Category: 52997-43-0

52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: bromides-buliding-blocks

Di-tert-butyl thieno[3,2-b]thiophene-3,6-diyldicarbamate (20) (0.93 g, 2.5 mmol, 1.0 e.q.) wasdissolved in DMF (25 mL) and cooled to 0C. Sodium hydride (0.40 g, 60% dispersion in mineral oil, 10.0 mmol, 4.0 e.q.) was added and the solution was stirred at room temperature for 1hour. 7-(bromomethyl)pentadecane (2.29 g, 7.5 mmol, 3.0 e.q.) was added to the mixture and the solution was stirred at 80C for 3 hours. After the solution cooled to room temperature, the mixture was poured into iced water, followed by extraction with ethyl acetate for three times.The organic layers were combined, washed with water, brine and then dried over Mg504, concentrated. The resulting brown oil was purified via silica gel column chromatography with di15 chloromethane/petroleum ether (1:1) as the eluentto give di-tert-butyl thieno[3,2-b]thiophene-3,6-diylbis((2-hexyldecyl)carbamate) as a light brown oil (21) (1.64 g, 2.0 mmol, 80 % yield). 1HNMR (400 MHz, CDCI3) 67.04 (s, 2H), 3.62 (d, J= 7.2 Hz, 4H), 1.58-1.48 (m, 2H), 1.34-1.11(m, 48H), 0.87 (q, J= 6.8 Hz, 12H). 13C NMR (101 MHz, CDCI3) 6 154.13, 134.76, 133.70,119.18, 80.64, 53.38, 36.93, 31.90, 31.77, 31.21, 30.03, 29.68, 29.52, 29.29, 28.15, 26.31,26.25, 22.66, 22.62, 14.08.

The synthetic route of 52997-43-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; FLORES, Jean-Charles; HAYOZ, Pascal; MCCULLOCH, Iain; ONWUBIKO, Nkechinyerem; KAELBLEIN, Daniel; (65 pag.)WO2017/148864; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 52997-43-0, name is 7-(Bromomethyl)pentadecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 52997-43-0

General procedure: General procedure for the synthesis of a1-a6: To a solution of indoline-2,3-diones (10 mmol) in DMF (40 mL) was added K2CO3(15 mmol, 2.073 g) and 7-(bromomethyl)pentadecane (11 mmol,3.358 g) under nitrogen. The mixture was stirred at 70 C and monitoredby TLC. After the reaction completed, water was added, andextracted with EtOAc. The organic layer was combined and dried withMgSO4. After evaporation of the solvent, the residue was purified bycolumn chromatograph (eluent: Petroleum/EtOAc=20:1) to give thetarget compound.

The synthetic route of 7-(Bromomethyl)pentadecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Qian; Jiang, Hua; Cui, Zhihua; Chen, Weiguo; Dyes and Pigments; vol. 173; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 52997-43-0,Some common heterocyclic compound, 52997-43-0, name is 7-(Bromomethyl)pentadecane, molecular formula is C16H33Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2,7-dibromopyrene-4,5,9,10-tetraone (0.50 g, 1.2 mmol), n-Bu4NBr (0.50 g, 1.5 mmol), Na2S2O4 (2.5 g, 14 mmol), THF (8 mL), and H2O (4 mL) is stirred at 25 C. for 10 minutes 1-Bromo-2-hexyldecane (1.7 g, 7.9 mmol) and aqueous potassium hydroxide (4 mL, 36 mmol) are added to the solution and the mixture is stirred at 70 C. for 5 h. Then, THF and brine are added and the organic phase is washed with brine (3 times) and dried over MgSO4 and concentrated in vacuum. The residue is purified by column chromatography (SiO2, hexane: CH2Cl2=10:1) to give a colorless oil (0.62 g) in 53% yield. [0194] FD-MS (8 KV): m/z 986.3 (100%), calculated 985.1. [0195] 1H-NMR (CD2Cl2, 250 MHz): delta=0.84-0.86 (m, 24H), 0.98-1.00 (m, 12H), 1.47-2.00 (m, 40H), 4.23-4.36 (m, 8H), 8.50 (s, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-(Bromomethyl)pentadecane, its application will become more common.

Reference:
Patent; BASF SE; Kawano, Shin-Ichiro; Baumgarten, Martin; Muellen, Klaus; Murer, Peter; Schaefer, Thomas; Saleh, Moussa; US2014/357898; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52997-43-0, name is 7-(Bromomethyl)pentadecane, This compound has unique chemical properties. The synthetic route is as follows., Formula: C16H33Br

Compound 2. To a solution of compound 1 (1 g, 7.5 mmol) and KOH (421 mg, 7.5 mmol) in EtOH (50 mL) was stirred at 80 C for 4 h and then cooled to room temperature. After the solvent evaporated, 7-(bromomethyl)pentadecane dissolved in DMF( 50 mL) was added and the mixture was stirred at 120 C for 12 h. After reaction, dichloromethane (100 mL) and water (100 mL) were added and the layers were separated, the organic layer was collected and dried with anhydrous sodium sulfate and the solvent evaporated to afford a brownish red oil 2 (3-(2-hexyldecyl)-2-thioxothiazolidin-4-one).

According to the analysis of related databases, 52997-43-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Guo, Yiting; Zhang, Andong; Li, Cheng; Li, Weiwei; Zhu, Daoben; Chinese Chemical Letters; vol. 29; 3; (2018); p. 371 – 373;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0, Computed Properties of C16H33Br

TPh (1.6 g, 5.3 mmol), potassium carbonate (3.68 g, 26.7 mmol), potassium iodide (0.044 g, 0.3 mmol) and N, N-dimethylformamide (hereinafter abbreviated as ” DMF) (10 mL) and stirred at room temperature. Then 2-n-hexyl-1-bromodecane (2.1 g, 6.9 mmol) was added dropwise. After completion of the dropwise addition at room temperature overnight. After the reaction was completed, the mixture was extracted with water and methylene chloride and concentrated. Separation and purification on a silica gel column gave 1.23 g of 1- (2-hexyldecyl) -2- (thiophen-2-yl) -1H-phenan- thro [9,10- (Hereinafter referred to as TPh-C16). Yield 50.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Bromomethyl)pentadecane, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing University of Posts and Telecommunications; Wang Lianhui; Zhao Baomin; Zhai Liuqing; He Cong; Wang Suiliang; Fu Nina; (11 pag.)CN105820169; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0, Formula: C16H33Br

The aqueous NaOH solution (13.5 ml, 6 M) was placed in a reaction flask,Ventilation (nitrogen) three times,A solution of p-bromophenethyl mercaptan (9.77 g, 45 mmol) was added dropwise under nitrogen,After dripping,The phase transfer catalyst was added tetrabutylammonium iodide (catalyst amount, 1.99 g).Ten minutes later, 61 ml of tetrahydrofuran was added,To be uniform,Ethyl 2-hexyl decane (16.50 g, 54 mmol) was added dropwise over 10 min.The temperature was then raised to 45 C,The reaction was stirred overnight under vigorous stirring.Reaction is completed,The reaction solution was poured into dilute hydrochloric acid (1 M)Extracted with dichloromethane,Dried over anhydrous sodium sulfate,The solvent was distilled off under reduced pressure,The column was crystallized from 16.3 g of a colorless transparent liquid in 85% yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Bromomethyl)pentadecane, and friends who are interested can also refer to it.

Reference:
Patent; Beijing Institute of Printing; Wang, Wenguang; Yang, Mingcong; Pu, Jialing; (29 pag.)CN104961665; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52997-43-0, name is 7-(Bromomethyl)pentadecane, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 52997-43-0

250 mL of a condenser equipped with a magnetic stirrer and a reflux condenserAdd three bottles4-bromothiophenol10 g (52.89 mmol),N, N-dimethylformamide100 mL,Anhydrous potassium carbonate 10.94 g (79.33 mmol)Argon protection,Stirred at room temperature for 30 minutes,With a constant pressure dropping funnel1-bromo-2-hexyl decane16.2 mL (52.89 mmol) was added dropwise to the reaction system and the reaction was gradually progressedThe temperature was raised to 85 C and the reaction was carried out for 24 hours. The reaction was completed, cooled to room temperature, the reaction solution was poured into 150 mL of ice water,Stirring for 10 minutes, and then petroleum ether as extractant extraction 3 times, each 100mL, the organic phase, organic phase with distilled waterWash 3 times, each time 150mL. The organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was spin-dried using a rotary evaporator to giveThe crude product was obtained by column chromatography using petroleum ether as eluent4-bromo-1- (2-hexylDecylthio) benzene(Colorless transparent liquid, 20.12 g, yield 92.0%)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52997-43-0.

Reference:
Patent; Xiangtan University; Zhao, Bin; Liu, Hailu; Huang, Meihua; Tang, Bo; (8 pag.)CN106380431; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52997-43-0, name is 7-(Bromomethyl)pentadecane, A new synthetic method of this compound is introduced below., Safety of 7-(Bromomethyl)pentadecane

General procedure: The general procedure for the alkylation of fluorene (C-alkylation) is as follows. A two-neck flask with a three-way stopcock and a rubber septum was charged with fluorene (4mmol, 0.664 g) and dry THF (20 mL). KOtBu (12mmol, 1.346 g) was added to the flask at room temperature, then the mixture was heated at reflux for 20min. The flask was allowed to reach room temperature with stirring for 30min. 1-Bromododecane (8.8mmol, 2.20 g) was slowly added to the reaction mixture at 0 C, then again the flask was allowed to reach room temperature with stirring for overnight. 2.2.1 The First Posttreatment: After checking TLC and the 1HNMR spectrum, the reaction mixture refluxed for one hour. The reaction was quenched by the addition of sat. NH4Cl aqueous solution, extracted into n-hexane (50 3 mL), was hed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the reaction mixture(including the target dialkylated fluorene and olefin.). 2.2.2 The Second Posttreatment: 2-(a): To a mixtureof the crude mixture of the first posttreatment, 5wt% Pd/C(0.100 g) and acetic acid (AcOH, 4mmol) in THF (10 mL) were slowly added portionwise NaBH4 (4mmol, 0.151 g), andthe resulting mixture was stirred at room temperature for 12 hours. Thereafter, the mixture was filtered and the precipitate was washed with hexane and concentrated by rotary evaporatorfor NMR measurement. 2-(b): Since the alkylation was an almost quantitative reaction, the expected amount of olefin in the mixture was equalto the excess amount of starting alkyl halide (0.8mmol in the above case). It could be assumed that 0.8 mmol of olefin should be treated with the small excess of 9-BBN (1.2mmol, 1.5 eqvs olefin). A two neck flask with a three-way stopcock and a rubber septum was charged with the above reaction mixture and dry THF (20 mL). 0.5M 9-BBN in THF (1.2mmol, 2.4mL) was added to the flask at 0 C and then the flask was allowed to warm to room temperature and stirred for one hour. To quench the remaining 9-BBN in the reaction, aminoalcohol (2-dimethylaminoethanol, 0.5mmol, 0.045 g) was added to the flask and stirred for another hour. 39 The final reaction mixture was quenched by the addition of water (5 mL), extracted into EtOAc (50 3 mL), washed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the crude mixture. 2.2.3 The Third Posttreatment: The crude product was purified on short silica-gel [5 cm (diameter of column) 10 cm (length of deposition of silica-gel) was enough for this scale] with n-hexane as eluent to give the dialkylated fluorene.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Okamoto, Ken; Lu, Fengniu; Nakanishi, Takashi; Bulletin of the Chemical Society of Japan; vol. 91; 8; (2018); p. 1258 – 1263;,
Bromide – Wikipedia,
bromide – Wiktionary

52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 7-(Bromomethyl)pentadecane

Di-tert-butyl thieno[3,2-b]thiophene-3,6-diyldicarbamate (20) (0.93 g, 2.5 mmol, 1.0 e.q.) wasdissolved in DMF (25 mL) and cooled to 0C. Sodium hydride (0.40 g, 60% dispersion in mineral oil, 10.0 mmol, 4.0 e.q.) was added and the solution was stirred at room temperature for 1hour. 7-(bromomethyl)pentadecane (2.29 g, 7.5 mmol, 3.0 e.q.) was added to the mixture and the solution was stirred at 80C for 3 hours. After the solution cooled to room temperature, the mixture was poured into iced water, followed by extraction with ethyl acetate for three times.The organic layers were combined, washed with water, brine and then dried over Mg504, concentrated. The resulting brown oil was purified via silica gel column chromatography with di15 chloromethane/petroleum ether (1:1) as the eluentto give di-tert-butyl thieno[3,2-b]thiophene-3,6-diylbis((2-hexyldecyl)carbamate) as a light brown oil (21) (1.64 g, 2.0 mmol, 80 % yield). 1HNMR (400 MHz, CDCI3) 67.04 (s, 2H), 3.62 (d, J= 7.2 Hz, 4H), 1.58-1.48 (m, 2H), 1.34-1.11(m, 48H), 0.87 (q, J= 6.8 Hz, 12H). 13C NMR (101 MHz, CDCI3) 6 154.13, 134.76, 133.70,119.18, 80.64, 53.38, 36.93, 31.90, 31.77, 31.21, 30.03, 29.68, 29.52, 29.29, 28.15, 26.31,26.25, 22.66, 22.62, 14.08.

The synthetic route of 52997-43-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; FLORES, Jean-Charles; HAYOZ, Pascal; MCCULLOCH, Iain; ONWUBIKO, Nkechinyerem; KAELBLEIN, Daniel; (65 pag.)WO2017/148864; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 52997-43-0, name is 7-(Bromomethyl)pentadecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 52997-43-0

General procedure: General procedure for the synthesis of a1-a6: To a solution of indoline-2,3-diones (10 mmol) in DMF (40 mL) was added K2CO3(15 mmol, 2.073 g) and 7-(bromomethyl)pentadecane (11 mmol,3.358 g) under nitrogen. The mixture was stirred at 70 C and monitoredby TLC. After the reaction completed, water was added, andextracted with EtOAc. The organic layer was combined and dried withMgSO4. After evaporation of the solvent, the residue was purified bycolumn chromatograph (eluent: Petroleum/EtOAc=20:1) to give thetarget compound.

The synthetic route of 7-(Bromomethyl)pentadecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Qian; Jiang, Hua; Cui, Zhihua; Chen, Weiguo; Dyes and Pigments; vol. 173; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary