Category: 49764-63-8

Electric Literature of 49764-63-8, These common heterocyclic compound, 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Triphenylstibane(35.5 mg, 0.1 mmol, 10 mol%) and diamine 2 (1.2 mmol) were added to a solution of -hydroxy ketone 1(1 mmol) in toluene (6 mL) under air. The solution was stirred at room temperature and monitored byTLC. The reaction mixture was concentrated under reduced pressure and the residue was purified bycolumn chromatography (CH2Cl2) on silica gel. The products were confirmed by comparison of mp,NMR data, and MS spectra with that in the literature. 822:

The synthetic route of 49764-63-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Matsumura, Mio; Takada, Rie; Ukai, Yuu; Yamada, Mizuki; Murata, Yuki; Kakusawa, Naoki; Yasuike, Shuji; Heterocycles; vol. 93; 1; (2016); p. 75 – 83;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, A new synthetic method of this compound is introduced below., Recommanded Product: 4,5-Dibromobenzene-1,2-diamine

This compound was synthesized according to a modified literature procedure. 30 Cylcohexane octahydrate SM4 (1.17 g, 3.76 mmol), 4,5-dibromo benzene-1,2-diamine QZ-IB-8 (3.00 g, 11.3 mmol) were refluxed in 450 ml of glacial acetic acid (additional volume of glacial acetic acid was added because the solution was hard to stir), for 24 hours at 140 C. The solution was then filtered and the obtained powder was washed with 120 ml of hot glacial acetic acid and was then refluxed in 200 ml of 30 % nitric acid for 23 hours. The solution was filtered to yield 3.06 g (95 %) of greenish powder. (at)H (300 MHz, DMSO-d6) 88.97 (s, 6H). MALDI-TOF MS (MH+H) : m/z 853.5, 855.5, 857.5,859.5, 861.5, 863.5; calcd for C24H7Br6N6, 858.8. An amount of 1 g was sublimed under high vacuum (ca. 10-6 torr) at ca. 400 C. An amount of 252 mg of yellow solid was isolated. Anal. Calcd. for C24H6Br6N6: C, 33.61, H, 0.71, Br, 55.89, N, 9.80. Found: C, 33.74, H, 0.75, Br, 55.66, N, 9.55.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GEORGIA TECH RESEARCH CORPORATION; WO2005/123737; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

49764-63-8,Some common heterocyclic compound, 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, molecular formula is C6H6Br2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of intermediate 6 (1.0 equiv.) and substituted o-phenylenediamine (1.0 equiv.) in 15 mL acetonitrile was stirred at roomtemperature overnight. TLC was used to monitor the progress of the reaction. When the reaction finished, the mixture was addedBOP (1.5 equiv.) and DBU (2.0 equiv.) and was stirred at room temperature. TLC was used to monitor the progressof the reaction. The solutionwas treated with water and ethyl acetate. The organic phases were combined anddried over and evaporated to dryness under reduced pressure. Purification bychromatography using petroleum ether/ethyl acetate 2:1 yielded 7a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 49764-63-8, its application will become more common.

Reference:
Article; Bu, Huagang; Jia, Lejiao; Li, Jun; Li, Zhenyu; Li, Zhiying; Shen, Chengwu; Tang, Hui; Wu, Xingkang; Zhang, Rui; Bioorganic and medicinal chemistry letters; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

49764-63-8, Adding a certain compound to certain chemical reactions, such as: 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 49764-63-8.

General procedure: Intermediate1 (3.17 g, 8.7 mmol) and 4,5-dibromobenzene-1,2-diamine (3.02 g, 11.35 mmol) were dissolved in 90 mL acetic acid,and then heated to reflux for 16 h. After cooling down, the resultingmixture was poured into water and neutralized by sodium hydroxide.The suspension was extracted with chloroform(50 mL 3), and the combined organic layer was washed withwater and dried over anhydrous sodium sulfate. After that, thesolvent was removed by vacuum distillation and the rest solid waspurified with a silica gel column. Using dichloromethane/methanol(v/v) 20:1 as eluent and gave the target compound as light yellowsolid (4.3 g, yield: 83%).

According to the analysis of related databases, 49764-63-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yin, Xiaojun; Sun, Hengda; Zeng, Weixuan; Xiang, Yepeng; Zhou, Tao; Ma, Dongge; Yang, Chuluo; Organic electronics; vol. 37; (2016); p. 439 – 447;,
Bromide – Wikipedia,
bromide – Wiktionary

A common compound: 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 49764-63-8

6,7-Dibromo-1,4-dihydroquinoxaline-2,3-dione. A mixture of 4,5-dibromo-1,2-phenylenediamine (1.862 g, 7.0 mmol) and oxalic acid dihydrate (1.06 g, 8.4 mmol) in 2N HCl (100 mL) was heated at 125 C. for 2 h then allowed to cool to 25 C. The solid was collected by vacuum filtration, washed with water and dried at 40 C. under 1 mmHg for 10 h affording 2.053 g (92%) of the title compound as a light brown powder. 1 H NMR (DMSO-d6) 11.995 (s, 2H), 7.361 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 49764-63-8, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California; US5514680; (1996); A;,
Bromide – Wikipedia,
bromide – Wiktionary