Category: 5401-62-7

Some common heterocyclic compound, 5401-62-7, name is 1,2-Dibromocyclohexane, molecular formula is C6H10Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks

General procedure: To a stirred solution of bisphenol (5/12) (1 mmol) in MeCN (15 mL) was added K2CO3 (5 mmol) and theresultant suspension was stirred for 30 min. Then, 1,6-dibromohexane (3 mmol) was added dropwise overa period of 10 min. Further, the crude reaction mixture was stirred for 12 h at reflux. At the conclusion ofthe reaction (TLC monitoring), the crude mixture was filtered through celite pad (washed with CH2Cl2)and concentrated under reduced pressure. The crude product was purified by column chromatography.Cyclophane products (7 and 18) data obtained by this procedure was compared with data obtained byhydrogenation process.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5401-62-7, its application will become more common.

Reference:
Article; Kotha, Sambasivarao; Waghule, Gopalkrushna T.; Heterocycles; vol. 90; 2; (2015); p. 1289 – 1298;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5401-62-7, name is 1,2-Dibromocyclohexane, A new synthetic method of this compound is introduced below., Recommanded Product: 5401-62-7

General procedure: To a stirred solution of bisphenol (5/12) (1 mmol) in MeCN (15 mL) was added K2CO3 (5 mmol) and theresultant suspension was stirred for 30 min. Then, 1,6-dibromohexane (3 mmol) was added dropwise overa period of 10 min. Further, the crude reaction mixture was stirred for 12 h at reflux. At the conclusion ofthe reaction (TLC monitoring), the crude mixture was filtered through celite pad (washed with CH2Cl2)and concentrated under reduced pressure. The crude product was purified by column chromatography.Cyclophane products (7 and 18) data obtained by this procedure was compared with data obtained byhydrogenation process.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kotha, Sambasivarao; Waghule, Gopalkrushna T.; Heterocycles; vol. 90; 2; (2015); p. 1289 – 1298;,
Bromide – Wikipedia,
bromide – Wiktionary