Adding some certain compound to certain chemical reactions, such as: 461-96-1, name is 1-Bromo-3,5-difluorobenzene, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 461-96-1. 461-96-1
Under a nitrogen atmosphere, 2,2,6,6-tetramethylpiperidine (7.3 g) was dissolved in THF (30 mL) and cooled to -70 C. or lower.To the solution, a 1.6 M butyl lithium / hexane solution (32 mL) was added dropwise at a rate such that the internal temperature did not reach -65 C. and then stirred at -70 C. or lower for 30 min.Subsequently, a solution prepared by dissolving 3,5-difluorobromobenzene (10 g) in THF (50 mL) was added dropwise to the stirring reaction solution at a rate such that the internal temperature did not exceed -65 C., At room temperature for 1 hour to prepare phenyllithiums.In a separate reaction vessel, difluorodibromomethane (16.3 g) was dissolved in THF (160 mL)The dissolved solution was cooled to -70 C. or lower, and a solution of phenyllithium prepared in advance was added to the solution using a cannula, followed by stirring at -70 C. or lower for 1 hour, then cooled to room temperature .Water and hexane were added to the reaction solution to separate the organic layer, and the organic layer was washed twice with saturated brine.Sodium sulfate was added to the organic layer after washing and dried, the solvent was distilled off under reduced pressure, and the residue was purified by silica gel column chromatography to obtain 4-bromo-2,6-difluoro- (bromodifluoromethyl) benzene and 1,4 – dibromo-2,6-difluorobenzene (13.7 g).When the ratio of each compound in the mixture was measured by gas chromatography,81.6% of 4-bromo-2,6-difluoro- (bromodifluoromethyl) benzene and 18.4% of 1,4-dibromo-2,6-difluorobenzene.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1-Bromo-3,5-difluorobenzene.
Reference:
Patent; DIC Corporation; Tojo, Kenta; Kusumoto, Tetsuo; Takatsu, Haruyoshi; (11 pag.)JP6047884; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary