Category: 5003-71-4

Reference of 5003-71-4, These common heterocyclic compound, 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

di-tert-Butyl dicarbonate (3.71 g, 16.9 mmol) and triethylamine (10 mL) were added to a solution of 3-bromopropylamine hydrobromide 7b (3.72 g, 16.9 mmol) in dichloromethane (100 mL). The reaction mixture was stirred at room temperature for 12 h. The progress of the reaction was monitored by TLC. After this time, reaction was complete. The solvent was removed under reduced pressure. A saturated solution of sodium chloride (100 mL) was added to this residue and the mixture was extracted with diethyl ether (2×50 mL). The organic phases were combined, washed with a saturated solution of sodium chloride (3×50 mL) and dried over sodium sulfate. After filtration, the solvent was removed under reduced pressure to give compound 8 in the form of a slightly brown solid. The compound was sufficiently pure to be used in the rest of the synthesis without additional purification (3.50 g, 87%). M.p.: 32-33 C. 1H NMR (200 MHz, CDCl3) delta: 4.63 (s, 1H), 3.42 (t, J=6.5 Hz, 2H), 3.26 (td, J=6.5; 6.5 Hz, 2H), 2.03 (m, J=6.5 Hz, 2H), 1.43 (s, 9H); 13C NMR (125 MHz, CDCl3) delta: 156.09, 79.54, 39.96, 32.82, 30.90, 28.48. HRMS (ESI+) calculated for C8H16NO2Br [M+H]+, m/z 255.0703. found: 255.0695. Rf=0.59 (silica; cyclohexane-ethyl acetate 50:50).

The synthetic route of 5003-71-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CISBIO BIOASSAYS; LAMARQUE, Laurent; PARKER, David; BUTLER, Stephen J.; DELBIANCO, Martina; US2015/361116; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-Bromopropan-1-amine hydrobromide

To 3-bromopropylamine hydrobromide (139.32 g, 636.40 mmol) was added a solution of di-tert-butyl dicarbonate (112.46 g, 510.13 mmol) in MIBK (800 mL) and 2.5 M sodium hydroxide (310 mL). The resulting mixture was stirred for 1 hour at room temperature. The reaction was monitored by TLC (9:1 isohexane: ethyl acetate, potassium permanganate stain). Water (345 mL) was added and the mixture stirred for 10 minutes. The phases were separated and the lower (aqueous) phase discarded. To the retained organic phase was added 3-benzyl-9- oxa-3,7-diazabicyclo[3.3.1]nonane dihydrochloride (148.43 g, 509.68 mmol; .; see WO 02/083690) and 2.5 M sodium hydroxide (660 mL). This mixture was heated at 65C for 7 hours. At 650C, the phases were separated and the lower (aqueous) phase discarded. The organic phase was re-heated to 650C and extracted with 10% w/w aqueous citric acid (562 mL). The phases were separated and the upper (organic) phase discarded. To the resulting aqueous phase was added MIBK (800 mL) and 5 M sodium hydroxide (230 mL) containing approximately 10% w/v EPO sodium chloride (22.84 g). The resulting mixture was stirred at room temperature for 15 minutes. The phases were separated and the lower (aqueous) phase discarded. The organic phase was azeo-dried by removal of solvent (300 mL) by distillation under reduced pressure (keeping the temperature below 7O0C). The mixture was clarified by filtration whilst still hot and the residue washed with MIBK (115 mL). The temperature was adjusted to 6O0C and a solution of purified (see J. Am. Pharm. Assoc. 239-241 (1949)) 4-chlorobenzenesulfonic acid (99.24 g, 515.20 mrnol) in MIBK (225 mL) was added over 90 minutes. The reaction mixture was then cooled to room temperature causing the product to crystallize from solution. The mixture was cooled to 5C, the product was collected by filtration and the cake washed with MIBK (225 mL). The product was dried as far as possible on the filter, then oven dried in vacuo (50C, 24 h) to give the title compound as a white solid (257.44 g, 453.13 mmol, 89%). 1H NMR (300 MHz, DMSO-d6) delta 7.61 (d, J= 8.7 Hz, 2H), 7.46 – 7.35 (m, 7H), 7.10 (t, J= 5.7 Hz, IH), 4.15 (s, 2H), 3.70 (s, 2H), 3.40 (d, J= 12.1 Hz, 3H), 3.07 (d, J= 11.9 Hz, 4H), 2.97 (q, J= 6.3 Hz, 2H), 2.84 (t, J= 7.1 Hz, 2H), 2.76 (d, J= 11.9 Hz, 2H), 1.70 (quintet, J= 6.7 Hz, 2H), 1.45 (s, 9H).

The synthetic route of 5003-71-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2006/137770; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 5003-71-4,Some common heterocyclic compound, 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, molecular formula is C3H9Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step A N-Benzyloxycarbonyl-3-bromopropylamine To a stirred suspension of 3-bromopropylamine hydrobromide (2 g, 9.14 mM) in 40 mL dry THF was added, via hypodermic syringe, benzyl chloroformate (1.64 g, 9.60 mM) at room temperature. After cooling to 0 C., diisopropylethylamine (1.6 mL, 9.20 mM) was added dropwise via syringe and the reaction mixture was allowed to stir at 0 C. for 1 hour. The crude reaction mixture was filtered over a pad of Celite and solvents were evaporated. The residue was flash chromatographed on silica gel, eluding with 10-20-30% EtOAc/hexane to afford 1.56 g desired product as a liquid, homogeneous by TLC in 80:20 hexane-EtOAc; 1 H-NMR (200 MHz, CDCl3, ppm) delta2.06 (m, 2H), 3.37 (m, 4H), 4.92 (br, 1H), 5.10 (s, 2H), 7.34 (s, 5H). Mass spectrum (FAB) m/e 273 (M+1)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromopropan-1-amine hydrobromide, its application will become more common.

Reference:
Patent; Merck & Co., Inc.; US5411980; (1995); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 5003-71-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows.

Triethylamine (30 mL) was added dropwise to 3-bromopropan-1-aminium bromide (10.84 g, 50 mmol) in DCM (50 mL). After 15 min stirring, di-tert-butyl dicarbonate (21.8 g, 100 mmol) in DCM (40 mL) was added dropwise to the solution for 1 h, and the resulting mixture was stirred for 2 days at room temperature. The resulting solution was washed with 1 N aqueous HCl, water × 2, saturated aqueous NaHCO3, and brine. The organic phase was dried with Na2SO4, and thes olvent was removed in vacuo to give tert-butyl (3-bromopropyl) carbamate (20.54 g, yield = 88%).

The chemical industry reduces the impact on the environment during synthesis 3-Bromopropan-1-amine hydrobromide. I believe this compound will play a more active role in future production and life.

Reference:
Article; Qin, Huihuan; Li, Lingling; Li, Kun; Xiaoqi, Yu; Chinese Chemical Letters; (2019); p. 71 – 74;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, A new synthetic method of this compound is introduced below., Product Details of 5003-71-4

Di-tert-butyl dicarbonate (1.01 g, 4.6mmol) was dissolved in N,N-dimethylacetamide (12ml) and added with 3-bromoaminopropane hydrobromide (1.01 g, 4.6mmol) and potassium carbonate(0.64 g, 4.6mmol). The reaction was carried out at 45-50C for 1 hour. 2-(5-Nitropyridine-2-yl)phenol(0.50 g, 2.3mmol) synthesized in Example 63 (i) and potassium carbonate (0.64 g, 4.6mmol) were added. The reaction was carried out at 50C for 20 minutes and at 75-80C for 1 hour. The reaction was cooled and extracted with addition of water and ethyl acetate. The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The precipitated crystals were filtered with addition of water. The resulting crystals were dissolved in methanol, and hydrolyzed with dropwise addition of hydrochloric acid at 50C. The solution was concentrated and neutralized with saturated aqueous sodium bicarbonate. The precipitated crystals were filtered to give the title compound (0.57 g, 66.4%).

The synthetic route of 5003-71-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Daito Chemix Corporation; Kyoto University; KAKIZUKA, Akira; HORI, Seiji; SHUDO, Toshiyuki; FUCHIGAMI, Tomohiro; EP2599771; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 5003-71-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A solution of 3-bromopropylamine hydrobromide (1.0 g, 4.6 mmol) in a 2:1 dioxane/H2O (45 mL) was cooled to 0 C. and treated with K2CO3 (6.22 g, 45 mmol) and di-tert-butyl dicarbonate (1.5 g, 6.9 mmol). The reaction was stirred for 15 h while warming to room temperature. The dioxane was removed in vacuo and the remaining aqueous mixture was acidified with 5 N HCl and extracted with ethyl acetate (5*25 mL). The combined organic layers were dried with MgSO4 and yielded 3-bromo-N-(tert-butoxycarbonyl)propylamine as a colorless oil (0.93 g, 93%). 1H-NMR (CDCl3/TMS, ppm): 1.41 (s 9H, CH3), 2.02 (quintet, J=6.4 Hz, 2H, CH2), 3.23 (m, 2H, NCH2), 3.41 (t, J=6.6 Hz, CH2Br), 4.8 (broad, 1H, NH); 13C-NMR (CDCl3, ppm): 28.3 (CH3), 30.7, 32.6, 38.9 (CH2), 79.3 (quaternary C), 155.9 (CO); MS (CI, m/z): 239, 241 (M+H+ Calc. for C8H16BrNO2 237.03644).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromopropan-1-amine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Research Development Foundation; US6703384; (2004); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5003-71-4, COA of Formula: C3H9Br2N

To a mixture of 3-bromopropan-1 -amine hydrobromide (98.5 g, 45 mmol, 1 .0 eq) and Boc20 (93.3 g, 42.8 mmol, 0.95 eq) in DCM (500 ml) was added dropwise DIPEA (64.0 g, 49.5 mmol). The resulting mixture was stirred at room temperature overnight. Then, the reaction mixture was washed with water, 1 N HCI and brine, dried over Na2S04 and filtered. The solvent was evaporated to give the expected compound (95.8 g, 94% yield) as a white solid.To a suspension of NaH (60 % in mineral oil) (1 1.1 g, 278 mmol, 1 .3 eq) in DMF (150 ml) was added dropwise a solution of 2-(1 H-indol-3-yl)acetamide (37.2 g, 214 mmol, 1 .0 eq) in DMF (150 ml) at 0C under N2 and the reaction mixture was stirred for 30 min. Then a solution of the previous compound (55.9 g, 235 mmol, 1.1 eq) in DMF (100 ml) was added dropwise at 0 C. The mixture was stirred at 0 C for 30 min and at room temperature for 10 hrs. The reaction mixture was diluted in water (500 ml) and extracted with ethyl acetate. The organic phase was washed with brine, dried over Na2S04 and filtered. The solvent was evaporated under vacuum. The crude product was purified by column chromatography over silica gel eluted with MeOH/DCM (0/100 to 3/97) to give the intermediate 3 (52.8 g, 75% yield) as a solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromopropan-1-amine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; AMAKEM NV; LEYSEN, Dirk; DEFERT, Olivier; BOLAND, Sandro; WO2013/4709; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 5003-71-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5003-71-4, name is 3-Bromopropan-1-amine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows.

Di-tert-butyl dicarbonate (3.71 g, 16 9 mmol) and triethylamine (10 mL). were added to a solution of 3-bromopropylamine hydrobromide 3 (3.72 g, 16.9 mmol) in dichloromethane (100 mL). The reaction mixture was stirred at room temperature for 12 hours. The reaction progress was monitored by TLC. After this period, the reaction was complete. The solvent was removed under reduced pressure. Saturated sodium chloride solution (100 mL) was added to this residue and the mixture was extracted with diethyl ether (2×50 mL). The organic phases were combined, washed with saturated sodium chloride solution (3×50 mL) and dried over sodium sulfate. After filtration, the solvent was removed under reduced pressure to give compound 4 in the form of a slightly brown solid. The compound was sufficiently pure to be used in the rest of the synthesis without further purification (3.50 g, 87%). 1H NMR (200 MHz, CDCl3) delta: 4.63 (s, 1H), 3.42 (t, J=6.5 Hz, 2H), 3.26 (td, J=6.5; 6.5 Hz, 2H), 2.03 (m, J=6.5 Hz, 2H), 1.43 (s, 9H). HMRS (ESI) calculated for C8H16NO2Br [M+H+], m/z 255.0703. found: 255.0695.

The chemical industry reduces the impact on the environment during synthesis 3-Bromopropan-1-amine hydrobromide. I believe this compound will play a more active role in future production and life.

Reference:
Patent; CISBIO BIOASSAYS; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; ECOLE NORMALE SUPERIEURE DE LYON; Lamarque, Laurent; Maury, Olivier; Parker, David; Zwier, Jurriaan; Walton, James W.; Bourdolle, Adrien; US2014/336373; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 5003-71-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, SMILES is [H+].C(Br)CCN.[Br-], belongs to bromides-buliding-blocks compound. In a article, author is Tran, Nhu L., introduce new discover of the category.

Observation of Charge Generation via Photoinduced Stark Effect in Mixed-Cation Lead Bromide Perovskite Thin Films

Extensive transient absorption studies on hybrid organic-inorganic lead halide perovskites have elucidated many optical properties important for their device performance. Despite the enormous progress, the derivative shaped photoinduced absorption feature in transient spectra that is above the bandgap has many explanations, including the photoinduced Stark effect, where the bandgap is blue shifted due to a local electric field generated by charges. In this work, we employ broad band transient absorption and two-dimensional electronic spectroscopy (2DES) to examine the early transient events after photoexcitation of [CH(NH2)(2)](0.83) Cs0.17PbBr3 (FA(0.83)Cs(0.17)PbBr(3)). 2DES resolves a photomodulation feature at the excitation energy of the exciton, suggesting the presence of a dipole field created by a polaron pair shifting the exciton transition to higher energies. As this polaron pair dissociates over 200 fs, the exciton transition shifts to higher energies over the same time scale, evidenced by the 2DES diagonal energy spectra. Given that the observations are well explained in terms of the Stark effect, our work provides extra grounds to support the Stark effect assignment of the above-gap photoinduced absorption. Furthermore, our study reports on the time scale of charge generation, contributing to the fundamental understanding of mixed-cation lead bromide perovskite photophysics.

Synthetic Route of 5003-71-4, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 5003-71-4.

Reference of 5003-71-4, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 5003-71-4, Name is 3-Bromopropan-1-amine hydrobromide, SMILES is [H+].C(Br)CCN.[Br-], belongs to bromides-buliding-blocks compound. In a article, author is Moshikur, Rahman Md, introduce new discover of the category.

Formation and potential application of micelles composed of biocompatible N-lauroyl-amino acid ionic liquids surfactant

Surface-active ionic liquid (SAIL) surfactants have attracted attention as promising alternatives to conventional surfactants because of their tailor-made and tunable properties. SAILs also address the limitations associated with conventional surfactants including toxicity and formation of unstable micelles. Here, we investigated the aggregation behavior of three biocompatible choline N-lauroyl-amino add (NIAA)-based ILs with different amino acid side chains in aqueous solutions. The micellar behaviors of NLAA-ILs were investigated using surface tensiometry, conductometry, dynamic light scattering (DLS) and transmission electron microscopy (TEM). The critical micellar concentration (CMC) of the NLAA-ILs was found to be 2 to 4-fold lower compared with the conventional surfactant sodium dodecyl sulfate (SDS). The thermodynamic behavior confirmed that the micelle formation of NLAA-ILs was stable, spontaneous and entropy driven at room temperature. DLS and TEM studies revealed that the size and shape of the micelles depended on the presence of an N-hydrogen group in the head group of the anion. Choline N-lauroyl glycinate ([Cho][NLG]) and dicholine N-lauroyl aspartate ([Cho](2)[NLA]) were predominantly produced as unilamellar vesicles in water whereas choline N-lauroyl sarcosinate ([Cho][NLS]) formed small spherical micelles. Importantly, SAIL [Cho][NLG] showed lower toxicity toward mammalian cells compared with the analogous Rs or the conventional surfactant SDS and similar toxicity to the conventional surfactant Tween 80. SAIL [Cho][NLG] was more efficient at forming hydrophobic ion pairs with the macromoleadar drug heparin compared with SAIL [Cho][NLS]. These results clearly suggest that the biocompatible NLAA-ILs represent promising potential substitutes for conventional surfactants in various biomedical applications. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 5003-71-4, The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 5003-71-4 is helpful to your research.