Category: 539-74-2

The author of 《Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy》 were Chen, Yang; Yang, Cejun; Mao, Juan; Li, Haigang; Ding, Jinsong; Zhou, Wenhu. And the article was published in RSC Advances in 2019. Computed Properties of C5H9BrO2 The author mentioned the following in the article:

Tumor targeting delivery of chemotherapeutic drugs by nanocarriers has been demonstrated to be a promising strategy for cancer therapy with improved therapeutic efficacy. In this work, we reported a novel type of active targeting micelle with pH-responsive drug release by using biodegradable poly(lactide)-poly(2-ethyl-2-oxazoline) di-block copolymers functionalized with spermine (SPM). SPM has been considered as a tumor binding ligand through its specific interaction with the polyamine transport system (PTS), a transmembrane protein overexpressed on various types of cancer cell, while its application in nano-drug delivery systems has rarely been explored. The micelles with spherical shape (~110 nm) could load hydrophobic paclitaxel (PTX) with high capacity, and release the payload much faster at acidic pH (4.5-6.5) than at pH 7.4. This pH-responsive property assisted the rapid escape of drug from the endo/lysosome after internalization as demonstrated by confocal laser scanning microscopy images using coumarin-6 (Cou-6) as a fluorescent probe. With surface SPM modification, the micelles displayed much higher cellular uptake than SPM lacking micelles in various types of cancer cells, demonstrating tumor targeting ability. The uptake mechanism of SPM modified micelles was explored by flow cytometry, which suggested an energy-consuming sag vesicle-mediated endocytosis pathway. As expected, the micelles displayed significantly enhanced anti-cancer activity. This work demonstrates that SPM modified pH-sensitive micelles may be potential drug delivery vehicles for targeting and effective cancer therapy. In the experimental materials used by the author, we found Ethyl 3-bromopropanoate(cas: 539-74-2Computed Properties of C5H9BrO2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. Computed Properties of C5H9BrO2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Direct synthesis of N-functionalized dipropargylamine linkers as models for use in peptide stapling》 were Renzetti, Andrea; Rutherford, Ryan N.; Fukumoto, Kozo; Kunciw, Dominique; Sore, Hannah F.; Spring, David R.. And the article was published in Synlett in 2019. SDS of cas: 539-74-2 The author mentioned the following in the article:

N-Substituted dipropargylamines that are suitable as functionalized linkers for peptide stapling can be synthesized in one step under mild conditions from com. available starting materials (41% to quant. yield). The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-bromopropanoate(cas: 539-74-2SDS of cas: 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. SDS of cas: 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: 539-74-2In 2019 ,《Synthesis of a Variety of Activated Pyrrolo[3,2,1- ij ]quinolines》 appeared in Synthesis. The author of the article were Jumina, Jumina; Wenholz, Daniel S.; Kumar, Naresh; Black, David StC.. The article conveys some information:

A range of 7,9-dimethoxypyrrolo[3,2.1- ij]quinolines have been prepared by the cyclization of 7-formyl-1-diethylcarbethoxyindoles. The functionality at C5 has been varied by the conversion of the carbethoxy group into carboxy, azidocarbonyl and isocyanate groups. The hydroboration of a previously reported pyrroloquinolone gave a related 5-hydroxypyrrolo[3,2,1- ij]quinolone, and the hydroxyl group was sequentially converted into tosylate, azido and amino groups. In the experiment, the researchers used Ethyl 3-bromopropanoate(cas: 539-74-2Recommanded Product: 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. The most pervasive is the naturally produced bromomethane.Recommanded Product: 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Trunks, Thomas M.; Babra, Jasraj Singh; Westwood, James; Smith, Christopher D. published an article in SynOpen. The title of the article was 《A Homocoupling Approach to the Key Dione of CyMe 4-BTPhen-Vital Ligands for Nuclear Clean-Up by the SANEX Process》.Safety of Ethyl 3-bromopropanoate The author mentioned the following in the article:

The synthesis of the CyMe4 fragment beginning from readily available hydroxypivalic acid. It featured a cobalt-catalyzed homocoupling of a neopentyl bromide to provided the key bisester precursor, thereby avoiding the requirement for tech. challenging low-temperature LDA-mediated aldol chemistries. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2Safety of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Safety of Ethyl 3-bromopropanoate Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Fengze; Tong, Yi; Zou, Gang published an article in Organic Letters. The title of the article was 《Nickel-Catalyzed, Manganese-Assisted Denitrogenative Cross-Electrophile-Coupling of Benzotriazinones with Alkyl Halides for ortho-Alkylated Benzamides》.Category: bromides-buliding-blocks The author mentioned the following in the article:

A nickel-catalyzed denitrogenative cross-electrophile-coupling of benzotriazinones with unactivated alkyl halides (X = Cl, Br, I) in the presence of manganese powder as a reductant has been developed. The reaction furnishes ortho-alkylated secondary benzamides in modest to good yields under mild conditions. The scope of the reaction is demonstrated with 25 examples, showing good tolerance of steric hindrance and common functional groups, thus providing an efficient protocol to ortho-alkylated benzamide derivatives without the use of preprepared organometallic reagents. The experimental process involved the reaction of Ethyl 3-bromopropanoate(cas: 539-74-2Category: bromides-buliding-blocks)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Category: bromides-buliding-blocks Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cruz, Cole L.; Montgomery, John published their research in Chemical Science in 2021. The article was titled 《Nickel-catalyzed reductive coupling of unactivated alkyl bromides and aliphatic aldehydes》.Application In Synthesis of Ethyl 3-bromopropanoate The article contains the following contents:

A mild, convenient coupling of aliphatic aldehydes e.g., BnCH2CHO and unactivated alkyl bromides e.g., Br(CH2)3C(O)OEt has been developed. The catalytic system features the use of a common Ni(II) precatalyst and a readily available bioxazoline ligand and affords silyl-protected secondary alcs. e.g., BnCH2CH(OTES)(CH2)3C(O)OEt. The reaction is operationally simple, utilizes Mn as a stoichiometric reductant, and tolerates a wide range of functional groups. The use of 1,5-hexadiene as an additive is an important reaction parameter that provides significant benefits in yield optimizations. Initial mechanistic experiments support a mechanism featuring an alpha-silyloxy Ni species that undergoes formal oxidative addition to the alkyl bromide via a reductive cross-coupling pathway. In addition to this study using Ethyl 3-bromopropanoate, there are many other studies that have used Ethyl 3-bromopropanoate(cas: 539-74-2Application In Synthesis of Ethyl 3-bromopropanoate) was used in this study.

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Moreover, several studies demonstrate that the average proportion of bromine in drugs is significantly higher than that in natural products. Application In Synthesis of Ethyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Brewster, Richard C.; Hulme, Alison N. published an article in 2021. The article was titled 《Halomethyl-Triazoles for Rapid, Site-Selective Protein Modification》, and you may find the article in Molecules.Application In Synthesis of Ethyl 3-bromopropanoate The information in the text is summarized as follows:

Post-translational modifications (PTMs) are used by organisms to control protein structure and function after protein translation, but their study is complicated and their roles are not often well understood as PTMs are difficult to introduce onto proteins selectively. Designing reagents that are both good mimics of PTMs, but also only modify select amino acid residues in proteins is challenging. Frequently, both a chem. warhead and linker are used, creating a product that is a misrepresentation of the natural modification. We have previously shown that biotin-chloromethyl-triazole is an effective reagent for cysteine modification to give S-Lys derivatives where the triazole is a good mimic of natural lysine acylation. Here, we demonstrate both how the reactivity of the alkylating reagents can be increased and how the range of triazole PTM mimics can be expanded. These new iodomethyl-triazole reagents are able to modify a cysteine residue on a histone protein with excellent selectivity in 30 min to give PTM mimics of acylated lysine side-chains. Studies on the more complicated, folded protein SCP-2L showed promising reactivity, but also suggested the halomethyl-triazoles are potent alkylators of methionine residues. In the part of experimental materials, we found many familiar compounds, such as Ethyl 3-bromopropanoate(cas: 539-74-2Application In Synthesis of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Alkyl bromides are mainly used as alkylating agents and also find application as a solvent to extract oil from seeds and wool. Application In Synthesis of Ethyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of Ethyl 3-bromopropanoateIn 2022 ,《Photochemical aerobic oxidation of sulfides to sulfoxides: the crucial role of wavelength irradiation》 was published in Green Chemistry. The article was written by Skolia, Elpida; Gkizis, Petros L.; Nikitas, Nikolaos F.; Kokotos, Christoforos G.. The article contains the following contents:

Herein, a novel, sustainable, light-driven protocol was reported for photochem. aerobic oxidation of sulfides to sulfoxides RS(O)R1 [R = Ph, naphth-2-yl, n-Bu, etc.; R1 = Me, Et, n-Pr, etc.], where the impact of wavelength irradiation on sulfide aerobic photooxidation was examined In this work, two different low-catalyst loading (0.05-0.5 mol%) protocols, utilizing anthraquinone as the photocatalyst (under CFL lamps or 427 nm irradiation) were developed and a catalyst-free protocol (under 370 nm irradiation) was also assessed. In addition, a broad scope of substrates was tested and extensive mechanistic studies were performed, in order to distinguish the mechanistic pathways that were followed in the different cases of aryl or alkyl sulfide oxidation under different wavelength irradiation Also implemented this protocols toward the oxidation of several intermediates en route to Sulforaphane. After reading the article, we found that the author used Ethyl 3-bromopropanoate(cas: 539-74-2Reference of Ethyl 3-bromopropanoate)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Reference of Ethyl 3-bromopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cruz, Daniel A.; Sinka, Victoria; de Armas, Pedro; Steingruber, Hugo Sebastian; Fernandez, Israel; Martin, Victor S.; Miranda, Pedro O.; Padron, Juan I. published their research in Organic Letters in 2021. The article was titled 《Iron(II) and Copper(I) Control the Total Regioselectivity in the Hydrobromination of Alkenes》.Related Products of 539-74-2 The article contains the following contents:

A new method that allowed the complete control of the regioselectivity of the hydrobromination reaction of alkenes was described. Herein, a radical procedure with TMSBr and oxygen as common reagents, where the formation of the anti-Markovnikov product occurs in the presence of ppm amounts of the Cu(I) species and the formation of the Markovnikov product occurred in the presence of 30 mol % iron(II) bromide was reported. D. functional theory calculations combined with Fukui’s radical susceptibilities support the obtained results. In the experiment, the researchers used Ethyl 3-bromopropanoate(cas: 539-74-2Related Products of 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.Related Products of 539-74-2

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Linfeng; Zheng, Jing; Zou, Wenya; Shu, Yongqi; Yang, Weiran published an article in 2021. The article was titled 《Microwave-Assisted Nickel-Catalyzed Rapid Reductive Coupling of Ethyl 3-iodopropionate to Adipic Acid》, and you may find the article in Catalysis Letters.Application of 539-74-2 The information in the text is summarized as follows:

3-Iodopropionic acid (3-IPA) can be efficiently synthesized from the glycerol derivative glyceric acid (GA), which is a potential biomaterial-based platform mol. In this report, Et 3-iodopropionate was rapidly dimerized to di-Et adipate in a microwave reactor using NiCl2.6H2O as a catalyst, co-catalyzed by Mn and the 1, 10-Phenanthroline monohydrate ligand. Under the optimum reaction conditions, di-Et adipate can be obtained with 84% yield at 90°C in just 5 min. Di-Et adipate was hydrolyzed to obtain the adipic acid (AA) in 89% yield with an acid catalyst. AA is an important chem. and a monomer for producing a wide range of high-performance polymeric substances. This rapid coupling method is also applicable to other alkyl halides. The experimental part of the paper was very detailed, including the reaction process of Ethyl 3-bromopropanoate(cas: 539-74-2Application of 539-74-2)

Ethyl 3-bromopropanoate(cas: 539-74-2) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application of 539-74-2 Due to the reactivity of bromide, they are used as potential precursors or important intermediates in organic synthesis.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary