Category: 53784-83-1

Molecular organization in the 6-bromo-6-deoxycyclodextrins, formation of molecular layers, and the first crystal structure of a selectivity perfunctionalized 閻?cyclodextrin was written by Nicolis, Ioannis;Coleman, Anthony W.;Charpin, Pierrette;Villain, Francoise;Zhang, Ping;Ling, Chang Chung;de Rango, Colette. And the article was included in Journal of the American Chemical Society in 1993.Synthetic Route of C42H63Br7O28 This article mentions the following:

6-Bromo-6-deoxycyclodextrins form stable monomol. at the air-H₂O interface, with mol. areas of 180, 220 and 260 闁?sup>2 for 濞?, 閻? and 缂?Br-CD. In the case of the heptakis-bromo-閻?CD compound 3 dimensional crystal structure was determined The heptakis-Br-閻?CD compound is monoclinic, space group P2₁, with a 15.714(3), b 15.917(6), c 30.102(4) 闁? 閻?90.55(2)闁? Z = 2. The structure is as a novel packing of dimeric 閻?cyclodextrin systems in a square arrangement. The layers are held together by Br-Br Van der Waals interactions giving rise to a quasi-continuous hydrophobic interface between the layers. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Synthetic Route of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon闂佺偨鍎茶ぐ绲﹐mine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Physicochemical properties and membrane interactions of per(6-desoxy-6-halogenated) cyclodextrins was written by Debouzy, J.-C.;Crouzier, D.;Gadelle, A.. And the article was included in Annales Pharmaceutiques Francaises in 2007.Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin This article mentions the following:

Per(6-iodo-6-desoxy) cyclodextrins are synthesis intermediates used in the design of the cation chelating per(3,6-anhydro) cyclodextrins. The modifications of the properties of these mols. resulting from the nature of the halogen substituent and also the number of osidic building blocks were investigated by varying both factors, using ¹H and ³¹P-NMR and EPR spectroscopies. These nearly water insoluble mols. exhibits no complexing properties (for both ionic and apolar structures) but can be partially solubilized in micelles of detergent (SDS) and also in phospholipid vesicles. Dipolar connectivity (nOesy) NMR experiments show that they are embedded at the chain level of the micelles/vesicles, without any inclusion complex formation. Changing the number of glucose building blocks (6,7 or 8) or/and the nature of the halogen nuclei at the positions 6 strongly modify cyclodextrin affinities and membrane interactions. For instance the per(6-bromo-6-desoxy)-cyclomaltohexaose (ABR) and -cyclomalto-heptaose (BBR) exhibit a selective affinity for cobalt (apparent K_a of 2500 and 790 M^-1, resp.). In terms of interactions with membranes, 濞?derivatives induce sterical hindrance at the phosphorus level while destructuring the chains. Other derivatives are located deeper and rigidify the most superficial part of the chain, suppressing the jump in membrane fluidity at transition temperature In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Quality Control of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Per-halogenation of primary hydroxy groups of 閻?cyclodextrin was written by Aoki, Nobuyoshi;Hattori, Kenjiro. And the article was included in Kenkyu Hokoku – Kanagawa-ken Sangyo Gijutsu Sogo Kenkyusho in 2005.HPLC of Formula: 53784-83-1 This article mentions the following:

Per-halogenation of primary hydroxyl groups of 閻?cyclodextrin (閻?CD) was investigated as an important way for the regioselective modification of 閻?CD. The high regioselectivity in the halogenation was discussed in terms of the reactivity to the S_N2 reaction at each position on the anhydroglucopyranose unit. The reaction using halogenating reagent, such as, methanesulfonyl chloride, thionyl chloride, and thionyl bromide, yielded the corresponding per-6-chloro-per-6-deoxy-閻?CD (80 and 90% yield) or per-6-bromo-per-6-deoxy-閻?CD (70% yield) after several hours. The obtained product was halogenated only at C-6 and the halogenation at a secondary position was not observed The reactivity at C-3 of 閻?CD was lower than the corresponding reaction of other saccharides, such as cellulose. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1HPLC of Formula: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.HPLC of Formula: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of glycopolymer nanosponges with enhanced adsorption performances for boron removal and water treatment was written by Liao, Xueping;Wang, Bingyu;Zhang, Qiang. And the article was included in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2018.Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin This article mentions the following:

The high-affinity interactions between cis-diols and boric/boronic acid have been widely used as a tool for carbohydrate anal., protein separation and B removal. Here, we report the design and synthesis of cyclodextrin-scaffolded glycopolymers as bifunctional nanosponges for B removal and water treatment for the 1st time. Different glycopolymer nanosponges (GNs) were synthesized from monosaccharides and 閻?cyclodextrin via a combination of a crosslinking reaction, Fischer glycosylation and a click reaction. Such functional GNs are mesoporous polymer frameworks with cis-diol-containing saccharides immobilized on the surface, which have exhibited selective adsorption behavior towards boric acid depending on the structure of the GNs and the loaded saccharides. The GNs showed remarkable adsorption rates and capacities for an organic dye as a model pollutant in this work. Secondary bonding, such as H bonding and van der Waals forces between the immobilized saccharides and the adsorbates is believed to be responsible for the significantly enhanced adsorption rates and capacities. Such bifunctional materials may exhibit potential applications in seawater desalination and water treatment. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The hemolytic properties of chemically modified cyclodextrins was written by Bost, Mireille;Laine, Valerie;Pilard, Florence;Gadelle, Andree;Defaye, Jacques;Perly, Bruno. And the article was included in Journal of Inclusion Phenomena and Molecular Recognition in Chemistry in 1997.Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin This article mentions the following:

The hemolytic properties of natural cyclodextrins, especially of the more common cyclomaltoheptaose entity, severely hamper their potential use as carriers in pharmaceutical applications where parenteral administration is concerned. A systematic investigation on the role of chem. modifications with regard to the hemolytic character was carried out involving C-6 branched neutral, anionic, cationic and amphoteric derivatives From these data, conclusions have been drawn about the charge and the geometry of the modification: (1) substitution at primary hydroxyl groups usually decreases the hemolytic character and the geometry of the substituent affects the hemolytic property; (2) introduction of an amino group, resulting in a pos. charge at physiol. pH, decreases the hemolytic character; (3) neg. charges are comparatively less effective in reducing the hemolytic character; (4) zwitterionic groups seem to enhance the hemolytic character of the cyclodextrin mol. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mannosylated Poly(ethylene imine) Copolymers Enhance saRNA Uptake and Expression in Human Skin Explants was written by Blakney, Anna K.;Abdouni, Yamin;Yilmaz, Gokhan;Liu, Renjie;McKay, Paul F.;Bouton, Clement R.;Shattock, Robin J.;Becer, C. Remzi. And the article was included in Biomacromolecules in 2020.Electric Literature of C42H63Br7O28 This article mentions the following:

MRNA is a promising platform for both vaccines and therapeutics, and self-amplifying RNA (saRNA) is particularly advantageous, as it enables higher protein expression and dose minimization. Here, we present a delivery platform for targeted delivery of saRNA using mannosylated poly(ethylene imine) (PEI) enabled by the host-guest interaction between cyclodextrin and adamantane. We show that the host-guest complexation does not interfere with the electrostatic interaction with saRNA and observed that increasing the degree of mannosylation inhibited transfection efficiency in vitro, but enhanced the number of cells expressing GFP by 8-fold in human skin explants. Besides, increasing the ratio of glycopolymer to saRNA also enhanced the percentage of transfected cells ex vivo. We identified that these mannosylated PEIs specifically increased protein expression in the epithelial cells resident in human skin in a mannose-dependent manner. This platform is promising for further study of glycosylation of PEI and targeted saRNA delivery. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1Electric Literature of C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-閻?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Electric Literature of C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regioselective halogenation of primary alcohol groups of cyclodextrins with halomethylenemorpholinium halides Vilsmeier-Haack reagents was written by Chmurski, K.;Defaye, J.. And the article was included in Polish Journal of Chemistry in 1999.Recommanded Product: 53784-83-1 This article mentions the following:

Per(6-bromo-6-deoxy)cyclomalto-hexaose, -heptaose, and -octaose and the corresponding per(6-chloro-6-deoxy) derivatives were prepared in high yield by reaction of bromomethylenemorpholinium bromide or chloromethylenemorpholinium chloride, resp., with cyclomaltohexaose, cyclomaltoheptaose and cyclomaltooctaose in DMF. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Recommanded Product: 53784-83-1).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Recommanded Product: 53784-83-1

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Novel polycarboxylated EDTA-type cyclodextrins as ligands for lanthanide binding: study of their luminescence, relaxivity properties of Gd(III) complexes, and PM3 theoretical calculations was written by Maffeo, Davide;Lampropoulou, Maria;Fardis, Michael;Lazarou, Yannis G.;Mavridis, Irene M.;Mavridou, Despoina A. I.;Urso, Elena;Pratsinis, Harris;Kletsas, Dimitris;Yannakopoulou, Konstantina. And the article was included in Organic & Biomolecular Chemistry in 2010.Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

Novel EDTA-type cyclodextrin (CD) derivatives, AEDTA, BEDTA and GEDTA, bearing 6, 7 and 8 bis(carboxymethyl)amino (iminodiacetic acid) groups, resp., were prepared, and their complexation with Eu(III), Tb(III) and Gd(III) ions was studied. Luminescence titrations and mass spectrometry showed formation of multimetal complexes (AEDTA 2 to 3, BEDTA mainly 3 and GEDTA exactly 4 metal ions), whereas luminescence lifetime measurements revealed the presence of exchangeable water mols. Semiempirical quantum mech. calculations, performed by the PM3 method and assessed by DFT calculations on model ligands, indicated efficient multi-metal complexation, in agreement with the experiment The structures showed coordination of the metal ions in the outer primary side of the CDs via 4 carboxylate O atoms, 2 N atoms and a glucopyranose O atom per metal ion. Coordination of water mols. was also predicted, in accordance with exptl. results. Calculated bond lengths and angles were in agreement with literature exptl. values of lanthanide complexes. Calculated energies showed that complex stability decreases in the order GEDTA > BEDTA > AEDTA. ¹H NMR mol. relaxivity measurements for the Gd(iii) complexes of AEDTA, BEDTA or GEDTA in water afforded values 4 to 10 times higher than the relaxivity of a com. contrast agent at 12 MHz, and 6 to 20 times higher at 100 MHz. Solutions of BEDTA and GEDTA Gd(III) complexes in human blood plasma displayed relaxivity values at 100 MHz 7 and 12 times, resp., higher than the com. agent. MTT tests of the Gd(III) complexes using human skin fibroblasts did not show toxicity. Attempts to supramolecularly sensitize the luminescence of the lanthanide complexes using various aromatic CD guests were ineffective, evidently due to large guest-metal distances and inefficient inclusion. The described lanthanide complexes, could be useful as contrast agents in MRI. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Application In Synthesis of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Influence of Host’s Substitution on the Orientation of the Guest: Pseudo-rotaxanes of Charged Cyclodextrins with Methyl Orange in Solution was written by Mourtzis, Nikolaos;Eliadou, Kyriaki;Yannakopoulou, Konstantina. And the article was included in Supramolecular Chemistry in 2004.Formula: C42H63Br7O28 This article mentions the following:

Methyl orange (MO), an azo-dye mol. with an inherent dipole moment, has been used as a probe to explore the influence of anionic or cationic substituents of cyclodextrins (CDs) on the mode of insertion to form pseudorotaxanes, using NMR spectroscopy. MO is oriented in a single mode inside the 灏綜D cavity, with the dimethylamino group localized at the secondary side. This orientation is completely reversed when MO enters the anionic sodium heptakis[6-deoxy-6-(3-thiopropionate)]-灏綜D (灏緋sp) cavity, whereas inside the cationic heptakis(6-deoxy-6-amino)-灏綜D hydrochloride, MO flips once more, to adopt the same orientation as in 灏綜D. In the latter case the water solubility of MO is significantly lowered. The disposition of the guest in 灏綜D and in each 灏綜D derivative in a single mode was attributed principally to anti-parallel dipole-dipole stabilization. In the wider 绾珻D, the availability of more cavity space leads to 1:2 and 2:2 host/guest stoichiometries and the effect of dipoles is of secondary significance. In the anionic sodium octakis[6-deoxy-6-(3-thiopropionate)]-绾珻D, MO is positioned as in 灏緋sp, but a 1:2 adduct is also detected. Finally, MO does not dissolve in octakis(6-deoxy-6-amino)-绾珻D hydrochloride solution In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Formula: C42H63Br7O28).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Formula: C42H63Br7O28

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Regulation of Protein Binding Capability of Surfaces via Host-Guest Interactions: Effects of Localized and Average Ligand Density was written by Shi, Xiujuan;Zhan, Wenjun;Chen, Gaojian;Yu, Qian;Liu, Qi;Du, Hui;Cao, Limin;Liu, Xiaoli;Yuan, Lin;Chen, Hong. And the article was included in Langmuir in 2015.Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin This article mentions the following:

The protein binding capability of biomaterial surfaces can significantly affect subsequent biol. responses, and appropriate ligand presentation is often required to guarantee the best functions. Herein, a new facile method for regulating this capability by varying the localized and average ligand d. is presented. Binding between lysine and plasminogen relevant to a fibrinolysis system was chosen as a model. We integrated different lysine-modified 灏?cyclodextrin (灏?CD) derivatives onto bioinert copolymer brushes via host-guest interactions. The localized and average lysine d. can be conveniently modulated by changing the lysine valency on 灏?CD scaffolds and by diluting lysine-persubstituted 灏?CD with pure 灏?CD, resp. Both the plasminogen adsorption and the plasminogen binding affinity were enhanced by lysine-persubstituted 灏?CD compared with those of lysine-monosubstituted 灏?CD, which is possibly due to the higher localized lysine d. and the multivalent binding of plasminogen on lysine-persubstituted 灏?CD surfaces. With a change in the ratio of lysine-persubstituted 灏?CD to 灏?CD, the average lysine d. can be tuned, leading to the linear regulation of the adsorption of plasminogen on surfaces. In the experiment, the researchers used many compounds, for example, Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin).

Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin (cas: 53784-83-1) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine.Safety of Heptakis(6-Bromo-6-Deoxy)-灏?Cyclodextrin

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary