CAS: 5437-45-6

In 2019,Organic Letters included an article by Lin, Ling-Zhi; Che, Yuan-Yuan; Bai, Peng-Bo; Feng, Chao. Related Products of 5437-45-6. The article was titled 《Sulfinate-Engaged Nucleophilic Addition Induced Allylic Alkylation of Allenoates》. The information in the text is summarized as follows:

A strategically novel Pd-catalyzed nucleophilic addition induced allylic alkylation reaction (NAAA) of allenoates has been successfully accomplished. By judiciously integrating ZnCl2-promoted Michael addition with Pd-catalyzed allylic alkylation, allenoates readily undergo allyl-sunfonylation at the internal double bond, thus providing a straightforward avenue for the rapid assembly of a host of structurally diversified α-allyl-β-sufonylbut-3-enoate derivatives The success of this transformation profits from a delicate control of the reaction kinetic of each elementary step, thanks to the synergistic interaction of Pd/Zn bimetallic system, thus suppressing either direct allylic sulfonylation or premature quenching of therein in situ generated ester enolate intermediate. Furthermore, by expanding the scope of workable Michael acceptor beyond those previously required doubly activated ones, such as methylenemalononitrile, the present work substantially enriches the repertoire of NAAA reactions. In the part of experimental materials, we found many familiar compounds, such as Benzyl 2-bromoacetate(cas: 5437-45-6Related Products of 5437-45-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Jingjing’s team published research in Organic Letters in 2019 | CAS: 5437-45-6

Benzyl 2-bromoacetate(cas: 5437-45-6) belongs to benzyl acetate. Benzyl acetate is an aromatic chemical, usually appearing as a clear liquid with a moderate sweet-jasmine fragrance. This compound appears as a component of some of our fragrance blends.Name: Benzyl 2-bromoacetate

The author of 《Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source》 were Zhao, Jingjing; Li, Pan; Xu, Yaohua; Shi, Yixin; Li, Fuwei. And the article was published in Organic Letters in 2019. Name: Benzyl 2-bromoacetate The author mentioned the following in the article:

A nickel-catalyzed transformation of diazoacetates to α-carbonyl methylene radicals has been disclosed in the presence of hyperoxide using ethanol as a hydrogen source and solvent. This strategy is successfully applied in the formation of indolin-2-ones or 1,4-dicarbonyl compounds from acrylamides or enamides in moderate to good yields. These reactions underwent radical addition onto C-C double bonds followed by a cyclization/oxidation or an oxidation/hydrolysis process, resp. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6Name: Benzyl 2-bromoacetate)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jung, Garyn L.’s team published research in NeuroToxicology in 2022 | CAS: 5437-45-6

In 2022,Jung, Garyn L.; McDaniel, Katherine L.; LoPachin, Richard M.; Geohagen, Brian C.; Smith, Alicia; Huffstickler, Mitchell; Herr, David W. published an article in NeuroToxicology. The title of the article was 《In vivo neurophysiological assessment of in silico predictions of neurotoxicity: Citronellal, 3,4-dichloro-1-butene, and benzyl bromoacetate》.Application In Synthesis of Benzyl 2-bromoacetate The author mentioned the following in the article:

Neurotoxicants may be widespread in the environment and can produce serious health impacts in the human population. Screening programs that use in vitro methods have generated data for thousands of chems. However, these methods often do not evaluate repeated or prolonged exposures, which are required for many neurotoxic outcomes. Addnl., the data produced by such screening methods may not include mechanisms which play critical biol. roles necessary for in vivo neurotoxicity. The Hard and Soft Acids and Bases (HSAB) in silico model focuses on chem. structure and electrophilic properties which are important to the formation of protein adducts. A group of structurally diverse chems. have been evaluated with an in silico screening approach incorporating HSAB parameters. However, the predictions from the expanded chem. space have not been evaluated using in vivo methods. Three chems. predicted to be cumulative toxicants were selected for in vivo neurotoxicol. testing. Adult male Long-Evans rats were treated orally with citronellal (CIT), 3,4-dichloro-1-butene (DCB), or benzyl bromoacetate (BBA) for 8 wk. Behavioral observations were recorded weekly to assess motor function. Peripheral neurophysiol. measurements were derived from nerve excitability (NE) tests which involved compound muscle action potentials (CMAPs) in the tail and foot, and mixed nerve action potentials (MNAPs) in the tail. Compound nerve action potentials (CNAPs) and nerve conduction velocity (NCV) in the tail were also quantified. Peripheral inputs into the central nervous system were examined using somatosensory evoked potentials recorded from the cortex (SEPCTX) and cerebellum (SEPCEREB). CIT or BBA did not result in significant alterations to peripheral nerve or somatosensory function. DCB reduced grip-strength and altered peripheral nerve function. The MNAPs required less current to reach 50% amplitude and had a lower calculated rheobase, suggesting increased excitability. Increased CNAP amplitudes and greater NCV were also observed Novel changes were found in the SEPCTX with an abnormal peak forming in the early portion of the waveforms of treated rats, and decreased latencies and increased amplitudes were observed in SEPCEREB recordings. These data contribute to testing an expanded chem. space from an in silico HSAB model for predicting cumulative neurotoxicity and may assist with prioritizing chems. to protect human health. In the experiment, the researchers used Benzyl 2-bromoacetate(cas: 5437-45-6Application In Synthesis of Benzyl 2-bromoacetate)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, He’s team published research in Nature Communications in 2022 | CAS: 5437-45-6

In 2022,Zhao, He; Wu, Yang; Ci, Chenggang; Tan, Zhenda; Yang, Jian; Jiang, Huanfeng; Dixneuf, Pierre H.; Zhang, Min published an article in Nature Communications. The title of the article was 《Intermolecular diastereoselective annulation of azaarenes into fused N-heterocycles by Ru(II) reductive catalysis》.HPLC of Formula: 5437-45-6 The author mentioned the following in the article:

Derivatization of azaarenes can create mols. of biol. importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II) reductive catalysis, proceeding with excellent selectivity, mild conditions, and broad substrate and functional group compatibility. Mechanistic studies reveal that the products are formed via hydride transfer-initiated β-aminomethylation and α-arylation of the pyridyl core in the azaarenes, and that paraformaldehyde serves as both the C1-building block and reductant precursor, and the use of Mg(OMe)2 base plays a critical role in determining the reaction chemoselectivity by lowering the hydrogen transfer rate. The present work opens a door to further develop valuable reductive functionalization of unsaturated systems by taking profit of formaldehyde-endowed two functions. The results came from multiple reactions, including the reaction of Benzyl 2-bromoacetate(cas: 5437-45-6HPLC of Formula: 5437-45-6)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Duan, Jingxiang’s team published research in Organic Letters in 2021 | CAS: 5437-45-6

Duan, Jingxiang; Xiong, Zongli; Zhou, Yuqiao; Yao, Weijun; Li, Xiaoyi; Zhang, Min; Wang, Zhen published their research in Organic Letters in 2021. The article was titled 《Access to Chiral Chromenones through Organocatalyzed Mannich/Annulation Sequence》.Recommanded Product: Benzyl 2-bromoacetate The article contains the following contents:

An efficient and practical method to access chiral chromenones I (R1 = H, 5-OBn, 6-Cl, 7-OMe, etc.; R2 = H, Me, n-pentyl, 2-phenylethenyl, etc.; R3 = Ph, TMS, cyclohexyl, etc.), II bearing one α-amino stereogenic center in the β position of the carbonyl group was reported. The quinine-derived squaramide could efficiently promote Mannich/cycloketalization/dehydration tandem reactions between 1-(2-hydroxyaryl)-1,3-diketones 2-OH-R4C6H3C(O)CH2C(O)R2 (R4 = H, 5-Cl, 4-OMe, 4-OBn, etc.) and functionalized imines R3CCCH(NHBoc)OEt/R5N(OBoc)CH2COOBn (R5 = Cbz, Boc) generated in situ, providing a wide range of chiral chromenones with propargylamine I or α-amino ester moieties II with good results (54 examples, up to 98% ee). In the experimental materials used by the author, we found Benzyl 2-bromoacetate(cas: 5437-45-6Recommanded Product: Benzyl 2-bromoacetate)

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary