Category: 50592-87-5

Oxacyclanes was written by Kirrmann, A.;Hamaide, N.. And the article was included in Bulletin de la Societe Chimique de France in 1957.Quality Control of 1-Bromo-6-methoxyhexane This article mentions the following:

Oxacyclanes were formed by heating 绾? 鏈? or 钄?methoxylated alkyl bromides with FeCl₃. NaOMe (1 mole) in MeOH added slowly with stirring to 1 mole dibromoalkane at 60鎺? the mixture boiled gently 4 hrs. and cooled, the washed and dried product distilled, and the bromo methoxy alkane fraction carefully redistilled in vacuo gave MeO(CH₂)₆Br, b₁₄ 94鎺? n_D²⁰ 1.458, d₂₀ 1.1942, MeCH(OMe)CH₂CH₂CHBrMe, b₃₅ 100鎺? n_D²⁰ 1.441, d₂₀1.1824, MeO(CH₂)₅Br, b₁₅ 76鎺? n_D²⁰ 1.455, d₂₀ 1.2420, and MeO(CH₂)₄Br (I), b₁₅ 60鎺? n_D²⁰ 1.452, d₂₀ 1.3052, in 56, 53, 55, and 57% yields, resp. Regulated mild distillation of these products in the presence of a few mg. FeCl₃ gave the oxacyclanes (compound, % yield, b.p., n_D²⁰, d₂₀, 浣?in 娓?: tetrahydrofuran, 100, 67鎺? 1.407, 0.8874, 3.34, 6.85, 9.34; tetrahydropyran, 100, 88鎺? 1.4205, 0.8851, 3.30, 6.92, 9.12, 11.46, 12.26; hexamethylene oxide, 70, 116鎺? 1.4355, 0.895, 3.42, 6.90, 8.80, 9.02, 10.04, 10.30, 12.22, 12.44; 2,5-dimethyltetrahydrofuran, 80, 96鎺? 1.410, 0.8373, 3.3, 6.8, 7.2, 9.1, 11.3, 11.94, 12.1. The MeBr formed in the cyclization of I was condensed at -15鎺?with anhydrous Et₂O and Mg, the MeMgBr treated with BzH and the MePhCHOH formed identified as the phenylurethan. The mechanism of the reaction was interpreted through the intermediary formation of a tertiary oxonium salt. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Quality Control of 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Oxacyclanes was written by Kirrmann, A.;Hamaide, N.. And the article was included in Bulletin de la Societe Chimique de France in 1957.Quality Control of 1-Bromo-6-methoxyhexane This article mentions the following:

Oxacyclanes were formed by heating γ, δ, or ε-methoxylated alkyl bromides with FeCl₃. NaOMe (1 mole) in MeOH added slowly with stirring to 1 mole dibromoalkane at 60°, the mixture boiled gently 4 hrs. and cooled, the washed and dried product distilled, and the bromo methoxy alkane fraction carefully redistilled in vacuo gave MeO(CH₂)₆Br, b₁₄ 94°, n_D²⁰ 1.458, d₂₀ 1.1942, MeCH(OMe)CH₂CH₂CHBrMe, b₃₅ 100°, n_D²⁰ 1.441, d₂₀1.1824, MeO(CH₂)₅Br, b₁₅ 76°, n_D²⁰ 1.455, d₂₀ 1.2420, and MeO(CH₂)₄Br (I), b₁₅ 60°, n_D²⁰ 1.452, d₂₀ 1.3052, in 56, 53, 55, and 57% yields, resp. Regulated mild distillation of these products in the presence of a few mg. FeCl₃ gave the oxacyclanes (compound, % yield, b.p., n_D²⁰, d₂₀, λ in μ): tetrahydrofuran, 100, 67°, 1.407, 0.8874, 3.34, 6.85, 9.34; tetrahydropyran, 100, 88°, 1.4205, 0.8851, 3.30, 6.92, 9.12, 11.46, 12.26; hexamethylene oxide, 70, 116°, 1.4355, 0.895, 3.42, 6.90, 8.80, 9.02, 10.04, 10.30, 12.22, 12.44; 2,5-dimethyltetrahydrofuran, 80, 96°, 1.410, 0.8373, 3.3, 6.8, 7.2, 9.1, 11.3, 11.94, 12.1. The MeBr formed in the cyclization of I was condensed at -15° with anhydrous Et₂O and Mg, the MeMgBr treated with BzH and the MePhCHOH formed identified as the phenylurethan. The mechanism of the reaction was interpreted through the intermediary formation of a tertiary oxonium salt. In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Quality Control of 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Quality Control of 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Total synthesis of linoleic acid was written by Baudart, Pierre. And the article was included in Bulletin de la Societe Chimique de France in 1944.Recommanded Product: 1-Bromo-6-methoxyhexane This article mentions the following:

A linoleic acid was synthesized and shown to be a stereoisomer of the natural acid. Intermediates prepared include 1-methoxypentane, b₇₆₀ 100-2°; 1-bromopentane, b₇₆₀ 122-4°, n_D²⁵ 1.4290, d₄²⁵ 1.1552; 1,6-hexanediol, b₃ 121-4°; 1,6-dibromohexane, b₃ 77-80°; 1-bromo-6-methoxyhexane, n_D²⁵ 1.4469, d₄²⁵ 1.1887. Glutardialdoxime (cf. Shaw, C.A. 31, 3008.1) (180 g.) and 240 g. EtONO were added gradually in alternate portions to 50 mL. 95% EtOH containing 5 mL. AcOH at 0°. The mixture was acidified with EtOH-HCl and allowed to stand 5 h. at 0° and 48 h. at room temperature over CaCl₂, yielding after ether extraction and distillation 175 g. glutaraldehyde bis(di-Et acetal) (I), b₃ 97-100°, n_D²⁵ 1.4232; d²⁵ 0.9009. I was reacted with 290 g. PCl₅.EtCl at 30-40°, the POCl₃ removed under vacuum, and the residue of 1,5-diethoxy-1,5-dichloropentane (II) distilled, b_0.8 90-100° (partial decomposition); yield 118 g. II with Br at 0° gave 240 g. impure, very unstable 1,5-diethoxy-1, 2, 4, 5-tetrabromopentane (III), which was used at once. To III in Et₂O at 0° were added Et₂O solutions of 78 g. AmMgBr and 120 g. MeO(CH₂)₆Br (cf. Dionneau, C.A. 1, 2683). The product was isolated and reduced with powd. Zn in BuOH (cf. Boord, et al., C.A. 27, 4770), yielding after distillation 11 g. impure 1-methoxy-7,10-hexadecadiene (IV), b₃ 144-7, as well as 6, 9-pentadecadiene and 1, 17-dimethoxy-7, 10-heptadecadiene. IV (9 g.) was reacted with Br at 0°, then with HBr at 100-130°, and finally debrominated with Zn in EtOH to produce 8 g. 1-bromo-7, 10-hexadecadiene (V), b_0.3 136-40°. V was transformed to the iodide with NaI in acetone, reacted with NaCH(CO₂Et)₂, decarboxylated, and distilled, giving 3.2 g. of a linoleic acid, b_0.8 179-83°; iodine number 152. Bromination of 2 g. of acid produced a large amount of an oily bromide and 0.35 g. of a tetrabromide, m. 77-8°, identical with the bromide of natural linoleic acid elaidinized by Se (cf. Kass and Burr, C.A. 33, 6239.8). In the experiment, the researchers used many compounds, for example, 1-Bromo-6-methoxyhexane (cas: 50592-87-5Recommanded Product: 1-Bromo-6-methoxyhexane).

1-Bromo-6-methoxyhexane (cas: 50592-87-5) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 1-Bromo-6-methoxyhexane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary