Category: 52997-43-0

Adding a certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0, Safety of 7-(Bromomethyl)pentadecane

General procedure: The solution of dihydroxyacetophenone (4, 1.0 equiv.), anhydrous potassium carbonate (2.0 equiv.) and corresponding alkyl bromides (1.1 equiv.) in acetonitrile was stirred at 70-80 C for 4-5 h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Lee, Ki-Cheul; Sharma, Niti; Park, Sun-Hong; Kim, Youngsoo; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 54; (2012); p. 379 – 386;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52997-43-0, name is 7-(Bromomethyl)pentadecane, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 52997-43-0

To the reaction flask was added 3,6-dibromofluorene (3.24 g, 10.0 mmol)6.7 mL of 1-bromo-2-hexyl decane,0.1 g of tetrabutylammonium iodide (catalyst),10 mL of a 50% aqueous solution of sodium hydroxide and 15 mL of DMSO.And heated to 100 C for 18 hours under nitrogen protection.After the raw material is completely reacted, the reaction will be quenched by adding water,Then washed with water, extracted with petroleum ether,The resulting organic phase was dried over anhydrous magnesium sulfate and filtered,The crude product was concentrated, separated by silica gel column chromatography, and petroleum ether was used as eluent and dried in vacuo to give compound 1,A total of 6.41 g, the yield was 8

According to the analysis of related databases, 52997-43-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wuhan University of Technology; Xiao, Shengqiang; Yang, Mingyan; You, Wei; Zhan, Chun; (11 pag.)CN104557972; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52997-43-0, name is 7-(Bromomethyl)pentadecane, A new synthetic method of this compound is introduced below., SDS of cas: 52997-43-0

General procedure: General procedure for the synthesis of a1-a6: To a solution of indoline-2,3-diones (10 mmol) in DMF (40 mL) was added K2CO3(15 mmol, 2.073 g) and 7-(bromomethyl)pentadecane (11 mmol,3.358 g) under nitrogen. The mixture was stirred at 70 C and monitoredby TLC. After the reaction completed, water was added, andextracted with EtOAc. The organic layer was combined and dried withMgSO4. After evaporation of the solvent, the residue was purified bycolumn chromatograph (eluent: Petroleum/EtOAc=20:1) to give thetarget compound.

The synthetic route of 52997-43-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Qian; Jiang, Hua; Cui, Zhihua; Chen, Weiguo; Dyes and Pigments; vol. 173; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52997-43-0 as follows.

Under nitrogen protection, nitrogen is protected. The intermediate product 1, 2 – bis (4 -hydroxyphenyl) ethane -1, 2 – diketone (2g, 8.26 mmol), potassium carbonate (2.4g, 0.2 mmol), tetrabutylammonium bromide (1.33g, 4.13 mmol) were dissolved in N 70 ml) solutions, followed by 60 C stirring 1h, followed by 7 – (bromomethyl) pentadecane (4.04g, 13.2 mmol), 120 C and refluxing 24h out unitunit_ type. After completion of the reaction, the reaction was completed. The reaction solution was cooled to room temperature, and saturated 200 ml brine and dichloromethane were added thereto to extract, and the organic phase, dried over anhydrous magnesium sulfate, concentrated, and then subjected to column chromatography separation and purification. The eluate containing the objective compound was collected by column 300 – 400 silica gel as a 1:3 stationary phase, eluting, with a dichloromethane/petroleum ether volume ratio timetime mixture and dried, yielding a yellow powdery intermediate product 1, 2 – bis (4 – (hexadecyloxy) phenyl) ethane -1, was obtained. 2 – Diketone 3.05g, yield=unitz 45.4%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 52997-43-0, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University of Technology; Lv Xiaojing; Bi Qian; Ouyang Mi; Qian Liang; Xu Xinjia; Zha Lixia; (13 pag.)CN110066287; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, Adding some certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0.

General procedure: General procedure for the synthesis of a1-a6: To a solution of indoline-2,3-diones (10 mmol) in DMF (40 mL) was added K2CO3(15 mmol, 2.073 g) and 7-(bromomethyl)pentadecane (11 mmol,3.358 g) under nitrogen. The mixture was stirred at 70 C and monitoredby TLC. After the reaction completed, water was added, andextracted with EtOAc. The organic layer was combined and dried withMgSO4. After evaporation of the solvent, the residue was purified bycolumn chromatograph (eluent: Petroleum/EtOAc=20:1) to give thetarget compound. 1-(2-Hexyldecyl)indoline-2,3-dione (a1) Orange oil, 3.46 g, 93%.FT-IR (KBr) nu=1743 and 1612 cm-1 (C]O). 1H NMR (400 MHz,CDCl3) delta 7.60-7.55 (m, 2H), 7.10 (dd, J1=7.2 Hz, J2=7.6 Hz, 1H),6.86 (d, J=8.0 Hz, 1H), 3.59 (d, J=7.2 Hz, 2H), 1.86-1.81 (m, 1H),1.34-1.23 (m, 24H), 0.88-0.83 (m, 6H); 13C NMR (100 MHz, CDCl3) delta183.28, 158.19, 151.21, 138.20, 124.90, 123.32, 117.29, 110.30,44.42, 35.78, 31.64, 31.54, 31.27, 29.73, 29.40, 29.29, 29.06, 26.12,26.09, 22.44, 22.41, 13.88, 13.84. ESI-MS(100%, negative) m/z=371.2 (M-).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52997-43-0.

Reference:
Article; Hu, Qian; Jiang, Hua; Cui, Zhihua; Chen, Weiguo; Dyes and Pigments; vol. 173; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 52997-43-0, name is 7-(Bromomethyl)pentadecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 52997-43-0

In an oven-dried two-neck round-bottom flask, Cs2CO3 (15.6 g, 48.0 mmol) was dissolved in anhydrous DMF (100 mL) and the mixture was heated to reflux under a nitrogen atmosphere. After 15 min, phenol (3.76 g, 40.0 mmol), and, after an additional 40 min, 7-(bromomethyl)pentadecane (S1) (202 g, 66.3 mmol) were added. The progress of the reaction was monitored via TLC and after complete conversion of phenol, the reaction mixture was cooled to r.t. and the solvent was removed under reduced pressure. The residue was taken up in CH2Cl2, filtered, and washed with water and brine. Purification by column chromatography (silica gel, hexanes) afforded the title compound as a colorless oil. Yield: 10.8 g (33.9 mmol, 85%). 1H NMR (400 MHz, 298 K, CDCl3): delta = 7.37-7.33 (m, 2 H), 7.02-6.98(m, 3 H), 3.92 (d, 3J = 5.7 Hz, 2 H), 1.91-1.86 (m, 1 H), 1.61-1.31 (m,24 H), 1.02-0.99 (m, 6 H). 13C NMR (100 MHz, 298 K, CDCl3): delta = 159.4, 129.3, 120.3, 114.5, 70.7,38.0, 32.0, 31.9, 31.5, 31.4, 30.1, 29.8, 29.6, 29.4, 26.9, 26.9, 22.7, 14.1. MS (EI): m/z calcd for C22H38O+: 318.3; found: 318.3 [M+], 225.2 [M -OC6H5]+.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52997-43-0.

Reference:
Article; Bothe, Michael; Montero-Rama, Maria Pilar; Viterisi, Aurelien; Cambarau, Werther; Stenta, Caterina; Palomares, Emilio; Marsal, Lluis F.; Von Delius, Max; Synthesis; vol. 50; 4; (2018); p. 764 – 771;,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, The chemical industry reduces the impact on the environment during synthesis 52997-43-0, name is 7-(Bromomethyl)pentadecane, I believe this compound will play a more active role in future production and life.

In a two-necked RBF (100 mL), compound 3 (3.34 g, 10 mmol), KOH(2.81 g, 50 mmol) and KI (0.17 g, 1 mmol) were mixed in the dry THF(50 mL). The mixture was degassed with N2 flow for 20 min, and 1-bromo-2-hexyldecane (3.66 g, 12 mmol) was added. The solution wasstirred at 65 C for 12 h under N2 before it was cooled to room temperature.The organic layer was extracted with DCM and dried overNa2SO4, and the solvent was removed by rotary evaporation. The residuewas purified by silica gel chromatography (PE as the eluent) toyield the yellow viscous liquid (5.14 g, 92%). 1H NMR (400 MHz,CDCl3) delta 7.54 (d, J=8.4 Hz, 1H), 7.47 (s, 1H), 7.25 (m, 3H), 7.08 (s,1H), 7.06-7.04 (m, 1H), 4.05 (d, J=7.5 Hz, 2H), 2.04 (s, 1H),1.29-1.23 (m, 24H), 0.89-0.84 (m, 6H). 13C NMR (100 MHz, CDCl3) delta145.81, 142.05, 139.07, 138.47, 127.99, 124.58, 123.70, 122.37,120.57, 119.80, 115.82, 114.62, 113.05, 107.11, 49.77, 38.29, 31.86,31.78, 31.62, 29.90, 29.70, 29.58, 29.51, 29.27, 26.38, 26.35, 22.65,22.62, 14.09, 14.06. MALDI-TOF-MS (m/z) 559.27 for [M]+.

The chemical industry reduces the impact on the environment during synthesis 52997-43-0. I believe this compound will play a more active role in future production and life.

Reference:
Article; Zhou, Xingbao; Lu, Jurong; Huang, Hongyan; Yun, Yikai; Li, Zhaoning; You, Fei; Zhao, Baomin; Qin, Tianshi; Gao, Deqing; Huang, Wei; Dyes and Pigments; vol. 160; (2019); p. 16 – 24;,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, Adding some certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0.

General procedure: General procedure for the synthesis of a1-a6: To a solution of indoline-2,3-diones (10 mmol) in DMF (40 mL) was added K2CO3(15 mmol, 2.073 g) and 7-(bromomethyl)pentadecane (11 mmol,3.358 g) under nitrogen. The mixture was stirred at 70 C and monitoredby TLC. After the reaction completed, water was added, andextracted with EtOAc. The organic layer was combined and dried withMgSO4. After evaporation of the solvent, the residue was purified bycolumn chromatograph (eluent: Petroleum/EtOAc=20:1) to give thetarget compound.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52997-43-0.

Reference:
Article; Hu, Qian; Jiang, Hua; Cui, Zhihua; Chen, Weiguo; Dyes and Pigments; vol. 173; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52997-43-0, name is 7-(Bromomethyl)pentadecane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The general procedure (Table 1, entry 5 and 6) for the synthesis of alkylation of aniline (N-alkylation) and phenol (O-alkylation) is as follows. A two neck flask with a three-way stopcock and a rubber septum was charged with aniline (4 mmol, 0.373 g), 1-bromododecane (15 mmol, 3.74 g), K2CO3 (8 mmol, 1.11 g) and dry DMF (3.0 mL). The flask was heated at 120 C overnight. The first posttreatment: After checking of TLC and 1H NMR spectrum (Figure S3(a)), KOtBu (12 mmol, 1.346 g) was added to the flask at room temperature, then the mixture was heated to reflux overnight. The reaction was quenched by the addition of sat. NH4Cl aqueous solution, extracted into CH2Cl2 (50 ¡Á 3 mL), washed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the reaction mixture (including target dialkylated aniline and corresponding olefin, Figure S3(b)).The second posttreatment: Since the N-alkylation was almost quantitative reaction, the expected amount of olefin in the mixture was equal to the excess amount of starting alkylhalide (7.0 mmol in the above case). It could be assumed that 7.0 mmol of olefin should be treated with the small excess of 9-BBN (10.5 mmol, 1.5 eq vs olefin). A two neck flask with a three-way stopcock and a rubber septum was charged with the above reaction mixture and dry THF (20 mL). 0.5 M 9-BBN in THF (10.5 mmol, 21 mL) was added to the flask at 0 C and then the flask allowed to warm to room temperature and stirred for one hour. To quench the remaining 9-BBN in the reaction, aminoalcohol (2-dimethylaminoethanol, 4.5 mmol, 0.405 g) was added to the flask and stirred for another one hour. The final reaction mixture was quenched by the addition of water (5 mL), extracted into EtOAc (50 ¡Á 3 mL), washed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the crude mixture (Figure S5(a)). The third post-treatment: The crude product was purified by short silica-gel column chromatography (5 cm (diameter of column) ¡Á 10 cm (length of deposition of silicag-gel was enough for this scale) with n-hexane as eluent to give the dialkylated aniline (Figure S5(b)).

The synthetic route of 7-(Bromomethyl)pentadecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Okamoto, Ken; Lu, Fengniu; Nakanishi, Takashi; Bulletin of the Chemical Society of Japan; vol. 91; 8; (2018); p. 1258 – 1263;,
Bromide – Wikipedia,
bromide – Wiktionary