Category: 49764-63-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H6Br2N2

To a Schlenk flask containing a mixed solution of 1,4-dioxane and water (100 mL, 1,4-dioxane/water = 10/1, V/V) under nitrogen, sequentially added4,5-dibromo-o-phenylenediamine(1g, 3.76mmol),4-boronic acid triphenylamine(2.72g, 9.4mmol),K2CO3 (2.08 g, 15.04 mmol) and Pd(PPh3) 4 (87 mg, 0.075 mmol),The mixture was heated with stirring and allowed to react at 90 C overnight. After the reaction is completed, cool to room temperature.The reaction solution was poured into 100 mL of water and extracted with dichloromethane (DCM) (3×100 mL).The organic layer was collected and dried over anhydrous sodium sulfate.(petroleum ether/ethyl acetate, 2/1, V/V) afforded a pale yellow solid.That isN4,N4,N4″,N4″-tetraphenyl[1,1′:2′,1″-terphenyl]-4,4′,4″,5′-tetraamine(The compound of the formula A1 above, 1.79 g, 80%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 49764-63-8.

Reference:
Patent; Soochow University (Suzhou); Ran Quan; Zhu Huifang; Fan Jian; (34 pag.)CN109928936; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, A new synthetic method of this compound is introduced below., Safety of 4,5-Dibromobenzene-1,2-diamine

General procedure: To a 10 mL vial were added o-diaminobenzene 2 (0.2 mmol, 1.0 equiv), DIPEA(0.24 mmol, 1.2 equiv), and toluene (2 mL), followed by the slow addition of a solution of-acetoxy allenoate 1 (0.24 mmol,1.2 equiv) in toluene (2 mL). The solution was stirred for 12 h atroom temperature. The reaction mixture was concentrated under reduced pressure, and the residuewas purified by silica gel column chromatography using petroleum ether and ethyl acetate (30:1 to15:1 v/v) as the eluent to give the corresponding annulations product 3.

The synthetic route of 49764-63-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Yi-Fan; He, Cheng-Yu; Hou, Longlei; Tian, Ping; Lin, Guo-Qiang; Tong, Xiaofeng; Synlett; vol. 29; 9; (2018); p. 1176 – 1180;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H6Br2N2

iert-butyl (1-(5,6-dibromo-1 H-benzo[d]imidazol-2-yl)-2-(4- methoxyphenyl)ethyl)carbamate: In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 2-((terf-butoxycarbonyl)amino)-3-(4- methoxyphenyl)propanoic acid (500 mg, 1.69 mmol) in AcCN (16.9 mL) was treated at rt with 4-ethylmorpholine (0.43 mL, 3.39 mmol), TBTU (544 mg, 1.69 mmol) and 4,5- dibromobenzene-1 ,2-diamine (450 mg, 1.69 mmol). The reaction mixture was stirred at rt until completion. The reaction mixture was diluted with EA and water. The org. phase was dried over MgS04, filtered, and the solvent was removed under reduced pressure. The residue was dissolved in glacial acetic acid (25 mL) and the reaction mixture was stirred at 60 C for 1 h. The mixture was cooled to rt and the solvent was removed under reduced pressure. The residue was partitioned between EA (25 mL) and sat. aq. NaHC03 (25 mL). The org. layer was washed with sat. aq. NaHC03 (twice 25 mL), dried over MgS04, filtered, and the solvent was removed under reduced pressure. Purification of the residue by FC (4:6 EA-heptane) gave the title compound as beige solid: TLC: rf (4:6 EA-heptane) = 0.35. LC-MS-conditions 12: tR = 0.88 min; [M+H]+ = 525.61.

According to the analysis of related databases, 49764-63-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; CORMINBOEUF, Olivier; CREN, Sylvaine; LEROY, Xavier; POZZI, Davide; WO2015/19325; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 4,5-Dibromobenzene-1,2-diamine

A mixture of 4,5-dibromo-o-phenylenediamine(40 mg, 0.15 mmol), 3-tert-butyl-5-nitrosalicylaldehyde(70 mg, 0.31 mmol) and Zn(OAc)2·2H2O (40 mg, 0.18 mmol) in MeOH (20 mL) was stirred for 4 h at room temperature. The orange product was then isolated by filtration and dried

The synthetic route of 49764-63-8 has been constantly updated, and we look forward to future research findings.

Reference:
Conference Paper; Anselmo, Daniele; Escudero-Adan, Eduardo C.; Martinez Belmonte, Marta; Kleij, Arjan W.; European Journal of Inorganic Chemistry; 29; (2012); p. 4694 – 4700;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 49764-63-8, A common heterocyclic compound, 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, molecular formula is C6H6Br2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 100 ml of toluene, 10 g (0.036 mol) of the compound of example 12.3, 9.65 g (0.079 mol) of phenylboronic acid, 10 g of potassium carbonate and 1 .05 g of tetrakistriphenylphosphinepalladium was heated at 70C for 5 h. Then, the reaction mixture was mixed with water. The phases were separated to give 10.7 g of a crude product which was purified by column chromatography (toluene) to give 8.1 g (79%)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BASF SE; Koeneman, Martin; Materan, Gabriele; Bagain, Plast Gerhard; Ivanovic, Sorin; St., Robert; (100 pag.)KR2016/38052; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4,5-Dibromobenzene-1,2-diamine

To a Schlenk flask containing a mixed solution of 1,4-dioxane and water (100 mL, 1,4-dioxane/water = 10/1, V/V) under nitrogen, sequentially added4,5-dibromo-o-phenylenediamine(1g, 3.76mmol),4-boronic acid triphenylamine(2.72g, 9.4mmol),K2CO3 (2.08 g, 15.04 mmol) and Pd(PPh3) 4 (87 mg, 0.075 mmol),The mixture was heated with stirring and allowed to react at 90 C overnight. After the reaction is completed, cool to room temperature.The reaction solution was poured into 100 mL of water and extracted with dichloromethane (DCM) (3×100 mL).The organic layer was collected and dried over anhydrous sodium sulfate.(petroleum ether/ethyl acetate, 2/1, V/V) afforded a pale yellow solid.That isN4,N4,N4″,N4″-tetraphenyl[1,1′:2′,1″-terphenyl]-4,4′,4″,5′-tetraamine(The compound of the formula A1 above, 1.79 g, 80%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 49764-63-8.

Reference:
Patent; Soochow University (Suzhou); Ran Quan; Zhu Huifang; Fan Jian; (34 pag.)CN109928936; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 49764-63-8, The chemical industry reduces the impact on the environment during synthesis 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, I believe this compound will play a more active role in future production and life.

General procedure: A solution of 3 (1.87g, 10mmol) and o-phenylenediamine derivatives (10mmol) in methanol (80mL) was stirred at 65C for 4h, then cooled to room temperature and filtered to give a yellow powder.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Dibromobenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lu, Xing; Wu, Yi-Ming; Yang, Jing-Mei; Ma, Feng-E.; Li, Liang-Ping; Chen, Sheng; Zhang, Ye; Ni, Qing-Ling; Pan, Ying-Ming; Hong, Xue; Peng, Yan; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 226 – 236;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 49764-63-8, The chemical industry reduces the impact on the environment during synthesis 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, I believe this compound will play a more active role in future production and life.

General procedure: Furoin 2 (1.0 mmol, 192 mg) and o-phenylenediamines(1.0 mmol) were dissolved in 3mL H2O. Amberlyst-15 (100 mg)wasadded, the mixture was then heated to reflux for 10 h and cooled toroom temperature. Ethyl acetate (10 mL) was added, the organicphase was washed with water (3 x 10 mL), dried over MgSO4, andconcentrated. The crude products were purified by column chromatography,affording 3a-h and Hit-01.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,5-Dibromobenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Ning; Yu, Zhimei; Yang, Xiaohong; Zhou, Yan; Tang, Qing; Hu, Ping; Wang, Jia; Zhang, Shao-Lin; Wang, Ming-Wei; He, Yun; European Journal of Medicinal Chemistry; vol. 157; (2018); p. 37 – 49;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 49764-63-8, Recommanded Product: 49764-63-8

Add to a pre-dried 100ml two-necked bottle, Triphenylamine 4-boronic acid (773mg),4,5-Dibromo-o-diaminobenzene (138 mg), Pd(PPh3)2Cl2 (40 mg), K2CO3 (424 mg). After nitrogen protection, 30 ml of toluene and 2 ml of deionized water were added, the temperature was raised to 80 C, and the reaction was carried out for 24 hours. After the reaction, the mixture was washed and extracted with dichloromethane and water several times. The organic phase was collected, dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and then purified by column chromatography. 200-300 mesh silica gel was used as a stationary phase, and a dichloromethane / petroleum ether volume ratio 3: 1 mixture was used as a mobile phase to elute. The eluate containing the target compound was collected, and the solvent was distilled off under reduced pressure and dried. 488 mg of pink solid was obtained by thin layer chromatography with a yield of 82%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4,5-Dibromobenzene-1,2-diamine, and friends who are interested can also refer to it.

Reference:
Patent; Zhejiang University of Technology; Li Weijun; Xu Ning; Chen Zhangxin; Zhang Cheng; (14 pag.)CN110713493; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 49764-63-8, name is 4,5-Dibromobenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C6H6Br2N2

To a solution of methyl (S)-4-(2-(2-formylbenzoyl)-5,5,8a-trimethyl-1,2,3,5,8,8a- hexahydroisoquinolin-6-yl)benzoate (50 mg, 0.113 mmol) and 4,5-dibromobenzene-1,2- diamine (30 mg, 0.113 mmol) in DMF (2 ml) was added sodium metabisulfite (24 mg, 0.124 mmol). The mixture was stirred at 60 C overnight. The mixture was concentrated in vacuo. The residue was partitioned between EtOAc (20 ml) and H2O (20 ml). The separated aqueous layer was extracted with EtOAc (20 ml). The combined organic layers were washed brine (20 ml), dried over Na2S04, and concentrated in vacuo. The crude product was purified by silica gel column eluted with 35 % EtOAc / hexanes to give the desired product (62 mg, 80 %) as a solid. LC/MS m/z 688.10 (M+H)+, 2.91 min (Method 2).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 49764-63-8.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; CHEN, Jie; MEANWELL, Nicholas A.; REGUEIRO-REN, Alicia; SIT, Sing-Yuen; SWIDORSKI, Jacob; (267 pag.)WO2018/2848; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary