Category: 460-00-4

Electric Literature of 460-00-4,Some common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Carbazole (5.03 g, 30.1 mmol), 1-Fluoro-4-bromobenzene (14.0 mL, 127 mmol) and Cs2CO3 (39.9 g, 122 mmol) were added to 100 mL of DMF under nitrogen gas, and the mixture was stirred at room temperature for 16 hours. After the reaction mixture was cooled to room temperature and filtered under reduced pressure, the filtrate was washed with distilled water (100 mL X 3) and extracted with EtOAc (100 mL X 3). The organic layer was dried with MgSO 4, filtered under reduced pressure, and the solvent was removed. The reaction mixture was separated by Silica column chromatography (Hexanes ? Hexane: DCM (dichloromethane) = 1: 1) and recrystallized with DCM / MeOH to give 6.42 g (yield: 66%) of pure compound 1-3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-fluorobenzene, its application will become more common.

Reference:
Patent; LG Display Co., Ltd.; Yoon Dae-w; Seo Bo-min; Ryu Mi-sang; Kim Chun-gi; (39 pag.)KR2019/68072; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 460-00-4, A common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: An oven-dried Schlenk tube was charged with CuI (4 mg, 0.02 mmol), aryl bromide (1 mmol), L10 (9 mg, 0.04 mmol) and CsOH (504 mg, 3 mmol) (or KOH (168 mg, 3 mmol)). The tube was evacuated and backfilled with argon, and then DMSO (1 mL), t-BuOH (1 mL) and H2O (0.1 mL) were added. The reaction mixture was stirred at indicated temperatures until the starting material was completely converted (monitored by TLC). The cooled solution mixture was acidified to pH = 1-2 with 2 N HCl, and then extracted with EtOAc. The combined organic layers were washed with H2O and brine, dried over Na2SO4. After removal of the solvent in vacuo, the residue was purified with flash chromatography to give the corresponding phenol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Jia, Jianhuan; Jiang, Chenglin; Zhang, Xiaojing; Jiang, Yongwen; Ma, Dawei; Tetrahedron Letters; vol. 52; 43; (2011); p. 5593 – 5595;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 460-00-4, name is 1-Bromo-4-fluorobenzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-4-fluorobenzene

Synthesis of compound 42C10H7FS M = 178.23 g.mol”1 19F NMR (CDCh 282.5MHz): -109.8 (m, IF, Ar-F).Mass (GC-MS): 133 (41%); 178 (100%)Into a freshly degassed mixture of EtOH (69mL) and H20 (9mL) was added Pd2dba3 (534mg, 0.58mmol, 0.025eq), PCy3 (660mg, 2.35mmol, O.leq), 2-thiophene boronic acid (3.00g, 23.4mmol, leq), K2C03 (6.48g, 46.9mmol, 2eq), and 4- bromofluorobenzene (5.17mL, 47.0mmol, 2eq). The resultant mixture was stirred overnight at 90C and then allowed to reach room temperature. MgS04 was added to quench water and the mixture was filtered on a pad of Celite using ethyl acetate. The filtrate was concentrated and purified on silica gel chromatography (cyclohexane/ ethyl acetate 100:0 to 95:5) to afford compound 42 (3.84g, 92% yield) as a white solid.

The synthetic route of 460-00-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig; WO2012/160218; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-4-fluorobenzene

The reaction of 1-bromo-4-fluorobenzene(0.175 g, 1.0 mmol), aniline (0.093 g, 1.0 mmol), copper powder (0.0064 g, 0.1mmol), MI (0.036 g, 0.2 mmol), Cs2CO3 (0.720 g, 2.2 mmol), TBAHS (0.068 g, 0.2mmol) produced 0.148 g (79%) of 4-fluoro-N-phenylaniline as a brown oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 460-00-4, its application will become more common.

Reference:
Article; Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Chen, Guoliang; Tetrahedron Letters; vol. 60; 29; (2019); p. 1938 – 1941;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 460-00-4,Some common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

30 g (0.26 mol) of indole in a 250 mL round bottom flaskAnd 44.8 g (0.26 mol) of 4-fluorobromobenzene,Potassium fluorine 29.8 g (0.51 mol),1.35 g (5 mmol) of 18-crown-6 and 300 ml of dimethyl sulfoxide were added and refluxed for 24 hours.After the reaction was completed, the reaction mixture was cooled to room temperature, extracted, and the organic layer was concentrated under reduced pressure, separated by column chromatography using hexane and ethyl acetate, and dried to obtain 47.6 g (68.3%) of the compound represented by Chemical Formula 11-a.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-fluorobenzene, its application will become more common.

Reference:
Patent; SFC Ltd.; Che Jong-tae; Jeong Seong-uk; Park Ji-hui; Ryu Yeon-gwon; (47 pag.)KR101996648; (2019); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 460-00-4, name is 1-Bromo-4-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 460-00-4, Recommanded Product: 460-00-4

Under nitrogen protection,Add carbazole (5 g, 30 mmol) to a 250 mL single-necked flask,P-fluorobromobenzene (10.47g, 60mmol),Cesium carbonate (21.5 g, 62 mmol) was mixed in dimethyl sulfoxide DMSO (100 mL).Reacted at 160 C for 48 hours,Cool to room temperature, extract with dichloro/water solution, and pass through the column with dichloromethane/petroleum ether.After drying in vacuo, 7.7 g of white crystals were obtained.The yield was 80%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-fluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; Jilin University; Zhang Ming; Zhang Zhaoxia; (27 pag.)CN109988097; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 460-00-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-00-4, name is 1-Bromo-4-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of a fluorinated aryl halide (2.0 mmol), a carbazole (0.5 mmol), and a base (2.0 mmol) in solvent (2 mL) was allowed to react under air atmosphere. The reaction mixture was heated to the specified temperature for 24 h. After reaction completion, the mixture was added to brine (15 mL) and extracted with CH2Cl2 (3 × 15 mL). The combined extract was concentrated under reduced pressure and the product was isolated by short chromatography on a silica gel (200-300 mesh) column.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-fluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Wang, Lei; Ji, Enhui; Liu, Ning; Dai, Bin; Synthesis; vol. 48; 5; (2016); p. 737 – 750;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 460-00-4, name is 1-Bromo-4-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 460-00-4, Product Details of 460-00-4

General procedure: A 10 mL vial was charged with CuI (9.5 mg, 0.05 mmol), PSAP (30 mg,0.05 mmol, > 100 mesh), K3PO4 (424 mg, 2 mmol), aryl bromides (1mmol), amines (1.5 mmol), DEG (2 mL), and a magnetic stir bar. The vessel was sealed with a septum and placed into a preheated oil batchat 70 C. The reaction mixture was held at this temperature for 14 hours. After cooling to r.t., the reaction mixture was filtered, and the precipitates were thoroughly washed with water and EtOAc (3 × 20mL). The combined organic phases were washed with water and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. Theresidue was purified using flash column chromatography on silica gel(eluting with petroleum ether/EtOAc) to afford the desired products.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Yi, Zhou; Huang, Manna; Wan, Yiqian; Zhu, Xinhai; Synthesis; vol. 50; 19; (2018); p. 3911 – 3920;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 460-00-4,Some common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Carbazole (5.03 g, 30.1 mmol), 1-Fluoro-4-bromobenzene (14.0 mL, 127 mmol) and Cs2CO3 (39.9 g, 122 mmol) were added to 100 mL of DMF under nitrogen gas, and the mixture was stirred at room temperature for 16 hours. After the reaction mixture was cooled to room temperature and filtered under reduced pressure, the filtrate was washed with distilled water (100 mL X 3) and extracted with EtOAc (100 mL X 3). The organic layer was dried with MgSO 4, filtered under reduced pressure, and the solvent was removed. The reaction mixture was separated by Silica column chromatography (Hexanes ? Hexane: DCM (dichloromethane) = 1: 1) and recrystallized with DCM / MeOH to give 6.42 g (yield: 66%) of pure compound 1-3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-fluorobenzene, its application will become more common.

Reference:
Patent; LG Display Co., Ltd.; Yoon Dae-w; Seo Bo-min; Ryu Mi-sang; Kim Chun-gi; (39 pag.)KR2019/68072; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 460-00-4, name is 1-Bromo-4-fluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H4BrF

General procedure: A solution of precatalyst 2 (9.0 mg, 0.01 mmol, 1.0 mol%) in dry THF (1.5 mL) was stirred for 5 min at ambient temperature under N2. Then, bromobenzene (157 mg, 1.0 mmol) was added via syringe and the solution stirred for 5 min. Thereafter, 4-methoxyphenyl boronic acid (167 mg, 1.1 mmol) was added along with Na2CO3 (1 M (aqueous), 1 mL), and the resulting solution was stirred at 60 C for 3 h. At ambient temperature, aqueous H2O (10 mL) was added and the organic layer was extracted with EtOAc (3 x 10 mL). The combined organic layers were concentrated in vacuo and the remaining residue was purified by column chromatography (n-hexane/EtOAc: 200/1) to yield 4-Methoxybiphenyl (160 mg, 87%) as a colorless solid

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 460-00-4.

Reference:
Article; Shah, Parin; Santana, M. Dolores; Garcia, Joaquin; Serrano, J. Luis; Naik, Minal; Pednekar, Suhas; Kapdi, Anant R.; Tetrahedron; vol. 69; 5; (2013); p. 1446 – 1453;,
Bromide – Wikipedia,
bromide – Wiktionary