Category: 52723-82-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52723-82-7, name is 4-Bromo-5-fluoro-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 52723-82-7

EXAMPLE 47 4-Amino-2-fluoro-5-methylbenzonitrile Using the method of Example 15, 4-bromo-3-fluoro-6-methylaniline is converted into the title compound.

According to the analysis of related databases, 52723-82-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; American Cyanamid Company; US4863959; (1989); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 52723-82-7, name is 4-Bromo-5-fluoro-2-methylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52723-82-7, HPLC of Formula: C7H7BrFN

Acetic anhydride (1.488 mL, 15.77 mmol) was added to a suspension of 4-bromo-5- fluoro-2-methylaniline (1.6087 g, 7.88 mmol) in chloroform (18 mL) under ice-bath cooling and the mixture stirred at RT for 5 min. Potassium acetate (0.812 g, 8.28 mmol), a solution of 18-crown-6 (0.417 g, 1.577 mmol) In chloroform (4 mL) and then t-butyl nitrite (2.186 mL, 16.56 mmol) were then added and the mixture heated at 75°C for 16 h. The dark brown mixture was then cooled, DC (20 mL) added and the organic layer washed with saturated aqueous sodium bicarbonate solution (ca. 20 mL) then reduced. The residue was purified by chromatography on silica gel eluting with a gradient of 0-30percent ethyl acetate in hexane. Impure fractions were purified further by chromatography on silica gel eluting with a gradient of 0-20percent ethyl acetate in isohexane. All pure fractions were combined and then reduced to afford the title compound as a light orange solid (984 mg). 1H N R (CDCl3l 400MHz) delta ppm: 2.79 (3H, s), 7.95 (1 H, dd, 6.5 Hz, 0.5 Hz), 8.07 (1H, d, J 1.0 Hz), 8.25 (1 H, dd, J 9.0, 0.5 Hz).

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Reference:
Patent; GLAXO GROUP LIMITED; BAILEY, James; KING, Nigel Paul; LIN, Xichen; REN, Feng; TAN, Kheng-Chuan; MAK, Sing Yeung; WO2011/72488; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 52723-82-7, These common heterocyclic compound, 52723-82-7, name is 4-Bromo-5-fluoro-2-methylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of 4-bromo-5-fluoro-2-methylaniline (10.2 g, 50 mmol) and 3- chlorobenzenecarboperoxoic acid (34.5 g, 200 mmol) in DCE (10 mL) was stirred under nitrogen at reflux for 2 hours. After cooling to rt, the mixture was dispersed between DCM and saturated aqueous Na2S03 solution. The organic layer was collected, concentrated to dryness and purified by flash column chromatography to give the title compound as a brown oil (7.02 g, 60.0percent yield).

The synthetic route of 52723-82-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; ARORA, Nidhi; BACANI, Genesis M.; BARBAY, Joseph Kent; BEMBENEK, Scott D.; CAI, Min; CHEN, Wei; DECKHUT, Charlotte Pooley; EDWARDS, James P.; GHOSH, Brahmananda; HAO, Baoyu; KREUTTER, Kevin; LI, Gang; TICHENOR, Mark S.; VENABLE, Jennifer D.; WEI, Jianmei; WIENER, John J. M.; WU, Yao; ZHU, Yaoping; ZHANG, Feihuang; ZHANG, Zheng; XIAO, Kun; (1000 pag.)WO2017/100668; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 52723-82-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52723-82-7 as follows.

Example 47 4-Amino-2-fluoro-5-methylbenzonitrile Using the method of Example 15, 4-bromo-3-fluoro-6-methylaniline is converted into the title compound.

According to the analysis of related databases, 52723-82-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMERICAN CYANAMID COMPANY; EP224001; (1991); B1;,
Bromide – Wikipedia,
bromide – Wiktionary