Category: 518-67-2

Doerfler, H. D. published the artcileMiscibility behavior of ternary lipid/phospholipid/water systems, Formula: C20H18BrN3, the publication is Colloid and Polymer Science (1990), 268(6), 559-66, database is CAplus.

Differential-scanning-calorimetry was applied to study the lyotropic and thermotropic properties of the 2 ternary systems dimyristoylcephaline (di-(C14:0)-PE)/palmitic acid (C₁₅COOMe)/H₂O in dispersions with excess H₂O (50 weight%). The phase diagrams of both systems showed that the 2 systems differ in their miscibility behavior. The system di(C14:0)-PE/C₁₅COOH/H₂O is completely miscible in its high-temperature phase. In the low-temperature phase, a miscibility gap was found within the concentration range of C₁₅COOH was also indicated by a maximum value of the transition enthalpy of the pseudo-binary mixtures In the pseudo-binary system di(C14:0)-PCCOOMe/H₂O, the tendency towards demixing is much more pronounced. It was observed that the incorporated C₁₅COOMe melted above its normal m.p., but below the transition temperature of di-(C14:0)-PE/H₂O system; therefore, the phase transition started at lower temperature In the low-temperature phase, both lipids are partially miscible. The demixing range of the phase diagram lies within the concentration region of C₁₅COOMe. Up to mol fraction x_C15COOMe = 0.43 C₁₅COOMe can be incorporated into the L_β-phase of the system di-(Cl14:0)-PE/H₂O.

Colloid and Polymer Science published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Formula: C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Anghel, D. F. published the artcileAnionic surfactant analysis from micellar solutions, Recommanded Product: Dimidium bromide, the publication is Revue Roumaine de Chimie (1978), 23(2), 251-3, database is CAplus.

The content of Na alkylarenesulfonate or petroleum sulfonate in micellar solutions used for petroleum recovery was determined by the 2-phase titration method using methylene blue [61-73-4], bromcresol green [76-60-8], or dimidium bromide [518-67-2]-Disulphine Blue VN [129-17-9] mixture as the indicator. The last 2 indicators gave the most accurate determinations, but the bromcresol green method gave high values when the hydrocarbon of the micellar solution contained fatty acids. The presence of crude oil caused difficulties in end-point determination Nonionic surfactants and alcs. did not interfere.

Revue Roumaine de Chimie published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Woolfe, G. published the artcileTrypanocidal action of phenanthridine compounds: effect of changing the quaternary groups of known trypanocides, Safety of Dimidium bromide, the publication is British Journal of Pharmacology and Chemotherapy (1956), 330-3, database is CAplus and MEDLINE.

cf. Ann. Trop. Med. Parasitol. 46, 285(1952). The effect on trypanocidal activity of replacing the Me quaternating group of 6-(4-aminophenyl)-8-aminophenanthridinium halide and 3,8-diamino-6-alkyl (or aryl)-phenanthridinium halide with Et, Pr, or allyl was examined Trypanocidal activity measured against Trypanosoma congolense, T. brucei, T. rhodesiense, and T. gambiense was generally enhanced and was greatest with compounds originally of high activity. Toxicities for mice were also reported.

British Journal of Pharmacology and Chemotherapy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C28H29NO4, Safety of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wien, R. published the artcileChemotherapeutic action of amidine and phenanthridinium compounds in Trypanosoma congolense infections, SDS of cas: 518-67-2, the publication is British Journal of Pharmacology and Chemotherapy (1946), 65-80, database is CAplus and MEDLINE.

These compounds were tested against 5 strains of T. congolense in mice: 7-Amino-9-p-aminophenyl-10-methylphenanthridinium chloride and 4,4′-diamidino-α,β-dimethylstilbene di-HCl were compared as to activity. The former compound was twice as toxic and active against the acute strains, the therapeutic indexes being the same, but it was less active against 1 chronic strain. An evaluation of 2,7-diamino-9-phenyl-10-methyl-phenanthridinium bromide (1553) showed that by subcutaneous injection in acute infections the C.D. 50(50% of animals free of trypanosomes for at least 28 days, 42 for chronic strains) was 0.0004 mg./g., the LD 50 was 0.061 mg./g. and the therapeutic index 152. A very complete study of the correlation between chem. structure and activity against T. congolense of diamidine and phenanthridinium compounds is reported. The pharmacol. actions of compound 1553 are reported. The compound has a depressant action on the circulation and respiratory center and, in high doses, a toxic action on liver and kidneys.

British Journal of Pharmacology and Chemotherapy published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C17H14F3N3O2S, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ryley, J. F. published the artcileThe chemotherapy of Babesia infections, Computed Properties of 518-67-2, the publication is Annals of Tropical Medicine & Parasitology (1957), 38-49, database is CAplus and MEDLINE.

A screening test is described for anti-Babesia drugs by using mice infected with B. rodhaini. The maximum tolerated dose and min. effective dose (as mg./20 g. × 3) are, resp.: acapron, 0.1 and 0.01; dimidium bromide, 0.5 and 0.01; ethidium bromide, 1 and 0.025; pentamidine (as base), 0.75 and 0.25; propamidine (as base), 0.5 and >0.5; stilbamidine (as base), 0.75 and 0.1; trypan blue, >5 and >5; acriflavine, 0.5 and 0.1; berenil, 0.25 and 0.1; antrycide dimethyl sulfate, 0.5 and 0.1; 4-amino-6-(2-amino-1,6-dimethyl-4-pyrimidinylamino)-2-phenyl-1-methylquinolinium dichloride (Compound 10,073), 0.5 and 0.005; bis(1,2-dimethyl-4-methylamino-6-quinolyl)-amine bis(methyl sulfate) (Compound 14,911), 1 and 0.005. Mepacrine, chloroquine, paludrine, and Daraprim had no effect against B. rodhaini. Compound 10,073, in doses up to 8 mg./kg., was effective in treating B. bovis in calves with no apparent toxicity. Reversible toxic symptoms were elicited with 10 mg./kg.

Annals of Tropical Medicine & Parasitology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Computed Properties of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lerman, L. S. published the artcileSymposium on molecular action of mutagenic and carcinogenic agents. Acridine mutagens and DNA structure, Recommanded Product: Dimidium bromide, the publication is Journal of Cellular and Comparative Physiology (1964), 64(2;Pt. II;Suppl. 1), 1-13, discussion 13-18, database is CAplus.

Evidence for intercalation of acridine compounds between 2 otherwise sequential base pairs was obtained by studies of sedimentation, low angle x-ray scattering, flow dichroism, flow-polarized fluorescence, and chem. reactivity. Such binding requires a local untwisting and extension of the double helix. The intercalated mols. have a decreased chem. reactivity. They increase the stability of the double helix as shown by an increase in the thermal transition temperature Intercalation into complexes formed between polyadenylic and polyuridylic acids makes the double helix more stable than the triple. Intercalation seems to be a prerequisite for mutagenicity of the insertion-deletion type but the acridine structure is not essential and not all intercalating mols. are mutagenic.

Journal of Cellular and Comparative Physiology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Henderson, J. Frank published the artcileInhibition of purine metabolism in Ehrlich ascites carcinoma cells by phenanthridinium compounds related to ethidium bromide, Name: Dimidium bromide, the publication is Cancer Research (1963), 491-5, database is CAplus and MEDLINE.

The effect of 10 phenanthridinium derivatives on the incorporation of adenine and glycine into the nucleic acids and proteins of Ehrlich ascites carcinoma cells in vitro, has been studied. Only 1 compound markedly inhibited incorporation of glycine into nucleic acids and proteins, whereas all the drugs inhibited incorporation of adenine into nucleic acids.

Cancer Research published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Name: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Grzadka, E. published the artcileCompetitive adsorption in the system: carboxymethylcellulose/surfactant/electrolyte/Al₂O₃, Recommanded Product: Dimidium bromide, the publication is Cellulose (Dordrecht, Netherlands) (2011), 18(2), 291-308, database is CAplus.

The adsorption of CM-cellulose (CMC) in the presence or absence of the surfactants: anionic SDS, nonionic Triton X-100 and their mixture SDS/TX-100 from the electrolyte solutions (NaCl, CaCl₂) on the alumina surface (Al₂O₃) was studied. In each measured system the increase of CMC adsorption in the presence of surfactants was observed This increase was the smallest in the presence of SDS, a bit larger in the presence of Triton X-100 and the largest when the mixture of SDS/Triton X-100 was used. These results are a consequence of formation of complexes between the CMC and the surfactant particles. Moreover, the dependence between the amount of surfactants’ adsorption and the CMC initial concentration was measured. It comes out that the surfactants’ adsorption amount is not dependent on the CMC initial concentration and moreover, it is unchanged in the whole measured concentration range. The influence of kind of electrolyte, its ionic strength as well as pH of a solution on the amount of the CMC adsorption at alumina surface was also measured. The amount of CMC adsorption is larger in the presence of NaCl than in the presence of CaCl₂ as the background electrolyte. It is a result of the complexation reaction between Ca²⁺ ions and the functional groups of CMC belonging to the same macromol. As far as the electrolyte ionic strength is concerned the increase of CMC adsorption amount accompanying the increase of electrolyte ionic strength is observed The reason for that is the ability of electrolyte cations to screen every electrostatic repulsion in the adsorption system. Another observation is that the increase of pH caused the decrease of CMC adsorption. The explanation of this phenomenon is connected with the influence of pH on both dissociation degree of polyelectrolyte and kind and concentration of surface active groups of the adsorbent.

Cellulose (Dordrecht, Netherlands) published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gill, B. S. published the artcileSurra. XI. Chemotherapeutic susceptibility of Trypanosoma evansi, Synthetic Route of 518-67-2, the publication is Indian Journal of Animal Sciences (1973), 43(4), 226-9, database is CAplus.

The median effective and curative doses of 39 trypanocidal agents are reported for T. evansi infections in rats. These two parameters indicated the comparative chemotherapeutic susceptibility of the organism, which is the causative agent for surra disease in domestic animals. Arsenicals, antimonials, acriflavine, diamidines, sulfonated naphthylamine derivatives, aminoquinaldine derivatives, phenanthridines, nitrofurazone, and terephthalanilide compounds were tested.

Indian Journal of Animal Sciences published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dougherty, Geoffrey published the artcileThe unwinding of circular DNA by intercalating agents as determined by gel electrophoresis, SDS of cas: 518-67-2, the publication is Bioscience Reports (1983), 3(5), 453-60, database is CAplus and MEDLINE.

An accurate and precise method is described to determine the unwinding angle of the circular DNA helix of plasmid pBR322/RcβG by ethidium bromide and other intercalating agents of electrophoresis in 1.4% agarose gels containing chloroquine, followed by densitometry of the photog. negs. of the gels. Under the electrophoresis conditions used, native (form I) DNA and partially relaxed samples, running faster or slower than it, were resolved. Contaminating nicked (form II) DNA did not interfere, since it was clearly separated during electrophoresis.

Bioscience Reports published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary