Category: 5392-10-9

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Application In Synthesis of 5392-10-9.

Li, Xin;He, Songtao;Song, Qiuling research published 《 Rapid incorporation of a difluoroacetate radical into para-quinone methides via radical 1,6-conjugate addition》, the research content is summarized as follows. A simple but efficient protocol to rapidly incorporate difluoroacetate radical into para-quinone methides I (R = 4-methoxyphenyl, thiophen-2-yl, Me, etc.; R¹ = t-Bu, i-Pr, Me; R² = t-Bu, i-Pr) through dialkylzincs induced radical 1,6-conjugate addition pathway. Besides achieving high yields and excellent functional group compatibility, this protocol allowed the incorporation of a gem-difluoromethylene motif to be accomplished within minutes.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Application In Synthesis of 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde.

Li, Heng;Zhu, Yan;Jiang, Cong;Wei, Jia;Liu, Ping;Sun, Peipei research published 《 HOAc catalyzed three-component reaction for the synthesis of 3,3′-(arylmethylene)bis(1H-indoles)》, the research content is summarized as follows. An efficient HOAc catalyzed three-component cyclization and cascade condensation of o-alkynyl anilines with aromatic aldehydes of 2-(arylethynyl)anilines with arylaldehydes was achieved, which leads to the generation of 3,3′-(arylmethylene)bis(1H-indoles) I [R¹ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; R² = 5-Me, 5-Cl, 6-Me, etc.; R³ = Ph, 4-MeC₆H₄, 4-BrC₆H₄, etc.] with good to excellent yields and high regioselectivity under transition-metal-free conditions. Four new C-C and C-N bonds were effectively formed in a one-pot procedure.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Category: bromides-buliding-blocks.

Li, Ling;Liu, Zhen-Ting;Hu, Xiang-Ping research published 《 Copper-Catalyzed One-Pot Cascade Cyclization for the Synthesis of Isoindolo[2,1-a]quinoxalines》, the research content is summarized as follows. A copper-catalyzed one-pot cascade cyclization of 2-(1-(acetyloxy)propargyl)benzaldehydes with o-phenylenediamines for an access to substituted isoindolo[2,1-a]quinoxalines has been developed. The reaction features readily available starting materials, simple operational procedure, and broad substrate scopes. Under optimal conditions, various isoindolo[2,1-a]quinoxalines were afforded in 41-88% yields.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 5392-10-9, formula is C9H9BrO3, The most pervasive is the naturally produced bromomethane. SDS of cas: 5392-10-9

Li, Lin-Ping;Han, Jia-Qi;Liu, Yun-Ting;Yang, Fan;Wu, Xiong;Xie, Jian-Hua;Zhou, Qi-Lin research published 《 A Three-Step Process to Facilitate the Enantioselective Assembly of Cis-Fused Octahydrophenanthrenes with a Quaternary Stereocenter》, the research content is summarized as follows. A three-step process for the enantioselective assembly of cis-fused octahydrophenanthrenes with a quaternary stereocenter was reported. This synthetic strategy relied on a regioselective γ-alkylation, a one-pot sequence of asym. hydrogenation and oxidation and an intramol. enolate arylation to facilitate the rapid and enantioselective construction of cis-fused octahydrophenanthrene scaffolds with an arylated all-carbon quaternary stereocenter concisely and efficiently.

SDS of cas: 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 5392-10-9.

Lalvani, Khushbu K.;Socha, Bhavesh N.;Patel, Urmila H.;Gandhi, Sahaj;Alalawy, Mohammed Dawood;Barot, V. M.;Patel, Mukesh research published 《 Synthesis, crystallographic investigation, DFT studies and Hirshfeld surface analysis of novel bromo hydrazine derivative: (E)-2-(2-bromo-4,5-dimethoxybenzilidene)-1-(4,5-dimethoxy-2-methylphenyl)-1-hydroxyhydrazine》, the research content is summarized as follows. A novel bromo hydrazine derivative: (E)-2-(2-bromo-4,5-dimethoxybenzilidene)-1-(4,5-dimethoxy-2-methylphenyl)-1-hydroxyhydrazine is synthesized and characterized by different relevant techniques. The optical bonding conformed using ¹H NMR spectroscopic and Uv-vis studies. The crystallog. data confirmed that the bromo hydrazine derivative crystalizes in monoclinic space group P21/n and consists of bromo dimethoxy Ph ring and Me dimethoxy Ph ring interlinked to each other via hydrazide moiety. The mol. geometry, HOMO-LUMO (frontier MO) energies, Mol. electrostatic potential (MEP), MPA (Mulliken population anal.), NBO (natural bond orbital), hypercharge polarizability of the title compound has been explored using D. Functional Theory (DFT) calculation via B3LYP method with LAV2P** basis set. Moreover, to visualize the intermol. interactions and their distribution over the crystal structure, Hirshfeld surfaces and 3D energy framework analyses have been investigated using Crystal Explorer 17.5. In the absence of conventional forces, the weak but collective contribution of C-H… O/N/Br interactions along with direction specific π…π, C-H…π interaction having highest contribution from dispersion energy responsible for mol. stability. Lipophilicity index (log P value) represents significant biol. activity of the mol., correlates well with the contribution of C-H…π interaction. The probable binding modes between title mol. with different active sites of S. aureus (PDB code: 4ALI), E. coli (PDB code: 1QG6), colon cancer (PDB code: 2hq6), lung cancer (PDB code: 1x2j) and 1BNA (DNA) receptors are investigated by mol. docking studies using ArgusLab software.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Electric Literature of 5392-10-9

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Reference of 5392-10-9.

Korch, Katerina M.;Watson, Donald A. research published 《 Total Synthesis of (±)-Impatien A via Aza-Heck Cyclization》, the research content is summarized as follows. The first total synthesis of the natural product impatien A is described. This concise synthesis features an aza-Heck cyclization to construct the complex spirocyclic ring system and provides a rare example of the use of aza-Heck cyclizations in complex mol. synthesis. To enable this key cyclization of an electrophilic nitrogen atom with a tetrasubstituted alkene, we utilized high-throughput experimentation to identify a new ligand and ultimately deliver impatien A in seven steps from known compounds

Reference of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde.

Kim, Taejung;Kim, Young-Joo;Jeong, Kyu-Hyuk;Park, Young-Tae;Kwon, Hyukjoon;Choi, Pilju;Ju, Ha-Neul;Yoon, Cheol Hee;Kim, Ji-Yool;Ham, Jungyeob research published 《 The efficient synthesis and biological evaluation of justicidin B》, the research content is summarized as follows. A facile new synthetic method for the preparation of a Type-A 1-arylnaphthalene lactone skeleton was developed and used to synthesize justicidin B I [R = 1,3-benzodioxol-5-yl] and several derivatives I [R = 3-furyl, 4-MeOC₆H₄, CH=CHPh, etc.]. Key synthesis steps included Hauser-Kraus annulation of a phthalide intermediate and Suzuki-Miyaura cross coupling between a triflated naphthalene lactone intermediate and various potassium organotrifluoroborates. With two exceptions, the derivatives showed significant inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophages. Moreover, several compounds, including justicidin B, had marked cytotoxicity towards six human tumor cell lines.

Recommanded Product: 2-Bromo-4,5-dimethoxybenzaldehyde, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde, Electric Literature of 5392-10-9

Jesus, Ana;Duraes, Fernando;Szemeredi, Nikoletta;Freitas-Silva, Joana;da Costa, Paulo Martins;Pinto, Eugenia;Pinto, Madalena;Spengler, Gabriella;Sousa, Emilia;Cidade, Honorina research published �BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections� the research content is summarized as follows. The growing number of infectious diseases around the world threatens the effective response of antibiotics, contributing to the increase in antibiotic resistance seen as a global health problem. Currently, one of the main challenges in antimicrobial drug discovery is the search for new compounds that not only exhibit antimicrobial activity, but can also potentiate the antimicrobial activity and revert antibiotics�resistance, through the interference with several mechanisms, including the inhibition of efflux pumps (EPs) and biofilm formation. Inspired by macroalgae brominated bromophenol BDDE with antimicrobial activity, a series of 18 chalcone derivatives, including seven chalcones (9-15), six dihydrochalcones (16-18, and 22-24) and five diarylpropanes (19-21, and 25 and 26), was prepared and evaluated for its antimicrobial activity and potential to fight antibiotic resistance. Among them, chalcones 13 and 14 showed promising antifungal activity against the dermatophyte clin. strain of Trichophyton rubrum, and all compounds reversed the resistance to vancomycin in Enterococcus faecalis B3/101, with 9, 14, and 24 able to cause a four-fold decrease in the MIC of vancomycin against this strain. Compounds 17-24 displayed inhibition of EPs and the formation of biofilm by S. aureus 272123, suggesting that these compounds are inhibiting the EPs responsible for the extrusion of mols. involved in biofilm-related mechanisms. Interestingly, compounds 17-24 did not show cytotoxicity in mouse embryonic fibroblast cell lines (NIH/3T3). Overall, the results obtained suggest the potential of dihydrochalcones 16-18 and 22-24, and diarylpropanes 19-21, 25 and 26, as hits for bacterial EPs inhibition, as they are effective in the inhibition of EPs, but present other features that are important in this matter, such as the lack of antibacterial activity and cytotoxicity.

Electric Literature of 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. SDS of cas: 5392-10-9.

Jiang, Xunjin;Zeng, Zhixiong;Shi, Dong;Liu, Chenguang;Zhang, Yandong research published ã€?Divergent total syntheses of pseudoberberine and nitidine through C-H vinylation and switchable 6π electrocyclizationsã€? the research content is summarized as follows. Quaternary protoberberine alkaloids and quaternary benzophenanthridine alkaloids are two biosynthetically related natural product families of biol. importance. Although significant advances have been achieved in the synthetic chem. of these alkaloids, a unified approach to these tetracyclic pyridinium-contained alkaloids remains elusive until our recent report. Herein, the authors report a concise, modular, divergent approach to two of them, pseudoberberine and nitidine, based on our newly developed strategy in five and seven steps. The key transformations include an Ag-promoted annulation, an isoquinoline-directed C-H vinylation, and switchable aza-6π- or all-carbon-6π-electrocyclization.

SDS of cas: 5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., 5392-10-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 5392-10-9, formula is C9H9BrO3, Name is 2-Bromo-4,5-dimethoxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Category: bromides-buliding-blocks.

Iwumene, Ndidi U. N.;Moseley, Daniel. F.;Pullin, Robert D. C.;Willis, Michael C. research published ã€?Diverse saturated heterocycles from a hydroacylation/conjugate addition cascadeã€? the research content is summarized as follows. Rhodium-catalyzed hydroacylation using alkynes substituted with pendant nucleophiles, delivers linear α,β-unsaturated enone intermediates with excellent regioselectivity. These adducts are used to construct a broad range of diversely substituted, saturated O-, N- and S-heterocycles in a one-pot process. Judicious choice of cyclisation conditions enabled isolation of O-heterocycles with high levels of diastereoselectivity. A variety of derivatization reactions are also performed, generating functionalized hydroacylation products. This sequence serves as a general approach for the synthesis of fully saturated heterocycles.

5392-10-9, 2-Bromo-4,5-dimethoxybenzaldehyde is a useful research compound. Its molecular formula is C9H9BrO3 and its molecular weight is 245.07 g/mol. The purity is usually 95%.
2-Bromo-4,5-dimethoxybenzaldehyde is a synthetic compound that has been shown to be an effective agent for inducing apoptosis in leukemia cells. It is an efficient method for synthesizing the compound and ha2-Bromo-4,5-dimethoxybenzaldehyde induces cell death by topoisomerase-mediated DNA cleavage, which results in chromosomal fragmentation and high levels of reactive oxygen species in the cell., Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary