Category: 5153-40-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5153-40-2 as follows. SDS of cas: 5153-40-2

General procedure: A mixture of aryl silane (0.5 mmol), aryl bromides (0.5 mmol), PdCl2(MeCN)2 (5 mol%), and CsF (0.5 mmol) was stirred at 100oC for 6 h in NMP under CO (1atm) (5 mL). Afterwards, 2 mL water was added to the reaction solution and then filtered through a filter paper and the solution was extracted by Et2O (2 mL) for three times. The organic phase was combined and evaporated under reduced pressure. The residue was purified on a SiO2 column to afford the desired product(ethyl acetate/hexane).

According to the analysis of related databases, 5153-40-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chang, Sheng; Jin, Ying; Zhang, Xiu Rong; Sun, Yong Bing; Tetrahedron Letters; vol. 57; 19; (2016); p. 2017 – 2020;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 5153-40-2, name is 1-Bromo-2,3,4,5,6-pentamethylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5153-40-2, Recommanded Product: 1-Bromo-2,3,4,5,6-pentamethylbenzene

Nl ,N5-bis(2.3.4.5.6-pentamethylphenyOpentane- 1 ,5-diamine (Example 8) [0082] In a drybox, 2,3,4,5,6-pentamethylbromobenzene (750.0 mg, 3.30 mmol), 1,5-pentanediamine (195.2 muL, 1.67 mmol), sodium tertbutoxide (396.6 mg, 4.13 mmol), 3.0 mL of dimethyoxyethane, and 10.0 mM Pd(OAc)2 / CyPF-Z-Bu (82.5 muL, 8.25 x 10-4 mmol) were added to a 20 mL scintillation vial equipped with a magnetic stirbar and sealed with a cap containing a PTFE septum. The reaction was placed into a temperature controlled aluminum heating block and stirred at 100 0C for 6 h. After cooling to room temperature, the reaction mixture was partitioned between 100 mL H2O/Diethyle ether (Et20) (1 : 1), the organic phase separated and dried over MgSO4, followed by the removal of all volatiles to afford 619 mg (95.0 %) of the title compound.|0083) 1H NuMR spectra were obtained at 400 MHz and recorded relative to residual protio solvent. 13C NuMR spectra were obtained at 101 MHz and recorded relative to the residual solvent resonance. The spectra recorded are as follows: 1H NMR (CDC13, 400 MHz, 22 0C): delta 1.50-1.71(m, 6H), 2.21 (s, 6H), 2.22 (s, 12H), 2.25 (s, 12H), 2.84 (t, J = 12 Hz, 4H), 2.88 (br s, 2H). 13C NMR (CDC13, 101 MHz, 22 0C): delta 14.8, 16.5, 16.9, 25.0, 30.9, 49.9, 126.8, 129.6, 132.9, 143.7.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; UNIVATION TECHNOLOGIES, LLC; JOHNS, Adam, M.; WO2010/53696; (2010); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5153-40-2 as follows. category: bromides-buliding-blocks

General procedure: A mixture of aryl silane (0.5 mmol), aryl bromides (0.5 mmol), PdCl2(MeCN)2 (5 mol%), and CsF (0.5 mmol) was stirred at 100oC for 6 h in NMP under CO (1atm) (5 mL). Afterwards, 2 mL water was added to the reaction solution and then filtered through a filter paper and the solution was extracted by Et2O (2 mL) for three times. The organic phase was combined and evaporated under reduced pressure. The residue was purified on a SiO2 column to afford the desired product(ethyl acetate/hexane).

According to the analysis of related databases, 5153-40-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Chang, Sheng; Jin, Ying; Zhang, Xiu Rong; Sun, Yong Bing; Tetrahedron Letters; vol. 57; 19; (2016); p. 2017 – 2020;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5153-40-2,Some common heterocyclic compound, 5153-40-2, name is 1-Bromo-2,3,4,5,6-pentamethylbenzene, molecular formula is C11H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 15.92 g (80 mmol) 2,4,6-Me3C6H2Br in 80 mL THF was added dropwise to 2.32 g (96 mmol) Mg, activated with 3 g (16 mmol) 1,2-Br2C2H4, in 20 mL THF. The reaction mixture was refluxed for 2 h and afterward allowed to cool to r.t. To the Grignard reagent solution was added dropwise a solution of 7.55 g (16 mmol) 2,4,6-I3C6H2OH and0.44 g (0.64 mmol) [(IPr)PdCl2(3-ClC5H4N)]. The reaction mixture was refluxed for another 21 h and quenched with2 mL H2O stirring under argon for 30 min. After solvent removal, the obtained residue was dissolved in 80 mL Et2Oand 20 mL CH2Cl2 and filtered over a 2 cm alumina pad. Solvent removal at reduced pressure afforded a brown oil which was eluted over a 10 cm alumina column witha mixture of Et2O-pentane 2:1 (v/v). To the pale-yellow oil obtained after the solvent removal, methanol was added. After sonication, 1 precipitated as a colorless solid. Filtration and vacuum drying afforded 3.8 g (52 %) of 1.

The synthetic route of 5153-40-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; olea, Atena B.; Olaru, Marian; Silvestru, Cristian; Ra, Ciprian I.; Zeitschrift fur Naturforschung – Section B Journal of Chemical Sciences; vol. 70; 1; (2015); p. 77 – 81;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 5153-40-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5153-40-2 name is 1-Bromo-2,3,4,5,6-pentamethylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The synthesis of salicylaldimine 13 was accomplished in five steps (FIG. 21). Negishi cross-coupling of 1 and pentamethylbromobenzene[Ref 54] afforded biphenyl species 9. Subsequent steps are similar to the synthesis of ligands 7-s and 7-a. Bromination, followed by lithium-halogen exchange and DMF treatment installed the formyl moiety to give 11. Deprotection of the ether group and condensation with 2,6-diisopropyl aniline provided 13 in 14% overall yield.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2,3,4,5,6-pentamethylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; RADLAUER, Madalyn; WIENSCH, Joshua D.; BUCKLEY, Aya K.; AGAPIE, Theodor; US2013/66029; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary