Category: 53784-83-1

Cyclodextrin-Derived Host Molecules as Reversal Agents for the Neuromuscular Blocker Rocuronium Bromide: Synthesis and Structure-Activity Relationships was written by Adam, Julia M.;Bennett, D. Jonathan;Bom, Anton;Clark, John K.;Feilden, Helen;Hutchinson, Edward J.;Palin, Ronald;Prosser, Alan;Rees, David C.;Rosair, Georgina M.;Stevenson, Donald;Tarver, Gary J.;Zhang, Ming-Qiang. And the article was included in Journal of Medicinal Chemistry in 2002.COA of Formula: C42H63Br7O28 This article mentions the following:

A series of mono- and per-6-substituted cyclodextrin derivatives were synthesized as synthetic receptors (or host mols.) of rocuronium bromide, the most widely used neuromuscular blocker in anesthesia. By forming host-guest complexes with rocuronium, these cyclodextrin derivatives reverse the muscle relaxation induced by rocuronium in vitro and in vivo and therefore can be used as reversal agents of the neuromuscular blocker to assist rapid recovery of patients after surgery. Because this supramol. mechanism of action does not involve direct interaction with the cholinergic system, the reversal by these compounds is not accompanied by cardiovascular side effects usually attendant with acetylcholinesterase inhibitors such as neostigmine. The structure-activity relationships are consistent with this supramol. mechanism of action and are discussed herein. These include the effects of binding cavity size and hydrophobic and electrostatic interaction on the reversal activities of these compounds In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1COA of Formula: C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.COA of Formula: C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of regioselectively and uniformly modified maltoheptaose derivatives from cyclomaltoheptaose precursors was written by Lesur, David;Gassama, Abdoulaye;Moreau, Vincent;Pilard, Serge;Djedaini-Pilard, Florence. And the article was included in Carbohydrate Research in 2005.Synthetic Route of C42H63Br7O28 This article mentions the following:

Heptadeoxy-6^I-VII-halo, -azido, and hepta-6^I-VII S-hepta(N-Boc-2-amino)ethyl-6^I-VII-heptathiomaltoheptaose derivatives were prepared by acetolysis of the corresponding per-C-6-modified 灏?cyclodextrin derivatives The rapid and convenient structural characterization of all of the modified oligosaccharides by ESIMS is described. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Synthetic Route of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of heptakis(2-O-methyl)-灏?cyclodextrin was written by Takeo, Kenichi;Kuge, Takashi. And the article was included in Staerke in 1976.Synthetic Route of C42H63Br7O28 This article mentions the following:

The title compound, I (R = OH, R1 = Me) (II), was prepared in 80% yield by methylation of I (R = Br, R1 = H) with Me2SO4-BaO-Ba(OH)2 in DMF at room temperature for 40 hr, followed by treatment with NaOBz in (Me2N)3PO at 90鎺?and deesterification with NaOMe in MeOH. NMR comparison of II and the tetradeca-O-methyl ether (III) of 灏?dextrin confirmed that the Me groups in III are located at O-2 and O-6. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Synthetic Route of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Synthetic Route of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cyclodextrin-based facial amphiphiles: assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities was written by Pflueger, Iris;Charrat, Coralie;Mellet, Carmen Ortiz;Garcia Fernandez, Jose M.;Di Giorgio, Christophe;Benito, Juan M.. And the article was included in Organic & Biomolecular Chemistry in 2016.HPLC of Formula: 53784-83-1 This article mentions the following:

Exhaustive structure-efficacy relation studies on nonviral gene delivery systems are often hampered by the ill-defined or polydisperse nature of the formulations. Facial amphiphiles based on rigid cage-type mol. scaffolds offer unique possibilities towards these studies. Taking advantage of regioselective functionalization schemes, we have synthesized a library of cationic cyclodextrin (CD) derivatives combining a range of hydrophilic and lipophilic domains. We have scrutinized how the hydrophilic-lipophilic balance (HLB) around the CD scaffold determines their self-assembly capabilities and the DNA binding and release abilities of the corresponding CD : DNA nanocomplexes (CDplexes). These features have been ultimately correlated with their capabilities to deliver a reporter luciferase-encoding pDNA into COS-7 cells. The ensemble of results demonstrates that fine tuning of the HLB is critical to induce compaction of DNA by the CD-based facial amphiphiles into transfection-productive CDplexes. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1HPLC of Formula: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.HPLC of Formula: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Magnetic glyconanoparticles for selective lectin separation and purification was written by Oz, Yavuz;Abdouni, Yamin;Yilmaz, Gokhan;Becer, C. Remzi;Sanyal, Amitav. And the article was included in Polymer Chemistry in 2019.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

A modular platform for the separation and purification of lectins using polymer coated iron oxide nanoparticles is developed. Supramol. host-guest interactions based on an adamantane beta-cyclodextrin (灏?CD) dyad are utilized to modify the polymeric interface. Poly(ethylene glycol) based hydrophilic polymer-coated magnetic iron oxide nanoparticles are fabricated using reversible addition-fragmentation chain transfer polymerization, followed by their chain-end modification to install adamantane groups on the nanoparticle surface. These adamantyl containing nanoparticles could be surface modified using 灏?CDs appended with appropriate ligands for intended applications. In this study, we exploit this supramol. system for the purpose of separation and purification of lectins. Therefore, a polymer-coated magnetic nanoparticle interface was decorated with two types of mannose-containing 灏?CD constructs, a monodisperse heptamannose conjugated CD and a CD-based 7-arm star shaped glycopolymer for selective binding towards the Con A (ConA) lectin. The monodisperse and polydisperse CD derivatives were compared in terms of their efficiency for binding to ConA. It was demonstrated that the polymeric CD construct significantly improved the binding of magnetic nanoparticles and provided an effective system for the separation and purification of ConA from a mixture of ConA and peanut agglutinin (PNA). Moreover, the surface bound isolated protein could be simply regenerated by the addition of competitive ligands such as mannose. Specificity to bind a particular lectin can be tailored by choosing the appropriate sugar based ligand, as demonstrated by the specific capture of PNA using a galactose-containing polymer. The modular nature of functionalization of the nanoparticle interface that is tunable by host-guest chem. affords a universal system that can be easily tailored for the purification of specific proteins from mixtures In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs was written by Becker, Lisa F.;Schwarz, Dennis H.;Wenz, Gerhard. And the article was included in Beilstein Journal of Organic Chemistry in 2014.Electric Literature of C42H63Br7O28 This article mentions the following:

Me and Et thioether groups were introduced at all primary positions of 浼?, 灏?, and 绾?cyclodextrin by nucleophilic displacement reactions starting from the corresponding per-(6-deoxy-6-bromo)cyclodextrins. Further modification of all 2-OH positions by etherification with iodo terminated triethylene glycol monomethyl ether (and tetraethylene glycol monomethyl ether, resp.) furnished water-soluble hosts. Especially the 灏?cyclodextrin derivatives exhibit very high binding potentials towards the anesthetic drugs sevoflurane and halothane. Since the resulting inclusion compounds are highly soluble in water at temperatures 閳?7 鎺矯 they are good candidates for new aqueous dosage forms which would avoid inhalation anesthesia. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Electric Literature of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Electric Literature of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cationic 灏?cyclodextrin derivative for chiral separations was written by Haynes, Judson L. III;Shamsi, Shahab A.;O’Keefe, Frank;Darcey, Raphel;Warner, Isiah M.. And the article was included in Journal of Chromatography A in 1998.Product Details of 53784-83-1 This article mentions the following:

A novel hepta-substituted 灏?cyclodextrin bearing the methoxyethylamine group linked to the upper cyclodextrin rim was successfully used as a chiral selector for enantiomeric separation of nonsteroidal anti-inflammatory drugs (NSAIDs) and phenoxypropionic acid herbicides (PPAHs). Separation parameters such as pH and concentration have major influences on enantiomeric resolution of the NSAIDs and PPAHs. Heptakis(6-methoxyethylamine-6-deoxy)-灏?cyclodextrin [灏?CD-OMe (VII)] performs exceptionally well for the enantiomeric resolution of NSAIDs: indoprofen and fenoprofen (R_s = 11 and 14, resp.). Baseline enantiomeric separation of a mixture of six pairs of PPAHs was achieved in under 30 min. Compared to other cationic 灏?cyclodextrins reported in the literature, the 灏?CD-OMe (VII) showed improved selectivity for both classes of the aforementioned anionic racemates. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Product Details of 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Product Details of 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Schiff bases formed between pyridoxal 5′-phosphate and amino-灏?cyclodextrins: intramolecular remote ion pair interactions of the phosphate with ammonium moieties was written by Tamagaki, Seizo;Takahashi, Masahiko;Kanamori, Junji;Tagaki, Waichiro. And the article was included in Supramolecular Chemistry in 1994.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

Equilibrium involved in the Schiff base formations of pyridoxal 5′-phosphate (PLP) and 5′-deoxypyridoxal with mono-, di-, and peraminocyclodextrins have been studied to determine equilibrium binding constants in aqueous media at several pH values. These results, as well as the CD study, show that remote electrostatic interactions between the neg. charged 5′-phosphate group and a second ammonium group on the cyclodextrins play a significant role in the complexation. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Multichromophoric cyclodextrins. 1. Synthesis of O-naphthoyl-灏?cyclodextrins and investigation of excimer formation and energy hopping was written by Berberan-Santos, Mario N.;Canceill, Josette;Brochon, Jean Claude;Jullien, Ludovic;Lehn, Jean Marie;Pouget, Jacques;Tauc, Patrick;Valeur, Bernard. And the article was included in Journal of the American Chemical Society in 1992.Formula: C42H63Br7O28 This article mentions the following:

The synthesis and photophys. properties of 灏?cyclodextrins bearing seven 2-naphthoyloxy chromophores in specific positions, either on the primary face or the secondary face, or 14 naphthoyloxy chromophores, seven on each face, are reported. These multichromophoric cyclodextrins are good models for the study of excitation energy migration among chromophores in well-defined positions. The investigation was performed in CH₂Cl₂ and in a mixture of EtOH and MeOH that can form in a glass at low temperature The absorption spectra show that the interactions between chromophores in the ground state are weak, whereas the fluorescence spectra reveal the existence of excimers at room temperature but not at low temperature in a rigid glass. Further evidence of excimer formation is provided by the fluorescence decays. Since excimers act as energy traps, the energy hopping process was studied in a rigid glass at low temperature by steady-state and time-resolved fluorescence depolarization techniques. The steady-state anisotropy is found to be one seventh of the theor. limiting anisotropy 0.4, which means that excitation energy hops between chromophores with essentially randomly oriented transition moments at a rate much higher than the chromophore intrinsic decay rate. Energy hopping is indeed very fast as shown by the fluorescence anisotropy decay which is at least as fast as the apparatus time resolution (a few tens of picoseconds). In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Formula: C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Formula: C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Efficient perfacial derivatization of cyclodextrins at the primary face was written by Gorin, Boris I.;Riopelle, Richard J.;Thatcher, Greogory R. J.. And the article was included in Tetrahedron Letters in 1996.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

Synthesis of thirteen cyclodextrin (CD) derivatives via the per-6-bromo-6-deoxy-CD is reported in order to demonstrate the efficiency and ease of perfacial functionalization of 浼? 灏?and 绾珻D employing a Vilsmeier-haack reagent. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Name: Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary