Category: 51605-97-1

Cheredilin, D. N.; Sheloumov, A. M.; Senin, A. A.; Kozlova, G. A.; Afanas’ev, V. V.; Bespalova, N. B. published the artcile< Catalytic Properties of Chromium Complexes Based on 1,2-Bis(diphenylphosphino)benzene in the Ethylene Oligomerization Reaction>, Formula: C9H12BrN, the main research area is ethylene oligomerization bisdiphenylphosphinobenzene chromium complex catalytic property.

The activity of the catalyst systems of a number of diphosphine ligands and chromium complexes based on 1,2-bis(diphenylphosphino)benzene in the ethylene oligomerization reaction has been studied. Structural modifications of diphosphine ligands have been performed to create selective catalyst systems for ethylene oligomerization. It has been shown that the introduction of ortho-functional groups into one of the Ph substituents at the phosphorus atom in diphosphine ligands makes it possible to carry out the process of ethylene oligomerization to 1-hexene with the selectivity of 90 weight% and above. One of the complexes (chromium complex 15) with a functionalized diphosphine ligand has been characterized by X-ray structure anal. The influence of the change in the amount of the activator and its type on the activity of the catalyst systems has been studied. It has been shown that the replacement of some organoaluminum activator, methylaluminoxane, by trimethylaluminum does not decrease the productivity and selectivity of the catalyst systems based on diphosphine chromium complexes.

Petroleum Chemistry published new progress about Crystal structure. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Formula: C9H12BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ban, Jaeyoung; Lim, Minkyung; Shabbir, Saira; Baek, Junghyun; Rhee, Hakjune published the artcile< Site-Specific Synthesis of Carbazole Derivatives through Aryl Homocoupling and Amination>, Synthetic Route of 51605-97-1, the main research area is carbazole preparation; aniline acetylation Ullmann homocoupling intramol amination.

Author synthesized various carbazoles I (R = H, 2,7-Me, 3,6-F, etc.) from anilines through a three-step process with good overall yields (up to 48%). This process comprises N-acetylation, copper(0)-mediated Ullmann homocoupling, and acid-mediated intramol. amination. It permits various functional groups on the substrate. Scale-up of the developed three-step synthetic route to carbazoles was also demonstrated.

Synthesis published new progress about Acetylation. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Synthetic Route of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Qiao, Lulin; Zhang, An-An; Chen, Jingchao; Li, Gao-Wei; Gao, Yuan-Yuan; Fan, Baomin; Liu, Lantao published the artcile< Palladium-catalyzed disilylation of 2-bromoarylferrocenes: An efficient approach to 1-Trimethylsilyl-2-(2-trimethylsilylaryl)ferrocenes>, Quality Control of 51605-97-1, the main research area is crystal structure mol disilylated ferrocene preparation; palladium catalyst disilylation bromoaryl ferrocene mechanism.

An unprecedented method for the palladium-catalyzed disilylation of 2-bromoarylferrocenes with hexamethyldisilane has been developed. The catalytic cycle is initiated by oxidative addition of 2-bromoarylferrocenes to Pd(0), followed by C-H activation to form a reactive five-membered C,C-palladacycle. By using this protocol, a variety of disilylated ferrocene compounds were obtained in moderate to good yields.

Tetrahedron Letters published new progress about C-H bond activation. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Quality Control of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mo, Cheng; Zhang, Zhang; Li, Yupeng; Huang, Minhao; Zou, Jian; Luo, Jinfeng; Tu, Zheng-Chao; Xu, Yong; Ren, Xiaomei; Ding, Ke; Lu, Xiaoyun published the artcile< Design and Optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors>, Application In Synthesis of 51605-97-1, the main research area is imidazo pyrazinyl carboxamide derivative preparation DDR1 inhibitor cancer.

DDR1 is considered as a promising target for cancer therapy, and selective inhibitors against DDR1 over other kinases may be considered as promising therapeutic agents. Herein, we have identified a series of 3′-(imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as novel selective DDR1 inhibitors. Among these, compound 8v potently inhibited DDR1 with an IC50 of 23.8 nM, while it showed less inhibitory activity against DDR2 (IC50 = 1740 nM) and negligible activities against Bcr-Abl (IC50 > 10μM) and c-Kit (IC50 > 10μM). 8v also exhibited excellent selectivity in a KINOMEscan screening platform with 468 kinases. This compound dose-dependently suppressed NSCLC cell tumorigenicity, migration, and invasion. Collectively, these studies support its potential application for treatment of NSCLC.

ACS Medicinal Chemistry Letters published new progress about Antitumor agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Application In Synthesis of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhan, Bei-Bei; Wang, Lei; Luo, Jun; Lin, Xu-Feng; Shi, Bing-Feng published the artcile< Synthesis of Axially Chiral Biaryl-2-amines by PdII-Catalyzed Free-Amine-Directed Atroposelective C-H Olefination>, Recommanded Product: 2-Bromo-4-isopropylaniline, the main research area is arylamine palladium chiral spiro phosphoric acid atroposelective olefination catalyst; axially chiral biarylamine stereoselective preparation; C−H olefination; atroposelectivity; biaryl-2-amines; chiral spiro phosphoric acids; palladium.

A simple and ubiquitously present group, free amine, is used as a directing group to synthesize axially chiral biaryl compounds by PdII-catalyzed atroposelective C-H olefination. A broad range of axially chiral biaryl-2-amines can be obtained in good yields with high enantioselectivities (up to 97% ee). Chiral spiro phosphoric acid (SPA) proved to be an efficient ligand and the loading could be reduced to 1 mol % without erosion of enantiocontrol in gram-scale synthesis. The resulting axially chiral biaryl-2-amines also provide a platform for the synthesis of a set of chiral ligands.

Angewandte Chemie, International Edition published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Recommanded Product: 2-Bromo-4-isopropylaniline.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Han, Xiao-Qing; Wang, Lei; Yang, Ping; Liu, Jing-Yuan; Xu, Wei-Yan; Zheng, Chao; Liang, Ren-Xiao; You, Shu-Li; Zhang, Junliang; Jia, Yi-Xia published the artcile< Enantioselective Dearomative Mizoroki-Heck Reaction of Naphthalenes>, Recommanded Product: 2-Bromo-4-isopropylaniline, the main research area is naphthoylamino bromoarene palladium catalyst enantioselective dearomative Mizoroki Heck reaction; spirooxindole naphthalene preparation; bromobenzoyl naphthylamine palladium catalyst enantioselective dearomative Mizoroki Heck reaction; spiro oxoisoindoline naphthalene preparation.

A palladium-catalyzed intramol. enantioselective Mizoroki-Heck reaction of naphthalenes was developed via dearomative migratory insertion of an endocyclic π-bond of naphthalene, followed by δ-hydride elimination. This reaction relies on the use of chiral sulfonamide phosphine type Xu-Phos ligand, which successfully inhibited the competitive and undesired C-H arylation reaction and efficiently promoted the formation of spirooxindole and spiroisoindolin-1-one products. Synthetic transformations of the product afforded a series of unique heterocyclic compounds with enantiomeric excess (ee) values retained.

ACS Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Recommanded Product: 2-Bromo-4-isopropylaniline.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Mahmood, Abid; Ali Shah, Syed Jawad; Iqbal, Jamshed published the artcile< Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders>, Quality Control of 51605-97-1, the main research area is adamantanoyl thiourea preparation SAR receptor inhibitor inflammation docking; Ca(2+) flux assay; Carboxamides; Fura-2 AM dye; Molecular docking studies; P2XR antagonists; Purinergic signaling; Thiourea derivatives.

Adamantane ring has been reported to exhibit significant inhibitory potential towards P2X receptors, especially for P2X7R. Uniqueness of adamantan radicals in synthesized compounds RC(O)NHC(S)NHR1 [R = adamantan-1-yl; R1 = 2-bromo-4-isopropylphenyl, quinolin-8-yl, 3-(dimethylamino)propan-1-yl, etc.] introduced different substitutes to improve potency and selectivity for the P2XR subtypes used. Among synthesized derivatives, RC(O)NHC(S)NHR1 [R = adamantan-1-yl; R1 = 2-bromo-4-isopropylphenyl, quinolin-8-yl] were found to be most potent and selective inhibitors for h-P2X4R and h-P2X7R, resp. Compound RC(O)NHC(S)NHR1 [R = adamantan-1-yl; R1 = 2-bromo-4-isopropylphenyl] was found to be highly selective for h-P2X4R with IC50 ± SEM = 0.04 ± 0.01μM, that is 22 times more potent than BX-430, a standard selective inhibitor of h-P2X4R. Compound RC(O)NHC(S)NHR1 [R = adamantan-1-yl; R1 = quinolin-8-yl] has IC50 ± SEM of 0.073 ± 0.04μM, which is comparable with the known antagonists of h-P2X7R. In silico studies were also conducted to find the type of interactions as well as mode of inhibition. Compound RC(O)NHC(S)NHR1 [R = adamantan-1-yl; R1 = 2-bromo-4-isopropylphenyl, quinolin-8-yl] were studied for mode of inhibition of P2XRs and both were found to be neg. allosteric modulators.

European Journal of Medicinal Chemistry published new progress about Adamantanes Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Quality Control of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tung, Truong Thanh; Huy, Luong Xuan published the artcile< Metal-free synthesis of 2-mercaptobenzothiazoles and 6-(4-substituted-1H-1,2,3-triazol-1-yl)-2-mercaptobenzothiazoles via microwave-assisted synthesis pathway>, Product Details of C9H12BrN, the main research area is triazolyl mercaptobenzothiazole preparation metal free; haloaniline isopropylxanthic acid potassium salt cyclization microwave irradiation.

A simple, efficient, and metal-free methodol. for the preparation of 2-mercaptobenzothiazole and derivatives in excellent yields via microwave-assisted pathway is reported. These conditions provide a convenient protocol for the synthesis of a diverse collection of 2-mercaptobenzothiazoles I (R = 4-Me, 6-CF3, 6-OMe, etc.) and 6-(4-substituted-1H-1,2,3-triazol-1-yl)-2-mercaptobenzothiazoles II (R = 4-Ph, 4-Et-C6H4, 3-OMe-C6H4, etc.) with a very simple purification process. This report provides an alternative protocol for fast access to the wide range of compounds for sequence synthesis and biol. studies.

Synthetic Communications published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Product Details of C9H12BrN.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhan, Bei-Bei; Jia, Zhen-Sheng; Luo, Jun; Jin, Liang; Lin, Xu-Feng; Shi, Bing-Feng published the artcile< Palladium-Catalyzed Directed Atroposelective C-H Allylation via β-H Elimination: 1,1-Disubstituted Alkenes as Allyl Surrogates>, Recommanded Product: 2-Bromo-4-isopropylaniline, the main research area is unsaturated ester enantioselective synthesis allylation elimination alkene methacrylate; allylation palladium catalyst.

Transition-metal-catalyzed dehydrogenative C-H allylation with 1,1-disubstituted alkenes via β-H elimination remains challenging, because of the low reactivity and difficulty of controlling selectivity. Herein, the development of a Pd(II)-catalyzed directed atroposelective C-H allylation with methacrylates is described. Exclusive allylic selectivity was achieved. A vast array of axially chiral biaryl-2-amines are efficiently synthesized with excellent enantioselectivities (up to >99% enantiomeric excess).

Organic Letters published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Recommanded Product: 2-Bromo-4-isopropylaniline.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carullo, Gabriele; Mazzotta, Sarah; Giordano, Francesca; Aiello, Francesca published the artcile< Green synthesis of new pyrrolo [1,2-a] quinoxalines as antiproliferative agents in GPER-expressing breast cancer cells>, Computed Properties of 51605-97-1, the main research area is pyrroloquinoxaline GPER breast cancer antiproliferative activity.

4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biol. properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER). In this work, the synthesis and preliminary antiproliferative activity of a small set of new 4,5-dihydropyrrolo[1,2-a]quinoxalines (18-20) and pyrrolo[1,2-a]quinoxalines (21, 22) has been reported, inspired by known antiproliferative agents (G-1, G-15, and G-36). The synthesis of the pyrroloquinoxalinic core was employed following the Pictet-Spengler reaction, using the surfactant p-dodecylbenzene sulfonic acid (p-DBSA), as catalyst. It demonstrated efficiency in the catalysis of the 4-phenylpyrrole [1,2-a] quinoxaline type compound formation in mild solvents such as water, ethanol, and hydroalcoholic solutions In addition, the reactions proceeded in a short time (between 15 and 120 min) at room temperature and with high yields. The in vitro MTT assays showed that the presence of iso-Pr groups furnished promising antiproliferative compounds Although, the acetyl group provided also antiproliferative effects, breaking down its responsibility in the GPER transactivation. Nevertheless, it is possible to conclude that the 4,5-dihydropyrrolo[1,2-a]quinoxalines remain a feasible scaffold to develop anticancer agents against GPER-expressing cells.

Journal of Chemistry published new progress about Antiproliferative agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Computed Properties of 51605-97-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary