Category: 5003-71-4

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, molecular formula is C3H9Br2N, belongs to bromides-buliding-blocks compound, is a common compound. In a patnet, author is Rashid, Miah Muhammed Muktadir, once mentioned the new application about 5003-71-4, Category: bromides-buliding-blocks.

Aggregation, interaction and thermodynamic characteristics of cationic surfactant plus moxifloxacin hydrochloride mixture in aquatic solutions of mono-/di-hydroxy compounds

Herein, the interaction of the fourth-generation fluoroquinolone antibiotic drug, moxifloxacin hydrochloride (MFH), which is extensively used for the treatment of wider ranges of bacterial infections, like pneumonia, endocarditis, tuberculosis, and other complicated dermal lesions, and cetyltrimethylammonium bromide (CTAB, a cationic surfactant) has been observed by conductivity method in aqueous, alcoholic (C2H5OH, C3H7OH-2), and diol (C2H4(OH)(2), C3H6(OH)(2)) solutions. For all of the MFH + CTAB cases studied, the appearance of a critical micelle concentration (cmc) demonstrated that the micellar system is dependent on the variation of temperature and the concentration of different additives. A change in the value of cmc manifests the existence of strong interaction prevailing amongst MFH and CTAB molecules. In presence of alcohols/diols, the value of cmc for the MFH + CTAB system was found higher compared to those values obtained for the MFH + CTAB system carried out in H2O, which indicates a favourable micellization process. The values of counter-ion dissociation were also found to be dependent on temperature. The Delta G(m)(o) values were observed negative, which, again, manifests a spontaneous micellization process. The free energy of transfer and the enthalpy-entropy compensation were also calculated and discussed. [GRAPHICS]

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 5003-71-4. The above is the message from the blog manager. Category: bromides-buliding-blocks.

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, molecular formula is C3H9Br2N. In an article, author is Heshmati, Masoumeh,once mentioned of 5003-71-4, Computed Properties of C3H9Br2N.

Cytotoxicity and genotoxicity of silver nanoparticles in Chinese Hamster ovary cell line (CHO-K1) cells

Biomedical and pharmaceutical products comprising silver nanoparticles are attracting interest due to their potent antibacterial activities. For their safe use it has become imperative to test their cyto-genotoxic potential. In the present study the cytotoxicity and genotoxicity of three different sizes of AgNPs ranging from 15 to 22 nm and at concentrations 0.005-500 mu g/ml were studied in Chinese Hamster ovary cell line (CHO-K1) cells. Cytoxicity was assessed by MTT [3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide] assay and for genotoxicity comet, and micronucleus assays were utilized. AgNPs were able to internalize CHO-K1 cells and cause cytotoxicity at concentrations 0.005-500 mu g/ml. AgNP-induced cyto-genotoxicity in CHO-K1 cells could be attributed to its smaller primary size. AgNP-C of size similar to 15 nm was the most potent among the three AgNPs. The genotoxic response was biphasic that increased at lower concentrations (0.005-0.025 mu g/ml) and decreased at higher concentrations (0.05-0.1 mu g/ml) after 24 h of exposure. Such potential in vitro genotoxic effect of AgNPs remains to be further confirmed in animal cells in vivo.

Interested yet? Keep reading other articles of 5003-71-4, you can contact me at any time and look forward to more communication. Computed Properties of C3H9Br2N.

Electric Literature of 5003-71-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, SMILES is [H+].C(Br)CCN.[Br-], belongs to bromides-buliding-blocks compound. In a article, author is Keshavarz, Fatemeh, introduce new discover of the category.

Seed-Adsorbate Interactions as the Key of Heterogeneous Butanol and Diethylene Glycol Nucleation on Ammonium Bisulfate and Tetramethylammonium Bromide

Condensation particle counter (CPC) instruments are commonly used to detect atmospheric nanoparticles. They operate on the basis of condensing an organic working fluid on the nanoparticle seeds to grow the particles to a detectable size, and at the size of few nanometers, their efficiency depends on how well the working fluid interacts with the seeds under the measurement conditions. This study models the first steps of heterogeneous nucleation of two working fluids commonly used in CPCs (diethylene glycol (DEG) and n-butanol) onto two positively charged seeds, ammonium bisulfate and tetramethylammonium bromide. The nucleation process is modeled on a molecular level using a combination of systematic configurational sampling and density functional theory (DFT). We take into account the conformational flexibility of DEG and n-butanol and determine the key factors that can improve the efficiency of nanoparticle measurements by CPCs. The results show that hydrogen bonding between the seed and the working fluid molecules is central to the adsorption of the first DEG/n-butanol molecules onto the seeds. However, intermolecular hydrogen bonding between the adsorbed molecules can also enhance the nucleation process for the weakly adsorbing vapor molecules. Accordingly, the heterogeneous nucleation probability is higher for working fluid-nanoparticle combinations with a higher potential for hydrogen bonding; in this case, DEG and ammonium bisulfate. Moreover, conformational analysis and methodology evaluations indicate that the consideration of adsorbate conformers and step-wise addition of the vapor molecules to the seeds is not essential for qualitative modeling of heterogeneous nucleation systems, at least for systems where the adsorbate and seed chemical properties are clearly different. This is the first molecular-level modeling study reporting detailed chemical reasons for experimentally observed seed and working fluid preferences in CPCs and reproducing the experimental observations. Our presented approach can be likely used for predicting preferences in similar nucleating systems.

Electric Literature of 5003-71-4, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 5003-71-4 is helpful to your research.

Electric Literature of 5003-71-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, SMILES is [H+].C(Br)CCN.[Br-], belongs to bromides-buliding-blocks compound. In a article, author is Mortazavi, Shiva, introduce new discover of the category.

Make proper surfaces for immobilization of enzymes: Immobilization of lipase and alpha-amylase on modified Na-sepiolite

This paper has focused on making suitable carriers for the immobilization of alpha-amylase from Bacillus subtilis and lipase from Candida rugosa via adsorption on modified Na-sepiolite (SEP). Two modified carriers were prepared by changing the nature of SEP with cetrimonium bromide surfactant at concentrations below the CMC of the surfactant, to produce SEP with monolayer surfactant (MSEP) with hydrophobic properties and above the CMC of the surfactant to produce SEP with bilayer surfactant (BSEP) with hydrophilic properties. The enzymatic activity of immobilized lipase on MSEP (MSEPL) and immobilized alpha-amylase on BSEP (BSEPA) was successfully tested in the hydrolysis of olive oil and starch. The support modification and immobilization process were characterized by BET, XRD, and SEM techniques. The results demonstrated that the specific activity of MSEPL and BSEPA was 1.74 and 2.28 U/mg, respectively. The remained activity of MSEPL (56.7%) and BSEPA (40.4%) after their incubation at 60 degrees C for 4 h was much higher than that of free enzymes. The residual activity of MSEPL and BSEPA was 77.4% and 66.7%, after 30 days of storage at 4 degrees C. The MSEPL and BSEPA also showed good reusability, and their relative activities were 54.0% and 44.2% after ten cycles. (C) 2020 Elsevier B.V. All rights reserved.

Electric Literature of 5003-71-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5003-71-4.

Electric Literature of 5003-71-4, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, SMILES is [H+].C(Br)CCN.[Br-], belongs to bromides-buliding-blocks compound. In a article, author is Mortazavi, Shiva, introduce new discover of the category.

Make proper surfaces for immobilization of enzymes: Immobilization of lipase and alpha-amylase on modified Na-sepiolite

This paper has focused on making suitable carriers for the immobilization of alpha-amylase from Bacillus subtilis and lipase from Candida rugosa via adsorption on modified Na-sepiolite (SEP). Two modified carriers were prepared by changing the nature of SEP with cetrimonium bromide surfactant at concentrations below the CMC of the surfactant, to produce SEP with monolayer surfactant (MSEP) with hydrophobic properties and above the CMC of the surfactant to produce SEP with bilayer surfactant (BSEP) with hydrophilic properties. The enzymatic activity of immobilized lipase on MSEP (MSEPL) and immobilized alpha-amylase on BSEP (BSEPA) was successfully tested in the hydrolysis of olive oil and starch. The support modification and immobilization process were characterized by BET, XRD, and SEM techniques. The results demonstrated that the specific activity of MSEPL and BSEPA was 1.74 and 2.28 U/mg, respectively. The remained activity of MSEPL (56.7%) and BSEPA (40.4%) after their incubation at 60 degrees C for 4 h was much higher than that of free enzymes. The residual activity of MSEPL and BSEPA was 77.4% and 66.7%, after 30 days of storage at 4 degrees C. The MSEPL and BSEPA also showed good reusability, and their relative activities were 54.0% and 44.2% after ten cycles. (C) 2020 Elsevier B.V. All rights reserved.

Electric Literature of 5003-71-4, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 5003-71-4.

Synthetic Route of 5003-71-4,Some common heterocyclic compound, 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, molecular formula is C3H9Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Prepared from 3-bromopropylamine hydrobromide and BOC2O in the presence of base in dichloromethane, 9.89 mmol: 1H NMR (CDCl3) delta 5.07 (br, 1H), 3.31 (t, 2H, J=6.6 Hz), 3.12 (apparent br q, 2H, J=6.0 Hz), 1.92 (p, 2H, J=6.6 Hz), 1.30 (s, 9H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromopropan-1-amine hydrobromide, its application will become more common.

Reference:
Patent; Synaptic Pharmaceutical Corporation; US6727264; (2004); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks

Example 1 Preparation of Tert-Butyl 3-Bromopropylcarbamate To a solution of sodium hydroxide (105 g, 2.625 mol) in water (1.15 L) maintained at a temperature at or slightly below 10 C. was added a solution of di-tert-butyl dicarbonate (229 g, 1.05 mol) in heptane (1.03 L). The flask containing the solution of di-tert-butyl dicarbonate was rinsed with heptane (125 mL) and the rinsate was added to the reaction mixture. The resulting mixture was cooled to a temperature at or slightly below 10 C. and a solution of 3-bromopropylamine hydrobromide (251 g, 1.15 mol) in water (250 mL) was added dropwise at a rate that allowed the internal reaction temperature to be maintained below about 20 C. The flask containing the solution of 3-bromopropylamine hydrobromide was rinsed with water (20 mL) and the rinsate was added to the reaction mixture. After the addition was complete, the reaction mixture was allowed to slowly warm to room temperature (about 22 C.) and stirring was continued for about 2 hours at room temperature. The stirring was discontinued and the mixture was allowed to stand for 30 minutes. The lower aqueous layer was separated from the organic layer and discarded. To the organic layer was added a saturated aqueous sodium chloride solution (250 mL) and the resulting mixture was stirred for 5 min. The mixture was allowed to stand for 30 minutes and the lower aqueous layer was separated and discarded. The organic layer was concentrated to a volume of about 350 mL and this concentrated solution was cooled to 5 C. and stirred for 4 hours at 5 C. The resulting precipitate was collected by vacuum filtration to provide the title compound as a white crystalline solid (211 g, 84% yield). The filtrate was concentrated and the concentrated solution was cooled to 5 C. and stirred for 4 hours at 5 C. The resulting additional precipitate was collected by vacuum filtration to provide an additional amount of the title compound (17 g, 6.8% yield). 1H NMR (400 MHz, DMSO-d6) delta 1H NMR (400 MHz, DMSO-d6) delta 3.50 (t, J=6.8 Hz, 2H), 3.03 (q, J=6.8 Hz, 2H), 1.91 (m, J=6.8 Hz, 2H), 1.38 (s, 9H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THERAVANCE, INC.; Zhang, Weijiang; Tracey, Michael R.; Lee, Junning; US2014/275554; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5003-71-4, Product Details of 5003-71-4

In a solution of 3-bromopropan-1 -amine hydrobromide (1.00 g, 0.46 mmol) in THE (40m1) trimethylamine (imI, 0.58 mmol) is added and the resulting reaction mixture isstirred for half an hour, then catalytic amount of 2-methylaminopyridine is added into the reaction mixture. Einally, in ice cold condition 1.23 ml of Boc anhydride is also added into it, in a dropwise manner and the reaction mixture is stirred for overnight. Now slowly, the reaction mixture is quenched with ammonium chloride and extracted with ethyl acetate. The combined organic phase is washed with brine and finally dried over anhydrousNa2504. The crude product is further purified by flash chromatography by using 60-1 20mesh silica gel and ethyl acetate/hexane as mobile phase. The product tert-butyl (3-bromopropyl)carbamate is obtained as a yellowish solid upon cooling at 4 00 (Yield: 0.9 g(83%))

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromopropan-1-amine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; SHIV NADAR UNIVERSITY; ROY, Gouriprasanna; BANERJEE, Mainak; KARRI, Ramesh; CHALANA, Ashish; DAS, Ranajit; (61 pag.)WO2017/168451; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5003-71-4, These common heterocyclic compound, 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

di-tert-Butyl dicarbonate (3.71 g, 16.9 mmol) and triethylamine (10 mL) were added to a solution of 3-bromopropylamine hydrobromide 7b (3.72 g, 16.9 mmol) in dichloromethane (100 mL). The reaction mixture was stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. After this time, reaction was complete. The solvent was removed under reduced pressure. A saturated solution of sodium chloride (100 mL) was added to this residue and the mixture was extracted with diethyl ether (2¡Á50 mL). The organic phases were combined, washed with a saturated solution of sodium chloride (3¡Á50 mL) and dried over sodium sulfate. After filtration, the solvent was removed under reduced pressure to give compound 8 in the form of a slightly brown solid. The compound was sufficiently pure to be used in the rest of the synthesis without additional purification (3.50 g, 87%). M.p.: 32-33 C. 1H NMR (200 MHz, CDCl3) delta: 4.63 (s, 1H), 3.42 (t, J=6.5 Hz, 2H), 3.26 (td, J=6.5; 6.5 Hz, 2H), 2.03 (m, J=6.5 Hz, 2H), 1.43 (s, 9H); 13C NMR (125 MHz, CDCl3) delta: 156.09, 79.54, 39.96, 32.82, 30.90, 28.48. HRMS (ESI+) calculated for C8H16NO2Br [M+H]+, m/z 255.0703. found: 255.0695. Rf=0.59 (silica; cyclohexane-ethyl acetate 50:50).

The synthetic route of 5003-71-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CISBIO BIOASSAYS; LAMARQUE, Laurent; PARKER, David; BUTLER, Stephen J.; DELBIANCO, Martina; US2015/361116; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

5003-71-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows.

TERT-BUTYL N-(3-BROMOPROPYL)CARBAMATE: was prepared from 3-bromopropylamine hydrobromide and BOC2O in the presence of base in dichloromethane.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Synaptic Pharmaceutical Corporation; US6727264; (2004); B1;,
Bromide – Wikipedia,
bromide – Wiktionary